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The Human Cerebrospinal Fluid Metabolome.

David Scott Wishart, Michael John Lewis, Joshua A Morrissey, Mitchel D Flegel, Kevin Jeroncic, Yeping Xiong, Dean Cheng, Roman Eisner, Bijaya Gautam, Dan Tzur, Summit Sawhney, Fiona Bamforth, Russ Greiner, Lanjuan Li
Published 2008 · Chemistry, Medicine
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With continuing improvements in analytical technology and an increased interest in comprehensive metabolic profiling of biofluids and tissues, there is a growing need to develop comprehensive reference resources for certain clinically important biofluids, such as blood, urine and cerebrospinal fluid (CSF). As part of our effort to systematically characterize the human metabolome we have chosen to characterize CSF as the first biofluid to be intensively scrutinized. In doing so, we combined comprehensive NMR, gas chromatography-mass spectrometry (GC-MS) and liquid chromatography (LC) Fourier transform-mass spectrometry (FTMS) methods with computer-aided literature mining to identify and quantify essentially all of the metabolites that can be commonly detected (with today's technology) in the human CSF metabolome. Tables containing the compounds, concentrations, spectra, protocols and links to disease associations that we have found for the human CSF metabolome are freely available at http://www.csfmetabolome.ca.



This paper is referenced by
10.1016/j.mrfmmm.2010.07.008
An "Omics" based survey of human colon cancer.
Prashant R. Nambiar (2010)
10.1155/2014/756138
A Metabolomic Perspective on Coeliac Disease
Antonio Calabrò (2014)
10.1002/9781118958841.CH8
Metabolomics of plant phosphorus‐starvation response
Christopher S. Jones (2015)
10.1016/j.jpba.2017.07.044
Quality assurance procedures for mass spectrometry untargeted metabolomics. a review
Danuta Dudzik (2018)
10.3389/fmicb.2018.02227
Analysis of the Rumen Microbiome and Metabolome to Study the Effect of an Antimethanogenic Treatment Applied in Early Life of Kid Goats
Leticia Abecia (2018)
10.1212/WNL.0000000000000274
Untargeted 1H-NMR metabolomics in CSF
Hélène Blasco (2014)
NMR Metabolomics Techniques and Mathematical Tools as an Aid in Neurological Diagnosis
Niko Jukarainen (2009)
10.2217/bmm.10.6
Human bile as a rich source of biomarkers for hepatopancreatobiliary cancers.
G. A. Nagana Gowda (2010)
1H NMR metabolomics of stress
Douglas Kiss (2016)
10.2217/bmm.09.22
Combining nuclear magnetic resonance spectroscopy and mass spectrometry in biomarker discovery.
G. A. Nagana Gowda (2009)
10.1371/journal.pone.0073076
The Human Urine Metabolome
S. Bouatra (2013)
10.1021/pr2004874
Characterization of the human tear metabolome by LC-MS/MS.
Liyan Chen (2011)
10.1007/978-1-4614-1689-0_11
Systems Biology Resources Arising from the Human Metabolome Project
David Scott Wishart (2012)
Metabolomics in Alzheimer's disease
Mohammed Zubair (2013)
10.1016/J.TRAC.2013.08.002
The effects of the intake of plant foods on the human metabolome
Sonia Medina (2013)
10.1097/QAD.0000000000000303
Cerebrospinal fluid metabolomics reveals altered waste clearance and accelerated aging in HIV patients with neurocognitive impairment
Edana Cassol (2014)
10.1007/978-981-10-1503-8
Translational Biomedical Informatics
Bairong Shen (2016)
10.1016/J.TRAC.2011.08.009
Metabolite identification and quantitation in LC-MS/MS-based metabolomics.
Jun Feng Xiao (2012)
10.4155/bio.09.138
Computational strategies for metabolite identification in metabolomics.
David Scott Wishart (2009)
10.1002/9783527634705.CH3B
The Japanese toxicogenomics project: application of toxicogenomics - utilizing toxicogenomics into drug safety screening.
Takeki Uehara (2010)
10.1158/0008-5472.CAN-12-0755
An NMR metabolomics approach for the diagnosis of leptomeningeal carcinomatosis.
Hye Rim Cho (2012)
10.1007/s11306-015-0840-5
The human saliva metabolome
Zerihun T. Dame (2015)
10.1021/acs.jproteome.5b00885
Recommendations and Standardization of Biomarker Quantification Using NMR-Based Metabolomics with Particular Focus on Urinary Analysis
Abdul-Hamid Emwas (2016)
10.3390/metabo10010008
A Perspective and Framework for Developing Sample Type Specific Databases for LC/MS-Based Clinical Metabolomics
Nichole A Reisdorph (2019)
10.1002/anie.200905579
Targeted metabolomics for biomarker discovery.
William J Griffiths (2010)
10.1007/s11306-010-0227-6
Metabolomics reveals unhealthy alterations in rumen metabolism with increased proportion of cereal grain in the diet of dairy cows
Burim N. Ametaj (2010)
10.2174/138920111795909122
Metabolic profiling in multiple sclerosis and other disorders by quantitative analysis of cerebrospinal fluid using nuclear magnetic resonance spectroscopy.
Lutz Nw (2011)
10.1371/journal.pone.0078731
Metabonomics Study of the Therapeutic Mechanism of Gynostemma pentaphyllum and Atorvastatin for Hyperlipidemia in Rats
Miao Wang (2013)
10.1007/s11306-016-1041-6
NMR analysis of the CSF and plasma metabolome of rigorously matched amyotrophic lateral sclerosis, Parkinson’s disease and control subjects
Junfang Wu (2016)
ORBIS-Met: Optimization of R based integrative statistics for metabolome analyses
Joaquim Sol Culleré (2017)
10.1002/mnfr.200800516
The complex links between dietary phytochemicals and human health deciphered by metabolomics.
Claudine Manach (2009)
10.1007/s10493-012-9586-1
Antimicrobial activity in the egg wax of the tick Amblyomma hebraeum (Acari: Ixodidae) is associated with free fatty acids C16:1 and C18:2
Zhijun Yu (2012)
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