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Dynamic Control Of Needle-free Jet Injection.

J. Stachowiak, T. H. Li, A. Arora, S. Mitragotri, D. Fletcher
Published 2009 · Chemistry, Medicine

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Many modern pharmaceutical therapies such as vaccines and macromolecular drugs benefit from transdermal delivery. Conventional transdermal drug delivery via hypodermic needles causes pain, non-compliance, and potential contamination. Alternative transdermal strategies that deliver drugs in a quick, reliable, painless, and inexpensive way are needed. Jet injectors, which deliver drugs through the skin using a high-speed stream of liquid propelled by compressed springs or gasses, provide a needle-free method of trandermal drug delivery. However, poor reliability as well as painful bruising and bleeding characterize these devices, due in part to the high and constant jet velocity with which drugs are delivered. Toward improved reliability and reduced pain, we have developed a jet injector capable of dynamic control of jet velocity during a single injection pulse. Using this device, we demonstrate that temporal control of jet velocity leads to independent control of penetration depth, by adjusting time at high velocity, and delivered dose, by adjusting time at low velocity, in model materials. This dynamic control of jet velocity creates the potential for better control of needle-free injections, as demonstrated through injection studies on whole ex vivo human skin samples.
This paper references
10.1016/0304-4165(75)90223-8
The mechanical properties of stratum corneum. I. The effect of water and ambient temperature on the tensile properties of newborn rat stratum corneum.
Y. S. Papir (1975)
10.1007/3-540-26367-5_1
A
A. Spring (2005)
10.1016/J.JCONREL.2005.05.023
Jet-induced skin puncture and its impact on needle-free jet injections: experimental studies and a predictive model.
Joy Baxter (2005)
10.1097/00010694-200010000-00003
MECHANICAL PROPERTIES OF GELLAN AND POLYACRYLAMIDE GELS WITH IMPLICATIONS FOR SOIL STABILIZATION
G. Ferruzzi (2000)
10.1007/978-1-4613-1463-9
Piezoelectric Actuators and Ultrasonic Motors
K. Uchino (1996)
10.1016/J.JCONREL.2007.07.004
Quantitative structure-permeation relationship for iontophoretic transport across the skin.
Blaise Mudry (2007)
10.1016/J.JCONREL.2007.08.017
Piezoelectric control of needle-free transdermal drug delivery.
J. Stachowiak (2007)
10.1002/JPS.20848
Peptide drug delivery strategies for the treatment of diabetes.
N. Sadrzadeh (2007)
10.1016/J.ADDR.2005.12.003
Needle-free vaccine delivery.
E. Giudice (2006)
10.1023/A:1020753329492
Transdermal Drug Delivery by Jet Injectors: Energetics of Jet Formation and Penetration
J. Schramm (2004)
10.1007/BF00520089
Prüfung der mechanischen Eigenschaften von menschlicher Haut in Abhängigkeit von Alter und Geschlecht
H. Holzmann (2004)
Feedback Control of Dynamic Systems
G. Franklin (1986)
10.3109/03008207409152242
Correlation between tensile strength and collagen content in rat skin. Effect of age and cortisol treatment.
H. G. Vogel (1974)
10.1034/j.1600-0846.2000.006004214.x
In vivo model of the mechanical properties of the human skin under suction
S. Diridollou (2000)
10.1016/J.JCONREL.2006.12.017
Enhancement of skin permeation of high molecular compounds by a combination of microneedle pretreatment and iontophoresis.
Xue-Ming Wu (2007)
Physiology, biochemistry, and molecular biology of the skin
L. Goldsmith (1991)
10.1001/ARCHOPHT.120.9.1206
Intravascular drug delivery with a pulsed liquid microjet.
D. Fletcher (2002)
10.1073/pnas.0710355105
Microneedles permit transdermal delivery of a skin-impermeant medication to humans
D. Wermeling (2008)
10.1002/BIT.21324
Optimization of a jet‐propelled particle injection system for the uniform transdermal delivery of drug/vaccine
Y. Liu (2007)
10.1017/S0022112000003335
Dynamics of laser-induced cavitation bubbles near elastic boundaries: influence of the elastic modulus
E. Brujan (2001)
10.1016/J.JCONREL.2006.07.001
Insights into synergistic interactions in binary mixtures of chemical permeation enhancers for transdermal drug delivery.
P. Karande (2006)
10.1007/BF02072205
Risks of jet injection of insulin in children
G. Theintz (2005)
10.1073/pnas.0710875105
Unilamellar vesicle formation and encapsulation by microfluidic jetting
J. Stachowiak (2008)
Tensile strength, relaxation and mechanical recovery in rat skin as influenced by maturation and age.
Vogel Hg (1976)
10.1038/nri1728
Immunization without needles
S. Mitragotri (2005)
10.1063/1.1357452
Pulsed liquid microjet for microsurgery
D. Fletcher (2001)
10.1016/J.JBIOMECH.2003.12.006
Jet injection into polyacrylamide gels: investigation of jet injection mechanics.
Joy Schramm-Baxter (2004)
10.1016/0021-9290(90)90018-X
Mechanical and failure behaviour of the stratum corneum.
K. S. Koutroupi (1990)
Viscous Fluid Flow
F. White (1974)
10.1007/BF01983402
Painfulness of needle and jet injection in children with diabetes mellitus
U. Schneider (2005)
10.1016/J.JCONREL.2004.04.006
Needle-free jet injections: dependence of jet penetration and dispersion in the skin on jet power.
Joy Schramm-Baxter (2004)
10.1016/S0264-410X(01)00106-2
A model to assess the infection potential of jet injectors used in mass immunisation.
P. N. Hoffman (2001)
10.1073/pnas.0700182104
Needle-free delivery of macromolecules across the skin by nanoliter-volume pulsed microjets
A. Arora (2007)
10.1109/10.740886
Fluid mechanics analysis of a spring-loaded jet injector
A.B. Baker (1999)
10.1016/J.JCONREL.2006.10.017
Coated microneedles for transdermal delivery.
H. Gill (2007)
10.3181/00379727-122-31072
Collagen and Hexosamine Changes in Subcutaneous Granuloma Irradiated Locally with a Co60Source.∗
M. Nimni (1966)



This paper is referenced by
10.1109/TBME.2015.2482967
Analysis of Moving-Coil Actuator Jet Injectors for Viscous Fluids
R. Williams (2016)
10.1016/j.addr.2012.07.016
Devices for overcoming biological barriers: the use of physical forces to disrupt the barriers.
S. Mitragotri (2013)
10.1109/EMBC.2012.6346362
A computational model of a controllable needle-free jet injector
Rhys M. J. Williams (2012)
10.4236/JBISE.2015.89059
A Voice Coil Powered Controllable Micro-Jet Injection System
Kai Chen (2015)
Pharmacological aspects of insulin administration by jet stream
E.E.C. Engwerda (2016)
10.1002/adhm.201500419
Bioinspired Nanoparticulate Medical Glues for Minimally Invasive Tissue Repair.
Y. Lee (2015)
10.1007/s12206-019-1051-1
An experimental study of a spring-loaded needle-free injector: Influence of the ejection volume and injector orifice diameter
Dongping Zeng (2019)
10.1063/1.4940038
Continuous-wave laser generated jets for needle free applications.
C. Berrospe-Rodriguez (2016)
10.1016/j.colsurfb.2014.10.009
Needle-free transdermal delivery using PLGA nanoparticles: effect of particle size, injection pressure and syringe orifice diameter.
C. Park (2014)
10.1016/j.ejpb.2012.03.008
Preparation and validation of a skin model for the evaluation of intradermal powder injection devices.
Yibin Deng (2012)
10.2337/dc13-0492
Needle-Free Jet Injection of Rapid-Acting Insulin Improves Early Postprandial Glucose Control in Patients With Diabetes
E. Engwerda (2013)
10.1007/978-981-13-3642-3_8
Transdermal Drug Therapy: Emerging Techniques and Improved Patient Compliance
Avinash Kumar Seth (2019)
10.1016/j.jconrel.2016.05.019
Penetration and delivery characteristics of repetitive microjet injection into the skin.
A. M. Römgens (2016)
Transdermal Iontophoresis Delivery Control by Ion-Exchange Fibers and Nanocarriers
K Malinovskaja-Gomez (2016)
무고통 및 무패치의 슈팅 마이크로구조체
정형일 (2014)
10.1109/EMBC.2016.7590762
A device for controlled jet injection of large volumes of liquid
James W. Mckeage (2016)
10.29328/journal.hjb.1001004
Concise Review: Considerations for the Formulation, Delivery and Administration Routes of Biopharmaceuticals
A. M. Alsharabasy (2017)
10.2745/DDS.27.202
Mechanical Disruption of Skin Barrier for Vaccine Delivery
Mitragotri Samir (2012)
10.1159/000351947
Engineering Approaches to Transdermal Drug Delivery: A Tribute to Contributions of Prof. Robert Langer
Samir Mitragotri (2013)
10.1038/srep07914
A patchless dissolving microneedle delivery system enabling rapid and efficient transdermal drug delivery
S. F. Lahiji (2015)
10.1016/j.jconrel.2019.06.032
Characterization of skin blebs from intradermal jet injection: Ex-vivo studies.
J. A. Simmons (2019)
10.1109/EMBC.2017.8036820
Needle-free small-volume liquid injection system powered by a rotary actuator
Aoyu Zhang (2017)
10.1016/j.ijpharm.2015.03.017
Inkjet printing for pharmaceutics - A review of research and manufacturing.
Rónán Daly (2015)
10.3795/KSME-B.2011.35.5.547
Painless Microjet Injector Using Laser Pulse Energy
J. Yoh (2011)
10.1038/nrd4363
Overcoming the challenges in administering biopharmaceuticals: formulation and delivery strategies
S. Mitragotri (2014)
10.1017/cbo9781139026086
Essential Biomaterials Science
D. Williams (2014)
10.1088/0960-1317/23/3/035026
Microfluidic jet injection for delivering macromolecules into cells.
Andrea Adamo (2013)
Transdermal Iontophoresis – Delivery Control by Ion-Exchange Fibers and Nanocarriers
Dean Jouni Hirvonen (2016)
KINAM PARK
K. Park (2010)
Performance and design improvements toward the commercialization of a needle-free jet injector/
Ashin Modak (2013)
10.1109/ACCESS.2017.2778193
Electromagnetic Needleless Injector With Halbach Array Towards Intravitreal Delivery
Hongliang Ren (2018)
10.5021/ad.2018.30.1.102
Investigating Skin Penetration Following Needle-Free Injection Combined with Fractional Laser and Subcision
J. Seok (2018)
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