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One-step Synthesis Of Iron Oxide Polypyrrole Nanoparticles Encapsulating Ketoprofen As Model Of Hydrophobic Drug.
Mohamed F Attia, N. Anton, I. Khan, C. Serra, N. Messaddeq, Anshuman Jakhmola, R. Vecchione, T. Vandamme
Published 2016 · Medicine, Chemistry
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This study reports a novel one-step synthesis of hybrid iron oxide/polypyrrole multifunctional nanoparticles encapsulating hydrophobic drug and decorated with polyethylene glycol. The overall process is based on the in situ chemical oxidative polymerization of pyrrole along with the reduction of ferric chloride (FeCl3) in the presence of ketoprofen as model drug and PEGylated surfactants. The final product is a nanocomposite composed of polypyrrole and a mixture of FeO/Fe2O3. Different concentrations of ketoprofen were encapsulated in the nanocomposite, and were characterized by Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC). Encapsulation efficiency of the final product was measured by absorption, which can reach up to 98%. The release experiments confirmed complete drug release after about 3h in PBS solution. Morphological characterization of the nanocomposites was performed by electron microscopy (scanning and transmission electron microscopy) which confirmed the spherical geometry and opaque nature of nanoparticles with average particle size well below 50 nm. The final product is multifunctional system, which could act both as a nanocarrier for drug molecules as well as a contrasting agent. Magnetic relaxometry studies confirmed their possible applications as potential contrast agent in the field of magnetic resonance imaging (MRI).
This paper references
Conjugated polymer nanoparticles for drug delivery and imaging.
Xuli Feng (2010)
Relaxation times of colloidal iron platinum in polymer matrixes
M. Morales (2009)
Highly Conducting and Strongly Adhering Polypyrrole Coating Layers Deposited on Glass Substrates by a Chemical Process
F. Faverolle (1998)
Influence of Alternating and Static Magnetic Fields on Drug Release from Hybrid Hydrogels Containing Magnetic Nanoparticles
Marianna Uva (2014)
Dendrimers as carriers for delivery of chemotherapeutic agents.
S. Medina (2009)
Encapsulation and characterization of flurbiprofen loaded poly(є-caprolactone)–poly(vinylpyrrolidone) blend micropheres by solvent evaporation method
N. M. Ranjha (2009)
Polymeric nanomedicine for cancer MR imaging and drug delivery.
C. Khemtong (2009)
Multifunctional nanostructured materials for multimodal imaging, and simultaneous imaging and therapy.
J. Kim (2009)
Reductively labile PRINT particles for the delivery of doxorubicin to HeLa cells.
Robby A. Petros (2008)
Synthesis of novel hierarchical graphene/polypyrrole nanosheet composites and their superior electrochemical performance
C. Xu (2011)
Metal nanoparticles incorporation during the photopolymerization of polypyrrole
C. R. Martins (2006)
Preparation of polypyrrole-coated silver nanoparticles by one-step UV-induced polymerization
Xiaoming Yang (2005)
Evaluation of biocompatibility of polypyrrole in vitro and in vivo.
Xioadong Wang (2004)
Noninvasive visualization of in vivo drug delivery of poly(L-glutamic acid) using contrast-enhanced MRI.
Furong Ye (2006)
Synthesis and multi-applications of conductive magnetic stable polypyrrole dispersion with phase-convertible characteristics
Baoyu Zong (2015)
Optical and Electrochemical Transducers Based on Functionalized Conjugated Polymers
M. Leclerc (1999)
Continuous-flow encapsulation of ketoprofen in copolymer microbeads via co-axial microfluidic device: influence of operating and material parameters on drug carrier properties.
I. Khan (2013)
Fabrication and biocompatibility of polypyrrole implants suitable for neural prosthetics.
P. George (2005)
Biocompatibility implications of polypyrrole synthesis techniques.
J. Fonner (2008)
Nanostructured Electrodes and the Low‐Temperature Performance of Li‐Ion Batteries
C. R. Sides (2005)
One-step UV-induced modification of cellulose fabrics by polypyrrole/silver nanocomposite films.
Mohamed F Attia (2013)
The kinetics of vinyl acrylate photopolymerization
T. Lee (2003)
Chemical in situ polymerization of polypyrrole on bacterial cellulose nanofibers
D. Muller (2011)
Bioaffinity sensing using biologically functionalized conducting-polymer nanowire.
K. Ramanathan (2005)
Multifunctional inorganic nanoparticles for imaging, targeting, and drug delivery.
M. Liong (2008)
Perpendicular Actuation with Individually Controlled Polymer Microactuators
E. Jager (2001)
Conducting polymer blends : polypyrrole and poly(vinyl methyl ketone)
H. Wang (1992)
Conducting polymers with confined dimensions: Track-etch membranes for amperometric biosensor applications
A. Kros (2002)
Encapsulation of organic molecules in calcium phosphate nanocomposite particles for intracellular imaging and drug delivery.
Thomas T. Morgan (2008)
New strategies for polymer development in pharmaceutical science — a short review
A. Godwin (2001)
Synthesis of gadolinium nanoscale metal-organic framework with hydrotropes: manipulation of particle size and magnetic resonance imaging capability.
Wilasinee Hatakeyama (2011)
Electrochemically controlled release of dexamethasone from conducting polymer polypyrrole coated electrode.
Reecha Wadhwa (2006)
Bulk electropolymerization of alkylpyrroles
S. Ashraf (1996)
Electrochemical thin film deposition of polypyrrole on different substrates
C. Li (2005)
Polymer therapeutics: concepts and applications.
R. Haag (2006)
Carbon papers with conductive polymer coatings for use in solid-state supercapacitors
A. A. White (2004)
Biodegradable polymeric nanoparticles as drug delivery devices.
K. Soppimath (2001)
Iron oxide @ polypyrrole nanoparticles as a multifunctional drug carrier for remotely controlled cancer therapy with synergistic antitumor effect.
C. Wang (2013)
Autopolymerization of Pyrrole in the Presence of a Host/Guest Calixarene
D. Reece (2005)
Lipid-shelled vehicles: engineering for ultrasound molecular imaging and drug delivery.
K. Ferrara (2009)
Photopolymerized silver-containing conducting polymer films. Part I. An electronic conductivity and cyclic voltammetric investigation
Dalibor Hodko (2009)
Electrochemically controlled release of anticancer drug methotrexate using nanostructured polypyrrole modified with cetylpyridinium: Release kinetics investigation
N. Alizadeh (2014)
Multifunctional polymeric micelles as cancer-targeted, MRI-ultrasensitive drug delivery systems.
N. Nasongkla (2006)
Specific activity of polypyrrole nanoparticulate immunoreagents: comparison of surface chemistry and immobilization options.
M. Pope (1996)
Handbook of conducting polymers
T. Skotheim (1986)
Utilization of differential scanning calorimetry as a screening technique to determine the compatibility of ketoprofen with excipients
P. Mura (1995)
In vitro and in vivo near-infrared photothermal therapy of cancer using polypyrrole organic nanoparticles.
K. Yang (2012)
Conducting Polymer Nanocomposites: A Brief Overview
Rupali Gangopadhyay and (2000)
Size control of magnetic carbon nanoparticles for drug delivery.
W. Oh (2010)
Multifunctional conducting fibres with electrically controlled release of ciprofloxacin.
D. Esrafilzadeh (2013)
Polypyrrole based electro-conductive textiles for heat generation
Subhankar Maity (2014)
One-step synthesis of polypyrrole-coated silver nanocomposite particles and their application as a coloured particulate emulsifier
Syuji Fujii (2007)
Polyaniline/thermoplastic polyurethane blends: Preparation and evaluation of electrical conductivity
D. S. Vicentini (2007)
From Giant Vesicles to Filaments and Wires: Templates for Conducting Polymers
A. Kros (2004)
Structural investigation of N-arylpyrroles as iron corrosion inhibitors in hydrochloric acid
E. Stupnišvek-Lisac (1992)
Adhesion of electrochemically formed polypyrrole coatings to low carbon steel
J. Iroh (2002)
Enhanced Sensitivity of a Gas Sensor Incorporating Single‐Walled Carbon Nanotube–Polypyrrole Nanocomposites
K. An (2004)
Synthesis of PPy–silver nanocomposites via in situ oxidative polymerization
Morteza Farkhondekalam Ghadim (2014)
Polypyrrole–silver composites prepared by the reduction of silver ions with polypyrrole nanotubes
J. Škodová (2013)
Polymer latexes: Preparation, characterization, and applications
E. Daniels (1992)
This paper is referenced by
Iron Oxide Nanoparticles for Biomedical Applications: A Perspective on Synthesis, Drugs, Antimicrobial Activity, and Toxicity
L. S. Arias (2018)
Conducting Polymers, Hydrogels and Their Composites: Preparation, Properties and Bioapplications
M. Tomczykowa (2019)
Functional polypyrrole core-shell particles and flexible membranes for biomedical applications
Jifu Mao (2017)
Novel biodegradable nanocarriers for enhanced drug delivery.
M. Gagliardi (2016)
Electroactive biomaterials: Vehicles for controlled delivery of therapeutic agents for drug delivery and tissue regeneration
Biranche Tandon (2018)
Chapter 11 – Cancer Therapy
Saeid Zanganeh (2018)
Multifunctional polypyrrole@maghemite@silver composites: synthesis, physico-chemical characterization and antibacterial properties
B. Zasońska (2018)
Stimuli-responsive nanomaterials for controlled delivery by light, magnetic and electrical triggers
Meng Zhang (2017)
Design of hybrid clay/ polypyrrole decorated with silver and zinc oxide nanoparticles for anticorrosive and antibacterial applications
Khouloud Jlassi (2020)
Visible Light Degradation of Naproxen by Enhanced Photocatalytic Activity of NiO and NiS, Scavenger Study and Focus on Catalyst Support and Magnetization
F. Torki (2018)
Emerging Multifunctional NIR Photothermal Therapy Systems Based on Polypyrrole Nanoparticles
Mozhen Wang (2016)
Antibacterial and antitumor activities of 3-amino-phenyl-4(3H)-quinazolinone/polypyrrole chitosan core shell nanoparticles
Nehal A. Salahuddin (2016)