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Nanosuspensions Of Poorly Water-soluble Drugs Prepared By Bottom-up Technologies.

J. Du, X. Li, H. Zhao, Y. Zhou, L. Wang, Shushu Tian, Y. Wang
Published 2015 · Materials Science, Medicine

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In recent years, nanosuspension has been considered effective in the delivery of water-soluble drugs. One of the main challenges to effective drug delivery is designing an appropriate nanosuspension preparation approach with low energy input and erosion contamination, such as the bottom-up method. This review focuses on bottom-up technologies for preparation of nanosuspensions. The features and advantages of drug nanosuspension, including bottom-up methods as well as the corresponding characterization techniques, solidification methods, and drug delivery dosage forms, are discussed in detail. Certain limitations of commercial nanosuspension products are also reviewed.
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Strategies for the Formulation Development of Poorly Soluble Drugs via Oral Route
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