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PH-triggered Drug Carrier For Targeted Co-delivery Of Genes And Drugs.

M. Wang, R. Wang, Jingxiao Chen, J. Chen
Published 2015 · Chemistry, Medicine

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Cancer has been a most deadly disease [1]. In order to treat cancer, combination therapy of anti-tumor drugs has been evaluated by many researchers [2]. However, free drug has no selectivity, which causes toxicity to many healthy tissues. To overcome this problem, drug delivery carriers, such as nanoparticles, liposomes, micelles and nanofibers, have been developed [1]. The drug-loaded nanofibers can be fabricated into different shape and placed onto the lesions for treatment conveniently [1]. In this study, we aimed to load the hydrophobic drug hydroxycamptothecin (CPT) and hydrophilic drug doxorubicin (DOX) into PLGA nanofibers. The dual drugs-loaded PLGA (DOX&CPT@PLGA) nanofibers was first fabricated by electrospinning and then characterized intensively including its morphology, drug release behavior and cytotoxicity on cancer cells. The results showed that the DOX&CPT@PLGA nanofibers have an irregular surface morphology with a mean diameter of 789 nm and the drugs released from the nanofibers in a sustained manner (Fig. 1A). As shown in Fig. 1B, the dual drugs-loaded nanofibers more efficiently inhibited the growth of HeLa cells than the single drug-loaded nanofibers did. Our work suggests that the elecstrospun DOX&CPT@PLGA nanofibers have a promising application in local cancer treatment.
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