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Artificial Nose Technology: Status And Prospects In Diagnostics.

J. Fitzgerald, E. Bui, N. Simon, H. Fenniri
Published 2017 · Engineering, Medicine

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Biomimetic crossreactive sensor arrays have been used to detect and analyze a wide variety of vapor and liquid components in applications such as food science, public health and safety, and diagnostics. As technology has advanced over the past three decades, these systems have become selective, sensitive, and affordable. Currently, the need for noninvasive and accurate devices for early disease diagnosis remains a challenge. This Opinion article provides an overview of the various types of biomimetic crossreactive sensor arrays (also referred to as electronic noses or tongues in the literature), their current use and future directions, and an outlook for future technological development.
This paper references
10.1002/CHIN.200922265
Oxidative Stress in Psychiatric Disorders: Evidence Base and Therapeutic Implications
F. Ng (2009)
10.1002/wsbm.1198
Promise of personalized omics to precision medicine
R. Chen (2013)
10.1021/JA035665Q
Preparation, physical properties, on-bead binding assay and spectroscopic reliability of 25 barcoded polystyrene-poly(ethylene glycol) graft copolymers.
H. Fenniri (2003)
10.1016/J.BBAGEN.2012.12.006
Exhaled breath and fecal volatile organic biomarkers of chronic kidney disease.
S. Meinardi (2013)
10.1038/382697A0
A chemical-detecting system based on a cross-reactive optical sensor array
T. Dickinson (1996)
10.1021/JP070906S
Nanoimprinted SERS-Active Substrates with Tunable Surface Plasmon Resonances
R. Alvarez-Puebla (2007)
10.1016/0009-2797(96)03729-5
Oxidative stress associated with exercise, psychological stress and life-style factors.
P. Møller (1996)
10.1038/nrc1041
Early detection: The case for early detection
Ruth Etzioni (2003)
10.2217/nnm.12.105
Detection of Alzheimer's and Parkinson's disease from exhaled breath using nanomaterial-based sensors.
U. Tisch (2013)
10.1097/JTO.0b013e318233d80f
Exhaled Breath Analysis with a Colorimetric Sensor Array for the Identification and Characterization of Lung Cancer
P. Mazzone (2012)
Current trends in “artificial-nose
Dickinson (1998)
10.1097/MIB.0b013e3182802b26
A Novel Tool for Noninvasive Diagnosis and Tracking of Patients with Inflammatory Bowel Disease
R. Arasaradnam (2013)
10.1016/j.bbi.2010.04.014
Chronic psychosocial stress promotes systemic immune activation and the development of inflammatory Th cell responses
D. Schmidt (2010)
10.1021/LA700701X
Spectroscopically encoded microspheres for antigen biosensing.
José Raez (2007)
10.1016/J.SNB.2009.11.031
Design of a very large chemical sensor system for mimicking biological olfaction
R. Beccherelli (2010)
10.1021/CC050086Y
Spectroscopically encoded resins for high throughput imaging time-of-flight secondary ion mass spectrometry.
Sangki Chun (2006)
10.1001/ARCHPSYC.62.6.593
Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication.
R. Kessler (2005)
10.1016/j.lungcan.2009.11.003
An investigation on electronic nose diagnosis of lung cancer.
A. D'Amico (2010)
10.5772/19214
Relationship between Oxidative Stress and Anxiety: Emerging Role of Antioxidants within Therapeutic or Preventive Approaches
J. Bouayed (2011)
10.1136/jcp.48.5.466
Volatile organic compounds in the breath of patients with schizophrenia.
M. Phillips (1995)
10.1186/1741-7015-12-37
Personalized medicine: risk prediction, targeted therapies and mobile health technology
D. Hayes (2014)
10.1021/JP901469W
Single-Molecule SERRS Detection Platforms Obtained via Galvanic Displacement on Silver Fractals
J. Bravo-Vasquez (2009)
Arti fi cial noses
D. R. Walt (2012)
10.1002/ijc.28446
Electronic nose can discriminate colorectal carcinoma and advanced adenomas by fecal volatile biomarker analysis: proof of principle study
Tim G. Meij (2014)
10.1002/ANIE.200500939
Molecular recognition and discrimination of amines with a colorimetric array.
Neal A. Rakow (2005)
10.1007/978-94-007-6627-3_35
Real-time breath analysis in type 2 diabetes patients during cognitive effort.
A. Mazzatenta (2013)
10.1021/CC7001292
Preparation and infrared/raman classification of 630 spectroscopically encoded styrene copolymers.
H. Fenniri (2008)
10.1093/ecco-jcc/jjv102
Analysis of Exhaled Breath Volatile Organic Compounds in Inflammatory Bowel Disease: A Pilot Study.
L. Hicks (2015)
10.1007/s10549-010-1317-x
Classification of breast cancer precursors through exhaled breath
G. Shuster (2010)
10.1088/1752-7155/7/1/017103
Within-day and between-day repeatability of measurements with an electronic nose in patients with COPD.
Maria Bofan (2013)
10.1021/CC050128I
Classification of spectroscopically encoded resins by Raman mapping and infrared hyperspectral imaging.
H. Fenniri (2006)
10.1586/14737159.8.5.617
Metabolomics-based methods for early disease diagnostics
G. Gowda (2008)
10.1016/J.JPSYCHIRES.2006.06.009
Evidence for low-grade systemic proinflammatory activity in patients with posttraumatic stress disorder.
R. von Känel (2007)
10.1016/J.CCCN.2004.04.023
Diagnostic potential of breath analysis--focus on volatile organic compounds.
W. Miekisch (2004)
The case for early detection
R Etzoni (2003)
10.1016/j.jcis.2009.01.070
SERS-active Ag/Au bimetallic nanoalloys on Si/SiO(x).
R. Alvarez-Puebla (2009)
10.2147/NEDT.1.2.109.61049
Nitric oxide as inflammatory mediator in post-traumatic stress disorder (PTSD): evidence from an animal model
F. Oosthuizen (2005)
Spectroscopically encoded microspheres for antigen
J Raez (2007)
10.1007/s00216-014-7865-x
Noninvasive detection of colorectal cancer by analysis of exhaled breath
C. Wang (2014)
10.1016/J.SNB.2009.06.054
Optical-fiber arrays for vapor sensing
Matthew J. Aernecke (2009)
10.1016/j.juro.2014.01.113
Detection of prostate cancer by an electronic nose: a proof of principle study.
Antti N Roine (2014)
10.1523/JNEUROSCI.4723-04.2005
Structural Basis for a Broad But Selective Ligand Spectrum of a Mouse Olfactory Receptor: Mapping the Odorant-Binding Site
Sayako Katada (2005)
10.1038/sj.bjc.6605810
Detection of lung, breast, colorectal, and prostate cancers from exhaled breath using a single array of nanosensors
G. Peng (2010)
10.4161/OXIM.2.2.7944
Oxidative stress and anxiety Relationship and cellular pathways
J. Bouayed (2009)
10.2174/1568026616666151223113540
Electronic Nose and Exhaled Breath NMR-based Metabolomics Applications in Airways Disease.
G. Santini (2016)
10.1021/JA016375H
Barcoded resins: a new concept for polymer-supported combinatorial library self-deconvolution.
H. Fenniri (2001)
10.1056/NEJMp1006304
The path to personalized medicine.
M. Hamburg (2010)
10.1016/j.resp.2014.10.001
Volatile organic compounds (VOCs) fingerprint of Alzheimer's disease
A. Mazzatenta (2015)
10.1002/ADMA.200601368
Synthesis and SERS Properties of Nanocrystalline Gold Octahedra Generated from Thermal Decomposition of HAuCl4 in Block Copolymers
J. Zhang (2006)
10.1038/nrmicro823
Electronic noses and disease diagnostics
A. P. Turner (2004)
10.1016/j.neures.2010.08.007
Oxidative stress in anxiety and comorbid disorders
I. Hovatta (2010)
10.1002/1521-3773(20001215)39:24<4483::AID-ANIE4483>3.0.CO;2-4
Towards the DRED of Resin‐Supported Combinatorial Libraries: A Non‐Invasive Methodology Based on Bead Self‐Encoding and Multispectral Imaging
H. Fenniri (2000)
10.1021/JA028239Y
Enhancing vapor sensor discrimination by mimicking a canine nasal cavity flow environment.
S. Stitzel (2003)
10.1021/AC001137A
Optical multibead arrays for simple and complex odor discrimination.
K. J. Albert (2001)
10.1136/jcp.46.9.861
Increased pentane and carbon disulfide in the breath of patients with schizophrenia.
M. Phillips (1993)
10.1109/CISP-BMEI.2017.8302211
An investigation on electronic nose diagnosis of liver cancer
Lijun Hao (2017)
10.1016/j.bios.2014.10.023
Breath sensors for lung cancer diagnosis.
Y. Adiguzel (2015)
10.1016/j.resp.2013.02.016
Pathologies currently identified by exhaled biomarkers
A. Mazzatenta (2013)
10.1002/ANIE.200501120
Unraveling the sense of smell (Nobel lecture).
L. Buck (2005)
10.1073/pnas.0706533104
Exhaled methyl nitrate as a noninvasive marker of hyperglycemia in type 1 diabetes
B. J. Novak (2007)
10.1016/S0167-7799(98)01185-8
Current trends in 'artificial-nose' technology.
T. Dickinson (1998)
10.1002/smll.200801398
Robust Au-PEG/PS microbeads as optically stable platforms for SERS.
A. A. Farah (2009)
10.1016/j.cgh.2014.05.005
The scent of colorectal cancer: detection by volatile organic compound analysis.
N. D. de Boer (2014)
10.1038/srep25464
Cinema audiences reproducibly vary the chemical composition of air during films, by broadcasting scene specific emissions on breath
J. Williams (2016)
10.1016/J.SNB.2007.03.014
Self-encoded polymer beads for microarray technologies
J. Bravo-Vasquez (2007)
10.1021/cn2000603
Detection of multiple sclerosis from exhaled breath using bilayers of polycyclic aromatic hydrocarbons and single-wall carbon nanotubes.
Radu Ionescu (2011)
10.1016/j.bbi.2014.08.008
Salivary markers of inflammation in response to acute stress
Danica C. Slavish (2015)
10.1093/jb/mvr090
The scent of disease: volatile organic compounds of the human body related to disease and disorder.
M. Shirasu (2011)
10.1088/1752-7155/7/1/016004
Physiology and biochemistry of human subjects during entrapment.
A. Agapiou (2013)
10.1016/J.CPR.2004.06.001
Gaps in accessing treatment for anxiety and depression: challenges for the delivery of care.
K. Collins (2004)
10.1016/j.bios.2014.10.044
Development and application of a new electronic nose instrument for the detection of colorectal cancer.
E. Westenbrink (2015)
10.1159/000340044
The Electronic Nose in Respiratory Medicine
P. Montuschi (2012)
10.1016/0925-4005(94)87085-3
A brief history of electronic noses
J. Gardner (1994)
10.1002/bjs.8942
Exhaled volatile organic compounds identify patients with colorectal cancer
D. Altomare (2013)
10.1002/cmdc.200700085
SERS Classification of Highly Related Performance Enhancers
R. Alvarez-Puebla (2007)



This paper is referenced by
10.1063/1.5124525
Hydrophobin-functionalized film bulk acoustic wave resonators for sensitive and polarity-sensitive sensing of volatile organic compounds
Jin Tao (2019)
10.1021/acssensors.9b01227
Machine Learning Assisted Array-based Biomolecular Sensing Using Surface Functionalized Carbon Dots.
Subhendu Pandit (2019)
10.1016/j.jtho.2018.02.026
Breathprinting and Early Diagnosis of Lung Cancer
G. Rocco (2018)
10.3171/2019.3.JNS19274
Identifying brain tumors by differential mobility spectrometry analysis of diathermy smoke.
Ilkka Haapala (2019)
10.1016/j.compbiomed.2020.103706
Recognizing lung cancer using a homemade e-nose: A comprehensive study
W. Li (2020)
10.1088/1361-6439/AAC849
Intelligent gas-sensing systems and their applications
Yun-Chun Hsieh (2018)
10.1002/JRS.5400
SERS detection of food contaminants by means of portable Raman instruments
R. Pilot (2018)
10.1109/ISOEN.2017.7968844
Toward high-value gas sensing in wearable and distrubuted formats: Discrimination of complex patterns of volatiles using multi-response RFID sensors
R. Potyrailo (2017)
10.3390/s19173683
A Barcoded Polymer-Based Cross-Reactive Spectroscopic Sensor Array for Organic Volatiles
J. Fitzgerald (2019)
10.1007/s42853-020-00066-7
Feasibility Study for the Evaluation of Chicken Meat Storage Time Using Surface Acoustic Wave Sensor
Geonwoo Kim (2020)
10.18632/oncotarget.17910
Biomarkers for early diagnosis of malignant mesothelioma: Do we need another moonshot?
Sabrina Lagniau (2017)
10.1109/ACCESS.2019.2943188
Domain Transfer Broad Learning System for Long-Term Drift Compensation in Electronic Nose Systems
Bei Liu (2019)
10.1111/1755-0998.12999
Developing noninvasive methodologies to assess koala population health through detecting Chlamydia from scats
R. Cristescu (2019)
10.3390/s20195478
Advancements in Microfabricated Gas Sensors and Microanalytical Tools for the Sensitive and Selective Detection of Odors
Enric Perarnau Ollé (2020)
10.1063/1.5033306
Oxidative stress detection by MEMS cantilever sensor array based electronic nose
Anurag Gupta (2018)
10.3390/s18030742
Online Sensor Drift Compensation for E-Nose Systems Using Domain Adaptation and Extreme Learning Machine
Z. Ma (2018)
10.17226/25059
Science Breakthroughs to Advance Food and Agricultural Research by 2030
Board on Agriculture (2019)
10.1016/j.jtcvs.2018.01.031
What the nose knows: Trends in biomimetic sensor technology.
C. Hoang (2018)
10.3390/bios7040059
Cutting Edge Methods for Non-Invasive Disease Diagnosis Using E-Tongue and E-Nose Devices
J. Fitzgerald (2017)
10.1016/j.tibtech.2018.07.004
Protein- and Peptide-Based Biosensors in Artificial Olfaction.
A. J. M. Barbosa (2018)
Classification of daily life odours with an electronic nose
F. Pereira (2019)
10.1016/J.JCLEPRO.2017.10.248
Analytical assessment of asphalt odor patterns in hot mix asphalt production
Federico Autelitano (2018)
10.1002/adma.202004805
Portable Food-Freshness Prediction Platform Based on Colorimetric Barcode Combinatorics and Deep Convolutional Neural Networks.
L. Guo (2020)
10.1177/1553350618781267
Pilot Study: Detection of Gastric Cancer From Exhaled Air Analyzed With an Electronic Nose in Chinese Patients
V. Schuermans (2018)
10.3390/ijerph14020195
Volatile Profiles of Emissions from Different Activities Analyzed Using Canister Samplers and Gas Chromatography-Mass Spectrometry (GC/MS) Analysis: A Case Study
S. Orecchio (2017)
10.1093/infdis/jiy072
Breathprinting Reveals Malaria-Associated Biomarkers and Mosquito Attractants
Chad L Schaber (2018)
10.3390/s20164433
Peptides, DNA and MIPs in Gas Sensing. From the Realization of the Sensors to Sample Analysis
Sara Gaggiotti (2020)
10.1155/2018/8608407
Organizational and Technological Aspects of a Platform for Collective Food Awareness
Antonio Volpentesta (2018)
10.3390/cancers11060831
Breath Analysis: A Systematic Review of Volatile Organic Compounds (VOCs) in Diagnostic and Therapeutic Management of Pleural Mesothelioma
A. Catino (2019)
10.1039/C8ME00097B
Field-effect transistor array modified by a stationary phase to generate informative signal patterns for machine learning-assisted recognition of gas-phase chemicals
Toshihiro Yoshizumi (2019)
10.1002/jbio.201800165
Optical sensory arrays for the detection of urinary bladder cancer‐related volatile organic compounds
Simian Zhu (2018)
10.1016/j.bios.2018.05.050
Point-of-care microfluidic devices for pathogen detection.
B. Nasseri (2018)
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