Online citations, reference lists, and bibliographies.
← Back to Search

Combined Treatment Of Tyrosine Kinase Inhibitor-Labeled Gold Nanorod Encapsulated Albumin With Laser Thermal Ablation In A Renal Cell Carcinoma Model.

C. Callaghan, D. Peralta, J. Liu, S. Mandava, M. Maddox, S. Dash, M. Tarr, B. Lee
Published 2016 · Chemistry, Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
To characterize and evaluate human serum albumin-encapsulated nanoparticles for drug delivery of a tyrosine kinase inhibitor combined with induction of photothermal ablation combination therapy of renal cell carcinoma (RCC), nanoparticles of varying preparations and concentrations were characterized via zeta potential, drug loading, and release profile. Cytotoxicity and uptake trials were also studied using clear cell RCC cell line RCC 786-0, a human metastatic carcinoma. Target temperatures of >50°C were consistently attained by 0.1 and 0.05 μM concentrations of irradiated human serum albumin nanoparticle-gold nanorods (HSAP-AuNRs). Irradiated trials of HSAP-AuNRs demonstrated significantly decreased cell viabilities compared with nonirradiated "dark" controls (p < 0.01). Increasing loaded masses of sorafenib (SRF) also significantly decreased relative cell viability of RCC (p < 0.05). Photothermal ablation using HSAP-AuNRs is capable of inducing significant hyperthermia while the loading of SRF further enhances cytotoxicity relative to treatment with HSAP-AuNRs alone. HSAP-AuNR-SRFs have the potential to be an effective, novel combination treatment for advanced RCC.
This paper references
10.1002/jps.24318
Comparison of sorafenib-loaded poly (lactic/glycolic) acid and DPPC liposome nanoparticles in the in vitro treatment of renal cell carcinoma.
J. Liu (2015)
10.1016/S1076-6332(96)80443-0
Radiofrequency tissue ablation: importance of local temperature along the electrode tip exposure in determining lesion shape and size.
S. Goldberg (1996)
10.1007/s10103-007-0470-x
Plasmonic photothermal therapy (PPTT) using gold nanoparticles
X. Huang (2007)
10.1021/JA057254A
Cancer cell imaging and photothermal therapy in the near-infrared region by using gold nanorods.
X. Huang (2006)
10.1111/j.1464-410X.2004.04604.x
Increased expression of caveolin‐1 and microvessel density correlates with metastasis and poor prognosis in clear cell renal cell carcinoma
H. Joo (2004)
10.1016/j.addr.2011.03.005
Gold nanorods: their potential for photothermal therapeutics and drug delivery, tempered by the complexity of their biological interactions.
A. AlKilany (2012)
10.1158/0008-5472.CAN-08-4242
Computationally guided photothermal tumor therapy using long-circulating gold nanorod antennas.
G. von Maltzahn (2009)
10.1002/ADMA.200800921
Enhancing the Toxicity of Cancer Chemotherapeutics with Gold Nanorod Hyperthermia
Tanya S. Hauck (2008)
10.1007/978-1-4939-1622-1_1
Targeted Therapy for Metastatic Renal Cell Carcinoma: Introduction
R. Bukowski (2015)
10.3109/02652048.2013.788090
Fate of nanostructured lipid carriers (NLCs) following the oral route: design, pharmacokinetics and biodistribution
A. Beloqui (2014)
10.1158/1535-7163.MCT-09-0119
Sorafenib has soluble epoxide hydrolase inhibitory activity, which contributes to its effect profile in vivo
J. Liu (2009)
10.1016/J.DRUDIS.2006.07.005
Exploiting the enhanced permeability and retention effect for tumor targeting.
A. Iyer (2006)
10.1126/science.1203543
A Perspective on Cancer Cell Metastasis
Christine L Chaffer (2011)
10.1016/J.APRADISO.2004.03.114
Preparation and radiolabeling of human serum albumin (HSA)-coated magnetite nanoparticles for magnetically targeted therapy.
Zhang Chun-fu (2004)
10.3109/02652048.2014.940012
Encapsulating gold nanomaterials into size-controlled human serum albumin nanoparticles for cancer therapy platforms
D. Peralta (2014)
10.1021/NL050074E
Surface plasmon resonance scattering and absorption of anti-EGFR antibody conjugated gold nanoparticles in cancer diagnostics: applications in oral cancer.
I. El-Sayed (2005)
10.1038/clpt.2012.96
Pharmacogenomics Knowledge for Personalized Medicine
M. Whirl-Carrillo (2012)
10.1158/0008-5472.CAN-12-4561
Challenges and key considerations of the enhanced permeability and retention effect for nanomedicine drug delivery in oncology.
Uma Prabhakar (2013)
10.1016/j.biomaterials.2013.11.001
Enzyme delivery using the 30Kc19 protein and human serum albumin nanoparticles.
Hong Jai Lee (2014)
10.1093/jnci/djr511
Targeted therapies for renal cell carcinoma: review of adverse event management strategies.
T. Eisen (2012)
10.3109/02652048.2011.590614
Preparation of the albumin nanoparticle system loaded with both paclitaxel and sorafenib and its evaluation in vitro and in vivo
J. Zhang (2011)
10.1016/S0378-5173(03)00134-0
Optimization of the preparation process for human serum albumin (HSA) nanoparticles.
K. Langer (2003)



This paper is referenced by
10.1002/jemt.23213
Detoxification and functionalization of gold nanorods with organic polymers and their applications in cancer photothermal therapy
Na Jin (2019)
10.1016/j.ijpharm.2019.118785
Nanoformulations of Small Molecule Protein Tyrosine Kinases Inhibitors Potentiate Targeted Cancer Therapy.
Yanlong Yin (2019)
10.1016/j.jconrel.2016.10.023
Hybrid protein-inorganic nanoparticles: From tumor-targeted drug delivery to cancer imaging.
Ahmed O Elzoghby (2016)
10.2174/1389450118666171027111050
Protein-inorganic Nanohybrids: A Potential Symbiosis in Tissue Engineering.
May S. Freag (2018)
10.7150/thno.19365
Strategies for Preparing Albumin-based Nanoparticles for Multifunctional Bioimaging and Drug Delivery
F. An (2017)
10.2217/nnm-2019-0417
Differential toxicity mechanism of gold nanoparticles in HK-2 renal proximal tubular cells and 786-0 carcinoma cells.
P. Zhao (2020)
10.2147/IJN.S210992
Capping gold nanoparticles with albumin to improve their biomedical properties
K. Bolaños (2019)
10.1111/bju.13708
Synergistic effects in combinational drug delivery and thermal ablation using nanotechnology
W. Dickson (2017)
10.1016/j.msec.2018.06.002
Hybrid folic acid-conjugated gold nanorods-loaded human serum albumin nanoparticles for simultaneous photothermal and chemotherapeutic therapy.
David Encinas-Basurto (2018)
10.1111/bju.13590
Nanotechnology combined therapy: tyrosine kinase‐bound gold nanorod and laser thermal ablation produce a synergistic higher treatment response of renal cell carcinoma in a murine model
J. Liu (2017)
10.1016/j.ajps.2020.07.003
Recent advances of sorafenib nanoformulations for cancer therapy: smart nanosystem and combination therapy
Fangmin Chen (2020)
Semantic Scholar Logo Some data provided by SemanticScholar