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Malignant Mesothelioma: Time To Translate?
A. Napolitano, M. Carbone
Published 2016 · Medicine
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Malignant mesothelioma is an aggressive cancer largely associated with asbestos exposure. In this review, we will discuss the significant advancements in our understanding of its genetics and molecular biology and their translational relevance. Remarkable findings included the discovery of germline and somatic mutations of BRCA1 associated protein-1 (BAP1) in patients, and the genome-wide characterization of pathways altered in mesothelioma that could be potentially exploited to design novel therapeutic approaches. Nevertheless, the clinical translation of these molecular findings has been slow and insufficient. In order to rapidly move translation from the bench to the bedside, we believe that cooperative research efforts have to be further endorsed and promoted at all levels.
This paper references
Diagnostic values of soluble mesothelin-related peptides for malignant pleural mesothelioma: updated meta-analysis
Ai Cui (2014)
Latest developments in our understanding of the pathogenesis of mesothelioma and the design of targeted therapies
A. Bononi (2015)
Chemokine (C-C motif) ligand 3 detection in the serum of persons exposed to asbestos: A patient-based study
J. Xu (2015)
Molecular pathogenesis of malignant mesothelioma and its relationship to simian virus 40.
A. Gazdar (2003)
Germline mutation of Bap1 accelerates development of asbestos-induced malignant mesothelioma.
Jinfei Xu (2014)
Targeting hypoxic response for cancer therapy
E. Paolicchi (2016)
Peroxiredoxins and tropomyosins as plasma biomarkers for lung cancer and asbestos exposure.
A. Rostila (2012)
Diameter and rigidity of multiwalled carbon nanotubes are critical factors in mesothelial injury and carcinogenesis
H. Nagai (2011)
The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma
Matthew J Bott (2011)
Targeted Next-Generation Sequencing of Cancer Genes in Advanced Stage Malignant Pleural Mesothelioma: A Retrospective Study
M. Lo Iacono (2015)
High Incidence of Somatic BAP1 Alterations in Sporadic Malignant Mesothelioma
Masaki Nasu (2015)
Molecular Pathways: Targeting Mechanisms of Asbestos and Erionite Carcinogenesis in Mesothelioma
M. Carbone (2011)
ENOX2-based early detection (ONCOblot) of asbestos-induced malignant mesothelioma 4–10 years in advance of clinical symptoms
D. Morré (2016)
A Novel Germline Mutation in BAP1 Predisposes to Familial Clear-Cell Renal Cell Carcinoma
Megan N Farley (2013)
Neoadjuvant chemotherapy and extrapleural pneumonectomy of malignant pleural mesothelioma with or without hemithoracic radiotherapy (SAKK 17/04): a randomised, international, multicentre phase 2 trial.
R. Stahel (2015)
Re-expression of the tumor suppressor NF2/merlin inhibits invasiveness in mesothelioma cells and negatively regulates FAK
P. Poulikakos (2006)
Extra-pleural pneumonectomy versus no extra-pleural pneumonectomy for patients with malignant pleural mesothelioma: clinical outcomes of the Mesothelioma and Radical Surgery (MARS) randomised feasibility study
T. Treasure (2011)
Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma.
N. Vogelzang (2003)
Minimal asbestos exposure in germline BAP1 heterozygous mice is associated with deregulated inflammatory response and increased risk of mesothelioma
A. Napolitano (2016)
Bap1 Is a Bona Fide Tumor Suppressor: Genetic Evidence from Mouse Models Carrying Heterozygous Germline Bap1 Mutations.
Yuwaraj Kadariya (2016)
Assessment of biomarkers in asbestos-exposed workers as indicators of cancer risk.
M. Amati (2008)
Evaluation of New Biomarkers in the Prediction of Malignant Mesothelioma in Subjects with Environmental Asbestos Exposure
Melike Demir (2016)
Merlin/NF2 loss-driven tumorigenesis linked to CRL4(DCAF1)-mediated inhibition of the hippo pathway kinases Lats1 and 2 in the nucleus.
W. Li (2014)
HMGB1 and Its Hyperacetylated Isoform are Sensitive and Specific Serum Biomarkers to Detect Asbestos Exposure and to Identify Mesothelioma Patients
A. Napolitano (2016)
Germline BAP1 mutations predispose to renal cell carcinomas.
Tatiana Popova (2013)
Germline mutations in BAP1 predispose to melanocytic tumors
T. Wiesner (2011)
Fibulin-3 as a blood and effusion biomarker for pleural mesothelioma.
H. Pass (2012)
Absence of germline mutations in BAP1 in sporadic cases of malignant mesothelioma.
S. Sneddon (2015)
Phase II clinical trial of amatuximab, a chimeric antimesothelin antibody with pemetrexed and cisplatin in advanced unresectable pleural mesothelioma.
R. Hassan (2014)
BAP1 and cancer
M. Carbone (2013)
Role of Merlin/NF2 Inactivation in Tumor Biology
A. Petrilli (2016)
Trial watch: Phase III and submission failures: 2007–2010
John Arrowsmith (2011)
Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB
Johanna C. Scheuermann (2010)
Combined Genetic and Genealogic Studies Uncover a Large BAP1 Cancer Syndrome Kindred Tracing Back Nine Generations to a Common Ancestor from the 1700s
M. Carbone (2015)
Genome-based Mutational Analysis by Next Generation Sequencing in Patients with Malignant Pleural and Peritoneal Mesothelioma.
G. Ugurluer (2016)
Consensus Report of the 2015 Weinman International Conference on Mesothelioma
M. Carbone (2016)
Serum mesothelin for diagnosing malignant pleural mesothelioma: an individual patient data meta-analysis.
Kevin Hollevoet (2012)
Profiling Tumor-Associated Markers for Early Detection of Malignant Mesothelioma: An Epidemiologic Study
M. Amati (2008)
Levels of 8-hydroxy-2'-deoxyguanosine in DNA of white blood cells from workers highly exposed to asbestos in Germany.
B. Marczynski (2000)
Mesothelioma incidence in 50 states and the District of Columbia, United States, 2003–2008
S. Jane Henley (2013)
The mortality of amphibole miners in South Africa, 1946-80.
G. K. Sluis‐Cremer (1992)
Comprehensive genomic analysis of malignant pleural mesothelioma identifies recurrent mutations, gene fusions and splicing alterations
R. Bueno (2016)
Loss of BAP1 function leads to EZH2-dependent transformation
Lindsay M. LaFave (2015)
Genetic-susceptibility factor and malignant mesothelioma in the Cappadocian region of Turkey
Iman Roushdy-Hammady (2001)
Simian virus 40: the link with human malignant mesothelioma is well established.
M. Carbone (2000)
BAP1 cancer syndrome: malignant mesothelioma, uveal and cutaneous melanoma, and MBAITs
M. Carbone (2012)
Aspirin delays mesothelioma growth by inhibiting HMGB1-mediated tumor progression
H. Yang (2015)
Increased Levels of C-C Chemokine RANTES in Asbestos Exposed Workers and in Malignant Mesothelioma Patients from an Hyperendemic Area
M. Comar (2014)
Germline BAP1 mutations predispose to malignant mesothelioma
J. Testa (2011)
Performance of osteopontin in the diagnosis of malignant pleural mesothelioma: a meta-analysis.
H. Lin (2014)
Germline BAP1 mutations predispose also to multiple basal cell carcinomas
A. de la Fouchardière (2015)
Evaluation of clonal origin of malignant mesothelioma
Sabahattin Comertpay (2014)
Asbestos is not just asbestos: an unrecognised health hazard.
F. Baumann (2013)
Malignant mesothelioma: Facts, Myths, and Hypotheses
M. Carbone (2012)
Molecular Classification of Malignant Pleural Mesothelioma: Identification of a Poor Prognosis Subgroup Linked to the Epithelial-to-Mesenchymal Transition
A. de Reyniès (2014)
Efficacy and safety of an intensified schedule of tremelimumab for chemotherapy-resistant malignant mesothelioma: an open-label, single-arm, phase 2 study.
L. Calabrò (2015)
Bevacizumab for newly diagnosed pleural mesothelioma in the Mesothelioma Avastin Cisplatin Pemetrexed Study (MAPS): a randomised, controlled, open-label, phase 3 trial
G. Zalcman (2016)
Prevalence of BRCA-1 associated protein 1 germline mutation in sporadic malignant pleural mesothelioma cases.
Andreas Rusch (2015)
Loss of the Tumor Suppressor Gene NF2, Encoding Merlin, Constitutively Activates Integrin-Dependent mTORC1 Signaling
M. López-Lago (2009)
Preclinical development of HIvax: Human survivin highly immunogenic vaccines
P. Hoffmann (2015)
Inconsistent results or inconsistent methods? A plea for standardisation of biomarker sampling in mesothelioma studies
K. Blyth (2014)
Comparison of fibulin-3 and mesothelin as markers in malignant mesothelioma
J. Creaney (2014)
Merlin Deficiency Predicts FAK Inhibitor Sensitivity: A Synthetic Lethal Relationship
I. Shapiro (2014)
Randomized phase III study of cisplatin with or without raltitrexed in patients with malignant pleural mesothelioma: an intergroup study of the European Organisation for Research and Treatment of Cancer Lung Cancer Group and the National Cancer Institute of Canada.
J. Van Meerbeeck (2005)
Frequent inactivation of the BAP1 gene in epithelioid‐type malignant mesothelioma
Yoshie Yoshikawa (2012)
Oncolytic measles viruses encoding interferon β and the thyroidal sodium iodide symporter gene for mesothelioma virotherapy
H. Li (2010)
The p53/mouse double minute 2 homolog complex deregulation in merlin‐deficient tumours
S. Ammoun (2015)
The neurofibromatosis 2 tumor suppressor gene product, merlin, regulates human meningioma cell growth by signaling through YAP.
Katherine Striedinger (2008)
Mesothelioma patients with germline BAP1 mutations have 7-fold improved long-term survival.
F. Baumann (2015)
Whole-exome sequencing reveals frequent genetic alterations in BAP1, NF2, CDKN2A, and CUL1 in malignant pleural mesothelioma.
Guangwu Guo (2015)
A recurrent germline BAP1 mutation and extension of the BAP1 tumor predisposition spectrum to include basal cell carcinoma
K.A.W. Wadt (2015)
Loss of the deubiquitylase BAP1 alters class I histone deacetylase expression and sensitivity of mesothelioma cells to HDAC inhibitors
J. Sacco (2015)
Vorinostat in patients with advanced malignant pleural mesothelioma who have progressed on previous chemotherapy (VANTAGE-014): a phase 3, double-blind, randomised, placebo-controlled trial.
L. Krug (2015)
This paper is referenced by
Utility of BRCA1‐associated protein 1 immunoperoxidase stain to differentiate benign versus malignant mesothelial proliferations in cytologic specimens
Z. McCroskey (2017)
FTY720 inhibits mesothelioma growth in vitro and in a syngeneic mouse model
Agata Szymiczek (2017)
Biological responses to asbestos inhalation and pathogenesis of asbestos-related benign and malignant disease
Eduardo Solbes (2018)
Improving the Accuracy of Mesothelioma Diagnosis in China
Zhenying Guo (2017)
The Cappadocia mesothelioma epidemic: its influence in Turkey and abroad.
S. Emri (2017)
Consensus report of the 8 and 9th Weinman Symposia on Gene x Environment Interaction in carcinogenesis: novel opportunities for precision medicine
M. Carbone (2018)
An Unpleasant Surprise: Abdominal Presentation of Malignant Mesothelioma
Dustin J. Uhlenhopp (2020)
High-density array-CGH with targeted NGS unmask multiple noncontiguous minute deletions on chromosome 3p21 in mesothelioma
Yoshie Yoshikawa (2016)
Pathologic considerations and standardization in mesothelioma clinical trials.
M. Tsao (2019)
Translating Mesothelioma Molecular Genomics and Dependencies into Precision Oncology-Based Therapies.
T. K. Hinz (2019)