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Formulation And Evaluation Of Cefuroxim Loaded Submicron Particles For Ophthalmic Delivery.

Gabriela Andrei, C. Peptu, M. Popa, J. Desbrières, Cristian Peptu, F. Gardikiotis, M. Costuleanu, D. Costin, J. C. Dupin, A. Uhart, B. Tamba
Published 2015 · Chemistry, Medicine

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Chitosan gelatin particles could be the ideal candidate for intraocular drug delivery due to their desirable properties. Double crosslinking in double emulsion has been used as an original and reliable method for particles preparation and their morphology has been optimized considering the main synthesis parameters such as polymers ratio, crosslinker amount, stirring speed, tensioactive amount and ionic crosslinking time, respectively. The particles have been analyzed for their physical-chemical properties (swelling degree, drug loading and release capacity, surface characteristics, etc.), the enzymatic degradation properties along with in vivo ocular investigations (ocular biodistribution, in vivo drug release). In the present study cefuroxim was used as a model drug, which is generally used in the prophylaxis of postoperative endophthalmitis following cataract surgery after intraocular administration. The present study proved that the dimensions and the physical-chemical properties of the particles can be modulated (by varying the preparation parameters) to facilitate the administration, the biodistribution and the drug release in the specific segment of the eye. This experimental study demonstrated also the ability of fluorescent nanoparticles to penetrate ocular tissues close to the administration site (intravitreal injection) and especially their tendency to migrate deep in the retina at time intervals of 72 h.
This paper references
Preparation and characterisation in simulated body conditions of glutaraldehyde crosslinked chitosan membranes
R. M. Silva (2004)
The effect of thermal burns on the release of collagenase from corneas of vitamin A--deficient and controls rats.
W. L. Seng (1980)
Modified PLA nano in situ gel: a potential ophthalmic drug delivery system.
R. C. Nagarwal (2011)
Human RPE cell lysis of extracellular matrix: functional urokinase plasminogen activator receptor (uPAR), collagenase and elastase.
S. Elner (2003)
Preparation and characterization of chitosan microparticles intended for controlled drug delivery.
J. A. Ko (2002)
Nanosuspensions: A Promising Drug Delivery Strategy
V. Shinde (2010)
Stepwise silver-staining-based immunosorbent assay for amyloid-beta autoantibody detection.
So-Youn Shim (2008)
Mucoadhesive ocular insert based on thiolated poly(acrylic acid): development and in vivo evaluation in humans.
Margit D Hornof (2003)
Recent Applications of Liposomes in Ophthalmic Drug Delivery
G. P. Mishra (2011)
Gelatin-based nanoparticles as drug and gene delivery systems: reviewing three decades of research.
Ahmed O Elzoghby (2013)
Couches minces d'oxynitrure de phosphore. Application aux structures MIS sur InP
D. Quan (1989)
High-Resolution X-Ray Photoemission Spectrum of the Valence Bands of Gold
D. Shirley (1972)
Chitosan Nanoparticles as New Ocular Drug Delivery Systems: In Vitro Stability, in Vivo Fate, and Cellular Toxicity
A. Campos (2005)
NIST-X-ray Photoelectron Spectroscopy Database 20 Version 3.4
C. D. Wagner (2003)
M. Martínez (2006)
Development and characterization of nano-fiber patch for the treatment of glaucoma.
Gagandeep (2014)
Designing Gelatin Nanocarriers as a Swellable System for Controlled Release of Insulin: An In-Vitro Kinetic Study
Shilpi Goswami (2009)
Nano chitosan peptide as a potential therapeutic carrier for retinal delivery to treat age-related macular degeneration
Melamangalam S. Jayaraman (2012)
Cyclosporine A Loaded PLGA Nanoparticles for Dry Eye Disease: In Vitro Characterization Studies
Vijay D. Wagh (2014)
Synthesis and characterization of biodegradable TPP/genipin co-crosslinked chitosan gel beads
F. L. Mi (2003)
Ocular drug delivery systems: An overview.
Ashaben Patel (2013)
Chemical modification of chitosan by phosphorylation: an XPS, FT-IR and SEM study
I. Amaral (2005)
Handbook of X-Ray Photoelectron Spectroscopy
J. Moulder (1992)
Preparation and characterization of chitosan microparticles intended for controlled drug
J. A. Ko (2002)
Particulates (Nanoparticles and Microparticles)
J. Kreuter (1993)
Collagenase (MMP-1) and TIMP-1 in destructive corneal disease associated with rheumatoid arthritis
G P Riley (1995)
The influence of multivalent phosphate structure on the properties of ionically cross-linked chitosan films for controlled drug release.
X. Shu (2002)
Swelling and de-swelling kinetics of gelatin hydrogels in ethanol-water marginal solvent.
S. Boral (2006)
A novel gene therapy vector based on hyaluronic acid and solid lipid nanoparticles for ocular diseases.
P. S. Apaolaza (2014)
Ocular toxicity after intracameral injection of very high doses of cefuroxime during cataract surgery
M. Delyfer (2011)
Nanomicellar formulations for sustained drug delivery: strategies and underlying principles.
Ruchit Trivedi (2010)
Double Cross-linked Chitosan—Gelatin Particulate Systems for Ophthalmic Applications
C. Peptu (2010)
Hartree-Slater subshell photoionization cross-sections at 1254 and 1487 eV
J. Scofield (1976)
High resolution XPS of organic polymers
G. Beamson (1992)
Controlled drug release properties of ionically cross-linked chitosan beads: the influence of anion structure.
X. Shu (2002)
Covalent and ionic co-cross-linking--an original way to prepare chitosan-gelatin hydrogels for biomedical applications.
Anca N Jătariu Cadinoiu (2011)

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L. Jiang (2018)
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Nanotechnology: from In Vivo Imaging System to Controlled Drug Delivery
M. Mir (2017)
Polysaccharides in Ocular Drug Delivery
N. Dubashynskaya (2019)
Non-invasive strategies for targeting the posterior segment of eye.
Asadullah Madni (2017)
Ocular applications of bioresorbable polymers—from basic research to clinical trials
A. Samanta (2017)
Nanostructured lipid carrier (NLC)-based novel hydrogels as potential carriers for nepafenac applied after cataract surgery for the treatment of inflammation: design, characterization and in vitro cellular inhibition and uptake studies
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Natural or Natural-Synthetic Hybrid Polymer-Based Fluorescent Polymeric Materials for Bio-imaging-Related Applications
X. Ma (2017)
Polymer‐based carriers for ophthalmic drug delivery
Julieta C. Imperiale (2018)
Endophthalmitis after cataract surgery: epidemiology, risk factors, and evidence on protection
P. Garg (2017)
Gamma sterilization of diclofenac sodium loaded- N-trimethyl chitosan nanoparticles for ophthalmic use.
Rathapon Asasutjarit (2017)
Safety and toxicity of nanomaterials for ocular drug delivery applications
N. Mehra (2016)
New hybrid magnetic nanoparticles based on chitosan-maltose derivative for antitumor drug delivery.
Liana Alupei (2016)
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