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Preparation Of Polymeric Nanoparticles Of Cyclosporin A Using Infrared Pulsed Laser.
G. Takebe, T. Takagi, M. Suzuki, M. Hiramatsu
Published 2011 · Materials Science, Medicine
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Nanoparticle formation of poorly water-soluble drugs is a means of providing much benefit for improving solubility and bioavailability. We showed that laser irradiation of drugs can be a novel tool for dispersing drug nanoparticles in water. Using our method, we were able to produce nanoparticles containing immunosuppressant drug, cyclosporin A, which shows poor solubility toward water, with high levels of the drug using polyvinyl pyrrolidone and sodium dodecyl sulfate as stabilizing agents. The absence of degradation products was confirmed and the loss of pharmaceutical activity with an inhibitory effect on the interleukin-2 production of Jurkat T cells did not occur. Cyclosporin A nanoparticles showed a spherical shape and their particle size was distributed uniformly around 200 nm. Powder X-ray diffraction analysis suggested that cyclosporin A in the nanoparticles was in an amorphous state. In the measurement of solubility rate, the nanoparticle formulation showed a higher rate than that which had not been processed. At present, although this laser irradiation technology has low productivity, it is expected as a new technology for drug nanoparticle manufacturing together with the development of a new laser device.
This paper references
Bioavailability and pharmacokinetics of cyclosporine A-loaded pH-sensitive nanoparticles for oral administration.
Xue-qing Wang (2004)
Substrate selectivity and sensitivity to inhibition by FK506 and cyclosporin A of calcineurin heterodimers composed of the alpha or beta catalytic subunit.
B. A. Perrino (2002)
Oral bioavailability of cyclosporine: solid lipid nanoparticles (SLN) versus drug nanocrystals.
R. Mueller (2006)
Challenges and solutions for the delivery of biotech drugs--a review of drug nanocrystal technology and lipid nanoparticles.
R. H. Muller (2004)
Lab-scale production unit design for nanosuspensions of sparingly soluble cytotoxic drugs.
Nanoparticle formation of poorly water-soluble drugs from ternary ground mixtures with PVP and SDS.
K. Itoh (2003)
Chemical and Structural Properties of Drug–protein Nanocomposites Prepared by Pulsed Laser Deposition from Conjugated Targets
S. Nagare (2006)
The effect of particle size distribution on dissolution rate and oral absorption
R. J. Hintz (1989)
Nanosizing: a formulation approach for poorly-water-soluble compounds.
E. Merisko-Liversidge (2003)
Laser fabrication and spectroscopy of organic nanoparticles.
T. Asahi (2008)
Excipient-drug interactions in parenteral formulations.
M. Akers (2002)
Solubility and mass and nuclear magnetic resonance spectroscopic studies on interaction of cyclosporin A with dimethyl-alpha- and -beta-cyclodextrins in aqueous solution.
K. Miyake (1999)
Indomethacin nanoparticles directly deposited on the fluidized particulate excipient by pulsed laser deposition
S. Nagare (2004)
Improved oral absorption of a poorly water-soluble drug, HO-221, by wet-bead milling producing particles in submicron region.
N. Kondo (1993)
Solid dispersion of poorly water-soluble drugs: early promises, subsequent problems, and recent breakthroughs.
A. T. Serajuddin (1999)
Cyclosporin: use outside transplantation.
A. Thomson (1991)
pH-sensitive nanoparticles for improving the oral bioavailability of cyclosporine A.
Jundong Dai (2004)
Solubility and Mass and Nuclear Magnetic Resonance Spectroscopic Studies on Interaction of Cyclosporin A with Dimethyl‐α‐ and ‐β‐Cyclodextrins in Aqueous Solution
K. Miyake (1999)
Inhibition of T‐Cell Activity by Cyclosporin A
L. Andrus (1981)
Drug-like properties and the causes of poor solubility and poor permeability.
C. Lipinski (2000)
The mechanisms of drug release from solid dispersions in water-soluble polymers.
D. Craig (2002)
Cyclosporin: an updated review of the pharmacokinetic properties, clinical efficacy and tolerability of a microemulsion-based formulation (neoral)1 in organ transplantation.
C. Dunn (2001)
Differential effect of cyclosporin A on activation signaling in human T cell lines
B. anger (1986)
The role of solid nanoparticle technology in the parenteral delivery of poorly water-soluble drugs.
J. Kipp (2004)
Cremophor EL: the drawbacks and advantages of vehicle selection for drug formulation.
H. Gelderblom (2001)
Nanocarriers: promising vehicle for bioactive drugs.
M. Rawat (2006)
Can the pharmaceutical industry reduce attrition rates?
I. Kola (2004)
Differential effect of cyclosporin A on activation signaling in human T cell lines.
B. Manger (1986)
Amorphous pharmaceutical solids: preparation, characterization and stabilization.
L. Yu (2001)
Micelles of methoxy poly(ethylene oxide)-b-poly(epsilon-caprolactone) as vehicles for the solubilization and controlled delivery of cyclosporine A.
H. M. Aliabadi (2005)
Multi-morphological biodegradable PLGE nanoparticles and their drug release behavior.
Hanwei Zhang (2009)
Particle size analysis of nanocrystals: improved analysis method.
C. Keck (2010)
Pharmaceutical innovation by the seven UK-owned pharmaceutical companies (1964-1985).
R. A. Prentis (1988)
Positively charged nanoparticles for improving the oral bioavailability of cyclosporin-A.
M. H. El-Shabouri (2002)
Solid lipid nanoparticles: production, characterization and applications.
W. Mehnert (2001)
Cyclosporine: a new immunosuppressive agent for organ transplantation.
D. Cohen (1984)
Improved Dose Linearity of Cyclosporine Pharmacokinetics from a Microemulsion Formulation
E. A. Mueller (2004)
Preparation of glass solutions of three poorly water soluble drugs by spray drying, melt extrusion and ball milling.
James E Patterson (2007)
Substrate selectivity and sensitivity to inhibition by FK506 and cyclosporin A of calcineurin heterodimers composed of the α or β catalytic subunit
B. A. Perrino (2002)
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Formulation and evaluation of novel vancomycin loaded lipidpolymer hybrid nanoparticles for effective antibiotic therapy.
Nasreen. Seedat (2015)
Nanonization of poorly water-soluble drug clobetasone butyrate by using femtosecond laser
Sunqiang Pan (2014)
Recent advancements in mechanical reduction methods: particulate systems
Jardin Leleux (2014)
Polymeric Nanoparticles, Magnetic Nanoparticles and Quantum Dots: Current and Future Perspectives
J. Ali (2012)
Reformulating cyclosporine A (CsA): More than just a life cycle management strategy.
M. Guada (2016)
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