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Interventions For Treating Sarcopenia: A Systematic Review And Meta-Analysis Of Randomized Controlled Studies.

Y. Yoshimura, H. Wakabayashi, M. Yamada, Hunkyung Kim, A. Harada, H. Arai
Published 2017 · Medicine

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BACKGROUND Much interest has been focused on interventions for treating sarcopenia; however, the effects have gained little evidence. OBJECTIVE To analyze the effectiveness of exercise, nutritional, drug, and combinational interventions for treating sarcopenia in older people. METHOD We systematically searched MEDLINE via PubMed, the Cochrane Library of Cochrane Reviews and Cochrane Central Register of Controlled Trials, and Ichushi-Web for randomized controlled trials (RCTs) from January 2000 to December 2016. We have assessed the type of intervention, the cohort used, the way sarcopenia was diagnosed, the outcomes, and the quality of evidence. We meta-analyzed the outcomes with the net difference between-group treatment from baseline to the end of the study. RESULTS We screened a total of 2668 records and included seven RCTs that investigated the effects of exercise (4 RCTs), nutrition (5 RCTs), drug (1 RCT), and combination (4 RCTs) on muscle mass, strength, and function in older people with sarcopenia. Very low to low-quality evidence suggests that (1) exercise interventions may play a role in improving muscle mass, muscle strength, and walking speed in 3 months of intervention; (2) nutritional interventions may be effective in improving muscle strength in 3 months of intervention; (3) as drug intervention, selective androgen receptor modulator had no clear effect on muscle mass, strength, and physical function; and (4) a combined intervention of exercise and nutrition may have positive effects in improving the walking speed in 3 months of intervention. CONCLUSION Our systematic review and meta-analysis showed some positive effects of exercise and nutritional interventions for treating sarcopenia in older people, although the quality of the evidence was low. Future high-quality RCTs should be implemented to strengthen the results.
This paper references
10.1016/j.jamda.2016.06.001
Sarcopenia Is Recognized as an Independent Condition by an International Classification of Disease, Tenth Revision, Clinical Modification (ICD-10-CM) Code.
L. Cao (2016)
10.1017/S0007114515002810
Collagen peptide supplementation in combination with resistance training improves body composition and increases muscle strength in elderly sarcopenic men: a randomised controlled trial
Denise Zdzieblik (2015)
10.1016/j.clnu.2013.02.011
Effect of β-hydroxy-β-methylbutyrate (HMB) on lean body mass during 10 days of bed rest in older adults.
N. Deutz (2013)
10.1007/s00198-012-1913-1
Frailty and sarcopenia: definitions and outcome parameters
C. Cooper (2012)
10.1016/j.archger.2015.06.020
Effect of beta-hydroxy-beta-methylbutyrate supplementation on muscle loss in older adults: a systematic review and meta-analysis.
Hong-mei Wu (2015)
10.1155/2012/109013
Alternative Exercise Technologies to Fight against Sarcopenia at Old Age: A Series of Studies and Review
W. Kemmler (2012)
10.1136/bmj.b2535
Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement
D. Moher (2009)
10.1007/S12603-009-0209-4
Validated treatments and therapeutics prospectives regarding pharmacological products for sarcopenia
G. Onder (2009)
10.1016/j.mad.2008.08.001
Modulation of GH/IGF-1 axis: Potential strategies to counteract sarcopenia in older adults
S. Giovannini (2008)
10.1093/jn/127.5.990S
Sarcopenia: origins and clinical relevance.
I. Rosenberg (1997)
10.1080/14712598.2016.1208168
Novel therapeutic options for cachexia and sarcopenia
A. Molfino (2016)
10.1111/j.1532-5415.2011.03776.x
Effects of Exercise and Amino Acid Supplementation on Body Composition and Physical Function in Community‐Dwelling Elderly Japanese Sarcopenic Women: A Randomized Controlled Trial
H. Kim (2012)
European working group on sarcopenia in older people. Sarcopenia: European consensus on definition and diagnosis: report of the European working group on sarcopenia in older people
A. Cruz-Jentoft (2010)
10.1016/j.jamda.2011.01.003
Sarcopenia: an undiagnosed condition in older adults. Current consensus definition: prevalence, etiology, and consequences. International working group on sarcopenia.
R. Fielding (2011)
10.2174/1381612820666140316132246
Interventions against sarcopenia in older persons.
V. Zanandrea (2014)
10.1111/ggi.12878
Optimal frequency/time combination of whole‐body vibration training for improving muscle size and strength of people with age‐related muscle loss (sarcopenia): A randomized controlled trial
N. Wei (2017)
10.1017/S0029665115002049
Nutritional interventions in sarcopenia: a critical review.
M. Hickson (2015)
10.1111/j.1447-0594.2012.00923.x
Effects of exercise and tea catechins on muscle mass, strength and walking ability in community‐dwelling elderly Japanese sarcopenic women: A randomized controlled trial
Hunkyung Kim (2013)
Myostatin and sarcopenia: Opportunities and challengesda mini-review. Gerontology 2014;60:289e293
TA White (2014)
10.1093/gerona/glu013
An Evidence-Based Comparison of Operational Criteria for the Presence of Sarcopenia
T. Dam (2014)
10.1159/000356740
Myostatin and Sarcopenia: Opportunities and Challenges - A Mini-Review
T. White (2014)
10.1016/j.jamda.2013.05.021
Evidence-based recommendations for optimal dietary protein intake in older people: a position paper from the PROT-AGE Study Group.
J. Bauer (2013)
10.1016/j.ijsu.2010.02.007
Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement.
D. Moher (2010)
10.1093/gerona/glu010
The FNIH Sarcopenia Project: Rationale, Study Description, Conference Recommendations, and Final Estimates
S. Studenski (2014)
10.1016/j.jamda.2012.08.001
Effectiveness of nutritional supplementation on muscle mass in treatment of sarcopenia in old age: a systematic review.
V. Malafarina (2013)
10.1093/GERONA/56.3.M146
Frailty in older adults: evidence for a phenotype.
L. Fried (2001)
10.2174/1381612821666150130122032
Treating sarcopenia in older and oldest old.
A. Martone (2015)
10.1016/j.jamda.2013.03.022
Frailty consensus: a call to action.
J. Morley (2013)
10.3305/nh.2015.31.4.8489
[Sarcopenia intervention with progressive resistance training and protein nutritional supplements].
M. V. Palop Montoro (2015)
10.2174/1574884708666131111192845
Comprehensive approach to sarcopenia treatment.
H. Wakabayashi (2014)
10.1016/j.clnu.2009.12.004
Consensus definition of sarcopenia, cachexia and pre-cachexia: joint document elaborated by Special Interest Groups (SIG) "cachexia-anorexia in chronic wasting diseases" and "nutrition in geriatrics".
M. Muscaritoli (2010)
10.1016/j.jamda.2016.05.016
Recent Advances in Sarcopenia Research in Asia: 2016 Update From the Asian Working Group for Sarcopenia.
Liang-Kung Chen (2016)
10.1093/ageing/afu115
Prevalence of and interventions for sarcopenia in ageing adults: a systematic review. Report of the International Sarcopenia Initiative (EWGSOP and IWGS)
A. Cruz-Jentoft (2014)
Effects of exercise and tea catechins onmuscle mass, strength and walking ability in community-dwelling elderly Japanese sarcopenic women: A randomized controlled trial
KimH (2013)
Frailty and Sarcopenia: The New Geriatric Giants.
J. Morley (2016)
10.1007/s12603-015-0570-4
Effects of nutritional supplements on muscle mass and activities of daily living in elderly rehabilitation patients with decreased muscle mass: A randomized controlled trial
Y. Yoshimura (2015)
10.1007/s12603-013-0335-x
A phase IIA randomized, placebo-controlled clinical trial to study the efficacy and safety of the selective androgen receptor modulator (SARM), MK-0773 in female participants with sarcopenia
D. A. Papanicolaou (2013)
10.3305/NH.2015.31.4.8489
Intervención en la sarcopenia con entrenamiento de resistencia progresiva y suplementos nutricionales proteicos
María Victoria Palop Montoro (2015)
10.1016/j.jamda.2015.05.021
Effects of a vitamin D and leucine-enriched whey protein nutritional supplement on measures of sarcopenia in older adults, the PROVIDE study: a randomized, double-blind, placebo-controlled trial.
J. Bauer (2015)
10.1016/j.jamda.2010.04.014
Nutritional recommendations for the management of sarcopenia.
J. Morley (2010)
10.1007/s00223-015-0022-5
Pharmacologic Options for the Treatment of Sarcopenia
J. Morley (2015)
10.1002/9781119536604
Cochrane Handbook for Systematic Reviews of Interventions
Michele Tarsilla (2010)
10.1007/s12603-014-0559-4
Effects of leucine-rich protein supplements on anthropometric parameter and muscle strength in the elderly: A systematic review and meta-analysis
B. Komar (2014)
10.1016/j.jamda.2014.07.018
Effects of a whole body vibration (WBV) exercise intervention for institutionalized older people: a randomized, multicentre, parallel, clinical trial.
Mercè Sitjà-Rabert (2015)
10.1002/9780470712184
Cochrane Handbook for Systematic Reviews of Interventions
J. P. Higgins (2019)
10.1016/j.jamda.2011.04.014
Sarcopenia with limited mobility: an international consensus.
J. Morley (2011)
10.1519/JSC.0000000000001255
The Effect of Resistance Training and Different Sources of Postexercise Protein Supplementation on Muscle Mass and Physical Capacity in Sarcopenic Elderly Men
M. Maltais (2016)
10.1007/s40266-016-0396-8
Angiotensin-Converting Enzyme Inhibitors and Parameters of Sarcopenia: Relation to Muscle Mass, Strength and Function: Data from the Berlin Aging Study-II (BASE-II)
D. Spira (2016)
10.1016/j.jamda.2013.11.025
Sarcopenia in Asia: consensus report of the Asian Working Group for Sarcopenia.
Liang-Kung Chen (2014)
10.1136/bmj.39489.470347.AD
GRADE: an emerging consensus on rating quality of evidence and strength of recommendations
G. Guyatt (2008)
10.1016/j.jamda.2016.06.016
Exercise and Nutritional Supplementation on Community-Dwelling Elderly Japanese Women With Sarcopenic Obesity: A Randomized Controlled Trial.
Hunkyung Kim (2016)



This paper is referenced by
10.3390/nu12123743
Undernutrition, Sarcopenia, and Frailty in Fragility Hip Fracture: Advanced Strategies for Improving Clinical Outcomes
T. Inoue (2020)
10.1371/journal.pone.0237454
Risk factors predicting osteosarcopenia in postmenopausal women with osteoporosis: A retrospective study
H. Okamura (2020)
10.1002/jcsm.12351
Feasibility of early multimodal interventions for elderly patients with advanced pancreatic and non‐small‐cell lung cancer
T. Naito (2019)
10.1245/s10434-019-07659-3
ASO Author Reflections: Current State of Surgical Sarcopenia in Esophageal Cancer
Shion Uemura (2019)
10.3389/fphys.2019.00871
Circulating Irisin and Myostatin as Markers of Muscle Strength and Physical Condition in Elderly Subjects
Cristina Planella-Farrugia (2019)
10.3390/nu12082257
Myoprotective Whole Foods, Muscle Health and Sarcopenia: A Systematic Review of Observational and Intervention Studies in Older Adults
A. Granic (2020)
10.1007/s12603-020-1429-x
Effectiveness of a Short-Term Mixed Exercise Program for Treating Sarcopenia in Hospitalized Patients Aged 80 Years and Older: A Prospective Clinical Trial
R. Wang (2020)
10.1016/j.jstrokecerebrovasdis.2020.105017
Muscle mass gain is positively associated with functional recovery in patients with sarcopenia after stroke.
F. Nagano (2020)
10.3390/nu12071928
The Effects of Timing of a Leucine-Enriched Amino Acid Supplement on Body Composition and Physical Function in Stroke Patients: A Randomized Controlled Trial
T. Ikeda (2020)
10.1016/j.endinu.2020.02.010
Efectos del ejercicio físico en el anciano con sarcopenia. Una revisión sistemática
David E. Barajas-Galindo (2020)
10.2490/PRM.20180011
Systemic Inflammation in the Recovery Stage of Stroke: Its Association with Sarcopenia and Poor Functional Rehabilitation Outcomes.
Y. Yoshimura (2018)
10.1016/j.afos.2019.12.001
Relationship between sarcopenia and pain catastrophizing in patients with lumbar spinal stenosis: A cross-sectional study
T. Wada (2019)
10.1111/hepr.13051
Relative changes in handgrip strength and skeletal muscle volume in patients with chronic liver disease over a 2‐year observation period
A. Hiraoka (2018)
10.1016/j.jamda.2018.09.012
Prevalence and Associated Factors of Sarcopenia in Nursing Home Residents: A Systematic Review and Meta-analysis.
Yanjiao Shen (2019)
10.1001/jamanetworkopen.2019.13346
Assessment of Sarcopenia Among Community-Dwelling At-Risk Frail Adults Aged 65 Years and Older Who Received Multidomain Lifestyle Interventions
Y. Lu (2019)
10.1007/s40520-020-01713-x
The additive effects of exercise and essential amino acid on muscle mass and strength in community-dwelling older Japanese women with muscle mass decline, but not weakness and slowness: a randomized controlled and placebo trial
Hunkyung Kim (2020)
10.1111/ggi.13780
Sarcopenia as a predictor of activities of daily living capability in stroke patients undergoing rehabilitation
Tatsuya Matsushita (2019)
10.1186/s12877-020-01915-y
Preoperative low muscle mass is a predictor of falls within 12 months of surgery in patients with lumbar spinal stenosis
Takashi Wada (2020)
10.1002/jcsm.12334
Angiotensin‐converting enzyme 2 deficiency accelerates and angiotensin 1‐7 restores age‐related muscle weakness in mice
Hikari Takeshita (2018)
10.1371/journal.pone.0235952
Feasibility and acceptability of a milk and resistance exercise intervention to improve muscle function in community-dwelling older adults (MIlkMAN): Pilot study
A. Granic (2020)
10.1002/ejhf.1926
Prevalence and prognostic impact of the coexistence of multiple frailty domains in elderly patients with heart failure: the FRAGILE‐HF cohort study
Y. Matsue (2020)
10.2512/JSPM.13.373
悪液質高リスクの高齢進行がん患者に対する在宅ベースの下肢筋力トレーニングプログラムの開発─NEXTAC-ONE試験の運動介入の詳細─
典篤 立松 (2018)
10.1016/j.clnu.2020.07.025
The clinical applicability of ultrasound technique for diagnosis of sarcopenia in hemodialysis patients.
R. Matsuzawa (2020)
10.1111/ggi.13998
Chair‐stand exercise improves post‐stroke dysphagia
Y. Yoshimura (2020)
10.1016/j.jamda.2020.03.029
Sarcopenic Obesity Is Associated With Activities of Daily Living and Home Discharge in Post-Acute Rehabilitation.
Y. Yoshimura (2020)
10.1123/japa.2019-0463
The Independent Relationship Between Leg Skeletal Muscle Mass Asymmetry and Gait Speed in Community-Dwelling Older Adults.
Chiharu Iwasaka (2020)
10.3929/ETHZ-B-000426862
Corticospinal Control of Human Locomotion: A New Determinant of Age-Related Sarcopenia?
F. Gennaro (2020)
10.1016/j.nut.2018.10.025
Impact of sarcopenia on clinical outcomes after radical gastrectomy for patients without nutritional risk.
Bingwei Ma (2019)
10.12998/wjcc.v8.i7.1188
Sarcopenia in patients with colorectal cancer: A comprehensive review.
O. Vergara-Fernández (2020)
10.1007/s12603-020-1537-7
Non-Pharmacological Interventions in Osteosarcopenia: A Systematic Review
R. Atlihan (2020)
10.1016/j.jamda.2020.04.012
Effects of Nutritional Interventions on Nutritional and Functional Outcomes in Geriatric Rehabilitation Patients: A Systematic Review and Meta-Analysis.
Janneke P van Wijngaarden (2020)
10.1093/nutrit/nuaa011
Nutritional interventions to improve muscle mass, muscle strength, and physical performance in older people: an umbrella review of systematic reviews and meta-analyses.
E. Gielen (2020)
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