Online citations, reference lists, and bibliographies.
← Back to Search

Increased Vagal Modulation In Atopic Dermatitis.

M. Boettger, K. Bär, A. Dohrmann, Helge Müller, L. Mertins, N. Brockmeyer, M. Agelink
Published 2009 · Medicine

Save to my Library
Download PDF
Analyze on Scholarcy Visualize in Litmaps
Share
Reduce the time it takes to create your bibliography by a factor of 10 by using the world’s favourite reference manager
Time to take this seriously.
Get Citationsy
BACKGROUND Atopic dermatitis has been shown to be associated with neurogenic and psychosocial factors. In related atopic diseases such as rhinitis or asthma, a shift in autonomic balance towards a parasympathetic modulation has been described. On the other hand, the psychiatric symptoms known for atopic dermatitis are often associated with decreased vagal modulation. Furthermore, an increased parasympathetic activity has been shown to exhibit anti-inflammatory effects, thus rather alleviating dermatitis symptoms. OBJECTIVE In order to address these intriguing discrepancies, we aimed to assess the autonomic state in patients suffering from atopic dermatitis. METHODS Heart rate variability assessment was performed in 30 patients and data were compared to those obtained from matched controls. Furthermore, questionnaires for disease activity and psychosocial stressors were employed. RESULTS Patients showed higher values for parasympathetic modulation than controls. This was mainly reflected by an increase in the root mean square of successive differences (RMSSD). This parameter further correlated with dermatological symptoms and the time since the last severe exacerbation of the disease. In addition, subgroups of patients with dyshidrosis or photophobia showed significant differences in autonomic modulation under deep respiration. Moreover, cardiac autonomic modulation was hardly altered upon postural change, indicating that autonomic reactivity is only mildly influenced in these patients. CONCLUSION Patients with atopic dermatitis showed an autonomic dysbalance which is comparable to other diseases related to atopy or allergy. Our findings point to the question whether these alterations are disease-inherent or counter-regulatory, which should be addressed in future studies.
This paper references
10.1111/J.2044-8260.1977.TB00241.X
Factorial invariance across gender for the primary symptom dimensions of the SCL-90.
L. Derogatis (1977)
Diagnostic features of atopic dermatitis
J. Hanifin (1980)
10.1126/SCIENCE.6166045
Power spectrum analysis of heart rate fluctuation: a quantitative probe of beat-to-beat cardiovascular control.
S. Akselrod (1981)
Anti-allergic effect of beta-2 agonists and cholinoceptor antagonists in vitro.
H. Morr (1983)
An improved method for measuring heart-rate variability: assessment of cardiac autonomic function.
C. Weinberg (1984)
10.2307/2530931
An improved method for measuring heart-rate variability: assessment of cardiac autonomic function.
Weinberg Cr (1984)
10.1152/AJPHEART.1985.248.1.H151
Assessment of autonomic function in humans by heart rate spectral analysis.
B. Pomeranz (1985)
10.3109/02770908509087111
Beat-to-beat variation of the heart rate in children with allergic asthma.
K. Tokuyama (1985)
10.1109/TBME.1986.325789
An Efficient Algorithm for Spectral Analysis of Heart Rate Variability
R. Berger (1986)
10.1016/0022-3999(87)90016-X
The relation of stress and family environment to atopic dermatitis symptoms in children.
K. Gil (1987)
10.1152/AJPHEART.1990.258.3.H713
Heart rate and muscle sympathetic nerve variability during reflex changes of autonomic activity.
J. P. Saul (1990)
10.1111/j.1464-5491.1992.tb01754.x
Assessment of Cardiovascular Autonomic Function: Age‐related Normal Ranges and Reproducibility of Spectral Analysis, Vector Analysis, and Standard Tests of Heart Rate Variation and Blood Pressure Responses
Dan Ziegler (1992)
10.1161/01.CIR.85.6.2073
Heart rate variability during the acute phase of myocardial infarction.
G. Casolo (1992)
10.1159/000247298
Severity Scoring of Atopic Dermatitis: The SCORAD Index
K. Schallreuter (1993)
10.1016/0022-3999(93)90058-N
Personality characteristics and serum IgE level in patients with atopic dermatitis.
G. Scheich (1993)
10.1016/0923-1811(93)91263-t
Severity scoring of atopic dermatitis: the SCORAD index. Consensus Report of the European Task Force on Atopic Dermatitis.
J. F. Stalder (1993)
10.1111/j.1749-6632.1999.tb08697.x
Depression Modulates Pruritus Perception: A Study of Pruritus in Psoriasis, Atopic Dermatitis and Chronic Idiopathic Urticaria a
MADHULIKA A. Gupta (1994)
10.1016/S0735-1097(95)80076-X
Assessment of cardiovascular autonomic function.
M. Siddiqui (1995)
10.1016/S0002-9149(99)80680-8
Decreased heart rate variability in men with phobic anxiety (data from the Normative Aging Study).
I. Kawachi (1995)
10.1093/OXFORDJOURNALS.EURHEARTJ.A014868
Heart rate variability. Standards of measurement, physiological interpretation, and clinical use
M. Malik (1996)
10.1161/01.CIR.93.5.1043
Heart rate variability: standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology.
A. J. Camm (1996)
10.1067/MHJ.2000.109981
Heart rate variability in depressive and anxiety disorders.
J. Gorman (2000)
10.1002/DA.1019
Heart rate and QT variability in children with anxiety disorders: A preliminary report
V. Yeragani (2001)
10.1016/S0006-3223(01)01347-6
Diminished chaos of heart rate time series in patients with major depression
V. Yeragani (2002)
10.1016/S0165-5728(02)00168-6
Stress-induced immunomodulation is altered in patients with atopic dermatitis
A. Buske-Kirschbaum (2002)
10.1210/JC.2001-010872
Altered responsiveness of the hypothalamus-pituitary-adrenal axis and the sympathetic adrenomedullary system to stress in patients with atopic dermatitis.
A. Buske-Kirschbaum (2002)
10.1038/nature01321
The inflammatory reflex
K. Tracey (2002)
10.1016/S0889-1591(02)00021-1
Stress and the inflammatory response: A review of neurogenic inflammation
P. Black (2002)
The inflammatory reflex. Nature 2002;420:853–9
KJ Tracey (2002)
10.1111/j.1749-6632.2003.tb03153.x
Endocrine and Immune Responses to Stress in Chronic Inflammatory Skin Disorders
A. Buske-Kirschbaum (2003)
10.1024/0040-5930.60.11.673
Stress, Depression und kardiale Arrhythmien
C. Brunckhorst (2003)
[Stress, depression and cardiac arrhythmias].
C. Brunckhorst (2003)
10.1038/nature01339
Nicotinic acetylcholine receptor α7 subunit is an essential regulator of inflammation
H. Wang (2003)
10.1016/J.JAD.2003.12.016
The influence of major depression and its treatment on heart rate variability and pupillary light reflex parameters.
Karl-Jürgen Bär (2004)
10.1055/S-2004-831919
Lateralization of Pupillary Light Reflex Parameters
K. Bär (2004)
10.1007/BF01983125
Immunological modulation of cholinergic histamine release in isolated rat mast cells
E. Masini (2005)
10.1111/j.1365-2133.2005.06449.x
Anxiety accelerates T‐helper 2‐tilted immune responses in patients with atopic dermatitis
H. Hashizume (2005)
10.1007/BF02291234
Autonomic cardiac abnormalities in alcohol-dependent patients admitted to a psychiatric department
T. Rechlin (2005)
10.1007/BF02322053
Standardized tests of heart rate variability: normal ranges obtained from 309 healthy humans, and effects of age, gender, and heart rate
M. Agelink (2006)
10.1016/J.DRUGALCDEP.2006.03.014
Reduced baroreflex sensitivity in acute alcohol withdrawal syndrome and in abstained alcoholics.
K. Bär (2006)
10.1016/J.JPSYCHORES.2005.10.011
Increased pulse-wave velocity in patients with anxiety: implications for autonomic dysfunction.
V. Yeragani (2006)
10.1172/JCI30555
Physiology and immunology of the cholinergic antiinflammatory pathway.
K. Tracey (2007)
10.7205/MILMED.172.1.98
Heart rate variability in patients with allergic rhinitis.
M. Yokuşoğlu (2007)
10.1016/j.clinph.2007.06.012
Non-linear complexity measures of heart rate variability in acute schizophrenia
K. Bär (2007)
10.1038/SJ.JID.5701079
Further exploring the brain-skin connection: stress worsens dermatitis via substance P-dependent neurogenic inflammation in mice.
S. Pavlovic (2008)
10.1111/j.1399-5618.2007.00503.x
Nonlinear broad band dynamics are less complex in major depression.
S. Boettger (2008)
10.1016/j.psychres.2007.04.021
Relationship between cardiovagal modulation and psychotic state in patients with paranoid schizophrenia
K. Bär (2008)
10.1111/j.1468-1331.2008.02173.x
Cardiovagal modulation upon postural change is altered in Huntington’s disease
K. Bär (2008)
10.1016/j.jad.2007.12.236
Gastric dysmotility in patients with major depression.
C. Ruhland (2008)
10.1038/sj.jid.5701171
Neuroimmune communication in skin: far from peripheral.
S. Hendrix (2008)



This paper is referenced by
10.3390/ijerph18052276
Cardiovascular Autonomic Control, Sleep and Health Related Quality of Life in Systemic Sclerosis
Angelica Carandina (2021)
10.1016/j.jaim.2019.04.003
Can the vagus nerve serve as biomarker for vata dosha activity?
V. Sumantran (2019)
10.1155/2019/1907578
Acupuncture Treatment for Symptom Management in Atopic Dermatitis: A Study Protocol for a Randomized, Participant- and Assessor-Blind, Sham-Controlled Trial
J. Park (2019)
10.1016/j.neubiorev.2018.01.009
The vicious cycle of itch and anxiety
K. M. Sanders (2018)
10.1016/j.ctim.2018.08.013
Acupuncture improves symptoms in patients with mild-to-moderate atopic dermatitis: A randomized, sham-controlled preliminary trial.
SeHyun Kang (2018)
10.1016/B978-0-323-35868-2.00096-7
Chapter 96 – Enhancing Heart Rate Variability
Malynn L. Utzinger (2018)
10.1111/ics.12373
Relationships between transepidermal water loss, cutaneous microcirculatory function and autonomic nervous activity
T. Nomura (2017)
10.1016/j.anai.2016.11.012
Autonomic function in adults with allergic rhinitis and its association with disease severity and duration.
M. Kim (2017)
10.17265/2328-2150/2017.01.009
Increased Heart Rate Variability in Allergic and Highly Trait Anxious Individuals
J. Rajcáni (2017)
10.1007/978-3-319-22243-1_3
Pathophysiology of Atopic Dermatitis/Eczema
J. Ring (2016)
Heart rate variability in psychosocial stress : Comparison between laboratory and real-life setting
J. Rajcáni (2016)
Etude descriptive du vieillissement cutané au sein d'une cohorte de 209 sujets et relations avec le système nerveux autonome
É. Cinotti (2016)
10.1186/s12890-015-0118-8
Patterns of heart rate variability and cardiac autonomic modulations in controlled and uncontrolled asthmatic patients
Mohamed Faisal Lutfi (2015)
Perioperative reflex bradycardia and cardiac arrest.
Alia S Dabbous (2014)
10.3233/NIB-140085
Physiological, Immunological and Evolutionary Perspectives of Labor as an Inflammatory Process
J. J. Reyes-Lagos (2014)
10.25011/CIM.V36I5.20126
Influence of cardiac dysfunction and systemic inflammation on pulmonary function and airway responsiveness in obese subjects.
Andrée-Anne Gagnon-Audet (2013)
10.1177/1358863X11398519
Acrocyanosis: The Flying Dutchman
A. Kurklinsky (2011)
10.6114/JKOOD.2011.24.3.065
The Correlation between Atopic Dermatitis Severity and Heart Rate Variability
Seung-min Yu (2011)
10.1007/s12016-010-8225-z
Atopic Dermatitis and the Nervous System
L. Misery (2011)
10.2340/00015555-1126
Differences in itch characteristics between psoriasis and atopic dermatitis patients: results of a web-based questionnaire.
J. O'Neill (2011)
Stress, Sleep, and Allergy
S. Jernelöv (2010)
10.2165/11533250-000000000-00000
Pompholyx: a review of clinical features, differential diagnosis, and management.
U. Wollina (2010)
10.2340/00015555-0890
Effect of itch, scratching and mental stress on autonomic nervous system function in atopic dermatitis.
Bryant W Tran (2010)
10.1002/eat.20765
Increased QT variability in patients with anorexia nervosa--an indicator for increased cardiac mortality?
M. Koschke (2010)
Semantic Scholar Logo Some data provided by SemanticScholar