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The Impact Of Subchondral Bone Cysts On Local Bone Stresses In The Medial Femoral Condyle Of The Equine Stifle Joint.
L. Frazer, E. Santschi, K. Fischer
Published 2017 · Medicine
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Subchondral lucency (SCL), also referred to as subchondral bone cysts, can cause clinical problems in horses and humans. In humans, SCLs occur in youths and adolescents  due to mechanical factors (often related to athletics) and in skeletally mature individuals secondary to osteoarthritis (OA). In horses, SCL most commonly occurs in the medial femoral condyle (MFC) of growing horses (without OA), and causes lameness. The cause of equine SCL is debated, but bone trauma due to overload is the likely mechanism. Investigating the biomechanics of the healthy and cystic MFC is important to understand cyst growth and to provide a foundation for new treatment strategies. We hypothesize that SCL alters the mechanical environment of surrounding bone, which in the presence of continued loading, may lead to enlargement of the SCL. In this study, we developed and validated a finite element model of an equine stifle joint and investigated the stresses associated with varying sizes of SCL. We found substantial differences in tensile and shear stress at various stages of SCL development that suggest further bone damage leading to SCL enlargement. These data provide a first step in understanding of the altered mechanics of subchondral bone surrounding a SCL. Additional studies may provide the basis for improved treatment strategies for SCL in young horses, and may improve the understanding of SCL in humans.
This paper references
Composition and Mechanical Properties of Cancellous Bone from the Femoral Head of Patients with Osteoporosis or Osteoarthritis
B. Li (1997)
Functional adaptation of articular cartilage from birth to maturity under the influence of loading: a biomechanical analysis.
H. Brommer (2005)
Shock absorbing ability of articular cartilage and subchondral bone under impact compression.
F. Malekipour (2013)
Osteochondral lesions in pediatric and adolescent patients.
Shahnaz Ghahremani (2014)
Arthroscopic surgery for subchondral cystic lesions of the medial femoral condyle in horses: 41 cases (1988-1991).
R. D. Howard (1995)
Methodology and sensitivity studies for finite element modeling of the inferior glenohumeral ligament complex.
B. Ellis (2007)
A Review of Translational Animal Models for Knee Osteoarthritis
Martin Gregory (2012)
Optimizing finite element predictions of local subchondral bone structural stiffness using neural network‐derived density‐modulus relationships for proximal tibial subchondral cortical and trabecular bone
Majid Nazemi (2017)
The forelimb in walking horses: 1. Kinematics and ground reaction forces.
E. Hodson (2000)
Tibiofemoral joint forces during isokinetic knee extension
R. Nisell (1989)
Clinical and radiological aspects of stifle bone cysts in the horse.
L. Jeffcott (1982)
Curettage of subchondral bone cysts in medial femoral condyles of the horse.
N. White (1988)
Biomechanical properties of knee articular cartilage.
M. Laasanen (2003)
Subject-specific finite element model of the pelvis: development, validation and sensitivity studies.
A. Anderson (2005)
The cause of subchondral bone cysts in osteoarthrosisA finite element analysis
H. Dürr (2004)
Upregulation of mRNA of interleukin-1 and -6 in subchondral cystic lesions of four horses.
B. von Rechenberg (2001)
Treatment of subchondral cystic lesions of the medial femoral condyle of mature horses with growth factor enhanced chondrocyte grafts: a retrospective study of 49 cases.
K. Ortved (2012)
How to select the elastic modulus for cancellous bone in patient-specific continuum models of the spine
I. Diamant (2006)
Shear strength behavior of human trabecular bone.
Arnav Sanyal (2012)
The Truth Behind Subchondral Cysts in Osteoarthritis of the Knee
Han Xinyun Audrey (2014)
Autologous osteochondral grafting (mosaic arthroplasty) for treatment of subchondral cystic lesions in the equine stifle and fetlock joints.
G. Bodó (2004)
Damage in trabecular bone at small strains.
E. Morgan (2005)
Application of the Tsai-Wu quadratic multiaxial failure criterion to bovine trabecular bone.
T. M. Keaveny (1999)
An analysis of the unconfined compression of articular cartilage.
C. Armstrong (1984)
Compressive creep behavior of bovine trabecular bone.
S. Bowman (1994)
Effect of age at presentation on outcome following arthroscopic debridement of subchondral cystic lesions of the medial femoral condyle: 85 horses (1993--2003).
M. Smith (2005)
Fibrous tissue of subchondral cystic lesions in horses produce local mediators and neutral metalloproteinases and cause bone resorption in vitro.
B. von Rechenberg (2000)
Prevalence of radiographic changes in yearling and 2-year-old Quarter Horses intended for cutting.
E. Contino (2012)
Osseous cyst-like lesions of the medial femoral condyle in the horse.
B. Stewart (1982)
Young's modulus, density and material properties in cancellous bone over a large density range
R. Hodgskinson (1992)
Contact analysis of biphasic transversely isotropic cartilage layers and correlations with tissue failure.
P. S. Donzelli (1999)
A retrospective study of diagnostic and surgical arthroscopy of the equine femorotibial joint.
Lewis Rd (1988)
Diminished cartilage creep properties and increased trabecular bone density following a single, sub‐fracture impact of the rabbit femoral condyle
J. Borrelli (2010)
Ex vivo equine medial tibial plateau contact pressure with an intact medial femoral condyle, with a medial femoral condylar defect, and after placement of a transcondylar screw through the condylar defect.
A. G. Bonilla (2015)
Aspects of the pathology of stifle bone cysts in the horse.
L. Jeffcott (1983)
The compressive behavior of bone as a two-phase porous structure.
D. Carter (1977)
Osteochondrosis Can Lead to Formation of Pseudocysts and True Cysts in the Subchondral Bone of Horses
K. Olstad (2015)
Deriving Hounsfield units using grey levels in cone beam computed tomography.
P. Mah (2010)
Finite element analysis of the spine: towards a framework of verification, validation and sensitivity analysis.
A. Jones (2008)
Preliminary investigation of the treatment of equine medial femoral condylar subchondral cystic lesions with a transcondylar screw.
E. Santschi (2015)
A finite element model of the human knee joint for the study of tibio-femoral contact.
T. Donahue (2002)
How the stiffness of meniscal attachments and meniscal material properties affect tibio-femoral contact pressure computed using a validated finite element model of the human knee joint.
T. H. Haut Donahue (2003)
Subchondral cysts create increased intra-osseous stress in early knee OA: A finite element analysis using simulated lesions.
D. McErlain (2011)
Finite element model of the knee for investigation of injury mechanisms: development and validation.
A. Kiapour (2014)
Ground reaction forces in the horse at the walk, trot and gallop measured with an instrumented shoe
D. Robin (2008)
Computational biomechanics of articular cartilage of human knee joint: effect of osteochondral defects.
R. Shirazi (2009)
Arthroscopic injection of corticosteroids into the fibrous tissue of subchondral cystic lesions of the medial femoral condyle in horses: a retrospective study of 52 cases (2001-2006).
T. W. Wallis (2008)
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