← Back to Search
Tumor Microenvironment-responsive Micelles For Pinpointed Intracellular Release Of Doxorubicin And Enhanced Anti-cancer Efficiency.
W. Chen, Shu-di Yang, F. Li, Ji-zhao Li, Z. Yuan, W. Zhu, Yifeng Liu, Xiao-Feng Zhou, C. Liu, X. Zhang
Published 2016 · Chemistry, Medicine
Download PDFAnalyze on Scholarcy
Internal stimuli, such as intracellular lysosomal pH, enzyme, redox and reduction, can be applied to improve biological specificity of chemotherapeutic drugs for cancer therapy. Thus, functionalized copolymers based on their response to specific microenvironment of tumor regions have been designed as smart drug vesicles for enhanced anti-cancer efficiency and reduced side effects. Herein, we reported dually pH/reduction-responsive novel micelles based on self-assembly of carboxymethyl chitosan-cysteamine-N-acetyl histidine (CMCH-SS-NA) and doxorubicin (DOX). The tailor-made dually responsive micelles demonstrated favorable stability in normal physiological environment and triggered rapid drug release in acidic and/or reduction environment. Additionally, the nanocarriers responded to the intracellular environment in an ultra-fast manner within several minutes, which led to the pinpointed release of DOX in tumor cells effectively and ensured higher DOX concentrations within tumor areas with the aid of targeted delivery, thereby leading to enhanced tumor ablation. Thus, this approach with sharp drug release behavior represented a versatile strategy to provide a promising paradigm for cancer therapy.
This paper references
Stealth CD44-targeted hyaluronic acid supramolecular nanoassemblies for doxorubicin delivery: probing the effect of uncovalent pegylation degree on cellular uptake and blood long circulation.
Xiaopeng Han (2015)
Dualfunctional liposomes based on pH-responsive cell-penetrating peptide and hyaluronic acid for tumor-targeted anticancer drug
T. Jiang (2012)
Glutathione-responsive nano-vehicles as a promising platform for targeted intracellular drug and gene delivery.
R. Cheng (2011)
Galactose-functionalized multi-responsive nanogels for hepatomatargeted drug
S. Lou (2015)
Multifunctional hybrid silica nanoparticles for controlled doxorubicin loading and release with thermal and pH dually response.
X. Hu (2013)
Redox-sensitive micelles self-assembled from amphiphilic hyaluronic acid-deoxycholic acid conjugates for targeted intracellular delivery of paclitaxel.
J. Li (2012)
Advanced drug delivery devices via self-assembly of amphiphilic block copolymers.
A. Rösler (2001)
The implications of recent advances in carboxymethyl chitosan based targeted drug delivery and tissue engineering applications.
Laxmi Upadhyaya (2014)
Tailor-made dual pH-sensitive polymer-doxorubicin nanoparticles for efficient anticancer drug delivery.
Jin-Zhi Du (2011)
N-acetyl histidine-conjugated glycol chitosan self-assembled nanoparticles for intracytoplasmic delivery of drugs: endocytosis, exocytosis and drug release.
J. Park (2006)
Nanodiamonds-mediated doxorubicin nuclear delivery to inhibit lung metastasis of breast cancer.
Jisheng Xiao (2013)
Effective co-delivery of doxorubicin and dasatinib using a PEG-Fmoc nanocarrier for combination cancer chemotherapy.
P. Zhang (2015)
Galactose-functionalized multi-responsive nanogels for hepatoma-targeted drug delivery.
Shaofeng Lou (2015)
Stimuli-responsive cancer therapy based on nanoparticles.
J. Yu (2014)
Co-delivery of thioridazine and doxorubicin using polymeric micelles for targeting both cancer cells and cancer stem cells.
Xi-Yu Ke (2014)
Liposomal doxorubicin extravasation controlled by phenotype-specific transport properties of tumor microenvironment and vascular barrier.
K. Yokoi (2015)
Dually pH/Reduction-Responsive Vesicles for Ultrahigh-Contrast Fluorescence Imaging and Thermo-Chemotherapy-Synergized Tumor Ablation.
Aijun Zhu (2015)
Reduction-sensitive polymers and bioconjugates for biomedical applications.
F. Meng (2009)
Integrin-targeted pH-responsive micelles for enhanced efficiency of anticancer treatment in vitro and in vivo.
Jinjian Liu (2015)
Stimuli-responsive nanocarriers for drug delivery.
S. Mura (2013)
Ligand conjugated low-density lipoprotein nanoparticles for enhanced optical cancer imaging in vivo.
J. Chen (2007)
Shape Transformation Following Reduction-Sensitive PEG Cleavage of Polymer/DNA Nanoparticles.
John-Michael Williford (2014)
Engineered breast tumor targeting peptide ligand modified liposomal doxorubicin and the effect of peptide density on anticancer activity.
M. Shahin (2013)
pH-sensitive polymeric nanoparticles for tumor-targeting doxorubicin delivery: concept and recent advances.
F. Meng (2014)
Carboxymethyl chitosan as a matrix material for platinum, gold, and silver nanoparticles.
Michael J. Laudenslager (2008)
The EPR effect for macromolecular drug delivery to solid tumors: Improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivo.
H. Maeda (2013)
Nanoparticle delivery of cancer drugs.
A. Wang (2012)
Terminal modi fi cation of polymeric micelles with pi - conjugated moieties for ef fi cient anticancer drug delivery
Nanocarriers as an emerging platform for cancer therapy
S. Wise (2007)
Interlayer-crosslinked micelle with partially hydrated core showing reduction and pH dual sensitivity for pinpointed intracellular drug release.
Jian Dai (2011)
Low-density lipoprotein-coupled N-succinyl chitosan nanoparticles co-delivering siRNA and doxorubicin for hepatocyte-targeted therapy.
Qiao-ling Zhu (2014)
Smart chemistry in polymeric nanomedicine.
R. Tong (2014)
pH and reduction dual-sensitive copolymeric micelles for intracellular doxorubicin delivery.
J. Chen (2011)
Reduction-sensitive polymeric nanocarriers in cancer therapy: a comprehensive review.
B. Deng (2015)
pH-Sensitive self-assembling nanoparticles for tumor near-infrared fluorescence imaging and chemo-photodynamic combination therapy.
Wenxiu Hou (2016)
Glutathioneresponsive nano-vehicles as a promising platform for targeted intracellular drug and gene
R. Cheng (2011)
Liposomal doxorubicin extravasation
J. Held-Warmkessel (2007)
Photothermal-chemotherapy with doxorubicin-loaded hollow gold nanospheres: A platform for near-infrared light-trigged drug release.
Jian You (2012)
Terminal modification of polymeric micelles with π-conjugated moieties for efficient anticancer drug delivery.
Yan Liang (2015)
Controlled delivery of recombinant adeno-associated virus serotype 2 using pH-sensitive poly(ethylene glycol)-poly-L-histidine hydrogels.
Y. Zeng (2012)
Dual targeting folate-conjugated hyaluronic acid polymeric micelles for paclitaxel delivery.
Y. Liu (2011)
Hyaluronic acid-chitosan nanoparticles for co-delivery of MiR-34a and doxorubicin in therapy against triple negative breast cancer.
Xiongwei Deng (2014)
pH-sensitive nano-systems for drug delivery in cancer therapy.
J. Liu (2014)
728–740 nanoparticles for intracytoplasmic delivery of drugs: endocytosis, exocytosis and drug release
W.- Chen (2016)
Reversibly crosslinked hyaluronic acid nanoparticles for active targeting and intelligent delivery of doxorubicin to drug resistant CD44+ human breast tumor xenografts.
Yinan Zhong (2015)
Multifunctional Mesoporous Silica Nanoparticles for Cancer-Targeted and Controlled Drug Delivery
Q. Zhang (2012)
pH-responsive polymer-liposomes for intracellular drug delivery and tumor extracellular matrix switched-on targeted cancer therapy.
Yi-Ting Chiang (2014)
The effect of kinetic stability on biodistribution and anti-tumor efficacy of drug-loaded biodegradable polymeric micelles.
A. Attia (2013)
Dual-functional liposomes based on pH-responsive cell-penetrating peptide and hyaluronic acid for tumor-targeted anticancer drug delivery.
Tianyue Jiang (2012)
Synergistic inhibition of breast cancer by co-delivery of VEGF siRNA and paclitaxel via vapreotide-modified core-shell nanoparticles.
Q. Feng (2014)
Redox and pH-responsive degradable micelles for dually activated intracellular anticancer drug release.
Wei Chen (2013)
Intracellular release of doxorubicin from core-crosslinked polypeptide micelles triggered by both pH and reduction conditions.
L. Wu (2013)
Nanoparticle and targeted systems for cancer therapy.
L. Brannon-Peppas (2004)
This paper is referenced by
Development of drug-loaded chitosan hollow nanoparticles for delivery of paclitaxel to human lung cancer A549 cells
J. Jiang (2017)
Doxorubicin and siRNA-PD-L1 co-delivery with T7 modified ROS-sensitive nanoparticles for tumor chemoimmunotherapy.
Wen-Jun Wan (2019)
Matrix metalloprotein-triggered, cell penetrating peptide-modified star-shaped nanoparticles for tumor targeting and cancer therapy
F. Guo (2020)
Multifunctional redox-responsive and CD44 receptor targeting polymer-drug nanomedicine based curcumin and alendronate: synthesis, characterization and in vitro evaluation
Xue Dong (2018)
H2O2-responsive nano-prodrug for podophyllotoxin delivery.
Kunyong Ou (2019)
Zonisamide-loaded triblock copolymer nanomicelles as a novel drug delivery system for the treatment of acute spinal cord injury
Jinglun Li (2017)
A shell-crosslinked polymeric micelle system for pH/redox dual stimuli-triggered DOX on-demand release and enhanced antitumor activity.
L. Wang (2017)
Effective improvement of the neuroprotective activity after spinal cord injury by synergistic effect of glucocorticoid with biodegradable amphipathic nanomicelles
Yuelong Wang (2017)
Stepwise pH/reduction-responsive polymeric conjugates for enhanced drug delivery to tumor.
S. Yang (2018)
Inhibiting PI3 kinase-γ in both myeloid and plasma cells remodels the suppressive tumor microenvironment in desmoplastic tumors.
X. Zhang (2019)
PEGylated self-assembled enzyme-responsive nanoparticles for effective targeted therapy against lung tumors
F. Guo (2018)
Low-density lipoprotein-coupled micelles with reduction and pH dual sensitivity for intelligent co-delivery of paclitaxel and siRNA to breast tumor
W. Zhu (2017)
Shear-responsive injectable supramolecular hydrogel releasing doxorubicin loaded micelles with pH-sensitivity for local tumor chemotherapy.
Z. Liu (2017)
Targeted Delivery of Doxorubicin via CD147-Mediated ROS/pH Dual-Sensitive Nanomicelles for the Efficient Therapy of Hepatocellular Carcinoma
Chenxi Qu (2018)