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Use Of Coarse Ethylcellulose And PEO In Beads Produced By Extrusion-spheronization.

R. Mallipeddi, Kalyan K. Saripella, S. Neau
Published 2010 · Materials Science, Medicine

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This study evaluated the potential of coarse ethylcellulose (CPEC) and high molecular weight polyethylene oxide (PEO) as excipients in the production of beads by extrusion-spheronization. CPEC was investigated as a diluent and PEO as an extrusion aid and a binder. Beads were manufactured with caffeine as a model drug. Release studies were conducted, and the bead size, shape, yield, and friability were determined. The effects of formulation and process variables and their interactions were studied by a sequential experimental design based on a response surface method. In the initial stage, a two level half fractional factorial design was employed as a screening design, which was subsequently augmented to a central composite design. Statistical analysis indicated that formulation variables including PEO content, microcrystalline cellulose (MCC) content, and water content, and two process variables, namely spheronizer speed and spheronization time, significantly affected the properties of the beads. Interactions between two factors have significant effects on several of the measured responses. Simultaneous optimization of the responses was conducted and validated by performing experiments at the optimal conditions. Overall, the results confirmed that immediate release, spherical beads with low friability and narrow size distribution could be produced with minimal amounts of MCC.
This paper references
10.1016/S0378-5173(99)00402-0
High molecular weight polyethylene oxides (PEOs) as an alternative to HPMC in controlled release dosage forms.
L. Maggi (2000)
10.3109/03639049809082366
Effects of drug solubility, drug loading, and polymer molecular weight on drug release from Polyox tablets.
C. J. Kim (1998)
10.1002/JPS.2600580504
Degradation mechanisms for water-soluble drugs in solid dosage forms.
J. Carstensen (1969)
10.1016/j.ejpb.2008.05.032
Extended release of a large amount of highly water-soluble diltiazem hydrochloride by utilizing counter polymer in polyethylene oxides (PEO)/polyethylene glycol (PEG) matrix tablets.
H. Kojima (2008)
10.1016/j.ejpb.2008.08.020
Immediate release pellets with lipid binders obtained by solvent-free cold extrusion.
J. Krause (2009)
Solid state interactions of two new antineoplastic drugs (mitonafide and amonafide) and common tablet excipients in preformulation studies
A. I. Torres (1994)
10.1081/PDT-100101375
Importance of the fraction of microcrystalline cellulose and spheronization speed on the properties of extruded pellets made from binary mixtures.
P. Kleinebudde (1999)
10.1080/00224065.1980.11980968
Simultaneous optimization of several response variables
G. Derringer (1980)
10.1016/J.IJPHARM.2005.09.021
PEO and MPEG in high drug load extruded and spheronized beads that are devoid of MCC.
M. Howard (2006)
10.1016/0378-5173(94)00311-R
Extrusion-spheronisation A literature review
C. Vervaet (1995)
High molecular weight polyethylene oxides ( PEOs ) asanalternative toHPMCincontrolled releasedosage forms
L. Maggi
10.3109/03639049309063205
A Factorial Approach to High Dose Product Development by an Extrusion/Spheronization Process
G. A. Hileman (1993)
10.3109/03639049309069323
Bead manufacture by extrusion/spheronization - a statistical design for process optimization
Cathy C. Ku (1993)
10.1081/PDT-120030250
Extruded and Spheronized Beads Containing No Microcrystalline Cellulose: Influence of Formulation and Process Variables
A. Agrawal (2004)
10.1016/J.EJPB.2005.10.003
Use of kappa-carrageenan as alternative pelletisation aid to microcrystalline cellulose in extrusion/spheronisation. II. Influence of drug and filler type.
M. Thommes (2006)
10.1081/PDT-100101387
Formulation of ranitidine pellets by extrusion-spheronization with little or no microcrystalline cellulose.
A. Basit (1999)
10.1208/pt0802050
Stabilization of hot-melt extrusion formulations containing solid solutions using polymer blends
S. Prodduturi (2008)
10.1016/j.ejpb.2008.08.005
Production of pellets via extrusion-spheronisation without the incorporation of microcrystalline cellulose: a critical review.
A. Dukić-Ott (2009)
10.1016/0378-5173(94)00288-G
Consolidation of ethylcellulose: Effect of particle size, press speed, and lubricants
Pruthvipathy R. Katikaneni (1995)
10.1016/J.EJPS.2006.11.020
The preparation of pellets containing a surfactant or a mixture of mono- and di-gylcerides by extrusion/spheronization.
J. M. Newton (2007)
10.3109/03639048609048032
Compatibility Study Between Clenbuterol and Tablet Excipients Using Differential Scanning Calorimetry
E. C. Signoretti (1986)
10.3109/03639048809151962
The Effect of Selected Direct Compression Excipients on the Stability of Aspirin as a Model Hydrolyzable Drug
N. K. Patel (1988)
Consolidationof ethylcellulose : effect ofparticle size , press speedand lubricants
P. R. atikaneni
10.1016/S0142-9612(01)00223-X
Dissolution behaviour of hydrophilic matrix tablets containing two different polyethylene oxides (PEOs) for the controlled release of a water-soluble drug. Dimensionality study.
L. Maggi (2002)
10.1016/0378-5173(96)04599-1
Effects of polymer particle size, compaction pressure and hydrophilic polymers on drug release from matrices containing ethylcellulose
M. A. Dabbagh (1996)
10.3109/10837459709022608
Drug solubility effects on predicting optimum conditions for extrusion and spheronization of pellets.
G. A. Hileman (1997)
10.1016/S0939-6411(02)00048-6
Pectinic acid, a novel excipient for production of pellets by extrusion/spheronisation: preliminary studies.
I. Tho (2002)
The influence of spheronizer load in extrusion – spheronization
J. P. arrau (1993)
10.1002/JPS.20855
Use of chitosan-alginate as alternative pelletization aid to microcrystalline cellulose in extrusion/spheronization.
N. Charoenthai (2007)
10.3109/03639049409041966
Investigation into the yellowing on aging of sabril® tablet cores
Ron C. George (1994)
10.1016/S0378-5173(00)00418-X
Influence of vitamin E TPGS on the properties of hydrophilic films produced by hot-melt extrusion.
M. Repka (2000)
10.1208/ps060215
Evaluation of the potential use of poly(ethylene oxide) as tablet- and extrudate-forming material
J. F. Pinto (2008)
10.1016/0142-9612(93)90215-N
Poly(ethylene oxide) (PEO) and different molecular weight PEO blends monolithic devices for drug release.
A. Apicella (1993)
10.1021/JS960039V
Characterization of compressibility and compactibility of poly(ethylene oxide) polymers for modified release application by compaction simulator.
L. Yang (1996)
10.1023/A:1012166809583
The Crystallite-Gel-Model for Microcrystalline Cellulose in Wet-Granulation, Extrusion, and Spheronization
P. Kleinebudde (2004)
10.1002/JPS.2600841003
Approaches for improving the stability of ketorolac in powder blends.
M. Brandl (1995)
10.1016/j.ijpharm.2008.01.002
Dissolution kinetics and physical characterization of three-layered tablet with poly(ethylene oxide) core matrix capped by Carbopol.
Sung In Hong (2008)
Extrusion – spheronization : a literature review
A. I. Torres
10.1021/JS950524A
Evaluation, by a statistically designed experiment, of an experimental grade of microcrystalline cellulose, Avicel 955, as a technology to aid the production of pellets with high drug loading.
I. Jover (1996)
10.1016/0378-5173(95)00060-V
Ethylcellulose matrix controlled release tablets of a water-soluble drug
Pruthvipathy R. Katikaneni (1995)



This paper is referenced by
Non Mcc Polymer as a Pelletisation Aid: A Review
B. Rajveer (2015)
Fabrication of solid dispersion based patches using hot melt injection moulding and fused deposition modelling 3D printing
Muqdad Alhijjaj (2017)
10.1016/J.INDCROP.2012.09.014
Design of Pistacia lentiscus (mastic gum) controlled release spheroids and investigating the influence of roll compaction
R. D. Deshpande (2013)
10.3390/pharmaceutics9030023
Effect of Polymers on the Physicochemical Properties and Biological Performance of Fenoprofen Calcium Dihydrate-Triacetyl-β-Cyclodextrin Complex
H. Ammar (2017)
10.3109/03639045.2012.707207
Preparation and characterization and release properties of Eudragit RS based ibuprofen pellets prepared by extrusion spheronization: effect of binder type and concentration
H. A. Garekani (2013)
10.4333/KPS.2010.40.S.001
Pharmaceutical Usefulness of Biopharmaceutics Classification System: Overview and New Trend
Y. Youn (2010)
10.1080/10837450.2016.1265556
Approaches to developing fast release pellets via wet extrusion-spheronization
Y. Xia (2018)
10.1016/S1773-2247(14)50095-0
Evaluation of Dis-Lub-Tout, a new co-processed tabletting excipient I. Study of physicochemical properties
S.A.S. Aly (2014)
10.4333/KPS.2010.40.S.103
Controlled-Release Pelletized Dosage Forms Using the Extrusion-Spheronization Process
Yun-Seok Rhee (2010)
10.1080/08982104.2017.1327541
Tri-block co-polymer nanocarriers for enhancement of oral delivery of felodipine: preparation, in vitro characterization and ex vivo permeation
Sinar Sayed (2018)
Development of vitamin C and E fixed-dose combination, multiple-unit, solid oral delivery systems
J. J. Bezuidenhout (2019)
10.1016/j.ijpharm.2016.11.067
The use of partially hydrolysed polyvinyl alcohol for the production of high drug-loaded sustained release pellets via extrusion-spheronisation and coating: In vitro and in vivo evaluation.
G. Verstraete (2017)
10.3109/03639045.2010.482590
Alternative extrusion–spheronization aids
S. Jain (2010)
10.1016/j.jsps.2013.11.001
Use of fine particle ethylcellulose as the diluent in the production of pellets by extrusion-spheronization.
R. Mallipeddi (2014)
10.22038/ijbms.2017.8086
Evaluation of ethylcellulose and its pseudolatex (Surelease) in preparation of matrix pellets of theophylline using extrusion-spheronization
H. A. Garekani (2017)
10.1517/17425247.2016.1166202
Combined mixture-process variable approach: a suitable statistical tool for nanovesicular systems optimization
Basant A Habib (2016)
DESIGN AND EVALUATION OFCARBOXYMETHYL TAMARIND KERNEL POLYSACCHARIDE (CMTKP) CONTROLLED RELEASE SPHEROIDS/PELLETS AND INVESTIGATING THE INFLUENCE OF COMPRESSION
D. Vishakant Gowda (2014)
10.1080/03639045.2020.1826509
Fabrication and evaluation of fast disintegrating pellets of cilostazol
Udit Arora (2020)
Partially hydrolyzed polyvinyl alcohol as functional excipient in oral solid dosage forms prepared via extrusion
W. D. Jaeghere (2016)
10.1080/03639045.2017.1405975
Use of extrusion aids for successful production of Kollidon® CL-SF pellets by extrusion–spheronization
N. Loka (2018)
10.1080/03639045.2016.1261150
Preparation and physicochemical characterization of matrix pellets containing APIs with different solubility via extrusion process
Diána Hegyesi (2017)
10.7324/japs.2013.3917
A Novel Directly Compressible Co-Processed Excipient for Sustained Release Formulation
A. Gangurde (2013)
10.1517/17425247.2011.605120
Developing oral drug delivery systems using formulation by design: vital precepts, retrospect and prospects
B. Singh (2011)
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