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α-Tocopherol Succinate-modified Chitosan As A Micellar Delivery System For Paclitaxel: Preparation, Characterization And In Vitro/in Vivo Evaluations.

N. Liang, Shaoping Sun, X. Li, H. Piao, Hongyu Piao, F. Cui, Liang Fang
Published 2012 · Chemistry, Medicine

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α-Tocopherol succinate hydrophobically modified chitosan (CS-TOS) containing 17 α-tocopherol groups per 100 anhydroglucose units was synthesized by coupling reaction. The formation of CS-TOS was confirmed by (1)H NMR and FT-IR analysis. In aqueous medium, the polymer could self-aggregate to form micelles, and the critical micelle concentration (CMC) was determined to be 5.8 × 10(-3) mg/ml. Transmission electron microscopy (TEM) observation revealed that both bare and paclitaxel-loaded micelles were near spherical in shape. The mean particle size and zeta potential of drug-loaded micelles were about 78 nm and +25.7 mV, respectively. The results of DSC and XRD analysis indicated that paclitaxel was entrapped in the micelles in molecular or amorphous state. In vitro cytotoxicity and hemolysis study revealed the effectiveness and safety of this delivery system, which was further confirmed by the in vivo antitumor evaluations. It can be concluded that the CS-TOS was a potential micellar carrier for paclitaxel.
This paper references
10.1021/LA9907634
Synthesis and the micellar characteristics of poly(ethylene oxide)-deoxycholic acid conjugates
Chulhee Kim (2000)
10.1016/S0378-5173(01)00701-3
The effect of α-tocopherol on the in vitro solubilisation of lipophilic drugs
P. Nielsen (2001)
10.1016/j.ejpb.2008.04.016
Mixed PEG-PE/vitamin E tumor-targeted immunomicelles as carriers for poorly soluble anti-cancer drugs: improved drug solubilization and enhanced in vitro cytotoxicity.
R. Sawant (2008)
10.1021/JF040188W
Linolenic acid-modified chitosan for formation of self-assembled nanoparticles.
C. Liu (2005)
10.1016/S0168-3659(97)00173-9
Preparation of chitosan self-aggregates as a gene delivery system.
K. Lee (1998)
10.1007/s11095-006-9132-0
Micellar Nanocarriers: Pharmaceutical Perspectives
V. Torchilin (2006)
10.1021/JF0208482
O/W emulsification for the self-aggregation and nanoparticle formation of linoleic acid-modified chitosan in the aqueous system.
Xueynn Chen (2003)
10.1021/LA971362W
Detection of intramolecular associations in hydrophobically modified pectin derivatives using fluorescent probes
A. Fischer (1998)
10.1016/S0142-9612(00)00126-5
Application of chitosan-based polysaccharide biomaterials in cartilage tissue engineering: a review.
Jung Kee Suh (2000)
10.1016/j.ejpb.2010.04.017
Enhanced antitumor efficacy by paclitaxel-loaded pluronic P123/F127 mixed micelles against non-small cell lung cancer based on passive tumor targeting and modulation of drug resistance.
Wei Zhang (2010)
10.1016/j.ijpharm.2010.05.001
Synthesis and characterization of low-toxic amphiphilic chitosan derivatives and their application as micelle carrier for antitumor drug.
Meirong Huo (2010)
10.1016/S0927-7765(99)00067-3
Development of copolymers of poly(d,l-lactide) and methoxypolyethylene glycol as micellar carriers of paclitaxel
H. Burt (1999)
10.1016/j.biomaterials.2009.11.038
Polymeric micelles for the pH-dependent controlled, continuous low dose release of paclitaxel.
Adam W G Alani (2010)
10.1016/S0168-3659(99)00248-5
Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review.
H. Maeda (2000)
10.1016/J.COLSURFB.2006.04.009
Shell cross-linked stearic acid grafted chitosan oligosaccharide self-aggregated micelles for controlled release of paclitaxel.
F. Hu (2006)
10.1016/J.BEJ.2005.08.021
Preparation and biocompatibility of chitosan microcarriers as biomaterial
X. Chen (2006)
10.1016/j.colsurfb.2009.07.027
Incorporation methods for cholic acid chitosan-g-mPEG self-assembly micellar system containing camptothecin.
T. Ngawhirunpat (2009)
10.1016/J.COLSURFB.2006.12.006
Preparation and characterization of N-succinyl-N'-octyl chitosan micelles as doxorubicin carriers for effective anti-tumor activity.
Xu Xiang-yang (2007)
10.1016/S0169-409X(96)00401-2
Polymeric micelles as new drug carriers
G. Kwon (1996)
10.1021/LA00092A038
Fluorescence probe techniques used to study micelle formation in water-soluble block copolymers
C. Zhao (1990)
10.1016/J.BIOMATERIALS.2005.05.042
Polymeric micelles for the solubilization and delivery of cyclosporine A: pharmacokinetics and biodistribution.
H. M. Aliabadi (2005)
10.1016/J.COLSURFB.2004.09.002
Self-assembly and characterization of paclitaxel-loaded N-octyl-O-sulfate chitosan micellar system.
C. Zhang (2004)
10.1016/J.EJPB.2007.09.018
Cellular uptake and cytotoxicity of shell crosslinked stearic acid-grafted chitosan oligosaccharide micelles encapsulating doxorubicin.
F. Hu (2008)
10.1016/j.ejps.2009.01.004
PEG conjugated N-octyl-O-sulfate chitosan micelles for delivery of paclitaxel: in vitro characterization and in vivo evaluation.
Guowei Qu (2009)
10.1016/S0168-3659(99)00133-9
Doxorubicin-loaded poly(ethylene glycol)-poly(beta-benzyl-L-aspartate) copolymer micelles: their pharmaceutical characteristics and biological significance.
K. Kataoka (2000)
10.1021/JA00449A004
Environmental effects on vibronic band intensities in pyrene monomer fluorescence and their application in studies of micellar systems
K. Kalyanasundaram (1977)
10.1016/j.ejpb.2009.06.015
Novel self-assembling PEG-p-(CL-co-TMC) polymeric micelles as safe and effective delivery system for paclitaxel.
F. Danhier (2009)
10.1016/S0168-3659(97)00136-3
Mucoadhesive polymers as platforms for peroral peptide delivery and absorption: synthesis and evaluation of different chitosan-EDTA conjugates.
A. Bernkop-Schnürch (1998)
10.1021/JS9605226
Solid-state characterization of paclitaxel.
R. Liggins (1997)
10.1016/S0959-8049(01)00171-X
Cremophor EL: the drawbacks and advantages of vehicle selection for drug formulation.
H. Gelderblom (2001)
10.1016/S0378-5173(01)00986-3
Paclitaxel and its formulations.
A. K. Singla (2002)



This paper is referenced by
10.2147/IJN.S213084
Vitamin E succinate-grafted-chitosan/chitosan oligosaccharide mixed micelles loaded with C-DMSA for Hg2+ detection and detoxification in rat liver
B. Wei (2019)
10.1039/c3nr33430a
Single-cell resolution diagnosis of cancer cells by carbon nanotube electrical spectroscopy.
M. Abdolahad (2013)
10.1007/s00396-015-3736-z
Self-assembly and paclitaxel loading capacity of α-tocopherol succinate-conjugated hydroxyethyl cellulose nanomicelle
Y. Guo (2015)
10.18632/oncotarget.13757
Novel amphiphilic folic acid-cholesterol-chitosan micelles for paclitaxel delivery
Li-chun Cheng (2017)
10.2147/IJN.S103556
Vitamin E succinate-conjugated F68 micelles for mitoxantrone delivery in enhancing anticancer activity
Y. Liu (2016)
10.1016/j.foodchem.2014.05.120
Development of chitosan/montmorillonite nanocomposites with encapsulated α-tocopherol.
M. V. Dias (2014)
10.2147/IJN.S43555
Application of the central composite design to optimize the preparation of novel micelles of harmine
Yong-yan Bei (2013)
10.1016/j.ejps.2014.06.022
A facile approach for crosslinker free nano self assembly of protein for anti-tumor drug delivery: factors' optimization, characterization and in vitro evaluation.
S. Asghar (2014)
10.15259/pcacd.19.18
BIODISTRIBUTION OF DOXORUBICIN-LOADED SUCCINOYL CHITOSAN NANOPARTICLES IN MICE INJECTED VIA INTRAVENOUS OR INTRANASAL ROUTES
A. Zubareva (2014)
10.2147/IJN.S36150
Fabrication and characterization of nuclear localization signal-conjugated glycol chitosan micelles for improving the nuclear delivery of doxorubicin
J. Yu (2012)
10.1016/j.ijpharm.2013.01.046
Development of a novel biocompatible poly(ethylene glycol)-block-poly(γ-cholesterol-L-glutamate) as hydrophobic drug carrier.
Q. Ma (2013)
10.1016/j.foodchem.2012.09.147
Alteration of α-tocopherol-associated protein (TAP) expression in human breast epithelial cells during breast cancer development.
Ka-Wai Tam (2013)
10.1021/acs.molpharmaceut.6b01068
Vitamin E Succinate-Grafted-Chitosan Oligosaccharide/RGD-Conjugated TPGS Mixed Micelles Loaded with Paclitaxel for U87MG Tumor Therapy.
Yanzuo Chen (2017)
10.1016/j.colsurfb.2012.08.062
Nano-formulation of paclitaxel by vitamin E succinate functionalized pluronic micelles for enhanced encapsulation, stability and cytotoxicity.
Youhua Tao (2013)
10.1080/09205063.2016.1236883
In vitro and in vivo evaluation of redox-responsive sorafenib carrier nanomicelles synthesized from poly (acryic acid) -cystamine hydrochloride-D-α-tocopherol succinate
Y. Liu (2016)
10.1155/2014/808703
Chitosan Hydrogels for Chondroitin Sulphate Controlled Release: An Analytical Characterization
A. Bianchera (2014)
10.1016/j.colsurfb.2017.07.019
Therapeutic supermolecular micelles of vitamin E succinate-grafted ε-polylysine as potential carriers for curcumin: Enhancing tumour penetration and improving therapeutic effect on glioma.
He-Lin Xu (2017)
10.1016/j.jpba.2016.11.026
Microfluidic device for label‐free quantitation and distinction of bladder cancer cells from the blood cells using micro machined silicon based electrical approach; suitable in urinalysis assays
S. A. Hosseini (2017)
10.3390/molecules20034337
Bioavailability Enhancement of Paclitaxel via a Novel Oral Drug Delivery System: Paclitaxel-Loaded Glycyrrhizic Acid Micelles
F. Yang (2015)
10.3390/ma8105332
Preparation, Characterization and Evaluation of α-Tocopherol Succinate-Modified Dextran Micelles as Potential Drug Carriers
Jingmou Yu (2015)
10.1016/j.biomaterials.2015.08.035
Tumor-specific penetrating peptides-functionalized hyaluronic acid-d-α-tocopheryl succinate based nanoparticles for multi-task delivery to invasive cancers.
D. Liang (2015)
10.1039/C2JM30290J
Paclitaxel-loaded tocopheryl succinate-conjugated chitosan oligosaccharide nanoparticles for synergistic chemotherapy
Youhua Tao (2012)
10.1007/s11095-018-2382-9
Transferrin-Modified Vitamin-E/Lipid Based Polymeric Micelles for Improved Tumor Targeting and Anticancer Effect of Curcumin
Omkara Swami Muddineti (2018)
10.1007/S11434-013-5733-2
Synthesis and evaluation of methionine and folate co-decorated chitosan self-assembly polymeric micelles as a potential hydrophobic drug-delivery system
Yuqi Chen (2013)
10.1016/J.FOODHYD.2017.05.032
Entrapment and delivery of α-tocopherol by a self-assembled, alginate-conjugated prodrug nanostructure
Fayin Ye (2017)
10.1016/J.CARBPOL.2019.04.024
Biotin and arginine modified hydroxypropyl-β-cyclodextrin nanoparticles as novel drug delivery systems for paclitaxel.
C. Yan (2019)
10.1016/j.ijbiomac.2015.05.062
Development and in vitro/in vivo evaluation of a novel targeted polymeric micelle for delivery of paclitaxel.
J. Emami (2015)
10.1007/s10853-019-03486-9
Biotin-modified bovine serum albumin nanoparticles as a potential drug delivery system for paclitaxel
Danfeng Wang (2019)
10.1016/J.EURPOLYMJ.2014.01.033
Strategies to improve chitosan hemocompatibility: A review
V. Balan (2014)
10.1016/j.msec.2019.110366
Disulfide-cleavage- and pH-triggered drug delivery based on a vesicle structured amphiphilic self-assembly.
Chengqiang Ding (2020)
10.1016/j.ijpharm.2014.09.011
Liprosomes loading paclitaxel for brain-targeting delivery by intravenous administration: in vitro characterization and in vivo evaluation.
B. Tang (2014)
10.3390/polym12020380
A Chitosan-Based Micellar System as Nanocarrier For the Delivery of Paclitaxel
Yang Han (2020)
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