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Apolipoprotein ε Alleles In Sporadic Inclusion Body Myositis: A Reappraisal

M. Needham, A. Hooper, I. James, F. V. Bockxmeer, A. Corbett, T. Day, Michael J. Garlepp, F. Mastaglia
Published 2008 · Medicine

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Previous studies have differed as to whether APOE e4 is a susceptibility factor for developing sporadic inclusion body myositis (sIBM), with a positive association being found only in an Australian cohort of cases. We have now re-examined this in a larger cohort of 57 sIBM cases and have also carried out a meta-analysis of all the published studies looking for evidence of a risk association or effect of APOEalleles on disease expression. Our findings argue against a specific role for any APOEalleles in conferring susceptibility to sIBM but have demonstrated a non-significant trend towards an earlier age-of-onset in patients with the e2allele.
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