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Amorphous Silica Nanoparticle-induced Pulmonary Inflammatory Response Depends On Particle Size And Is Sex-specific In Rats.

Hyoung-Yun Han, Jaewoo Cho, Eunsol Seong, E. Park, Gwang-Hee Lee, D. Kim, Young-Su Yang, J. Oh, Seokjoo Yoon, Tae Ok Lee, Tae-Won Kim, Eunjung Park
Published 2020 · Chemistry, Medicine

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Due to mass production and extensive use, the potential adverse health effects of amorphous silica nanoparticles (ASiNPs) have received a significant attention from the public and researchers. However, the relationship between physicochemical properties of ASiNPs and their health effects is still unclear. In this study, we manufactured two types of ASiNPs of different diameters (20 and 50 nm) and compared the toxic response induced in rats after intratracheal instillation (75, 150 or 300 μg/rat). There were no dose-related differences in mortality, body weight gain or organ weight between the groups. However both types of ASiNPs significantly decreased the proportion of neutrophils in male rats, whereas the levels of hemoglobin and hematocrit were markedly reduced only in female rats instilled with 20 nm-ASiNPs. ASiNPs-induced lung tissue damage seemed to be more evident in the 20 nm ASiNP-treated group and in female rats than male rats. Similarly, expression of caveolin-1 and matrix metalloproteinase-9 seemed to be most notably enhanced in female rats treated with 20 nm-ASiNPs. The total number of bronchial alveolar lavage cells significantly increased in rats instilled with 20 nm-ASiNPs, accompanying a decrease in the proportion of macrophages and an increase in polymorphonuclear leukocytes. Moreover, secretion of inflammatory mediators clearly increased in human bronchial epithelial cells treated with 20 nm-ASiNPs, but not in those treated with 50 nm-ASiNPs. These results suggest that pulmonary effects of ASiNPs depend on particle size. Sex-dependent differences should also be carefully considered in understanding nanomaterial-induced adverse health effects.
This paper references
Final report on the safety assessment of Aluminum Silicate, Calcium Silicate, Magnesium Aluminum Silicate, Magnesium Silicate, Magnesium Trisilicate, Sodium Magnesium Silicate, Zirconium Silicate, Attapulgite, Bentonite, Fuller's Earth, hectorite, Kaolin, Lithium Magnesium Silicate, Lithium Magnesiu
F. Andersen (2003)
Impaired lung repair during neutropenia can be reverted by matrix metalloproteinase-9
Jorge Blázquez-Prieto (2017)
Proinflammatory Effects of Pyrogenic and Precipitated Amorphous Silica Nanoparticles in Innate Immunity Cells.
Luisana Di Cristo (2016)
Deposition and biokinetics of inhaled nanoparticles
M. Geiser (2009)
Matrix metalloproteinase-2 and -9 are induced differently by metal nanoparticles in human monocytes: The role of oxidative stress and protein tyrosine kinase activation.
R. Wan (2008)
Differences in gene expression and cytokine production by crystalline vs. amorphous silica in human lung epithelial cells
T. N. Perkins (2011)
Physicochemical determinants in the cellular responses to nanostructured amorphous silicas.
E. Gazzano (2012)
Physico-chemical features of engineered nanoparticles relevant to their toxicity
B. Fubini (2010)
Short-term biodistribution and clearance of intravenously administered silica nanoparticles
N. Waegeneers (2018)
Five-day inhalation toxicity study of three types of synthetic amorphous silicas in Wistar rats and post-exposure evaluations for up to 3 months.
J. Arts (2007)
Amorphous nanosilica induce endocytosis-dependent ROS generation and DNA damage in human keratinocytes
H. Nabeshi (2010)
A Single Instillation of Amorphous Silica Nanoparticles Induced Inflammatory Responses and Tissue Damage until Day 28 after Exposure
E. Park (2011)
Ultrafine particle deposition and clearance in the healthy and obstructed lung.
J. Brown (2002)
Influence of protein corona and caveolae-mediated endocytosis on nanoparticle uptake and transcytosis.
Y. Ho (2018)
Particle size dependent deposition and pulmonary inflammation after short-term inhalation of silver nanoparticles
H. Braakhuis (2014)
The Role of Matrix Metalloproteinases in Development, Repair, and Destruction of the Lungs.
Amanda Y Hendrix (2017)
Simulated Biological Fluids with Possible Application in Dissolution Testing
M. Marques (2011)
Differences in the biokinetics of inhaled nano- versus micrometer-sized particles.
W. G. Kreyling (2013)
Matrix metalloproteinases in lung: multiple, multifarious, and multifaceted.
K. Greenlee (2007)
Deleterious effects in reproduction and developmental immunity elicited by pulmonary iron oxide nanoparticles
Eunjung Park (2017)
Differential cytotoxic and inflammatory potency of amorphous silicon dioxide nanoparticles of similar size in multiple cell lines
D. Breznan (2017)
Uptake, distribution, clearance, and toxicity of iron oxide nanoparticles with different sizes and coatings
Qiyi Feng (2018)
The nanosilica hazard: another variable entity
D. Napierska (2010)
Evidence of size-dependent effect of silica micro- and nano-particles on basal and specialized monocyte functions.
M. D. De Marzi (2017)
Exploring the interconnections between gender, health and nature.
S. Macbride-Stewart (2016)
Oxidative stress and pro-inflammatory responses induced by silica nanoparticles in vivo and in vitro.
E. Park (2009)
Physico-chemical properties of manufactured nanomaterials - Characterisation and relevant methods. An outlook based on the OECD Testing Programme
K. Rasmussen (2018)
Some Biochemical and Histological Effects of 2-Chloroethanol in Rats
L. Friedman (1982)
Unveiling the Variability of "Quartz Hazard" in Light of Recent Toxicological Findings.
C. Pavan (2017)
Biosafety of Mesoporous Silica Nanoparticles
Estelle Rascol (2018)
Comparative assessment of nanomaterial definitions and safety evaluation considerations.
D. Boverhof (2015)
Size-dependent toxicity of metal oxide particles--a comparison between nano- and micrometer size.
H. Karlsson (2009)
The toxicity of silica nanoparticles to the immune system.
L. Chen (2018)
Influence of size, surface area and microporosity on the in vitro cytotoxic activity of amorphous silica nanoparticles in different cell types
Virginie Rabolli (2010)
The effects of size and surface modification of amorphous silica particles on biodistribution and liver metabolism in mice.
X. Lu (2015)
Toxicology of silica nanoparticles: an update
S. Murugadoss (2017)
Nano-bio effects: interaction of nanomaterials with cells.
L. Cheng (2013)
In vitro and in vivo genotoxicity investigations of differently sized amorphous SiO2 nanomaterials.
Elena Maser (2015)
Nanoengineered silica: Properties, applications and toxicity.
A. Mebert (2017)
Regulation of matrix metalloproteinase‐9 release from IL‐8‐stimulated human neutrophils
S. Chakrabarti (2005)
Caveolin‐1 mediates tissue plasminogen activator‐induced MMP‐9 up‐regulation in cultured brain microvascular endothelial cells
Xinchun Jin (2015)
Sheet-type titania, but not P25, induced paraptosis accompanying apoptosis in murine alveolar macrophage cells.
Eunjung Park (2014)
The toxicological mode of action and the safety of synthetic amorphous silica-a nanostructured material.
Claudia Fruijtier-Pölloth (2012)
Heme degradation and iron release of hemoglobin and oxidative stress of lymphocyte cells in the presence of silica nanoparticles.
Samaneh Azimipour (2018)
Role of gelatinases MMP-2 and MMP-9 in tissue remodeling following acute lung injury.
M. Corbel (2000)
Deposition, retention, and clearance of inhaled particles.
M. Lippmann (1980)
In search of the chemical basis of the hemolytic potential of silicas.
C. Pavan (2013)
Matrix metalloproteinase-9-mediated tissue injury overrides the protective effect of matrix metalloproteinase-2 during colitis.
P. Garg (2009)
The dissolution rates of SiO2 nanoparticles as a function of particle size.
T. Diedrich (2012)
Gender differences in murine pulmonary responses elicited by cellulose nanocrystals
A. Shvedova (2016)

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