Online citations, reference lists, and bibliographies.

MiR-134: A Human Cancer Suppressor?

Jingyu Pan, Feng Zhang, Cheng-Cao Sun, Shu-jun Li, Guang Li, Feng-Yun Gong, Tao Bo, Jing He, Rui-xi Hua, Weidong Hu, Zhan-Peng Yuan, Xin Wang, Qi-qiang He, Dejia Li
Published 2017 · Medicine, Biology
Cite This
Download PDF
Analyze on Scholarcy
MicroRNAs (miRNAs) are small noncoding RNAs approximately 20–25 nt in length, which play crucial roles through directly binding to corresponding 3′ UTR of targeted mRNAs. It has been reported that miRNAs are involved in numerous of diseases, including cancers. Recently, miR-134 has been identified to dysregulate in handles of human cancers, such as lung cancer, glioma, breast cancer, colorectal cancer, and so on. Increasing evidence indicates that miR-134 is essential for human carcinoma and participates in tumor cell proliferation, apoptosis, invasion and metastasis, drug resistance, as well as cancer diagnosis, treatment, and prognosis. Nevertheless, its roles in human cancer are still ambiguous, and its mechanisms are sophisticated as well, referring to a variety of targets and signal pathways, such as STAT5B, KRAS, MAPK/ERK signal pathway, Notch pathway, etc. Herein, we review the crucial roles of miR-134 in scores of human cancers via analyzing latest investigations, which might provide evidence for cancer diagnose, treatment, prognosis, or further investigations.
This paper references
Targeting the epidermal growth factor receptor in cancer: apoptosis takes center stage.
C. Kari (2003)
MiR-134 functions as a regulator of cell proliferation, apoptosis, and migration involving lung septation
Xiaoying Zhang (2012)
MicroRNA Array Analysis Finds Elevated Serum miR-1290 Accurately Distinguishes Patients with Low-Stage Pancreatic Cancer from Healthy and Disease Controls
A. Li (2013)
YKT 6 expression , exosome release , and survival in non - small cell lung cancer
M. Ruiz-Martinez (2016)
Circulating microRNAs as stable blood-based markers for cancer detection
P. S. Mitchell (2008)
Microenvironmental regulation of epithelial-mesenchymal transitions in cancer.
Dingcheng Gao (2012)
Localization- and mutation-dependent microRNA (miRNA) expression signatures in gastrointestinal stromal tumours (GISTs), with a cluster of co-expressed miRNAs located at 14q32.31.
F. Haller (2010)
EGF-receptor-mediated mammary epithelial cell migration is driven by sustained ERK signaling from autocrine stimulation
E. Joslin (2007)
A unified model of mammalian BCL-2 protein family interactions at the mitochondria.
Fabien Llambi (2011)
Hyaluronic Acid Promotes the Expression of Progesterone Receptor Membrane Component 1 via Epigenetic Silencing of miR-139-5p in Human and Rat Granulosa Cells1
Guangfeng Zhao (2014)
Clinico-Pathological Association of Delineated miRNAs in Uveal Melanoma with Monosomy 3/Disomy 3 Chromosomal Aberrations
Nalini Venkatesan (2016)
MicroRNA and Target Protein Patterns Reveal Physiopathological Features of Glioma Subtypes
Elodie Lages (2011)
Targeting of syndecan-1 by microRNA miR-10b promotes breast cancer cell motility and invasiveness via a Rho-GTPase- and E-cadherin-dependent mechanism.
Sherif Abdelaziz Ibrahim (2012)
Inhibition of cyclin-dependent kinases by p21.
J. W. Harper (1995)
Regulation of mRNA translation and stability by microRNAs.
M. Fabian (2010)
Therapeutic Strategies Utilized in the Setting of Acquired Resistance to EGFR Tyrosine Kinase Inhibitors
Helena A. Yu (2014)
MicroRNA Expression and Identification of Putative miRNA Targets in Ovarian Cancer
Neetu Dahiya (2008)
Unambiguous identification of 146 Molecular Therapy: Nucleic Acids Vol. 6 March 2017 miRNA:target site interactions by different types of ligation reactions
S. Grosswendt (2014)
Diagnostic Value of Circulating Extracellular miR-134, miR-185, and miR-22 Levels in Lung Adenocarcinoma-Associated Malignant Pleural Effusion
Y. M. Shin (2014)
Remaining cancer sites: Brain, bone, soft tissue sarcoma and thyroid
T Brown (2012)
William Elison (2017)
Collective and Individual Migration following the Epithelial-Mesenchymal Transition
Ian Y. Wong (2014)
Clinical implications of dihydropyrimidine dehydrogenase (DPD) deficiency in patients with severe 5-fluorouracil-associated toxicity: identification of new mutations in the DPD gene.
A. V. van Kuilenburg (2000)
A radiosensitivity MiRNA signature validated by the TCGA database for head and neck squamous cell carcinomas
Ning Han Liu (2015)
An oncogenetic tree model in gastrointestinal stromal tumours (GISTs) identifies different pathways of cytogenetic evolution with prognostic implications.
B. Gunawan (2007)
Caspases and caspase inhibitors.
P. Villa (1997)
Tumor Suppressor WWOX Interacts with MEK2 and Activates ERK Pathway
Sayeon Cho (2011)
cDNA microarray analysis of invasive and tumorigenic phenotypes in a breast cancer model
H. Kluger (2004)
A brain-specific microRNA regulates dendritic spine development
G. Schratt (2006)
The secrets of the Bcl-2 family
Ana J. García-Sáez (2012)
Genome-Wide Screening Identified That miR-134 Acts as a Metastasis Suppressor by Targeting Integrin β1 in Hepatocellular Carcinoma
Ruopeng Zha (2014)
Deregulation of cancer-related miRNAs is a common event in both benign and malignant human breast tumors.
Andliena Tahiri (2014)
Down-regulation of c-Met and Bcl2 by microRNA-206, activates apoptosis, and inhibits tumor cell proliferation, migration and colony formation
Chengcao Sun (2015)
Unambiguous identification of miRNA:target site interactions by different types of ligation reactions.
Stefanie Grosswendt (2014)
Chronic administration tetrahydroxystilbene glucoside promotes Review hippocampal memory and synaptic plasticity and activates ERKs, CaMKII and SIRT1/miR-134 in vivo
T. Chen (2016)
Cancer statistics.
N Dubrawsky (1989)
Cancer statistics, 2015.
Rebecca L Siegel (2015)
miR-10b promotes cell invasion through RhoC-AKT signaling pathway by targeting HOXD10 in gastric cancer.
Z. Liu (2012)
Possible involvement of CCT5, RGS3, and YKT6 genes up-regulated in p53-mutated tumors in resistance to docetaxel in human breast cancers
A. Ooe (2006)
British Occupational Cancer Burden Study Group Occupational cancer in Britain. Remaining cancer sites: Brain, bone, soft tissue sarcoma and thyroid
T Brown (2012)
Diagnostic microRNA markers to screen for sporadic human colon cancer in stool: I. Proof of principle.
Farid E. Ahmed (2013)
Cancer statistics in China
W Chen (2015)
Hybrid-polymerase chain reaction to identify novel target genes of miR-134 in paclitaxel resistant human ovarian carcinoma cells.
Ting Shuang (2015)
Expression Profiles and Clinical Significance of MicroRNAs in Papillary Renal Cell Carcinoma
Yuzheng Ge (2015)
miRs-134 and -370 function as tumor suppressors in colorectal cancer by independently suppressing EGFR and PI3K signalling
Sherien M. El-Daly (2016)
miR-134 functions as a tumor suppressor in cell proliferation and epithelial-to-mesenchymal Transition by targeting KRAS in renal cell carcinoma cells.
Yiyang Liu (2015)
Hsa-miR-134 suppresses non-small cell lung cancer (NSCLC) development through down-regulation of CCND1
Cheng-Cao Sun (2016)
The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases
J. Harper (1993)
Mature miR-184 as Potential Oncogenic microRNA of Squamous Cell Carcinoma of Tongue
Thian-Sze Wong (2008)
Cyclin-dependent kinase pathways as targets for cancer treatment.
G. Shapiro (2006)
Epithelial to mesenchymal transition derived from repeated exposure to gefi tinib determines the sensitivity to EGFR inhibitors in A 549 , a non - small
J. K. Rho (2009)
Induction of apoptosis in human leukemic cell lines by diallyl disulfide via modulation of EGFR/ ERK/PKM2 signaling pathways. Asian Pac
N Luo (2015)
Genome-wide screening identified that miR-134 acts as a metastasis suppressor by targeting integrin b1 in hepatocellular carcinoma
R. Zha (2014)
MicroRNA-134 suppresses endometrial cancer stem cells by targeting POGLUT1 and Notch pathway proteins.
Yongtao Gao (2015)
A large imprinted microRNA gene cluster at the mouse Dlk1-Gtl2 domain.
Hervé Seitz (2004)
Epithelial to mesenchymal transition derived from repeated exposure to ge fitinib determines the sensitivity to EGFR inhibitors in A549, a non-small cell lung cancer cell line
J. K. Rho (2009)
MicroRNA187-3p mitigates non-small cell lung cancer (NSCLC) development through downregulation of BCL6
C. Sun (2016)
DLK1-DIO3 Genomic Imprinted MicroRNA Cluster at 14q32.2 Defines a Stemlike Subtype of Hepatocellular Carcinoma Associated with Poor Survival
John Moon-Ching Luk (2011)
Hepatocyte nuclear factor-4α reverses malignancy of hepatocellular carcinoma through regulating miR-134 in the DLK1-DIO3 region.
Chuan Yin (2013)
A novel saliva-based microRNA biomarker panel to detect head and neck cancers
Carolina Salazar (2014)
Two lung development-related microRNAs, miR-134 and miR-187, are differentially expressed in lung tumors.
Fatemeh Mirzadeh Azad (2016)
miR‐134 inhibits non‐small cell lung cancer growth by targeting the epidermal growth factor receptor
Qin Qin (2016)
MicroRNA-134 regulates lung cancer cell H69 growth and apoptosis by targeting WWOX gene and suppressing the ERK1/2 signaling pathway.
Tianjun Chen (2015)
Caspases Are Activated in a Branched Protease Cascade and Control Distinct Downstream Processes in Fas-induced Apoptosis
H. Hirata (1998)
MicroRNA-134 modulates resistance to doxorubicin in human breast cancer cells by downregulating ABCC1
Lin Lu (2015)
Hsa-miR-329 exerts tumor suppressor function through down-regulation of MET in non-small cell lung cancer
Cheng-Cao Sun (2016)
Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line.
S. Cole (1992)
Hsa-miR-326 targets CCND1 and inhibits non-small cell lung cancer development
Chengcao Sun (2016)
MicroRNA-134 modulates glioma cell U251 proliferation and invasion by targeting KRAS and suppressing the ERK pathway
Yuguang Zhao (2016)
MicroRNAs Are Part of the Regulatory Network that Controls EGF Induced Apoptosis, Including Elements of the JAK/STAT Pathway, in A431 Cells
Ibrahim O. Alanazi (2015)
Cancer statistics in China, 2015.
Wanqing Chen (2016)
Overexpression of hCLP46 enhances Notch activation and regulates cell proliferation in a cell type-dependent manner.
Qiaoyun Chu (2013)
Epithelial to mesenchymal transition derived from repeated exposure to gefitinib determines the sensitivity to EGFR inhibitors in A549, a non-small cell lung cancer cell line.
Jin Kyung Rho (2009)
Dysregulated expression of P1 and P2 promoter-driven hepatocyte nuclear factor-4alpha in the pathogenesis of human cancer.
T. Tanaka (2006)
Decreased miR-134 expression and its tumor-suppressive function in human osteosarcoma.
Y. Bao (2015)
The Fra-1–miR-134–SDS22 feedback loop amplifies ERK/JNK signaling and reduces chemosensitivity in ovarian cancer cells
J. Wu (2016)
Induction of Apoptosis in Human Leukemic Cell Lines by Diallyl Disulfide via Modulation of EGFR/ERK/PKM2 Signaling Pathways.
Nian Ji Luo (2015)
Evidence for miR-1792 and miR-134 gene cluster regulation of ovarian cancer drug resistance
H. Zhu (2016)
Upregulation of microRNA-451 increases cisplatin sensitivity of non-small cell lung cancer cell line (A549)
Hai-Bo Bian (2011)
MicroRNAs Genomics, Biogenesis, Mechanism, and Function
D. Bartel (2004)
BCL-2 family: regulators of cell death.
D. Chao (1998)
MiR-197 induces Taxol resistance in human ovarian cancer cells by regulating NLK
Dongling Zou (2015)
C/EBPα inhibits proliferation of breast cancer cells via a novel pathway of miR-134/CREB.
Jianxiang Zhang (2015)
Decreased Expression of MIR-134 and its Clinical Significance in Human Colorectal Cancer.
Yinghai Xie (2015)
Ordering the Cytochrome c–initiated Caspase Cascade: Hierarchical Activation of Caspases-2, -3, -6, -7, -8, and -10 in a Caspase-9–dependent Manner
E. Slee (1999)
microRNA target predictions in animals
N. Rajewsky (2006)
Effects of 1α,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells
W. Wang (2011)
MiRNA-10a is upregulated in NSCLC and may promote cancer by targeting PTEN
Tao Yu (2015)
Gene expression profiling of drug-resistant small cell lung cancer cells by combining microRNA and cDNA expression analysis.
Linlang Guo (2010)
Ordering the cytochrome cinitiated caspase cascade : hierarchical activation of caspases2 ,3 ,6 ,7 ,8 , and - 10 in a caspase9dependent manner
E. A. Slee (1999)
cDNAmicroarray analysis of invasive and tumorigenic phenotypes in a breast cancer
H. M. Kluger (2004)
A MicroRNA precursor surveillance system in quality control of MicroRNA synthesis.
X Sherry Liu (2014)
Reduced expression of microRNA-134 correlates with malignancy and poor prognosis in human glioma
Jianfeng Zhong (2015)
N-cadherin-mediated cell–cell adhesion promotes cell migration in a three-dimensional matrix
Wenting Shih (2012)
MicroRNA-187-3p mitigates non-small cell lung cancer (NSCLC) development through down-regulation of BCL6.
Chengcao Sun (2016)
Circulating MiR-19b-3p, MiR-134-5p and MiR-186-5p are Promising Novel Biomarkers for Early Diagnosis of Acute Myocardial Infarction
Ke-Jing Wang (2016)
miR-134 inhibits epithelial to mesenchymal transition by targeting FOXM1 in non-small cell lung cancer cells.
Jipeng Li (2012)
MiR-134 regulates the proliferation and invasion of glioblastoma cells by reducing Nanog expression
Chao-Shi Niu (2013)
Epithelial–mesenchymal transitions in tumour progression
J. Thiery (2002)
Apoptosis: Targets in Pancreatic Cancer
S. Westphal (2002)
Exon sequencing and high resolution haplotype analysis of ABC transporter genes implicated in drug resistance
G. Leschziner (2006)
Insulin analogues display IGF-I-like mitogenic and anti-apoptotic activities in cultured cancer cells.
Doron Weinstein (2009)
miRNA interventions serve as ‘magic bullets’ in the reversal of glioblastoma hallmarks
Luyue Chen (2015)
Occupational cancer in Britain
Terry P. Brown (2012)
miR-134 induces oncogenicity and metastasis in head and neck carcinoma through targeting WWOX gene.
Chung-Ji Liu (2014)
cDNAmicroarray analysis of invasive and tumorigenic phenotypes in a breast cancer model
H. M. Kluger (2004)
Chronic administration tetrahydroxystilbene glucoside promotes hippocampal memory and synaptic plasticity and activates ERKs, CaMKII and SIRT1/miR-134 in vivo.
Tao Chen (2016)
MicroRNA signatures in human cancers
G. Calin (2006)
Tumour invasion and metastasis initiated by microRNA-10b in breast cancer (Nature (2007) 449, (682-688))
L. Ma (2008)
Loss of has-miR-337-3p expression is associated with lymph node metastasis of human gastric cancer
Zishu Wang (2013)
MiR-134-dependent regulation of Pumilio-2 is necessary for homeostatic synaptic depression.
Roberto Fiore (2014)
Chrysin Inhibits Tumor Promoter-Induced MMP-9 Expression by Blocking AP-1 via Suppression of ERK and JNK Pathways in Gastric Cancer Cells
Yong Nian Xia (2015)
Genetic variation of the ABC transporter gene ABCC1 (Multidrug resistance protein 1 – MRP1) in the Polish population
Marcin Słomka (2015)
Genome Res
functions as a tumor suppressor in cell proliferation and epithelial-to-mesenchymal Transition by targeting KRAS in renal cell carcinoma cells
Y Liu (2015)
Dysregulated Serum MicroRNA Expression Profile and Potential Biomarkers in Hepatitis C Virus-infected Patients
Shaobo Zhang (2015)
MicroRNA-423-5p Promotes Autophagy in Cancer Cells and Is Increased in Serum From Hepatocarcinoma Patients Treated With Sorafenib.
P. Stiuso (2015)
Hsa-miR-139-5p inhibits proliferation and causes apoptosis associated with down-regulation of c-Met
Chengcao Sun (2015)
Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases
Xiao Dong Chen (2008)
Advances in the diagnosis of pleural disease in lung cancer
Kay Choong See (2011)
Multiple receptor tyrosine kinases converge on microRNA-134 to control KRAS, STAT5B, and glioblastoma
Y. Zhang (2014)
Circulating miRNA profile in HCV infected serum: novel insight into pathogenesis
Shivaprasad Shwetha (2013)
MiR-134/487b/655 Cluster Regulates TGF-β–Induced Epithelial–Mesenchymal Transition and Drug Resistance to Gefitinib by Targeting MAGI2 in Lung Adenocarcinoma Cells
Kazuhiro Kitamura (2013)
British Occupational Cancer Burden Study Group
T. Brown (2012)
Dihydropyrimidine dehydrogenase (DPD) expression is negatively regulated by certain microRNAs in human lung tissues.
Takeshi Hirota (2012)
Dysregulated expression of P 1 and P 2 promoterdriven hepatocyte nuclear factor4 alpha in the pathogenesis of human can
T. Tanaka (2006)
YKT6 expression, exosome release, and survival in non-small cell lung cancer
Marc Ruíz-Martínez (2016)
Mir-34: A New Weapon Against Cancer?
G. Misso (2014)
High-throughput screens identify microRNAs essential for HER2 positive breast cancer cell growth.
Suvi-Katri Leivonen (2014)
Evidence for miR-17-92 and miR-134 gene cluster regulation of ovarian cancer drug resistance.
Hong Zhu (2016)
MicroRNAs in the pathophysiology and treatment of status epilepticus
D. Henshall (2013)
Concurrent Targeting of KRAS and AKT by MiR-4689 Is a Novel Treatment Against Mutant KRAS Colorectal Cancer
Masayuki Hiraki (2015)
MicroRNAs: Target Recognition and Regulatory Functions
D. Bartel (2009)

This paper is referenced by
MRTF‐A‐miR‐206‐WDR1 form feedback loop to regulate breast cancer cell migration
Yuan Xiang (2017)
Non-Coding RNAs in Breast Cancer: Intracellular and Intercellular Communication
Carolyn M. Klinge (2018)
MicroRNA-134 prevents the progression of esophageal squamous cell carcinoma via the PLXNA1-mediated MAPK signalling pathway
Wei-wei Wang (2019)
Regulation of tumor angiogenesis by microRNAs: State of the art.
Nasser Hashemi Goradel (2019)
Tumores cerebrales y lesiones encefálicas por radiación ionizante
Víctor José Gil Aldana (2020)
The Circulating Transcriptome as a Source of Biomarkers for Melanoma
Carla Solé (2019)
Tumor suppressor microRNAs in lung cancer: An insight to signaling pathways and drug resistance.
Vahid Asghariazar (2019)
The clinicopathological significance of UBE2C in breast cancer: a study based on immunohistochemistry, microarray and RNA-sequencing data
Chao-Hua Mo (2017)
Long non-coding RNA XIST promotes TGF-β-induced epithelial-mesenchymal transition by regulating miR-367/141-ZEB2 axis in non-small-cell lung cancer.
C. Li (2018)
Exosomes in Triple Negative Breast Cancer: Garbage Disposals or Trojan Horses?
C. Y. Goh (2020)
miR-134 inhibits osteosarcoma cell invasion and metastasis through targeting MMP1 and MMP3 in vitro and in vivo.
Cheng-Long Chen (2019)
Low-Dose Exposure to Ionizing Radiation Deregulates the Brain-Specific MicroRNA-134 in Interventional Cardiologists.
Andrea Borghini (2017)
LncRNA LINC00460 promotes tumor growth of human lung adenocarcinoma by targeting miR-302c-5p/FOXA1 axis.
Jun-jie Ye (2019)
1 The circulating transcriptome as a source of 2 biomarkers for melanoma 3
Carla Solé (2018)
The miR-15a/16 gene cluster in human cancer: A systematic review.
Ting Liu (2019)
MiR-940 inhibits TGF-β-induced epithelial-mesenchymal transition and cell invasion by targeting Snail in non-small cell lung cancer
K. Jiang (2019)
The Importance of microRNAs in RAS Oncogenic Activation in Human Cancer
Roberta Roncarati (2019)
LncRNA DIGIT Accelerates Tube Formation of Vascular Endothelial Cells by Sponging miR-134.
Chaofeng Miao (2018)
Penicillin-binding protein 1A mutation-positive Helicobacter pylori promotes epithelial-mesenchymal transition in gastric cancer via the suppression of microRNA-134
Lu Huang (2019)
The miR-875-5p inhibits SATB2 to promote the invasion of lung cancer cells.
J. Wang (2018)
Antitumor Effect of Pyrogallol via miR-134 Mediated S Phase Arrest and Inhibition of PI3K/AKT/Skp2/cMyc Signaling in Hepatocellular Carcinoma
Hyojin Ahn (2019)
miR-134 targets PDCD7 to reduce E-cadherin expression and enhance oral cancer progression.
Shih-Yuan Peng (2018)
Emerging landscape of circular RNAs in lung cancer.
Wei Hu (2018)
hOXD-as 1 functions as an oncogenic cerna to promote nsclc cell progression by sequestering mir-147 a
Qing-hua Wang (2017)
Development and Validation of a MicroRNA Panel to Differentiate Between Patients with Rheumatoid Arthritis or Systemic Lupus Erythematosus and Controls
Michelle J Ormseth (2020)
Silencing of long non-coding RNA NCK1-AS1 inhibits cell proliferation and migration via inhibition of microRNA-134 in cervical cancer.
L. Huang (2019)
Circular RNAs: a rising star in respiratory diseases
Jian Wang (2019)
Modification of miRNA Expression through plant extracts and compounds against breast cancer: Mechanism and translational significance.
Fayyaz Ahmed (2020)
LINC00210 as a miR-328-5p sponge promotes nasopharyngeal carcinoma tumorigenesis by activating NOTCH3 pathway
S. Zhang (2018)
Long intergenic non-protein coding RNA 319 aggravates lung adenocarcinoma carcinogenesis by modulating miR-450b-5p/EZH2.
Zengwang Zhang (2018)
Long non-coding RNA PCAT7 regulates ELF2 signaling through inhibition of miR-134-5p in nasopharyngeal carcinoma.
Yejun Liu (2017)
MicroRNA-421 promotes the progression of non-small cell lung cancer by targeting HOPX and regulating the Wnt/β-catenin signaling pathway
Huagang Liang (2019)
See more
Semantic Scholar Logo Some data provided by SemanticScholar