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Spatial Learning And Memory In Male Mice With Altered Growth Hormone Action
A. Basu, H. McFarlane, J. Kopchick
Published 2017 · Psychology, Medicine
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Abstract Growth hormone (GH) has a significant influence on cognitive performance in humans and other mammals. To understand the influence of altered GH action on cognition, we assessed spatial learning and memory using a Barnes maze (BM) comparing twelve‐month old, male, bovine GH (bGH) and GH receptor antagonist (GHA) transgenic mice and their corresponding wild type (WT) littermates. During the acquisition training period in the BM, bGH mice showed increased latency, traveled longer path lengths and made more errors to reach the target than WT mice, indicating significantly poorer learning. Short‐term memory (STM) and long‐term memory (LTM) trials showed significantly suppressed memory retention in bGH mice when compared to the WT group. Conversely, GHA mice showed significantly better learning parameters (latency, path length and errors) and increased use of an efficient search strategy than WT mice. Our study indicates a negative impact of GH excess and a beneficial effect of the inhibition of GH action on spatial learning and memory and, therefore, cognitive performance in male mice. Further research to elucidate GH's role in brain function will facilitate identifying therapeutic applications of GH or GHA for neuropathological and neurodegenerative conditions. HighlightsSpatial learning and memory were measured in mice with altered GH action.Poor learning and memory retention were found in mice with increased GH action.Normal to better cognitive performance was found in mice with reduced GH action.Spatial cognition was positively associated with GH inhibition and vice versa in mice.
This paper references
Mouse models of growth hormone action and aging: A proteomic perspective
Juan Ding (2013)
Transcriptional profiling reveals regulated genes in the hippocampus during memory formation
C. Donahue (2002)
Behavioral profiles of inbred strains on novel olfactory, spatial and emotional tests for reference memory in mice
A. Holmes (2002)
Growth hormone receptor immunoreactivity is increased
A. Scheepens (2009)
Suppressor of cytokine signaling 2 regulates neuronal differentiation by inhibiting growth hormone signaling
A. Turnley (2002)
Role of IGF-I signaling in muscle bone interactions.
D. Bikle (2015)
Growth Hormone, Insulin-like Growth Factors
C. Wüster (2001)
Local expression of GH and IGF-1 in the hippocampus of GH-deficient long-lived mice
L. Sun (2005)
Could a deficiency
rameters. Horm (2004)
Distribution of growth hormone receptor mRNA in the brain stem and spinal cord of the rat
Y. Kastrup (2005)
The effects of growth hormone (GH
M. G. Falleti (2006)
High incidence of mental disorders, reduced mental well‐being and cognitive function in hypopituitary women with GH deficiency treated for pituitary disease
B. Bülow (2002)
Effects of Growth Hormone Substitution Therapy on Cognitive Functioning in Growth Hormone Deficient Patients: A Functional MRI Study
L. Arwert (2006)
The GH/IGF-1 axis
E. O. List (2014)
Growth hormone induces age-dependent alteration in the expression of hippocampal growth hormone receptor and N-methyl-d-aspartate receptor subunits gene transcripts in male rats
Madeleine le Grevès (2002)
Exogenous growth hormone attenuates cognitive deficits induced by intermittent hypoxia in rats
R. C. Li (2011)
Aspects of Growth Hormone and Insulin-Like Growth Factor-I Related to Neuroprotection, Regeneration, and Functional Plasticity in the Adult Brain
N. Åberg (2006)
Effects of GH on cognitive function in elderly patients with adult-onset GH deficiency: a placebo-controlled 12-month study.
M. Sathiavageeswaran (2007)
Evaluation of spatial memory of C57BL/6J and CD1 mice in the Barnes maze, the Multiple T-maze and in the Morris water maze
Sudarshan S. Patil (2009)
Developments of a water-maze procedure for studying spatial learning in the rat
R. Morris (1984)
Mechanisms of CaMKII action in long-term potentiation
J. Lisman (2012)
Spatial and nonspatial
R. S. Reiserer (2006)
Differential inhibition of postnatal brain, spinal cord and body growth by a growth hormone antagonist
D. McIlwain (2003)
Evidence of cognitive and neurophysiological impairment in patients with untreated naive acromegaly.
J. Leon-Carrion (2010)
A Molecular Circuit
N. R. 0106-9. Zearfoss (2008)
Regional distribution and ontogeny of the first exon variants of the rat growth hormone receptor mRNA in the brain and the pituitary gland.
H. Nogami (2011)
Role of IGF-I
C. Tahimic (2015)
Decreased psychological well‐being in adult patients with growth hormone deficiency
T. Rosén (1994)
Effect of growth hormone deficiency on brain
C. a (2012)
Distinct neuronal growth hormone receptor ligand specificity in the rat brain
T. A. E. Möderscheim (2007)
Growth hormone and hepatic lipoprotein metabolism.
B. Angelin (1994)
Spatial navigation strategies in Peromyscus: a comparative study
E. Jašarević (2012)
Growth hormone and protein metabolism.
N. Møller (2009)
Growth hormone (GH) and GH-releasing peptide-6 increase brain insulin-like growth factor-I expression and activate intracellular signaling pathways involved in neuroprotection.
L. Frago (2002)
Assessment of spatial memory in mice.
S. Sharma (2010)
The effect of growth
H. J. Schneider (2004)
Acromegaly Quality of Life Questionnaire (AcroQoL)
X. Badía (2004)
Functional antagonism between endogenous mouse growth hormone (GH) and a GH analog results in dwarf transgenic mice.
W. Y. Chen (1991)
Characterization of putative growth hormone receptors in human choroid plexus
Z. Lai (1991)
Growth hormone rescues hippocampal synaptic function after sleep deprivation.
Eunyoung Kim (2010)
GH-R-KO (Laron) mice
B. A. Kinney (2001)
Growth hormone enhances excitatory synaptic transmission in area CA1 of rat hippocampus.
Ghada S. Mahmoud (2006)
Comparing adiposity profiles in three mouse models with altered GH signaling.
D. Berryman (2004)
Growth hormone replacement in hypophysectomized rats affects spatial performance and hippocampal levels of NMDA receptor subunit and PSD-95 gene transcript levels
M. L. Grevès (2006)
Self-perception of cognitive function among patients with active acromegaly, controlled acromegaly, and non-functional pituitary adenoma: a pilot study
Chris G. Yedinak (2013)
Expression of a mutated bovine
W. Y. 1845–1852. Chen (1990)
Growth Hormone Receptor Antagonists: Discovery, Development, and Use in Patients With Acromegaly. 23:pp
J. J. Kopchick (2002)
Characterization of putative growth hormone
M. Emtner (1991)
Could a deficiency in growth hormone signaling be beneficial to the aging brain?
B. A. Kinney-Forshee (2004)
Endocrinol. Metab. 83:3184–3189
J. Clin (2004)
Effect of growth hormone deficiency on brain structure, motor function and cognition.
E. Webb (2012)
Growth hormone & IGF research regional distribution and ontogeny of the fi rst exon variants of the rat growth hormone recep - tormRNA in the brain and the pituitary gland
Memory deficits associated with senescence: a neurophysiological and behavioral study in the rat.
C. A. Barnes (1979)
The Essential Role of Hippocampal CA1 NMDA Receptor–Dependent Synaptic Plasticity in Spatial Memory
J. Tsien (1996)
Restoration of hip
C. M. 002. Vander Weele (2013)
Growth hormone and cognitive function
F. Nyberg (2013)
Neurocognitive Function in Acromegaly after Surgical Resection of GH-Secreting Adenoma versus Naïve Acromegaly
J. F. Martín-Rodríguez (2013)
Suppressor of cyto
A. M. Turnley (2002)
Glycine 119 of bovine growth hormone is critical for growth-promoting activity.
W. Y. Chen (1991)
The effect of peripheral administration of growth hormone on AD-like cognitive deficiency in NBM-lesioned rats
A. H. Doulah (2009)
Quality of life (QOL) in patients with acromegaly is severely impaired: use of a novel measure of QOL: acromegaly quality of life questionnaire.
S. Rowles (2005)
Endocrinol. Metab. 89:2048–2056
J. Clin (2002)
Bovine Growth Hormone Transgenic Mice Display Alterations in Locomotor Activity and Brain Monoamine Neurochemistry1.
Bo So Derpalm (1999)
Localization and ontogeny of growth
P. Lobie (1993)
Growth hormone is produced within the hippocampus where it responds to age, sex, and stress.
C. Donahue (2006)
Endogenous anxiety and stress responses in water maze and Barnes maze spatial memory tasks
F.E. Harrison (2009)
Cognition in the adult with childhood-onset growth hormone deficiency
I. C. V. Nieuwpoort (2008)
The aging brain: is function dependent on growth hormone/insulin-like growth factor-1 signaling?
B. A. Forshee (2006)
Restoration of hippocampal growth hormone reverses stress-induced hippocampal impairment
Caitlin M. Vander Weele (2013)
Expression of a mutated bovine growth hormone gene suppresses growth of transgenic mice.
W. Y. Chen (1990)
Evaluation of growth hormone (GH) action in mice: Discovery of GH receptor antagonists and clinical indications
J. Kopchick (2014)
Evaluation of growth
J. J. Kopchick (2014)
The effect of growth hormone substitution on cognitive performance in adult patients with hypopituitarism
H. Oertel (2004)
Localization and ontogeny of growth hormone receptor gene expression in the central nervous system.
P. Lobie (1993)
Growth hormone (GH) replacement therapy in adults
H. Turner (2009)
Functional antagonism between E2F family members.
M. Frolov (2001)
Spatial and nonspatial escape strategies in the Barnes maze.
F. E. Harrison (2006)
The effects of growth hormone (GH) deficiency and GH replacement on cognitive performance in adults: A meta-analysis of the current literature
M. Falleti (2006)
Childhood-onset growth hormone deficiency, cognitive function and brain N-acetylaspartate
P. V. Dam (2005)
Growth hormone and adipose tissue: beyond the adipocyte.
D. Berryman (2011)
The somatotrophic axis in brain function
F. Nyberg (2006)
Neurocognitive function in acromegaly after surgical ̈ve
Alterations in locomotor
M. Bohlooly-y (1999)
A Molecular Circuit Composed of CPEB-1 and c-Jun Controls Growth Hormone-Mediated Synaptic Plasticity in the Mouse Hippocampus
N. R. Zearfoss (2008)
イヌのgrowth hormone secretagogue receptor (GHS-R) 1aと血中グレリン動態に関する基礎的研究
北澤 多喜雄 (2012)
Enhanced spatial memory and hippocampal long‐term potentiation in p75 neurotrophin receptor knockout mice
G. Barrett (2010)
The GH/IGF-1 axis in ageing and longevity
R. Junnila (2013)
Growth hormone receptor immunoreactivity is increased in the subventricular zone of juvenile rat brain after focal ischemia: a potential role for growth hormone in injury-induced neurogenesis.
L. Christophidis (2009)
Quality of life in growth hormone deficiency and acromegaly.
S. Webb (2007)
Growth hormone rescues hippocam
L. M. Grover (2010)
Compar - ing adiposity pro fi les in three mouse models with altered GH signaling q
D. E. Berryman
Delayed and chronic treatment with growth hormone after endothelin-induced stroke in the adult rat
Praneeti Pathipati (2009)
Delayed and chronic treatment
A. Surus (2009)
Acromegaly Quality of Life Questionnaire (ACROQOL) a new health‐related quality of life questionnaire for patients with acromegaly: development and psychometric properties
S. Webb (2002)
In vitro and in vivo studies of the antagonistic effects of human growth hormone analogs.
W. Y. Chen (1994)
In vitro and in vivo studies of antagonistic effects of human growth hormone analogs.
W. Y. Chen (1994)
Effects of growth
D. J. Veltman (2006)
Adaptation of the circular
M. J. Mullan (1999)
High incidence ofmen
B. bone.2015.04.036. Bülow (2002)
Phenotypic characterization of cognition and social behavior in mice with heterozygous versus homozygous deletion of catechol-O-methyltransferase
D. Babovic (2008)
Adaptation of the circular platform spatial memory task for mice: use in detecting cognitive impairment in the APPSW transgenic mouse model for Alzheimer’s disease
P. Pompl (1999)
Visuo-spatial learning and memory deficits on the Barnes maze in the 16-month-old APPswe/PS1dE9 mouse model of Alzheimer's disease
T. O'Leary (2009)
Effects of physiological growth hormone (GH) therapy on cognition and quality of life in patients with adult-onset GH deficiency.
H. B. Baum (1998)
Assessment of spatial learning abilities of mice in a new circular maze
G. Koopmans (2003)
receptors in human choroid plexus
M. Le Grevès (2002)
Age-related and depot-specific changes in white adipose tissue of growth hormone receptor-null mice.
L. Sackmann-Sala (2014)
Effects of physiological growth hormone
K. E. Cannistraro (1998)
Barnes maze, a useful task to assess spatial reference memory in the mice
B. Sunyer (2007)
Mechanisms of CaMKII Activation in the Heart
Jeffrey R Erickson (2014)
Growth hormone receptor antagonists: discovery, development, and use in patients with acromegaly.
J. Kopchick (2002)
Growth hormone (GH) replacement therapy in adult-onset gh deficiency: effects on body composition in men and women in a double-blind, randomized, placebo-controlled trial.
A. Hoffman (2004)
Mouse models of growth hormone
J. s11248-011-9499-5. Ding (2013)
Distribution of Growth Hormone Receptor
Y. nrendo.2013.67.The. Kastrup (2005)
The effects of GH-releasing hormone/somatostatin on the 5'-promoter activity of the GH gene in vitro.
M. Morishita (2003)
The Insulin-Like Growth Factor System
D. L. Roith (2003)
Cognitive improvement by acute growth hormone is mediated by NMDA and AMPA receptors and MEK pathway
M. Ramis (2013)
Evidence That Ames Dwarf Mice Age Differently from Their Normal Siblings in Behavioral and Learning and Memory Parameters
B. A. Kinney (2001)
Medical progress: Acromegaly.
S. Melmed (2006)
Growth hormone, insulin-like growth factor I and the CNS: localization, function and mechanism of action.
P. Lobie (2000)
Bovine growth hormone transgenic mice display alterations in locomotor activity and brain monoamine neurochemistry.
B. Söderpalm (1999)
Evidence that age-induced decline in memory retention is delayed in growth hormone resistant GH-R-KO (Laron) mice
Bryan Kinney (2001)
Cognitive function in acromegaly: description and brain volumetric correlates
C. Sievers (2011)
Plasma proteomic profiles of bovine growth hormone transgenic mice as they age
J. Ding (2011)
Growth hormone as a neuronal rescue factor during recovery from CNS injury
A. Scheepens (2001)
Growth hormone, insulin-like growthfactor I and the CNS: Localization, function and mechanism of action
P. E. Lobiezz (2000)
Permeation of growth hormone across the blood-brain barrier.
W. Pan (2005)
Inhibitory Avoidance and Appetitive Learning in Aged Normal Mice: Comparison with Transgenic Mice Having Elevated Plasma Growth Hormone Levels
Charles J. Meliska (1997)
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Central Regulation of Metabolism by Growth Hormone
J. Donato (2021)
Hippocampal growth hormone modulates relational memory and the dendritic spine density in CA1.
Kamilla G Haugland (2020)
The effects of growth hormone on therapy resistance in cancer
Reetobrata Basu (2019)
Maternal high‐salt diet during pregnancy impairs synaptic plasticity and memory in offspring
Qian Ge (2021)
The enigmatic role of growth hormone in age-related diseases, cognition, and longevity
Gabriela Colon (2019)
MECHANISMS IN ENDOCRINOLOGY: Lessons from growth hormone receptor gene-disrupted mice: are there benefits of endocrine defects?
Reetobrata Basu (2018)
Growth hormone (GH) and synaptogenesis.
C. Martínez-Moreno (2020)
Growth Hormone and Aging: Updated Review
A. Bartke (2019)
More Than Growth? A Study of the Additional Functions of Growth Hormone in the Human Body
Damien Chance Hutchins (2019)
Growth Hormone (GH) and Gonadotropin-Releasing Hormone (GnRH) in the Central Nervous System: A Potential Neurological Combinatory Therapy?
C. Martínez-Moreno (2018)
Behavioural phenotyping, learning and memory in young and aged growth hormone-releasing hormone knockout mice.
S. Leone (2018)
Growth Hormone Receptor Regulation in Cancer and Chronic Diseases
G. J. Strous (2020)