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Hypoglossal Nerve Injury With Long Nerve Resection Leading To Slow Motoneuron Death

N. Fukushima, T. Kobayashi, Akira Kakegawa, T. Moriizumi
Published 2020 · Medicine

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Crush injury to peripheral nerves in adult animals is considered not to trigger retrograde neuronal cell death; however, several studies reported neuronal cell death following severe injuries including nerve transection, resection, or avulsion. However, the rate of neuronal cell death varied among studies. In this study, we evaluated the outcomes of very severe nerve injury by long nerve resection in adult rats. Right hypoglossal (XII) nerve was exposed, and a 9-mm section was resected. At 4, 8, and 12 weeks after the resection, the number of XII neurons were counted in from the rostral to caudal sections. The number of XII neurons in the injured right side was reduced after the XII nerve resection compared with the uninjured left side. The mean rates of surviving neurons at 4, 8, and 12 weeks after the nerve resection were 83.5%, 73.9%, and 61.1%, respectively, which were significantly lower than those of the control. The number of XII neurons after extensive XII nerve resection declined gradually over a relatively long time period, revealing that extensive nerve resection led to slow cell death of the injured neurons.
This paper references
The Rat Brain in Stereotaxic Coordinates
G. Paxinos (1983)
Influence of FK506, Cyclosporin A, Testosterone and Nimodipine on Motoneuron Survival Following Axotomy.
R. Tao (1998)
Time course of motoneurone death after neonatal sciatic nerve crush in the rat.
M. Lowrie (1994)
Stereological assessment of the total number of hypoglossal neurons after repeated crush injuries to the hypoglossal nerve in adult rats
N. Fukushima (2017)
Extensive neuronal cell death following intracranial transection of the facial nerve in the adult rat
P. Mattsson (1999)
Effects of various lengths of hypoglossal nerve resection on motoneuron survival
Mika Karasawa (2019)
Reciprocal changes in the expression of Bcl-2 and Bax in hypoglossal nucleus after axotomy in adult rats: possible involvement in the induction of neuronal cell death
N. Baba (1999)
Motor neurons essential for normal sciatic function in neonatally nerve-injured rats
Akira Kakegawa (2006)
Differential effects of hypoglossal and facial nerve injuries on survival and growth of rats at different developmental stages
T. Fukuyama (2006)
Effect of co‐activation of tongue protrudor and retractor muscles on tongue movements and pharyngeal airflow mechanics in the rat
D. Fuller (1999)
Quantitative analysis of survival of hypoglossal neurons in neonatally nerve-injured rats: Correlation with milk intake.
N. Fukushima (2014)
Regenerative process of the facial nerve: rate of regeneration of fibers and their bifurcations
Y. Kamijo (2003)
Regeneration of Hypoglossal Nerve Axons Following Blockade of the Axotomy‐induced Microglial Cell Reaction in the Rat
M. Svensson (1993)
Effects of hypoglossal and facial nerve injuries on milk-suckling
K. Fujita (2006)

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