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Utilization Of Molybdenum- And Palladium-catayzed Dynamic Kinetic Asymmetric Transformations For The Preparation Of Tertiary And Quaternary Stereogenic Centers: A Concise Synthesis Of Tipranavir.

B. Trost, N. Andersen
Published 2002 · Chemistry, Medicine

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Tipranavir, an important antiviral agent in clinical development for the treatment of HIV, is synthesized in 15 linear steps from readily available starting materials in 25% overall yield by utilizing Pd- and Mo-catalyzed DYKAT reactions to control the quaternary and tertiary stereogenic centers, respectively.



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