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The Role Of Endocannabinoid Transmission In Cocaine Addiction

J. Arnold
Published 2005 · Medicine, Psychology

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Research is beginning to outline a role for the endocannabinoid system in cocaine addiction. Human and animal studies indicate that exogenous cannabinoids modulate the acute rewarding effects of cocaine. These studies, however, cannot directly investigate the necessity of endocannabinoid transmission in cocaine addiction. Studies that do offer a direct assessment show that neither pharmacological antagonism nor deletion of the CB1 receptor alters the acute rewarding effects of cocaine. In contrast, CB1 receptors appear to be involved in the association of cocaine reward with environmental cues and reinstatement of cocaine self-administration. Together, these results point to CB1 receptor antagonists as potential anti-craving compounds in the treatment of cocaine addiction. Given the limitations of human population studies, animal research may be useful in discerning causal inferences between cannabis and cocaine use. While animal research suggests cannabis use may precipitate cocaine relapse, cross-sensitization between cannabinoids and cocaine has not been demonstrated and CB1 receptors do not mediate behavioral sensitization to cocaine. The effect of acute or chronic cocaine on endocannabinoid transmission in reward-related areas of the brain is relatively under-researched. Acute cocaine administration increases anandamide levels in the striatum, an effect that is mediated by dopamine D2-like receptors. Conversely, chronic cocaine exposure has no effect on anandamide, but decreases 2-arachidonylglycerol levels in the limbic forebrain. This review highlights research indicating that the endocannabinoid system may subserve certain aspects of cocaine addiction and suggests avenues for future investigation.
This paper references
10.1016/J.COPH.2003.11.002
Glutamate systems in cocaine addiction.
P. Kalivas (2004)
10.1038/nn832
Postsynaptic endocannabinoid release is critical to long-term depression in the striatum
G. Gerdeman (2002)
10.1073/pnas.082235799
A missense mutation in human fatty acid amide hydrolase associated with problem drug use
J. Sipe (2002)
10.1016/0024-3205(88)90036-7
Food reward and cocaine increase extracellular dopamine in the nucleus accumbens as measured by microdialysis.
L. Hernández (1988)
10.1016/S0166-2236(98)01283-1
Endocannabinoids: endogenous cannabinoid receptor ligands with neuromodulatory action
V. Marzo (1998)
10.1006/nbdi.1998.0219
Cannabinoid Transmission and Reward-Related Events
E. Gardner (1998)
10.1016/S0163-7258(01)00130-9
The endocannabinoid nervous system: unique opportunities for therapeutic intervention.
A. Porter (2001)
10.1016/0376-8716(93)80001-U
Behavioral effects of cocaine alone and in combination with ethanol or marijuana in humans.
R. W. Foltin (1993)
10.1196/annals.1300.013
Exogenous and Endogenous Cannabinoids Control Synaptic Transmission in Mice Nucleus Accumbens
D. Robbe (2003)
10.1016/S0306-4522(99)00214-6
A role for nucleus accumbens glutamate transmission in the relapse to cocaine-seeking behavior
J. Cornish (1999)
10.1038/35069076
Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses
R. Wilson (2001)
10.1016/S0306-4522(01)00509-7
Coexpression of the cannabinoid receptor type 1 with dopamine and serotonin receptors in distinct neuronal subpopulations of the adult mouse forebrain
H. Hermann (2002)
10.1038/nn757
Long-term depression in the nucleus accumbens: a neural correlate of behavioral sensitization to cocaine
M. Thomas (2001)
10.1046/j.1460-9568.2002.02041.x
SHORT COMMUNICATION Inhibition of GABAergic neurotransmission in the ventral tegmental area by cannabinoids
B. Szabó (2002)
10.1002/(SICI)1096-9861(20000626)422:2<159::AID-CNE1>3.0.CO;2-1
Localisation of cannabinoid receptors in the rat brain using antibodies to the intracellular C‐terminal tail of CB1
M. Egertová (2000)
10.1016/S0306-4522(97)00436-3
Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous system
K. Tsou (1998)
10.1046/J.1360-0443.2002.00280.X
Reassessing the marijuana gateway effect.
A. Morral (2002)
10.1124/pr.54.1.1
Neurobiology of Relapse to Heroin and Cocaine Seeking: A Review
U. Shalev (2002)
10.1016/0014-2999(75)90239-3
d-Amphetamine as a releaser or reuptake inhibitor of biogenic amines in synaptosomes.
M. Raiteri (1975)
10.1038/nature00839
The endogenous cannabinoid system controls extinction of aversive memories
G. Marsicano (2002)
Pathways to relapse: the neurobiology of drug- and stress-induced relapse to drug-taking.
J. Stewart (2000)
10.1126/SCIENCE.277.5329.1094
Functional role of high-affinity anandamide transport, as revealed by selective inhibition.
M. Beltramo (1997)
10.1016/S0014-2999(98)00851-6
Chronic (-)-delta9-tetrahydrocannabinol treatment induces sensitization to the psychomotor effects of amphetamine in rats.
M. A. Gorriti (1999)
10.1126/SCIENCE.276.5321.2048
Cannabinoid and heroin activation of mesolimbic dopamine transmission by a common mu1 opioid receptor mechanism.
G. Tanda (1997)
10.1016/j.euroneuro.2003.08.008
Pharmacological treatments for heroin and cocaine addiction
W. Brink (2003)
10.1124/pr.54.2.161
International Union of Pharmacology. XXVII. Classification of Cannabinoid Receptors
A. Howlett (2002)
10.1016/S0166-4328(99)00059-5
CB1 cannabinoid receptor agonist WIN 55, 212-2 decreases intravenous cocaine self-administration in rats
L. Fattore (1999)
10.1007/s00213-003-1393-2
Brain circuitry and the reinstatement of cocaine-seeking behavior
Peter W. Kalivas (2003)
10.1016/0091-3057(83)90324-6
The effects of levonantradol on rewarding brain stimulation thresholds in the rat
L. Kucharski (1983)
Dual activation and inhibition of adenylyl cyclase by cannabinoid receptor agonists: evidence for agonist-specific trafficking of intracellular responses.
D. Bonhaus (1998)
10.1523/JNEUROSCI.16-05-01591.1996
Psychostimulants depress excitatory synaptic transmission in the nucleus accumbens via presynaptic D1-like dopamine receptors
S. Nicola (1996)
10.1038/7268
Dopamine activation of endogenous cannabinoid signaling in dorsal striatum
A. Giuffrida (1999)
10.1016/0091-3057(75)90016-7
Drug-induced reinstatement of extinguished self-administration behavior in monkeys
G. Gerber (1975)
10.1016/S0169-328X(99)00207-7
Acute injection of drugs with low addictive potential (delta(9)-tetrahydrocannabinol, 3,4-methylenedioxymethamphetamine, lysergic acid diamide) causes a much higher c-fos expression in limbic brain areas than highly addicting drugs (cocaine and morphine).
M. Erdtmann-Vourliotis (1999)
10.1016/S0006-8993(98)01258-X
Behavioral phenotyping of transgenic and knockout mice: experimental design and evaluation of general health, sensory functions, motor abilities, and specific behavioral tests
J. Crawley (1999)
10.1016/S0006-8993(01)03127-4
The distribution of cannabinoid-induced Fos expression in rat brain: differences between the Lewis and Wistar strain
J. Arnold (2001)
10.1523/JNEUROSCI.23-32-10311.2003
Mediation of Amphetamine-Induced Long-Term Depression of Synaptic Transmission by CB1 Cannabinoid Receptors in the Rat Amygdala
Y. Huang (2003)
10.1097/00001756-200004270-00018
Carrier‐mediated transport and enzymatic hydrolysis of the endogenous cannabinoid 2‐arachidonylglycerol
M. Beltramo (2000)
10.1016/S0024-3205(99)00309-4
Influence of the cannabinoid agonist HU 210 on cocaine- and CQP 201-403-induced behavioural effects in rat.
F. Ferrari (1999)
10.1016/J.EJPHAR.2003.08.054
Monoamine transporters and psychostimulant drugs.
R. Rothman (2003)
10.1523/JNEUROSCI.21-23-09506.2001
Distribution of CB1 Cannabinoid Receptors in the Amygdala and their Role in the Control of GABAergic Transmission
I. Katona (2001)
10.1007/BF02245916
Δ9-Tetrahydrocannabinol produces naloxone-blockable enhancement of presynaptic basal dopamine efflux in nucleus accumbens of conscious, freely-moving rats as measured by intracerebral microdialysis
J. Chen (2005)
Conditioned place preference as a measure of drug reward.
G. Carr (1989)
10.1042/BJ3220671
Biosynthesis, release and degradation of the novel endogenous cannabimimetic metabolite 2-arachidonoylglycerol in mouse neuroblastoma cells.
T. Bisogno (1997)
10.1007/s00213-003-1470-6
The reinstatement model and relapse prevention: a clinical perspective
D. H. Epstein (2003)
10.1037/10107-000
Vulnerability to drug abuse
M. Glantz (1992)
10.1038/19208
Drug addiction: bad habits add up
T. Robbins (1999)
10.1523/JNEUROSCI.21-01-00109.2001
Localization and Mechanisms of Action of Cannabinoid Receptors at the Glutamatergic Synapses of the Mouse Nucleus Accumbens
D. Robbe (2001)
10.1037/e496672006-003
Stereochemical requirements for cannabimimetic activity.
R. Mechoulam (1987)
10.1016/0166-2236(91)90141-G
The dopamine hypothesis of the reinforcing properties of cocaine
M. Kuhar (1991)
10.1016/S0166-4328(02)00370-4
WIN 55,212-2 decreases the reinforcing actions of cocaine through CB1 cannabinoid receptor stimulation
S. Vlachou (2003)
10.1016/S0009-3084(02)00162-7
Addictive potential of cannabinoids: the underlying neurobiology.
E. Gardner (2002)
10.1016/0306-4522(89)90012-2
Amphetamine, cocaine, phencyclidine and nomifensine increase extracellular dopamine concentrations preferentially in the nucleus accumbens of freely moving rats
E. Carboni (1989)
10.1016/S0306-4522(01)00287-1
Novel cannabinoid-sensitive receptor mediates inhibition of glutamatergic synaptic transmission in the hippocampus
N. Hájos (2001)
10.1016/0306-4522(92)90409-U
Distribution of neuronal cannabinoid receptor in the adult rat brain: A comparative receptor binding radioautography and in situ hybridization histochemistry
P. Mailleux (1992)
10.1038/372686A0
Formation and inactivation of endogenous cannabinoid anandamide in central neurons
V. Marzo (1994)
10.1038/nm1001-1151
A cannabinoid mechanism in relapse to cocaine seeking
T. Vries (2001)
10.1016/S0014-2999(99)00656-1
Lack of morphine-induced dopamine release in the nucleus accumbens of cannabinoid CB(1) receptor knockout mice.
M. S. Mascia (1999)
10.1038/sj.npp.1300458
A Critical Interaction between Dopamine D2 Receptors and Endocannabinoids Mediates the Effects of Cocaine on Striatal GABAergic Transmission
D. Centonze (2004)
10.1016/0091-3057(91)90365-9
Marijuana's interaction with brain reward systems: Update 1991
E. Gardner (1991)
10.2105/AJPH.83.6.851
From beer to crack: developmental patterns of drug involvement.
D. Kandel (1993)
10.1001/JAMA.289.4.427
Escalation of drug use in early-onset cannabis users vs co-twin controls.
M. Lynskey (2003)
10.1523/JNEUROSCI.21-23-09499.2001
Absence of Δ-9-Tetrahydrocannabinol Dysphoric Effects in Dynorphin-Deficient Mice
Andreas Zimmer (2001)
10.1523/JNEUROSCI.22-09-03326.2002
Cannabinoid Addiction: Behavioral Models and Neural Correlates
R. Maldonado (2002)
10.1016/j.neubiorev.2003.11.007
Neurobiological mechanisms in the transition from drug use to drug dependence
G. Koob (2004)
Rotational behavior induced by cocaine analogs in rats with unilateral 6-hydroxydopamine lesions of the substantia nigra: dependence upon dopamine uptake inhibition.
R. Heikkila (1979)
10.1007/BF01959156
Enantiomeric cannabinoids: stereospecificity of psychotropic activity
R. Mechoulam (2005)
10.1016/j.neubiorev.2003.11.001
Sensitization of midbrain dopamine neuron reactivity and the self-administration of psychomotor stimulant drugs
P. Vézina (2004)
10.1016/S0014-2999(98)00433-6
Effects of pre-exposure and co-administration of the cannabinoid receptor agonist CP 55,940 on behavioral sensitization to cocaine.
J. Arnold (1998)
10.1523/JNEUROSCI.4177-03.2004
Limbic and Motor Circuitry Underlying Footshock-Induced Reinstatement of Cocaine-Seeking Behavior
K. McFarland (2004)
10.1016/0006-2952(82)90057-0
Evidence for carrier-mediated efflux of dopamine from corpus striatum.
N. Y. Liang (1982)
10.1007/BF00432175
Reinstatement of cocaine-reinforced responding in the rat
H. Wit (2004)
10.1001/JAMA.289.4.482
Does marijuana use cause the use of other drugs?
D. Kandel (2003)
10.1007/s00210-002-0588-0
Constitutive activity of G-protein-coupled receptors: cause of disease and common property of wild-type receptors
R. Seifert (2002)
10.1523/JNEUROSCI.18-06-01979.1998
Mechanisms of Amphetamine Action Revealed in Mice Lacking the Dopamine Transporter
S. Jones (1998)
10.1007/s002130050454
Extracellular dopamine, norepinephrine, and serotonin in the ventral tegmental area and nucleus accumbens of freely moving rats during intracerebral dialysis following systemic administration of cocaine and other uptake blockers
M. E. Reith (1997)
10.1037/E471922004-001
Cocaine treatment outcome: cocaine use following inpatient, outpatient, and no treatment.
R. Rawson (1986)
10.1016/0300-9629(91)90604-b
The Neuropharmacological basis of reward
J. Liebman (1989)
10.1016/S0166-4328(00)00311-9
Cannabinoid CB1 receptor knockout mice fail to self-administer morphine but not other drugs of abuse
G. Cossu (2001)
10.1007/s00213-004-1825-7
Effect of low doses of Δ9-tetrahydrocannabinol and cannabidiol on the extinction of cocaine-induced and amphetamine-induced conditioned place preference learning in rats
L. Parker (2004)
10.1016/0006-8993(89)90422-8
Cocaine reinforcement and extracellular dopamine overflow in rat nucleus accumbens: an in vivo microdialysis study
Y. Hurd (1989)
10.1074/jbc.M110813200
Astrocytes in Culture Produce Anandamide and Other Acylethanolamides*
Lisa Walter (2002)
10.1038/42015
A second endogenous cannabinoid that modulates long-term potentiation
N. Stella (1997)
10.1111/J.1360-0443.1991.TB01747.X
Drug abuse potential evaluation in animals.
R. L. Balster (1991)
10.1152/PHYSREV.00004.2003
Role of endogenous cannabinoids in synaptic signaling.
T. Freund (2003)
10.1016/S0376-8716(96)01315-4
Prevalence and demographic correlates of symptoms of last year dependence on alcohol, nicotine, marijuana and cocaine in the U.S. population.
D. Kandel (1997)
10.1016/S0896-6273(00)80109-9
Drug Addiction: The Yin and Yang of Hedonic Homeostasis
G. Koob (1996)
10.1016/S0006-8993(02)03344-9
Changes in endocannabinoid contents in the brain of rats chronically exposed to nicotine, ethanol or cocaine
Sara González (2002)
10.1038/sj.mp.4000247
Cannabinoid receptor gene (CNR1): association with IV drug use
D. Comings (1997)
10.1016/J.EJPHAR.2003.08.101
The endocannabinoid system in the basal ganglia and in the mesolimbic reward system: implications for neurological and psychiatric disorders
M. Stelt (2003)
10.1007/s002130051169
Cocaine-seeking produced by experimenter-administered drug injections: dose-effect relationships in rats
S. Schenk (1999)
10.1037/10107-009
Progression to regular marijuana involvement: Phenomenology and risk factors for near-daily use.
D. Kandel (1992)
10.1038/381
Cocaine self-administration in dopamine-transporter knockout mice
B. Rocha (1998)
10.1046/J.1360-0443.2002.00209.X
Pharmacological treatment of cocaine dependence: a systematic review.
M. D. de Lima (2002)
10.1016/S0166-2236(03)00065-1
It could be habit forming: drugs of abuse and striatal synaptic plasticity
G. Gerdeman (2003)
10.1016/S0014-2999(01)01355-3
The cannabinoid CB1 receptor antagonist SR 141716A reverses the antiemetic and motor depressant actions of WIN 55, 212-2.
N. Darmani (2001)
10.1073/pnas.122149199
Endogenous cannabinoids mediate long-term synaptic depression in the nucleus accumbens
D. Robbe (2002)
10.1074/jbc.272.35.22330
A Selective Inverse Agonist for Central Cannabinoid Receptor Inhibits Mitogen-activated Protein Kinase Activation Stimulated by Insulin or Insulin-like Growth Factor 1
M. Bouaboula (1997)
10.1523/JNEUROSCI.17-14-05327.1997
Concurrent Stimulation of Cannabinoid CB1 and Dopamine D2 Receptors Augments cAMP Accumulation in Striatal Neurons: Evidence for a Gs Linkage to the CB1 Receptor
M. Glass (1997)
10.1016/j.neuropharm.2003.08.003
Cannabinoids modulate neuronal firing in the rat basolateral amygdala: evidence for CB1- and non-CB1-mediated actions
M. Pistis (2004)
10.1016/S0024-3205(01)01366-2
Effects of the cannabinoid receptor agonist CP 55,940 and the cannabinoid receptor antagonist SR 141716 on intracranial self-stimulation in Lewis rats.
J. Arnold (2001)
10.1016/S0014-2999(01)00723-3
Cannabinoids inhibit GABAergic synaptic transmission in mice nucleus accumbens.
O. Manzoni (2001)
10.1523/JNEUROSCI.21-09-j0001.2001
Cocaine and Amphetamine Increase Extracellular Dopamine in the Nucleus Accumbens of Mice Lacking the Dopamine Transporter Gene
E. Carboni (2001)
10.1126/SCIENCE.831268
Morphine lowering of self-stimulation thresholds: lack of tolerance with long-term administration.
R. Esposito (1977)
10.1016/S0149-7634(99)00015-9
Preclinical research on cocaine self-administration: environmental determinants and their interaction with pharmacological treatment
M. Lesage (1999)
10.1007/s002130100875
Behavioural sensitization after repeated exposure to Δ9-tetrahydrocannabinol and cross-sensitization with morphine
C. Cadoni (2001)
10.1016/0091-3057(89)90291-8
Dopamine in the nucleus accumbens during cocaine self-administration as studied by in vivo microdialysis
H. Pettit (1989)
10.1016/0091-3057(94)90338-7
Marihuana smoking increases plasma cocaine levels and subjective reports of euphoria in male volunteers
S. Lukas (1994)
10.1007/s002130100734
Intravenous self-administration of the cannabinoid CB1 receptor agonist WIN 55,212-2 in rats
L. Fattore (2001)
10.1007/BF02247436
Effects of the cannabinoid CB1 receptor antagonist SR141716A on the behavior of pigeons and rats
R. Mansbach (2005)
10.1016/0006-2952(86)90148-6
Structural requirements for cocaine congeners to interact with dopamine and serotonin uptake sites in mouse brain and to induce stereotyped behavior.
M. E. Reith (1986)
10.1038/80577
Self-administration behavior is maintained by the psychoactive ingredient of marijuana in squirrel monkeys
G. Tanda (2000)
10.1016/S0306-4522(98)00052-9
Self-administration of the cannabinoid receptor agonist WIN 55,212-2 in drug-naive mice
M. C. Martellotta (1998)
10.1007/s00213-003-1485-z
Cannabinoids: reward, dependence, and underlying neurochemical mechanisms—a review of recent preclinical data
G. Tanda (2003)
10.1124/JPET.103.057620
D2 Dopamine Receptors Modulate Gα-Subunit Coupling of the CB1 Cannabinoid Receptor
A. Jarrahian (2004)
10.1192/BJP.178.2.123
Evaluating alternative cannabis regimes.
R. MacCoun (2001)
10.1152/JN.2001.85.1.72
Direct actions of cannabinoids on synaptic transmission in the nucleus accumbens: a comparison with opioids.
A. Hoffman (2001)
10.1016/S0893-133X(99)00157-8
Dissociation of Primary and Secondary Reward-Relevant Limbic Nuclei in an Animal Model of Relapse
Jeffrey W Grimm (2000)
10.1126/SCIENCE.283.5400.401
Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice.
C. Ledent (1999)
10.1007/s002130050518
Involvement of central cannabinoid (CB1) receptors in the establishment of place conditioning in rats
F. Chaperon (1998)
10.1146/ANNUREV.NE.19.030196.001535
Addictive drugs and brain stimulation reward.
R. Wise (1996)
10.1016/0165-0173(93)90013-P
The neural basis of drug craving: An incentive-sensitization theory of addiction
T. Robinson (1993)
10.1615/CRITREVNEUROBIOL.V13.I3.20
Behavioral effects of cannabinoid agents in animals.
F. Chaperon (1999)
10.1046/j.1460-9568.2000.00287.x
Cocaine, but not morphine, induces conditioned place preference and sensitization to locomotor responses in CB1 knockout mice
M. Martín (2000)
10.1523/JNEUROSCI.20-15-j0006.2000
Glutamate Transmission in the Nucleus Accumbens Mediates Relapse in Cocaine Addiction
J. Cornish (2000)
Amphetamine: evaluation of d- and l-isomers as releasing agents and uptake inhibitors for 3H-dopamine and 3H-norepinephrine in slices of rat neostriatum and cerebral cortex.
R. Heikkila (1975)
10.1046/J.1432-1327.2001.02072.X
The uptake by cells of 2-arachidonoylglycerol, an endogenous agonist of cannabinoid receptors.
T. Bisogno (2001)
10.1016/S0376-8716(01)00186-7
Chronic exposure to morphine, cocaine or ethanol in rats produced different effects in brain cannabinoid CB(1) receptor binding and mRNA levels.
S. González (2002)
10.1016/S0028-3908(01)00039-9
Chronic treatment with Δ9-tetrahydrocannabinol enhances the locomotor response to amphetamine and heroin. Implications for vulnerability to drug addiction
S. Lamarque (2001)
10.1074/JBC.270.11.6030
Anandamide Amidohydrolase Activity in Rat Brain Microsomes
F. Desarnaud (1995)



This paper is referenced by
10.1523/JNEUROSCI.4152-06.2007
Phasic Dopamine Release Evoked by Abused Substances Requires Cannabinoid Receptor Activation
J. Cheer (2007)
Role of the Endocannabinoid System in Extinction of Learned Behaviours Motivated by Opioid-Induced Reward and Aversion in Rats
L. A. Manwell (2013)
INTRINSIC MEMBRANE ADAPTATIONS TO COCAINE EXPOSURE AND SLEEP DEPRIVATION
Bradley D Winters (2012)
Development of new neurobiological strategies to treat patients with cocaine dependence
C. Crunelle (2008)
10.3389/fpsyt.2014.00092
Cannabinoid Regulation of Brain Reward Processing with an Emphasis on the Role of CB1 Receptors: A Step Back into the Future
G. Panagis (2014)
10.1038/sj.npp.1301467
Augmented Acquisition of Cocaine Self-Administration and Altered Brain Glucose Metabolism in Adult Female but not Male Rats Exposed to a Cannabinoid Agonist during Adolescence
A. Higuera-Matas (2008)
Drugs in pregnancy: the effects on mother and her progeny.
R. Šlamberová (2012)
10.20944/PREPRINTS201804.0311.V1
Gene Set Enrichment Analysis (GSEA) of Upregulated Genes in Cocaine Addiction Reveals miRNAs as Potential Therapeutic Agents
Ishtiaque Ahammad (2018)
10.1007/s00213-008-1450-y
Effects of cannabinoid CB1 receptor antagonist rimonabant in consolidation and reconsolidation of methamphetamine reward memory in mice
L. Yu (2008)
10.1016/j.euroneuro.2009.11.001
The nicotinic acetylcholine receptor partial agonist varenicline and the treatment of drug dependence: A review
C. Crunelle (2010)
10.3389/fpsyt.2015.00040
Clearing the Smokescreen: The Current Evidence on Cannabis Use
Elizabeth C. Temple (2015)
10.1001/archpsyc.65.7.816
Cannabinoid receptor 1 gene association with nicotine dependence.
X. Chen (2008)
10.1038/sj.npp.1301365
Subchronic Cannabinoid Agonist (WIN 55,212-2) Treatment during Cocaine Abstinence Alters Subsequent Cocaine Seeking Behavior
G. González-Cuevas (2007)
10.1515/revneuro.2007.18.5.383
Interaction Between Orexins and the Mesolimbic System for Overriding Satiety
M. Hirasawa (2007)
10.1016/j.neuroscience.2007.03.017
Chronic cocaine treatment alters dendritic arborization in the adult motor cortex through a CB1 cannabinoid receptor–dependent mechanism
I. Ballesteros-Yañez (2007)
10.2174/138161211796150873
Pharmacological treatments for cocaine dependence: is there something new?
L. Karila (2011)
10.1016/j.pharmthera.2009.11.002
New horizons for therapeutics in drug and alcohol abuse.
B. Jupp (2010)
10.1016/j.brainres.2012.02.052
Long-lasting increase in [3H]CP55,940 binding to CB1 receptors following cocaine self-administration and its withdrawal in rats
Przemysław Adamczyk (2012)
10.1016/J.BRAINRESREV.2006.05.003
An endocannabinoid mechanism in relapse to drug seeking: A review of animal studies and clinical perspectives
L. Fattore (2007)
10.1016/J.PLIPRES.2006.03.003
Biochemistry, pharmacology and physiology of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand.
T. Sugiura (2006)
10.2174/1874473710801030303
Hypothesis-driven medication discovery for the treatment of psychostimulant addiction.
Z. Xi (2008)
10.1134/S2079086411060028
Cannabinoids: Neurochemistry and neurobiology
A. I. Golovko (2011)
10.1038/npp.2008.206
Interaction between two independent CNR1 variants increases risk for cocaine dependence in European Americans
L. Zuo (2009)
10.1111/adb.12080
Cocaine‐induced endocannabinoid release modulates behavioral and neurochemical sensitization in mice
M. Mereu (2015)
The role of the endocannabinoid system in attention and nicotine addiction
W. V. Klinken (2011)
10.1016/j.pnpbp.2013.12.002
Changes in endocannabinoid and N-acylethanolamine levels in rat brain structures following cocaine self-administration and extinction training
B. Bystrowska (2014)
10.1073/pnas.1206303109
Cannabinoid receptor 1-expressing neurons in the nucleus accumbens
Bradley D Winters (2012)
10.1038/sj.npp.1301552
Cannabinoid CB1 Receptor Antagonists Attenuate Cocaine's Rewarding Effects: Experiments with Self-Administration and Brain-Stimulation Reward in Rats
Z. Xi (2008)
10.1016/S1054-3589(08)57007-4
Discovery of drugs to treat cocaine dependence: behavioral and neurochemical effects of atypical dopamine transport inhibitors.
G. Tanda (2009)
10.1007/S11920-007-0047-1
Targeted modulators of the endogenous cannabinoid system: Future medications to treat addiction disorders and obesity
D. Janero (2007)
10.1017/neu.2014.24
Neuroinflammation as a possible link between cannabinoids and addiction.
L. C. M. Rodrigues (2014)
Estudio psicofarmacológico de la modulación del sistema cannabinoide y su implicación neurocomportamental en la adicción a cocaína
G. G. Cuevas (2011)
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