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Estimating Meat Withdrawal Times In Pigs Exposed To Melamine Contaminated Feed Using A Physiologically Based Pharmacokinetic Model.
J. Buur, R. Baynes, J. Riviere
Published 2008 · Chemistry, Medicine
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Recently melamine was found to have contaminated the feed of multiple food production species leading to concern over the ability to establish an appropriate withdrawal interval and protect the safety of the food supply. To establish an appropriate withdrawal interval, a physiologically based pharmacokinetic (PBPK) model for melamine was developed for rats and extrapolated to pigs. The rat model underpredicted plasma concentrations, but better predicted tissue residues. Correlation values for plasma, kidney, and liver were 0.59, 0.76, and 0.73, respectively. The pig model underpredicted early plasma time points but had greater accuracy at later time points which is relevant to withdrawal times. Correlation (R(2)) between predicted and observed plasma values was 0.89 with a negative intercept of -0.76. The pig model estimated a withdrawal interval (based on kidney tissue residues) of 19.2 and 20.9h for single oral exposures of 3.0 and 5.12 mg/kg of melamine, respectively. Chronic oral dosing (3.0 and 5.12 mg/kg twice daily for 7 days) yielded withdrawal intervals of 20 and 21.3h, respectively. PBPK models, such as this one, provide evidence of the usefulness in species extrapolation over a range of dosing scenarios and can be used to protect the food supply after accidental exposure in the face of little in the target species.
This paper references
Organ blood flow and distribution of cardiac output in nonanesthetized swine.
W. Tranquilli (1982)
Systemic Distribution of Blood Flow in Swine while Awake and during 1.0 and 1.5 MAC Isoflurane Anesthesia with or without 50% Nitrous Oxide
G. Lundeen (1983)
Metabolism, disposition and excretion of [14C]melamine in male Fischer 344 rats.
R. Mast (1983)
Incorporation of in vitro enzyme data into the physiologically-based pharmacokinetic (PB-PK) model for methylene chloride: implications for risk assessment.
R. Reitz (1988)
Intestinal Absorption and Urinary Excretion of Melamine in Male Wistar Rats
T. Sugita (1991)
Evaluation of a three‐exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals
M. Shelby (1993)
Urinary bladder carcinogenesis induced by melamine in F344 male rats: correlation between carcinogenicity and urolith formation.
Hiroyuki Ogasawara (1995)
Organ weights and fat volume in rats as a function of strain and age.
D. J. Schoeffner (1999)
Comparative Pharmacokinetics: Principles, Techniques, and Applications
J. Riviere (1999)
Changes in intragastric meal distribution are better predictors of gastric emptying rate in conscious pigs than are meal viscosity or dietary fibre concentration
S. Guérin (2001)
Investigation of 5‐FU disposition after oral administration of capecitabine, a triple‐prodrug of 5‐FU, using a physiologically based pharmacokinetic model in a human cancer xenograft model: comparison of the simulated 5‐FU exposures in the tumour tissue between human and xenograft model
Y. Tsukamoto (2001)
Analysis of Methylmercury Disposition in Humans Utilizing A PBPK Model and Animal Pharmacokinetic Data
J. Young (2001)
Biology of the domestic pig
W. Pond (2001)
Physiologically-based pharmacokinetic simulation modelling.
G. M. Grass (2002)
A physiologically based pharmacokinetic model for oxytetracycline residues in sheep.
A. Craigmill (2003)
Application of a Physiologically Based Pharmacokinetic Model for Reference Dose and Reference Concentration Estimation for Acetone
P. R. Gentry (2003)
Assessing the dose-dependency of allometric scaling performance using physiologically based pharmacokinetic modeling.
C. Kirman (2003)
Evaluation of the potential impact of age- and gender-specific pharmacokinetic differences on tissue dosimetry.
H. Clewell (2004)
Evaluation of oral and intravenous route pharmacokinetics, plasma protein binding, and uterine tissue dose metrics of bisphenol A: a physiologically based pharmacokinetic approach.
J. Teeguarden (2005)
Development of a physiologic-based pharmacokinetic model for estimating sulfamethazine concentrations in swine and application to prediction of violative residues in edible tissues.
J. Buur (2005)
Use of Probabilistic Modeling within a Physiologically Based Pharmacokinetic Model To Predict Sulfamethazine Residue Withdrawal Times in Edible Tissues in Swine
J. Buur (2006)
Physiologically based pharmacokinetic study on a cyclosporin derivative, SDZ IMM 125
R. Kawai (2006)
Leptin inhibits gastric emptying in rats: role of CCK receptors and vagal afferent fibers.
B. Çakır (2007)
Events leading to the major recall of pet foods.
K. Burns (2007)
Recall shines spotlight on pet foods.
K. Burns (2007)
Assessment of Melamine and Cyanuric Acid Toxicity in Cats
B. Puschner (2007)
Pharmacokinetics of melamine in pigs following intravenous administration.
R. Baynes (2008)
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Physiologically based pharmacokinetic model calibration, evaluation, and performance assessment
Zhoumeng Lin (2020)
Bayesian population physiologically-based pharmacokinetic model for robustness evaluation of withdrawal time in tilapia aquaculture administrated to florfenicol.
Hsing-Chieh Lin (2020)
Physiologically based kinetic models for farm animals: Critical review of published models and future perspectives for their use in chemical risk assessment
L. Lautz (2019)
Investigating the interaction between melamine and cyanuric acid using a Physiologically‐Based Toxicokinetic model in rainbow trout
C. Tebby (2019)
The pig as a preclinical model for predicting oral bioavailability and in vivo performance of pharmaceutical oral dosage forms: a PEARRL review
Laura J Henze (2019)
Reproductive toxicity of melamine against male mice and the related mechanism
J. Huang (2018)
Pharmacokinetics of Mequindox and Its Marker Residue 1,4-Bisdesoxymequindox in Swine Following Multiple Oral Gavage and Intramuscular Administration: An Experimental Study Coupled with Population Physiologically Based Pharmacokinetic Modeling.
D. Zeng (2017)
Adverse reproductive effects of maternal low‐dose melamine exposure during pregnancy in rats
C. Y. Chu (2017)
Nanotechnology: Meat Safety Revolution
M. Baltic (2017)
Development and application of a population physiologically based pharmacokinetic model for penicillin G in swine and cattle for food safety assessment.
M. Li (2017)
Guide to FARAD resources: historical and future perspectives.
J. Riviere (2017)
Probabilistic modeling of aggregate lead exposure in children of urban China using an adapted IEUBK model.
Buqing Zhong (2017)
Physiologically based pharmacokinetic model for quinocetone in pigs and extrapolation to mequindox
X. Zhu (2017)
Mathematical modeling and simulation in animal health - Part II: principles, methods, applications, and value of physiologically based pharmacokinetic modeling in veterinary medicine and food safety assessment.
Zhoumeng Lin (2016)
A physiologically based pharmacokinetic model for polyethylene glycol-coated gold nanoparticles of different sizes in adult mice
Z. Lin (2016)
Developing a Physiologically-Based Pharmacokinetic Model Knowledgebase in Support of Provisional Model Construction
Jingtao Lu (2016)
Estimation of residue depletion of cyadox and its marker residue in edible tissues of pigs using physiologically based pharmacokinetic modelling
L. Huang (2015)
A physiologically based pharmacokinetic model for quinoxaline-2-carboxylic acid in rats, extrapolation to pigs.
X. Yang (2015)
Development and application of a multiroute physiologically based pharmacokinetic model for oxytetracycline in dogs and humans.
Z. Lin (2015)
The effect of grain and soya bean-based diets on chicken production, some egg quality traits, and the potential for allergen carryover to eggs and meat.
Adia-En-Michelle Dokora (2015)
Preparation of molecularly imprinted polymer with double templates for rapid simultaneous determination of melamine and dicyandiamide in dairy products.
J. Liu (2015)
A framework for meta-analysis of veterinary drug pharmacokinetic data using mixed effect modeling.
M. Li (2015)
Development of a physiologically based pharmacokinetic model for flunixin in cattle (Bos taurus)
T. Leavens (2014)
7. Physiologically Based Pharmacokinetic Modeling
J. Buur (2014)
The Food Animal Residue Avoidance Databank
T. Vickroy (2014)
Tissue deposition and residue depletion in rainbow trout following continuous voluntary feeding with various levels of melamine or a blend of melamine and cyanuric acid.
H. Liu (2014)
Risk Management of Chemical Contaminants in Livestock
R. Baynes (2014)
A physiologically based pharmacokinetic model for the prediction of the depletion of methyl-3-quinoxaline-2-carboxylic acid, the marker residue of olaquindox, in the edible tissues of pigs.
B. Yang (2014)
Isolation and characterization of melamine degrading Bacterial strains from soil
P. Doraisamy (2013)
Individual and Combined Effects of Melamine and Cyanuric Acid in Young Pekin Ducks
B. R. Landers (2013)
Tissue-to-blood distribution coefficients in the rat: utility for estimation of the volume of distribution in man.
P. Paixão (2013)See more