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Formation Of Self-assembled Monolayers By Chemisorption Of Derivatives Of Oligo(ethylene Glycol) Of Structure HS(CH2)11(OCH2CH2)mOH On Gold

C. Pale-Grosdemange, E. Simon, K. L. Prime, G. Whitesides
Published 1991 · Chemistry

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This paper describes the preparation of oligo(ethylene glycol)-terminated alkanethiols having structure HS- (CHz)'l(OCH2CHz),nOH (m = 3-7) and their use in the formation of self-assembled monolayers (SAMs) on gold. A combination of experimental evidence derived from X-ray photoelectron sp€ctroscopy (XPS), measurement of contact angles, and ellipsometry implies substantial disorder in the oligo(ethylene glycol)-containing segment. The order in the -(CHz)r- group is not defined by the available evidence. The SAMs are moderately hydrophilic: du(H2O) = 34-38o; d,(H2O) = 22-25". A study of monolayers containing mixtures of HS(CH2)rrCHr and HS(CH2)rr(OCH2CH 2)6OH suggests that the oligo(ethylene glycol) moieties are eflective at preventing underlying methylene groups from influencing wetting by water. A limited study demonstrates that these oligo(ethylene glycol)-containing SAMs resist the adsorption of protein from solution and suggests that SAMs will be a useful model system for studying the adsorption of proteins onto organic surfaces.
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