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Occurrence, Interactive Effects And Ecological Risk Of Diclofenac In Environmental Compartments And Biota - A Review.

P. Sathishkumar, R. Meena, T. Palanisami, V. Ashokkumar, T. Palvannan, F. Gu
Published 2020 · Medicine, Environmental Science

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Diclofenac, a nonsteroidal anti-inflammatory drug has turned into a contaminant of emerging concern; hence, it was included in the previous Watch List of the EU Water Framework Directive. This review paper aims to highlight the metabolism of diclofenac at different trophic levels, its occurrence, ecological risks, and interactive effects in the water cycle and biota over the past two decades. Increased exposure to diclofenac not only raises health concerns for vultures, aquatic organisms, and higher plants but also causes serious threats to mammals. The ubiquitous nature of diclofenac in surface water (river, lake canal, estuary, and sea) is compared with drinking water, groundwater, and wastewater effluent in the environment. This comprehensive survey from previous studies suggests the fate of diclofenac in wastewater treatment plants (WWTPs) and may predict its persistence in the environment. This review offers evidence of fragmentary available data for the water environment, soil, sediment, and biota worldwide and supports the need for further data to address the risks associated with the presence of diclofenac in the environment. Finally, we suggest that the presence of diclofenac and its metabolites in the environment may represent a high risk because of their synergistic interactions with existing contaminants, leading to the development of drug-resistant strains and the formation of newly emerging pollutants.
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10.1016/j.scitotenv.2014.04.097
Input of pharmaceuticals through coastal surface watercourses into a Mediterranean lagoon (Mar Menor, SE Spain): sources and seasonal variations.
R. Moreno-González (2014)
10.3390/ijerph110505251
Monitoring the Presence of 13 Active Compounds in Surface Water Collected from Rural Areas in Northwestern Spain
Alejandra Iglesias (2014)
10.1016/j.scitotenv.2013.08.079
Determination of 81 pharmaceutical drugs by high performance liquid chromatography coupled to mass spectrometry with hybrid triple quadrupole-linear ion trap in different types of water in Serbia.
M. Petrovíc (2014)
10.1016/j.chemosphere.2014.04.025
Concentrations of trace substances in sewage sludge from 28 wastewater treatment works in the UK.
Vera Jones (2014)
10.1021/jf404282y
Fate and Uptake of Pharmaceuticals in Soil–Plant Systems
L. Carter (2014)
10.1007/s11368-014-0884-6
Occurrence of pharmaceutical and personal care products (PPCPs) in marine sediments in the Todos os Santos Bay and the north coast of Salvador, Bahia, Brazil
M. Beretta (2014)
10.1016/J.JECE.2014.01.023
Seasonal occurrence and removal of pharmaceutical products in municipal wastewaters
Manuel José Fernández (2014)
10.1016/j.marpolbul.2014.06.024
Polar organic micropollutants in the coastal environment of different marine systems.
Karsten Nödler (2014)
10.1016/j.jhazmat.2014.03.001
Reduction of hexavalent chromium using Aerva lanata L.: elucidation of reduction mechanism and identification of active principles.
K. Poonkuzhali (2014)
10.1155/2014/253468
Effects of Mixture of Pharmaceuticals on Early Life Stages of Tench (Tinca tinca)
V. Stancová (2014)
10.1002/dta.1463
A proteomic evaluation of the effects of the pharmaceuticals diclofenac and gemfibrozil on marine mussels (Mytilus spp.): evidence for chronic sublethal effects on stress-response proteins.
W. Schmidt (2014)
10.1016/j.scitotenv.2013.08.041
Occurrence, fate and environmental risk assessment of endocrine disrupting compounds at the wastewater treatment works in Pietermaritzburg (South Africa).
T. Manickum (2014)
10.1016/j.yrtph.2014.04.006
Ecological risk assessment of the presence of pharmaceutical residues in a French national water survey.
Camille Bouissou-Schurtz (2014)
10.1016/j.jchromb.2014.02.047
Optimization of diclofenac quantification from wastewater treatment plant sludge by ultrasonication assisted extraction.
E. Topuz (2014)
10.1021/es5017894
Irrigation of root vegetables with treated wastewater: evaluating uptake of pharmaceuticals and the associated human health risks.
Tomer Malchi (2014)
10.1016/j.scitotenv.2014.05.087
Occurrence and human health risk of wastewater-derived pharmaceuticals in a drinking water source for Shanghai, East China.
Zhi-hao Wen (2014)
10.5897/JECE2013.0312
Determination of pharmaceutical compounds in surface and underground water by solid phase extraction-liquid chromatography
Olatunde James Olaitan (2014)
10.1039/C3RA46014B
Laccase mediated diclofenac transformation and cytotoxicity assessment on mouse fibroblast 3T3-L1 preadipocytes
P. Sathishkumar (2014)
10.1016/j.scitotenv.2013.10.124
Occurrence and bioaccumulation of pharmaceuticals in a fish species inhabiting the Suquía River basin (Córdoba, Argentina).
M. E. Valdés (2014)
10.1016/j.jhazmat.2014.03.015
Seasonal variation of diclofenac concentration and its relation with wastewater characteristics at two municipal wastewater treatment plants in Turkey.
S. Sari (2014)
10.1016/j.scitotenv.2013.09.032
Occurrence, fate and ecotoxicological assessment of pharmaceutically active compounds in wastewater and sludge from wastewater treatment plants in Chongqing, the Three Gorges Reservoir Area.
Q. Yan (2014)
10.1016/j.scitotenv.2013.09.092
Potential environmental implications of emerging organic contaminants in Taihu Lake, China: comparison of two ecotoxicological assessment approaches.
Zhenhua Yan (2014)
10.1016/j.scitotenv.2014.02.085
Occurrence of acidic pharmaceuticals and personal care products in Turia River Basin: from waste to drinking water.
E. Carmona (2014)
10.1007/s10661-014-3881-8
Occurrence of pharmaceuticals in urban wastewater of north Indian cities and risk assessment
K. Singh (2014)
10.1016/j.envint.2014.03.021
Fate of diclofenac in municipal wastewater treatment plant - a review.
N. Vieno (2014)
10.1124/dmd.113.054478
Evaluation and Mechanistic Analysis of the Cytotoxicity of the Acyl Glucuronide of Nonsteroidal Anti-Inflammatory Drugs
Taishi Miyashita (2014)
10.1080/15533174.2012.752009
Synthesis and Characterization of Coordination Behavior of Diclofenac Sodium Drug Toward Hg(II), Pb(II), and Sn(II) Metal Ions: Chelation Effect on Their Thermal Stability and Biological Activity
M. Refat (2014)
10.1007/s40572-014-0015-y
Pharmaceuticals in the Surface Water of the USA: A Review
R. Deo (2014)
10.1016/j.chemosphere.2014.02.004
Factory-discharged pharmaceuticals could be a relevant source of aquatic environment contamination: review of evidence and need for knowledge.
Olivier Cardoso (2014)
10.1016/j.aquatox.2014.01.011
Effects of non-steroidal anti-inflammatory drug (NSAID) diclofenac exposure in mussel Mytilus galloprovincialis.
M. González-Rey (2014)
10.1080/00958972.2014.903327
Four diclofenac complexes with cobalt(II) and nickel(II) ions: synthesis, spectroscopic properties, thermal decompositions, crystal structures, and carbonic anhydrase activities
Sema Çağlar (2014)
10.1016/j.scitotenv.2013.12.123
A year-long study of the spatial occurrence and relative distribution of pharmaceutical residues in sewage effluent, receiving marine waters and marine bivalves.
Gillian L McEneff (2014)
10.1016/j.chemosphere.2013.10.062
Occurrence and fate of pharmaceutically active compounds in the largest municipal wastewater treatment plant in Southwest China: mass balance analysis and consumption back-calculated model.
Q. Yan (2014)
10.1016/j.envpol.2013.10.038
Biodegradability of pharmaceutical compounds in agricultural soils irrigated with treated wastewater.
Amnon Grossberger (2014)
10.1016/j.chemosphere.2014.08.056
Occurrence and source apportionment of pharmaceuticals and personal care products in the Beiyun River of Beijing, China.
G. Dai (2015)
10.1016/j.watres.2014.09.018
Presence of pharmaceuticals in benthic fauna living in a small stream affected by effluent from a municipal sewage treatment plant.
K. Grabicová (2015)
10.1016/j.scitotenv.2014.11.097
Assessment of non-steroidal anti-inflammatory and analgesic pharmaceuticals in seawaters of North of Portugal: occurrence and environmental risk.
A. Lolić (2015)
10.1080/03067319.2015.1085520
Occurrence of pharmaceuticals in surface waters: analytical method development and environmental risk assessment
Christina I. Nannou (2015)
10.1016/j.jpba.2015.02.003
A systematic strategy for the identification and determination of pharmaceuticals in environment using advanced LC-MS tools: application to ground water samples.
K. Jindal (2015)
10.1016/j.envres.2014.09.041
Environmental impact of pharmaceuticals from Portuguese wastewaters: geographical and seasonal occurrence, removal and risk assessment.
A. Pereira (2015)
10.1016/J.WATRES.2014.10.040
Eco-efficiency analysis of Spanish WWTPs using the LCA + DEA method.
Yago Lorenzo-Toja (2015)
10.1016/j.envint.2015.09.023
Balancing the health benefits and environmental risks of pharmaceuticals: Diclofenac as an example.
V. Acuña (2015)
10.1080/00032719.2015.1033722
Optimization of the Temperature for the Extraction of Pharmaceuticals from Wastewater by a Hollow Fiber Silicone Membrane
R. Amdany (2015)
10.1016/j.jpba.2014.11.040
Pharmaceuticals in the environment: biodegradation and effects on natural microbial communities. A review.
A. Barra Caracciolo (2015)
10.1007/s00216-015-8654-x
Multianalyte method for the determination of pharmaceuticals in wastewater samples using solid-phase extraction and liquid chromatography–tandem mass spectrometry
Marilena E Dasenaki (2015)
10.1016/j.watres.2015.02.059
Occurrence of selected pharmaceuticals at drinking water purification plants in Japan and implications for human health.
D. Simazaki (2015)
10.1016/j.scitotenv.2014.05.089
Pharmaceutically active compounds in sludge stabilization treatments: anaerobic and aerobic digestion, wastewater stabilization ponds and composting.
Julia Martín (2015)
10.1016/j.marpolbul.2015.03.008
Contamination of the southern Baltic Sea waters by the residues of selected pharmaceuticals: Method development and field studies.
M. Borecka (2015)
10.1016/j.scitotenv.2014.12.033
Occurrence, bioaccumulation and risk assessment of lipophilic pharmaceutically active compounds in the downstream rivers of sewage treatment plants.
J. Liu (2015)
10.1016/j.scitotenv.2014.09.103
Ecotoxicity of ketoprofen, diclofenac, atenolol and their photolysis byproducts in zebrafish (Danio rerio).
M. Diniz (2015)
10.1016/j.chemosphere.2014.04.098
Occurrence and spatial distribution of emerging contaminants in the unsaturated zone. case study: Guadalete River basin (Cadiz, Spain).
C. Corada-Fernández (2015)
10.1016/j.envpol.2015.01.032
Ecotoxicogenomic assessment of diclofenac toxicity in soil.
G. Chen (2015)
10.1080/09593330.2015.1025105
Determination of para-arsanilic acid with improved diazotization reaction using differential pulse cathodic stripping voltammetry in aqueous system
M. Misni (2015)
10.1016/j.scitotenv.2015.07.129
Plant uptake of pharmaceutical and personal care products from recycled water and biosolids: a review.
X. Wu (2015)
10.1039/c4ra11786g
Modified phyto-waste Terminalia catappa fruit shells
P. Sathishkumar (2015)
10.1007/s10661-015-4497-3
Occurrence of pharmaceuticals, hormones, and perfluorinated compounds in groundwater in Taiwan
Yen-Ching Lin (2015)
10.1016/j.ecoenv.2015.01.008
Toxicity screening of diclofenac, propranolol, sertraline and simvastatin using Danio rerio and Paracentrotus lividus embryo bioassays.
Sílvia Ribeiro (2015)
10.1016/J.EMCON.2015.07.001
Occurrence, sources and fate of pharmaceuticals and personal care products in the groundwater: A review
Q. Sui (2015)
10.1016/j.talanta.2014.09.017
Development of an extraction and purification method for the determination of multi-class pharmaceuticals and endocrine disruptors in freshwater invertebrates.
B. Huerta (2015)
10.1007/s12403-015-0192-4
Managing Emerging Contaminants: Status, Impacts, and Watershed-Wide Strategies
Ammara Talib (2016)
10.1016/j.marenvres.2016.03.005
Ecotoxicological potential of non-steroidal anti-inflammatory drugs (NSAIDs) in marine organisms: Bioavailability, biomarkers and natural occurrence in Mytilus galloprovincialis.
M. Mezzelani (2016)
10.1016/j.envint.2016.03.022
Occurrence and fate of emerging trace organic chemicals in wastewater plants in Chennai, India.
T. Anumol (2016)
10.1016/j.scitotenv.2015.09.145
Occurrence and spatial distribution of 158 pharmaceuticals, drugs of abuse and related metabolites in offshore seawater.
Nikiforos A Alygizakis (2016)
10.1007/s10661-016-5481-2
Measured and predicted environmental concentrations of carbamazepine, diclofenac, and metoprolol in small and medium rivers in northern Germany
Wibke Meyer (2016)
10.1007/s11356-016-7959-4
Occurrence and behavior of selected pharmaceuticals during riverbank filtration in The Republic of Serbia
Srđan Kovačević (2016)
10.1016/j.scitotenv.2016.01.051
Occurrence of pharmaceuticals and cocaine in a Brazilian coastal zone.
C. Pereira (2016)
10.1016/j.envint.2016.09.014
Diclofenac and its transformation products: Environmental occurrence and toxicity - A review.
Linson Lonappan (2016)
10.1016/j.talanta.2015.10.044
PVDF-ErGO-GRC electrode: A single setup electrochemical system for separation, pre-concentration and detection of lead ions in complex aqueous samples.
Kunashegaran Hamsawahini (2016)
10.1016/j.chemosphere.2016.02.036
PPCPs in Jiulong River estuary (China): Spatiotemporal distributions, fate, and their use as chemical markers of wastewater.
Q. Sun (2016)
10.1007/s11356-016-6503-x
Status of hormones and painkillers in wastewater effluents across several European states—considerations for the EU watch list concerning estradiols and diclofenac
P. Schröder (2016)
10.1016/j.scitotenv.2015.11.047
Seasonal occurrence, removal, mass loading and environmental risk assessment of 55 pharmaceuticals and personal care products in a municipal wastewater treatment plant in Central Greece.
M. Papageorgiou (2016)
10.1016/j.aquatox.2016.03.017
Mediated effect of ultrasound treated Diclofenac on mussel hemocytes: First evidence for the involvement of respiratory burst enzymes in the induction of DCF-mediated unspecific mode of action.
E. Toufexi (2016)
10.1016/j.scitotenv.2016.08.089
Presence of pharmaceuticals in the Lis river (Portugal): Sources, fate and seasonal variation.
P. Paíga (2016)
10.1016/j.scitotenv.2016.03.053
Characterization of pharmaceutically active compounds in Dongting Lake, China: Occurrence, chiral profiling and environmental risk.
Ruixue Ma (2016)
10.1016/j.envpol.2016.03.044
Effects of soil properties on the uptake of pharmaceuticals into earthworms☆
L. Carter (2016)
10.1002/CLEN.201400249
Biodegradation Pathway of Acid Red 27 by White‐Rot Fungus Armillaria sp. F022 and Phytotoxicity Evaluation
Liyana Amalina Adnan (2016)
10.5897/JECE2015.0364
Quantification of pharmaceutical residues in wastewater impacted surface waters and sewage sludge from Lagos, Nigeria
O. Oluwatosin (2016)
10.1002/etc.3144
Occurrence and distribution pattern of acidic pharmaceuticals in surface water, wastewater, and sediment of the Msunduzi River, Kwazulu-Natal, South Africa.
F. Agunbiade (2016)
10.1016/j.jhazmat.2015.09.057
Possible ecological risk of two pharmaceuticals diclofenac and paracetamol demonstrated on a model plant Lemna minor.
M. Kummerová (2016)
10.1016/j.chemosphere.2015.10.100
Assessing environmental risk of pharmaceuticals in Portugal: An approach for the selection of the Portuguese monitoring stations in line with Directive 2013/39/EU.
A. Pereira (2016)
10.1111/cobi.12711
Metabolism of aceclofenac in cattle to vulture-killing diclofenac.
T. Galligan (2016)
10.1021/acs.jafc.6b01696
Pharmaceuticals, Their Metabolites, and Other Polar Pollutants in Field-Grown Vegetables Irrigated with Treated Municipal Wastewater.
Christina Riemenschneider (2016)
10.1002/etc.3240
Effects of trophic exposure to diclofenac and dexamethasone on hematological parameters and immune response in freshwater fish.
J. L. C. Ribas (2016)
10.1016/j.wasman.2016.03.029
Occurrence and treatment efficiency of pharmaceuticals in landfill leachates.
Mu-Chen Lu (2016)
10.1016/j.envpol.2016.01.014
Evaluation of polar organic micropollutants as indicators for wastewater-related coastal water quality impairment.
Karsten Nödler (2016)
10.1016/j.ijcard.2016.08.233
Diclofenac induces proteasome and mitochondrial dysfunction in murine cardiomyocytes and hearts.
Rajeshwary Ghosh (2016)
10.1007/s00216-016-9541-9
Rapid analysis of diclofenac and some of its transformation products in the three-spined stickleback, Gasterosteus aculeatus, by liquid chromatography-tandem mass spectrometry
Gaëlle Daniele (2016)
10.1016/J.EMCON.2016.10.001
Occurrence of micropollutants in the wastewater streams of cruise ships
Lena Westhof (2016)
10.1016/j.tiv.2015.11.020
Mitochondrial toxicity of diclofenac and its metabolites via inhibition of oxidative phosphorylation (ATP synthesis) in rat liver mitochondria: Possible role in drug induced liver injury (DILI).
Muzeeb Syed (2016)
10.1016/J.CRCI.2016.05.005
Occurrence, fate and removal efficiencies of pharmaceuticals in wastewater treatment plants (WWTPs) discharging in the coastal environment of Algiers
Amine Elmouatezz Bellah Kermia (2016)
10.1039/C6AY01336H
Fabrication of a composite modified glassy carbon electrode: a highly selective, sensitive and rapid electrochemical sensor for silver ion detection in river water samples
S. Azhari (2016)
10.1007/s11356-016-7751-5
Occurrence of pharmaceuticals in WWTP effluents and their impact in a karstic rural catchment of Eastern France
Axelle Chiffre (2016)
10.1016/j.chemosphere.2016.06.039
Markers of anthropogenic contamination: A validated method for quantification of pharmaceuticals, illicit drug metabolites, perfluorinated compounds, and plasticisers in sewage treatment effluent and rain runoff.
John Wilkinson (2016)
10.1016/j.jhazmat.2016.02.013
Investigating the formation and toxicity of nitrogen transformation products of diclofenac and sulfamethoxazole in wastewater treatment plants.
V. Osorio (2016)
10.1016/j.scitotenv.2016.03.054
Stress-related phenomena and detoxification mechanisms induced by common pharmaceuticals in alfalfa (Medicago sativa L.) plants.
A. Christou (2016)
10.1016/j.scitotenv.2016.05.206
Bioaccumulation of five pharmaceuticals at multiple trophic levels in an aquatic food web - Insights from a field experiment.
A. Lagesson (2016)
10.1016/j.watres.2016.02.047
Occurrence and removal of organic micropollutants: An overview of the watch list of EU Decision 2015/495.
Marta O. Barbosa (2016)
10.1016/j.chemosphere.2015.12.059
Emerging pollutants and plants--Metabolic activation of diclofenac by peroxidases.
C. Huber (2016)
10.1007/s00449-016-1686-6
Fabrication, characterization and application of laccase–nylon 6,6/Fe3+ composite nanofibrous membrane for 3,3′-dimethoxybenzidine detoxification
M. Jasni (2016)
10.1007/s11356-015-5997-y
Widespread occurrence and seasonal variation of pharmaceuticals in surface waters and municipal wastewater treatment plants in central Finland
P. Lindholm-Lehto (2016)
10.4172/2161-1009.1000255
Drug Metabolism and Oxidative Stress: Cellular Mechanism and NewTherapeutic Insights
S. Banerjee (2016)
10.1016/j.talanta.2016.04.016
Development of a multi-residue analysis of diclofenac and some transformation products in bivalves using QuEChERS extraction and liquid chromatography-tandem mass spectrometry. Application to samples from mesocosm studies.
Gaëlle Daniele (2016)
10.1007/s11356-016-7759-x
Monitoring of emerging pollutants in Guadiamar River basin (South of Spain): analytical method, spatial distribution and environmental risk assessment
Eva Garrido (2016)
10.1002/etc.3742
Inhibition of immune responses and related proteins in Rhamdia quelen exposed to diclofenac.
João L.C. Ribas (2017)
10.1016/j.envpol.2017.02.061
Mussels as bioindicators of diclofenac contamination in coastal environments.
S. Cunha (2017)
10.1016/j.jenvman.2017.02.022
Status of pharmaceuticals in African water bodies: Occurrence, removal and analytical methods.
L. M. Madikizela (2017)
10.1016/j.scitotenv.2017.02.200
Occurrence and ecological risk assessment of emerging organic chemicals in urban rivers: Guangzhou as a case study in China.
Fengjiao Peng (2017)
10.17221/125/2016-VETMED
Effects of the pharmaceutical contaminants ibuprofen, diclofenac, and carbamazepine alone, and in combination, on oxidative stress parameters in early life stages of tench (Tinca tinca)
V. Stancová (2017)
10.1007/s11356-017-0767-7
Spatio-temporal evaluation of emerging contaminants and their partitioning along a Brazilian watershed
D. N. R. D. Sousa (2017)
10.1016/j.aquatox.2017.05.017
Diclofenac affects kidney histology in the three-spined stickleback (Gasterosteus aculeatus) at low μg/L concentrations.
J. Näslund (2017)
10.1016/j.chemosphere.2016.09.116
Chronic diclofenac exposure affects gill integrity and pituitary gene expression and displays estrogenic activity in nile tilapia (Oreochromis niloticus).
Frederike Gröner (2017)
10.1124/dmd.116.074005
Integrated Assessment of Diclofenac Biotransformation, Pharmacokinetics, and Omics-Based Toxicity in a Three-Dimensional Human Liver-Immunocompetent Coculture System
Ujjal Sarkar (2017)
10.1016/j.aquatox.2016.12.020
Toxic effects of diclofenac on life history parameters and the expression of detoxification-related genes in Daphnia magna.
Y. Liu (2017)
10.1016/j.jhazmat.2016.05.030
Characterization of pharmaceutically active compounds in Beijing, China: Occurrence pattern, spatiotemporal distribution and its environmental implication.
Ruixue Ma (2017)
10.1016/j.scitotenv.2017.07.171
Effects of exposure to pharmaceuticals (diclofenac and carbamazepine) spiked sediments in the midge, Chironomus riparius (Diptera, Chironomidae).
E. Nieto (2017)
10.1016/j.jpba.2016.12.013
Development of a multi‐residue method for the determination of human and veterinary pharmaceuticals and some of their metabolites in aqueous environmental matrices by SPE‐UHPLC–MS/MS
P. Paíga (2017)
10.1016/j.chemosphere.2017.04.084
Eco-pharmacovigilance of non-steroidal anti-inflammatory drugs: Necessity and opportunities.
Bingshu He (2017)
10.1016/j.chemosphere.2017.01.101
The fate of pharmaceuticals and personal care products (PPCPs), endocrine disrupting contaminants (EDCs), metabolites and illicit drugs in a WWTW and environmental waters.
E. Archer (2017)
10.1016/j.chemosphere.2016.12.055
Non-steroidal anti-inflammatory drugs in the watercourses of Elbe basin in Czech Republic.
P. Maršík (2017)
10.1016/j.scitotenv.2017.07.039
Analysis of emerging organic contaminants in water, fish and suspended particulate matter (SPM) in the Joint Danube Survey using solid-phase extraction followed by UHPLC-MS-MS and GC–MS analysis
R. Loos (2017)
10.1177/1091581817700584
Involvement of Reactive Metabolites of Diclofenac in Cytotoxicity in Sandwich-Cultured Rat Hepatocytes
A. Kawase (2017)
10.1016/j.aquatox.2017.03.007
Evaluation of DNA damage and physiological responses in Nile tilapia, Oreochromis niloticus (Linnaeus, 1758) exposed to sub-lethal diclofenac (DCF).
P. Pandey (2017)
10.1007/s11356-017-9726-6
Pharmaceuticals and personal care products (PPCPs) in Arctic environments: indicator contaminants for assessing local and remote anthropogenic sources in a pristine ecosystem in change
R. Kallenborn (2017)
10.1016/j.chemosphere.2016.10.026
Mass loading and removal of pharmaceuticals and personal care products including psychoactives, antihypertensives, and antibiotics in two sewage treatment plants in southern India.
B. Subedi (2017)
10.1007/s11356-017-9228-6
Exposure of marine mussels to diclofenac: modulation of prostaglandin biosynthesis
F. Courant (2017)
10.1016/j.scitotenv.2016.09.095
Comparative study of diclofenac-induced embryotoxicity and teratogenesis in Xenopus laevis and Lithobates catesbeianus, using the frog embryo teratogenesis assay: Xenopus (FETAX).
Jesús Daniel Cardoso-Vera (2017)
10.1039/C7RA06730E
Preparation of cationic polymeric nanoparticles as an effective adsorbent for removing diclofenac sodium from water
T. Liu (2017)
10.1016/j.jenvman.2017.05.068
The presence of contaminations in sewage sludge – The current situation
K. Fijałkowski (2017)
10.1007/s11356-017-0966-2
Heavy metal pollution in immobile and mobile components of lentic ecosystems—a review
R. Meena (2017)
10.1016/j.jenvman.2016.12.073
Adsorption of non-steroidal anti-inflammatory drugs from aqueous solution using activated carbons: Review.
M. J. Ahmed (2017)
10.1016/j.chemosphere.2017.02.095
Occurrence of pharmaceuticals and personal care products in effluent-dominated Saudi Arabian coastal waters of the Red Sea.
Aasim M Ali (2017)
10.1016/j.scitotenv.2017.03.015
Degradation kinetics of pharmaceuticals and personal care products in surface waters: photolysis vs biodegradation.
R. M. Baena-Nogueras (2017)
10.1016/j.jcis.2017.02.022
Fabrication of novel visible-light-driven AgI/g-C(3)N(4) composites with enhanced visible-light photocatalytic activity for diclofenac degradation.
Wei Zhang (2017)
10.1016/j.envpol.2016.12.022
Diclofenac in Arabidopsis cells: Rapid formation of conjugates.
Qiuguo Fu (2017)
10.1016/j.ecoenv.2016.10.029
Ecological risk assessment of pharmaceuticals in the receiving environment of pharmaceutical wastewater in Pakistan.
M. Ashfaq (2017)
10.1016/j.ecoenv.2017.01.053
Effects of environmentally relevant concentrations of the anti-inflammatory drug diclofenac in freshwater fish Rhamdia quelen.
I. C. Guiloski (2017)
10.1016/j.tplants.2016.12.010
Pharmaceuticals and Personal-Care Products in Plants.
M. Bartrons (2017)
10.1016/j.scitotenv.2017.01.063
Metabolic profiling identification of metabolites formed in Mediterranean mussels (Mytilus galloprovincialis) after diclofenac exposure.
Bénilde Bonnefille (2017)
10.1007/s11356-017-1105-9
Activated carbons from avocado seed: optimisation and application for removal of several emerging organic compounds
A. B. Leite (2017)
10.1016/j.envpol.2017.05.060
Occurrence of pharmaceutical, recreational and psychotropic drug residues in surface water on the northern Antarctic Peninsula region.
S. González-Alonso (2017)
10.1016/j.scitotenv.2017.03.167
Spatial distribution of organic contaminants in three rivers of Southern England bound to suspended particulate material and dissolved in water.
John Wilkinson (2017)
10.1016/j.scitotenv.2017.02.074
Validation of a method to monitor the occurrence of 20 relevant pharmaceuticals and personal care products in 167 bottled waters.
S. Lardy-fontan (2017)
10.1016/j.envpol.2017.07.082
Contaminants of emerging concern in the open sea waters of the Western Mediterranean.
M. Brumovský (2017)
10.1016/j.chemosphere.2016.10.105
Detection and quantification of acidic drug residues in South African surface water using gas chromatography-mass spectrometry.
B. P. Gumbi (2017)
10.1016/j.scitotenv.2017.07.042
Impact of the NSAID diclofenac on survival, development, behaviour and health of embryonic and juvenile stages of brown trout, Salmo trutta f. fario.
S. Schwarz (2017)
10.1016/j.ecoenv.2016.11.014
A review of the occurrence of pharmaceuticals and personal care products in Indian water bodies.
K. Balakrishna (2017)
10.1016/j.jgar.2017.03.012
Synergistic effect of non-steroidal anti-inflammatory drugs (NSAIDs) on antibacterial activity of cefuroxime and chloramphenicol against methicillin-resistant Staphylococcus aureus.
Elaine Chan (2017)
10.1016/j.marenvres.2017.04.005
Assessing the impact of diclofenac, ibuprofen and sildenafil citrate (Viagra®) on the fertilisation biology of broadcast spawning marine invertebrates.
Norlaila Binti Mohd Zanuri (2017)
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