Online citations, reference lists, and bibliographies.
← Back to Search

Preparation Of Blue- And Green-emissive Nitrogen-doped Graphene Quantum Dots From Graphite And Their Application In Bioimaging.

Qi Xin, Hameed Shah, Wenjing Xie, Yuanyuan Wang, Xinrui Jia, A. Nawaz, Maoyong Song, J. Gong
Published 2021 · Medicine, Materials Science

Save to my Library
Download PDF
Analyze on Scholarcy Visualize in Litmaps
Share
Reduce the time it takes to create your bibliography by a factor of 10 by using the world’s favourite reference manager
Time to take this seriously.
Get Citationsy
Owing to the superior photoluminescence property, low toxicity and good biocompatibility, nitrogen-doped graphene quantum dots (NGQDs) have been regarded as promising nanomaterials for biological applications such as bioimaging. However, many of the preparation methods are complicated, high cost, eco-unfriendly, and with a low product yield. Here, we demonstrate a novel top-down approach for NGQDs preparation, in which the low cost graphite was used as a precursor, ammonium persulfate as an oxidative molecule and nitrogen source, and H2O2 as an oxidative agent, N-methyl-2-pyrrolidone as a solvent and potential functionalizer. Meanwhile, the solvent extraction was applied for the first time to purify NGQDs. The separated NGQDs display green and blue fluorescence, deriving from the difference sizes and nitrogen doped types. The total product yield of NGQDs is calculated to be about 52%, containing 88% of green-emissive NGQDs and 12% of blue-emissive NGQDs. Meanwhile, our NGQDs own low cytotoxicity, and display a good bioimaging performance in the in vitro and in vivo investigation. The synthesis idea in our work might be also applicable to obtain other kinds of quantum dots from the readily obtainable bulk materials.
This paper references
The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio.
P. Haffter (1996)
10.1016/S0008-6223(01)00165-8
Surface oxides on carbon and their analysis: a critical assessment
H. Boehm. (2002)
10.1126/SCIENCE.1102896
Electric Field Effect in Atomically Thin Carbon Films
K. Novoselov (2004)
10.1038/sj.clpt.6100223
Zebrafish: An Emerging Model System for Human Disease and Drug Discovery
G. Kari (2007)
10.1126/science.1154663
Chaotic Dirac Billiard in Graphene Quantum Dots
L. Ponomarenko (2008)
10.1038/nnano.2008.215
High-yield production of graphene by liquid-phase exfoliation of graphite.
Y. Hernández (2008)
10.1002/adma.200901996
Blue photoluminescence from chemically derived graphene oxide.
G. Eda (2010)
10.1021/nn100511a
A one-step, solvothermal reduction method for producing reduced graphene oxide dispersions in organic solvents.
S. Dubin (2010)
10.1039/c0cs00118j
Zebrafish as a good vertebrate model for molecular imaging using fluorescent probes.
Sung-Kyun Ko (2011)
10.1039/C1NJ20658C
One-pot hydrothermal synthesis of graphene quantum dots surface-passivated by polyethylene glycol and their photoelectric conversion under near-infrared light
Jianhua Shen (2012)
10.1039/c3nr33849e
Focusing on luminescent graphene quantum dots: current status and future perspectives.
Lingling Li (2013)
10.1039/c2nr33191h
Eco-friendly synthesis of size-controllable amine-functionalized graphene quantum dots with antimycoplasma properties.
Feng Jiang (2013)
10.1038/ncomms6357
Gram-scale synthesis of single-crystalline graphene quantum dots with superior optical properties.
Liang Wang (2014)
10.1016/J.APSUSC.2015.08.177
Heteroatom doped graphene in photocatalysis: A review
L. K. Putri (2015)
10.1039/C4RA17131D
Fluorescent graphene quantum dots for biosensing and bioimaging
Zetan Fan (2015)
10.1039/C4TB01650E
Application of paramagnetic graphene quantum dots as a platform for simultaneous dual-modality bioimaging and tumor-targeted drug delivery.
C. Huang (2015)
10.1002/smll.201402648
Glowing graphene quantum dots and carbon dots: properties, syntheses, and biological applications.
X. Zheng (2015)
10.1371/journal.pone.0144906
Synthesis of Luminescent Graphene Quantum Dots with High Quantum Yield and Their Toxicity Study
Dan Jiang (2015)
10.1039/c4nr07005d
Photoluminescent graphene quantum dots for in vivo imaging of apoptotic cells.
Prathik Roy (2015)
10.1038/srep11835
Carbon Quantum Dots for Zebrafish Fluorescence Imaging
Yan-Fei Kang (2015)
10.1039/c5nr07335a
Facile synthesis of N-rich carbon quantum dots by spontaneous polymerization and incision of solvents as efficient bioimaging probes and advanced electrocatalysts for oxygen reduction reaction.
Zhouyue Lei (2016)
10.1016/j.addr.2016.05.013
Graphene-based nanomaterials for bioimaging.
Jing Lin (2016)
10.1039/c5nr07579c
Chemically doped fluorescent carbon and graphene quantum dots for bioimaging, sensor, catalytic and photoelectronic applications.
Yan Du (2016)
10.1016/j.cis.2018.07.001
Nitrogen-doped graphene and graphene quantum dots: A review onsynthesis and applications in energy, sensors and environment.
M. Kaur (2018)
10.1515/NTREV-2017-0199
Synthesis and applications of graphene quantum dots: a review
Weifeng Chen (2018)
10.1016/J.MTCHEM.2018.09.007
Graphene quantum dots from chemistry to applications
P. Tian (2018)
10.1016/J.CEJ.2019.04.192
Graphene quantum dots with nitrogen and oxygen derived from simultaneous reaction of solvent as exfoliant and dopant
Gil-Seong Kang (2019)
10.1016/J.CARBON.2019.07.079
Utilizing ammonium persulfate assisted expansion to fabricate flexible expanded graphite films with excellent thermal conductivity by introducing wrinkles
Yuhang Liu (2019)
10.1016/j.biomaterials.2019.03.028
Nitrogen-doped graphene quantum dots (N-GQDs) perturb redox-sensitive system via the selective inhibition of antioxidant enzyme activities in zebrafish.
S. Deng (2019)
10.1002/adma.201808283
Recent Advances on Graphene Quantum Dots: From Chemistry and Physics to Applications.
Yibo Yan (2019)
10.1016/J.CARBON.2019.02.052
Largely enhanced oxidation of graphite flakes via ammonium persulfate-assisted gas expansion for the preparation of graphene oxide sheets
Yuhang Liu (2019)
10.1021/acs.langmuir.8b03489
Edge-Oxidation of Graphites by Hydrogen Peroxide.
Aniello Vittore (2019)
10.1039/c8cc08610a
Two photon excitable graphene quantum dots for structured illumination microscopy and imaging applications: lysosome specificity and tissue-dependent imaging.
Harwinder Singh (2019)



This paper is referenced by
Semantic Scholar Logo Some data provided by SemanticScholar