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Regulation Of Iodothyronine Deiodinases And Sodium Iodide Symporter MRNA Expression By Perchlorate In Larvae And Adult Chinese Rare Minnow (Gobiocypris Rarus).
W. Li, Jinmiao Zha, Lihua Yang, Zhaoli Li, Zijian Wang
Published 2011 · Chemistry, Medicine
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Perchlorate is a widespread contaminant in the aquatic environment. In the present work, the expressions of deiodinase enzymes (d1, d2, and d3) and sodium iodide symporter (nis) genes were determined after larval and adult rare minnow (Gobiocypris rarus) exposed to 5 and 50 μg/L perchlorate for 21 days. The results showed that deflation of swim bladder development was observed in larvae at 50 μg/L perchlorate treatment. An up-regulation of the d2 and nis mRNA levels were observed in the larve and in brain of adults. Meanwhile the expressions of d3 mRNA levels were significantly down-regulated in the liver. These results indicate the changes in d2, nis, and d3 mRNA expression brings about increased outer-ring deiodination, idodine uptake, and a further decrease of inner-ring deiodination, respectively reflecting auto-regulation of hypothalamic-pituitary-thyroid (HPT) axis in adult after perchlorate exposure. The larval fish development could be affected by perchlorate at environmentally relevant concentrations.
This paper references
Perchlorate Chemistry: Implications for Analysis and Remediation
E. Urbansky (1998)
Environmentally relevant concentrations of ammonium perchlorate inhibit thyroid function and alter sex ratios in developing Xenopus laevis.
W. L. Goleman (2002)
The pharmacokinetics of perchlorate and its effect on the hypothalamus-pituitary-thyroid axis in the male rat.
K. Yu (2002)
The sodium/iodide Symporter (NIS): characterization, regulation, and medical significance.
O. Dohán (2003)
Determination of trace levels of haloacetic acids and perchlorate in drinking water by ion chromatography with direct injection.
Y. Liu (2003)
Differential effects of natural flavonoids on growth and iodide content in a human Na*/I- symporter-transfected follicular thyroid carcinoma cell line.
J. P. Schröder-van der Elst (2004)
Developmental changes of thyroid hormones in the fathead minnow, Pimephales promelas.
Helen M Crane (2004)
Endocrine disrupting compounds and other emerging contaminants in the environment: A survey on new monitoring strategies and occurrence data
M. Petrovíc (2004)
Effects of Ammonium Perchlorate on Thyroid Function in Developing Fathead Minnows, Pimephales promelas
H. Crane (2005)
Perchlorate affects thyroid function in eastern mosquitofish (Gambusia holbrooki) at environmentally relevant concentrations.
C. M. Bradford (2005)
Novel biomarkers of perchlorate exposure in zebrafish.
Sandeep Mukhi (2005)
Thyroid hormone deiodination in fish.
A. Orozco (2005)
The thyroid endocrine disruptor perchlorate affects reproduction, growth, and survival of mosquitofish.
June-Woo Park (2006)
Perchlorate in fish from a contaminated site in east-central Texas.
C. Theodorakis (2006)
Gene expression profiles in fathead minnow exposed to 2,4-DNT: correlation with toxicity in mammals.
H. Wintz (2006)
Histological alternation and vitellogenin induction in adult rare minnow (Gobiocypris rarus) after exposure to ethynylestradiol and nonylphenol.
J. Zha (2007)
Effects of prolonged exposure to perchlorate on thyroid and reproductive function in zebrafish.
Sandeep Mukhi (2006)
Perchlorate in sewage sludge, rice, bottled water and milk collected from different areas in China.
Yali Shi (2007)
Thyroid disruption in walleye (Sander vitreus) exposed to environmental contaminants: cloning and use of iodothyronine deiodinases as molecular biomarkers.
Michelle Picard-Aitken (2007)
Uptake, elimination, and relative distribution of perchlorate in various tissues of channel catfish.
June-Woo Park (2007)
Effects of larval-juvenile treatment with perchlorate and co-treatment with thyroxine on zebrafish sex ratios.
Sandeep Mukhi (2007)
Effects of maternal exposure to ammonium perchlorate on thyroid function and the expression of thyroid-responsive genes in Japanese quail embryos.
Y. Chen (2008)
Levels and spatial distribution of chlorophenols - 2,4-dichlorophenol, 2,4,6-trichlorophenol, and pentachlorophenol in surface water of China.
Jijun Gao (2008)
A perchlorate sensitive iodide transporter in frogs.
D. Carr (2008)
Developmental Exposure to Perchlorate Alters Synaptic Transmission in Hippocampus of the Adult Rat
M. Gilbert (2008)
Dietary Exposure to 2,2′,4,4′-Tetrabromodiphenyl Ether (PBDE-47) Alters Thyroid Status and Thyroid Hormone–Regulated Gene Transcription in the Pituitary and Brain
S. Lema (2008)
Perchlorate: overview of risks and regulation.
G. Charnley (2008)
Occurrence and distribution of organochlorine pesticides - lindane, p,p'-DDT, and heptachlor epoxide - in surface water of China.
Jijun Gao (2008)
Occurrence and distribution of organochlorine pesticides – lindane
J. Gao (2008)
S. C. Lema (2008)
Effects of exposure to acetochlor on the expression of thyroid hormone related genes in larval and adult rare minnow (Gobiocypris rarus).
W. Li (2009)
Changes of thyroid hormone levels and related gene expression in Chinese rare minnow (Gobiocypris rarus) during 3-amino-1,2,4-triazole exposure and recovery.
W. Li (2009)
Competitive Inhibition of Thyroidal Uptake of Dietary Iodide by Perchlorate Does Not Describe Perturbations in Rat Serum Total T4 and TSH
Eva D. McLanahan (2009)
Thyroid gland development and function in the zebrafish model
P. Porazzi (2009)
Perchlorate and ethylenethiourea induce different histological and molecular alterations in a non-mammalian vertebrate model of thyroid goitrogenesis
R. Opitz (2009)
Perchlorate Exposure Induces Hypothyroidism and Affects Thyroid-Responsive Genes in Liver But Not Brain of Quail Chicks
Y. Chen (2009)
Perchlorate in Tap Water, Groundwater, Surface Waters, and Bottled Water From China and its Association with Other Inorganic Anions and with Disinfection Byproducts
Q. Wu (2010)
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F. Schmidt (2017)
Effects of exposure to microcystin-LR at environmentally relevant concentrations on the metabolism of thyroid hormones in adult zebrafish (Danio rerio).
Zidong Liu (2016)
SUBSTANCE EVALUATION CONCLUSION as required by REACH Article 48 and EVALUATION REPORT for ammonium perchlorate EC No 232-2351 CAS No 7790-989 Evaluating Member State ( s ) : Germany
Perchlorate disrupts embryonic androgen synthesis and reproductive development in threespine stickleback without changing whole-body levels of thyroid hormone.
A. M. Petersen (2015)
Waterborne exposure to microcystin-LR causes thyroid hormone metabolism disturbances in juvenile Chinese rare minnow (Gobiocypris rarus).
Zidong Liu (2015)
Changes in gastric sodium-iodide symporter (NIS) activity are associated with differences in thyroid gland sensitivity to perchlorate during metamorphosis.
J. Carr (2015)
Deiodinases and thyroid metabolism disruption in teleost fish.
Sergio Jarque (2014)
Effects of water temperature on perchlorate toxicity to the thyroid and reproductive system of Oryzias latipes.
S. Lee (2014)
Crosstalk between the thyroid hormone and androgen axes during reproductive development in Silurana tropicalis.
Diana E. K. Flood (2014)
Toxicological effects of clofibric acid and diclofenac on plasma thyroid hormones of an Indian major carp, Cirrhinus mrigala during short and long-term exposures.
M. Saravanan (2014)
Butachlor causes disruption of HPG and HPT axes in adult female rare minnow (Gobiocypris rarus).
Lifei Zhu (2014)
Effects of fluoride on metamorphosis, thyroid and skeletal development in Bufo gargarizans tadpoles
H. Zhao (2013)
Emerging Contaminants and Endocrine System Dysfunction
Daniele Costa (2013)
Exposure to monocrotophos pesticide causes disruption of the hypothalamic-pituitary-thyroid axis in adult male goldfish (Carassius auratus).
X. Zhang (2013)
Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses.
L. Vandenberg (2012)
Impairments of Endocrine Functions: Causes and Consequences
J. Amiard (2012)