Online citations, reference lists, and bibliographies.
← Back to Search

Formation Of Self-assembled Monolayers By Chemisorption Of Derivatives Of Oligo(ethylene Glycol) Of Structure HS(CH2)11(OCH2CH2)mOH On Gold

C. Pale-Grosdemange, E. Simon, K. L. Prime, G. Whitesides
Published 1991 · Chemistry

Cite This
Download PDF
Analyze on Scholarcy
This paper describes the preparation of oligo(ethylene glycol)-terminated alkanethiols having structure HS- (CHz)'l(OCH2CHz),nOH (m = 3-7) and their use in the formation of self-assembled monolayers (SAMs) on gold. A combination of experimental evidence derived from X-ray photoelectron sp€ctroscopy (XPS), measurement of contact angles, and ellipsometry implies substantial disorder in the oligo(ethylene glycol)-containing segment. The order in the -(CHz)r- group is not defined by the available evidence. The SAMs are moderately hydrophilic: du(H2O) = 34-38o; d,(H2O) = 22-25". A study of monolayers containing mixtures of HS(CH2)rrCHr and HS(CH2)rr(OCH2CH 2)6OH suggests that the oligo(ethylene glycol) moieties are eflective at preventing underlying methylene groups from influencing wetting by water. A limited study demonstrates that these oligo(ethylene glycol)-containing SAMs resist the adsorption of protein from solution and suggests that SAMs will be a useful model system for studying the adsorption of proteins onto organic surfaces.
This paper references

This paper is referenced by
Selective protein adsorption modulates platelet adhesion and activation to oligo(ethylene glycol)-terminated self-assembled monolayers with C18 ligands.
I. Gonçalves (2009)
Liquid Crystalline Materials for Biological Applications.
Aaron M. Lowe (2012)
Phase separation of binary self-assembled thiol monolayers composed of 1-hexadecanethiol and 3-mercaptopropionic acid on Au(111) studied by scanning tunneling microscopy and cyclic voltammetry
D. Hobara (1998)
Development of surface-based assays for transmembrane proteins: selective immobilization of functional CCR5, a G protein-coupled receptor.
V. Silin (2006)
Ionic strength mediated hydrophobic force switching of CF3-terminated ethylene glycol self-assembled monolayers (SAMs) on gold.
N. Bonnet (2007)
Conjugation of peptides to the passivation shell of gold nanoparticles for targeting of cell-surface receptors.
Lisa Maus (2010)
Characterization of protein-resistant dextran monolayers.
R. A. Frazie (2000)
Design of reversible "smart" surfaces for biomedical and nanotechnological applications
Thanh-Nga T. Tran (2003)
Membrane protein resistance of oligo(ethylene oxide) self-assembled monolayers.
Amit Vaish (2014)
Densely crosslinked polymer networks of poly(ethylene glycol) in trimethylolpropane triacrylate for cell-adhesion-resistant surfaces.
P. D. Drumheller (1995)
Three-dimensional self-assembly of millimetre-scale components
A. Terfort (1997)
The interaction of proteins and cells with self-assembled monolayers of alkanethiolates on gold and silver
E. Ostuni (1999)
12 – Self-assembly of peptides and its potential application
S. Fung (2005)
Molecular printboards on silicon oxide: lithographic patterning of cyclodextrin monolayers with multivalent, fluorescent guest molecules.
A. Mulder (2005)
Uniform grafting of poly(1,5-dioxepan-2-one) by surface-initiated, ring-opening polymerization
Kuk Ro Yoon (2006)
Electrochemical Behavior of Epinephrine at Two‐Component Self‐Assembled Monolayer of meso‐2,3‐Dimercaptosuccinic Acid and Penicillamine on Gold Electrode
Y. B. He (2007)
Bionanofabrication by Near-Field Optical Methods
G. Leggett (2007)
Photolithography of Dithiocarbamate-Anchored Monolayers and Polymers on Gold.
A. Leonov (2011)
Thin Metal Films in Resistivity-based Chemical Sensing
Pavel Pode (2013)
Carbohydrate arrays for the evaluation of protein binding and enzymatic modification.
B. Houseman (2002)
Nuclear transport receptor binding avidity triggers a self-healing collapse transition in FG-nucleoporin molecular brushes
Rafael L. Schoch (2012)
In Situ Modulation of Cell Behavior via Smart Dual-Ligand Surfaces
A. Pulsipher (2014)
Antifouling silicones based on surface-modifying additive amphiphiles.
M. A. Rufin (2017)
Inhibition of Escherichia coli Biofilm Formation by Self-Assembled Monolayers of Functional Alkanethiols on Gold
Shuyu Hou (2007)
Surface functionalization of thin-film diamond for highly stable and selective biological interfaces
Courtney J Stavis (2010)
Albumin adsorption on Cibacron Blue F3G-A immobilized onto oligo(ethylene glycol)-terminated self-assembled monolayers
M. Martins (2003)
Strategies for Engineering the Adhesive Microenvironment
D. Pirone (2004)
Model Glycol-Terminated Surfaces for Adhesion Resistance
Mathilde I. Béthencourt (2005)
Peptide-mediated surface-immobilized quantum dot hybrid nanoassemblies with controlled photoluminescence
Melvin T. Zin (2007)
Surface polyethylene glycol enhances substrate-mediated gene delivery by nonspecifically immobilized complexes.
A. Pannier (2008)
Protein-resistant polymer surfaces
A. Wörz (2012)
Silver Oxide Mediated Monotosylation of Poly(ethylene glycol) (PEG): Heterobifunctional PEG via Polymer Desymmetrization
H. Pohlit (2017)
See more
Semantic Scholar Logo Some data provided by SemanticScholar