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Physiochemical And Physiological Mechanisms For The Effects Of Food On Drug Absorption: The Role Of Lipids And PH.

W. Charman, C. J. Porter, S. Mithani, J. Dressman
Published 1997 · Chemistry, Medicine

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Drugs are absorbed after oral administration as a consequence of a complex array of interactions between the drug, its formulation, and the gastrointestinal (GI) tract. The presence of food within the GI tract impacts significantly on transit profiles, pH, and its solubilization capacity. Consequently, food would be expected to affect the absorption of co-administered drugs when their physicochemical properties are sensitive to these changes. The physicochemical basis by which ingested food/lipids induce changes in the GI tract and influence drug absorption are reviewed. The process of lipid digestion is briefly reviewed and considered in the context of the absorption of poorly water-soluble drugs. The effect of food on GI pH is reviewed in terms of location (stomach, upper and lower small intestine) and the temporal relationship between pH and drug absorption. Case studies are presented in which postprandial changes in bioavailability are rationalized in terms of the sensitivity of the physicochemical properties of the administered drug to the altered GI environment.
This paper references
10.1002/j.1552-4604.1991.tb03693.x
Drug Delivery Systems 5B. Oral Drug Delivery
V. Ranade (1991)
10.1016/0009-9236(95)90168-X
Differentiation of absorption and first‐pass gut and hepatic metabolism in humans: Studies with cyclosporine
C. Wu (1995)
10.1002/JPS.2600660423
Bioavailability of ampicillin and amoxicillin in fasted and nonfasted subjects.
Peter G. Welling (1977)
10.1016/S0950-3579(89)80021-4
Intestinal mucosal permeability and rheumatological diseases.
K. Katz (1989)
10.1038/182056A0
Effect of Bile Salts upon the Activity of Antibiotics
S. Schneierson (1958)
10.1002/JPS.2600680615
Dissolution systems for chloramphenicol tablet bioavailability.
H. Ogata (1979)
10.1002/JPS.2600810520
Solubilization and dissolution properties of a leukotriene-D4 antagonist in micellar solutions.
T. Kararli (1992)
10.1248/BPB1978.12.80
Enhancing effect of medium-chain triglycerides on intestinal absorption of d-alpha-tocopherol acetate from lecithin-dispersed preparations in the rat.
E. Fukui (1989)
10.1016/S0016-5085(56)80102-9
The secretion of electrolytes by the human pancreas.
D. Dreiling (1956)
Drug Absorption Enhancement
W Curatolo (1994)
Dissolution of steroids in bile salt solutions is modified by the presence of lecithin
L. J. Naylor (1995)
Pancreatic colipase: chemistry and physiology.
B. Borgström (1979)
10.1002/JPS.2600780405
Intestinal absorption of drugs. I: The influence of taurocholate on the absorption of dantrolene in the small intestine of the rat.
F. Poelma (1989)
10.7326/0003-4819-105-2-326_2
The Exocrine pancreas : biology, pathobiology, and diseases
V. Go (1986)
10.1016/0378-5173(82)90128-4
Study of the influence of sodium taurocholate (STC) and sodium glycocholate (SGC) on the mass transfer of certain drugs. Digoxin
M. Kassem (1982)
10.1016/0016-5085(85)90638-9
Omeprazole inhibits oxidative drug metabolism
R. Gugler (1985)
10.1002/JPS.2600620617
Dissolution kinetics of gallstones: physical model approach.
W. Higuchi (1973)
10.1016/0169-409X(88)90022-1
Some biological issues in oral, controlled drug delivery
P. Gruber (1987)
10.1136/bmj.4.5734.532
Interference of Iron with the Absorption of Tetracylines in Man
P. Neuvonen (1970)
10.1016/0005-2736(70)90006-4
The relationship between uptake in vitro of oleic acid and micellar solubilization.
N. Hoffman (1970)
10.1002/JPS.2600550906
Solubilizing properties of bile salt solutions. II. Effect of inorganic electrolyte, lipids, and a mixed bile salt system on solubilization of glutethimide, griseofulvin, and hexestrol.
T. R. Bates (1966)
10.1126/science.174.4013.1031
Unstirred Water Layers in Intestine: Rate Determinant of Fatty Acid Absorption from Micellar Solutions
F. Wilson (1971)
10.1146/ANNUREV.PH.45.030183.003251
Lipid digestion and absorption.
M. Carey (1983)
10.1172/JCI108465
The mechanism whereby bile acid micelles increase the rate of fatty acid and cholesterol uptake into the intestinal mucosal cell.
H. Westergaard (1976)
10.1093/BJA/65.5.616
Effect of oral omeprazole on intragastric pH and volume in women undergoing elective caesarean section.
T. Gin (1990)
10.3109/00365527909179858
Gastric morphology, function, and immunology in first-degree relatives of probands with pernicious anemia and controls.
K. Varis (1979)
10.1002/JPS.2600650514
Dissolution rate studies of cholesterol monohydrate in bile acid-lecithin solutions using the rotatingdisk method.
S. Prakongpan (1976)
10.1016/0165-6147(91)90535-Z
Comprehensive medicinal chemistry
H. Timmerman (1991)
10.1172/JCI113820
Uptake of fatty acids by jejunal mucosal cells is mediated by a fatty acid binding membrane protein.
W. Stremmel (1988)
10.1172/JCI107226
Gastric acid secretion rate and buffer content of the stomach after eating. Results in normal subjects and in patients with duodenal ulcer.
J. Fordtran (1973)
10.1002/JPS.3030470522
Investigation of drug release from solids. II. Theoretical and experimental study of influences of bases and buffers on rates of dissolution of acidic solids.
W. Higuchi (1958)
10.1016/0021-9797(69)90181-7
Micellar properties of dihydroxy and trihydroxy bile salts: effects of counterion and temperature.
M. Carey (1969)
10.1002/JPS.2600821008
Novel formulation strategies for improving oral bioavailability of drugs with poor membrane permeation or presystemic metabolism.
B. Aungst (1993)
10.1093/CLINIDS/10.1.138
Assessing and modeling heterosexual spread of the human immunodeficiency virus in the United States.
V. De Gruttola (1988)
10.1016/0378-5173(80)90086-1
Solubilization of diazepam in bile salts and in sodium cholate-lecithin-water phases
M. Rosoff (1980)
10.1016/0168-3659(95)00147-6
Intestinal drug metabolism and antitransport processes : A potential paradigm shift in oral drug delivery
L. Benet (1996)
10.1136/gut.27.8.886
Transit of pharmaceutical dosage forms through the small intestine.
S. Davis (1986)
10.1016/0169-409X(91)90046-F
Transport of lipophilic molecules by the intestinal lymphatic system
W. Charman (1991)
10.1016/S0016-5085(83)80160-7
Pancreatic polypeptide and intestinal migrating motor complex in humans. Effect of pancreaticobiliary secretion.
C. Owyang (1983)
; pp 1867 - 1907
P. Tso (1994)
10.1111/j.1440-1681.1986.tb00916.x
OMEPRAZOLE: EFFECTS ON OXIDATIVE DRUG METABOLISM IN THE RAT
D. Henry (1986)
10.1002/JPS.2600691203
Improving intestinal absorption of water-insoluble compounds: a membrane metabolism strategy.
G. Amidon (1980)
10.1016/0378-5173(79)90053-X
Improvement of absolute bioavailability of normally poorly absorbed drugs: inducement of the intestinal absorption of streptomycin and gentamycin by lipid-bile salt mixed micelles in rat and rabbit
Muranishi Shozo (1979)
10.1002/JPS.2600830904
Dissolution kinetics of griseofulvin in mixed micellar solutions.
J. D. de Smidt (1994)
10.1038/ICB.1972.35
The role of micellar solubilization in lipid absorption.
W. Simmonds (1972)
10.1098/rspb.1975.0150
Direct measurement by pH-microelectrode of the pH microclimate in rat proximal jejunum
M. Lucas (1975)
10.1016/0005-2760(89)90135-5
Interaction of bile salt monomer and cholesterol in the aqueous phase.
K. Chijiiwa (1989)
10.1002/JPS.2600550213
Solubilizing properties of bile salt solutions. I. Effect of temperature and bile salt concentration on solubilization of glutethimide, griseofulvin, and hexestrol.
T. R. Bates (1966)
10.1002/JPS.2600660812
Dissolution rates of model gallstones in human and animal biles and importance of interfacial resistance.
A. Molokhia (1977)
Similar bioavailability and lymphatic transport of benzo(a)pyrene when administered to rats in different amounts of dietary fat.
J. M. Laher (1984)
10.1016/0005-2760(89)90113-6
Fatty acids generated by gastric lipase promote human milk triacylglycerol digestion by pancreatic colipase-dependent lipase.
S. Bernbäck (1989)
10.1002/JPS.2600620737
Dissolution rates of cholesterol monohydrate crystals and human cholesterol gallstones in bile acid-lecithin solutions: enhancing effect of added alkyl quaternary ammonium salts.
W. Higuchi (1973)
10.1016/S0016-5085(19)31911-0
Gastric secretion and emptying after ordinary meals in duodenal ulcer.
J. Malagelada (1977)
10.1016/0003-9861(89)90528-6
Bile salt micelle can sustain more cholesterol in the intermicellar aqueous phase than the maximal aqueous solubility.
K. Chijiiwa (1989)
10.1080/21548331.1977.11707065
Drug bioavailability studies.
J. Wagner (1977)
10.3109/00365526809179909
The incidence of achlorhydria and hypochlorhydria in healthy subjects and patients with gastrointestinal diseases.
P. M. Christiansen (1968)
10.1056/NEJM197508212930802
Inhibition of gastric acid secretion by cimetidine in patients with duodenal ulcer.
R. M. Henn (1975)
10.1016/S0016-5085(76)80090-X
The effect of cimetidine, a new histamine H2-receptor antagonist, on meal-stimulated acid secretion, serum gastrin, and gastric emptying in patients with duodenal ulcer.
C. T. Richardson (1976)
10.1097/00004836-198804000-00008
Influence of oral cimetidine and ranitidine on gastric emptying in active duodenal ulcer.
K. Jonderko (1988)
10.1002/JPS.2600590502
Mechanisms of surfactant effects on drug absorption.
M. Gibaldi (1970)
10.1113/jphysiol.1990.sp017955
Mechanism of intestinal fatty acid uptake in the rat: the role of an acidic microclimate.
Y. Shiau (1990)
10.1002/j.1552-4604.1983.tb01800.x
Food Increases the Bioavailability of Isotretinoin
W. Colburn (1983)
10.1002/JPS.2600790706
Effect of adjuvants on charge-selective permeability and electrical resistance of rat jejunal membrane.
S. Yamashita (1990)
10.1080/00325481.1977.11712246
How food and fluid affect drug absorption: results of initial studies.
Peter G. Welling (1977)
10.1201/9781351071994
Fat Absorption.
W. R. Bloor (1949)
10.1021/JS9502229
Lymphatic transport of halofantrine in the conscious rat when administered as either the free base or the hydrochloride salt: effect of lipid class and lipid vehicle dispersion.
C. J. Porter (1996)
10.1021/JS950472P
A physicochemical basis for the effect of food on the absolute oral bioavailability of halofantrine.
A. Humberstone (1996)
10.1177/0148607195019005393
Effect of intragastric pH on the absorption of oral zinc acetate and zinc oxide in young healthy volunteers.
L. Henderson (1995)
10.1002/JPS.2600741109
Cholesterol monohydrate dissolution rate studies in aqueous micellar sodium chenodeoxycholate solutions.
S. Gupta (1985)
10.1016/0016-5085(91)90724-Y
Effect of age on gastric acid secretion and serum gastrin concentrations in healthy men and women.
M. Goldschmiedt (1991)
10.2165/00003088-199018030-00003
Effects of Antacids on the Clinical Pharmacokinetics of Drugs
R. Gugler (1990)
10.1016/0378-5173(94)90216-X
Compared effects of synthetic and natural bile acid surfactant on xenobiotic absorption. II: Studies with sodium glycocholate to confirm a hypothesis
T. Garrigues (1994)
10.1016/0378-5173(80)90002-2
Mechanism for the inducement of the intestinal absorption of poorly absorbed drugs by mixed micelles I. Effects of various lipid—bile salt mixed micelles on the intestinal absorption of streptomycin in rat
Muranushi Noriyuki (1980)
10.1016/0005-2760(86)90234-1
Importance of human gastric lipase for intestinal lipolysis: an in vitro study.
Y. Gargouri (1986)
10.1201/9780203748572
Lymphatic Transport of Drugs
W. Charman (1992)
10.1001/JAMA.1969.03160130061026
Physiology of the Gastrointestinal Tract
B. Fleshler (1969)
10.1056/NEJM198507113130202
Calcium absorption and achlorhydria.
R. Recker (1985)
10.1080/00365521.1977.12031121
Duodenal bile acid concentrations in fat malabsorption syndromes.
H. Westergaard (1977)
10.1111/J.1365-2125.1984.TB02544.X
The effect of omeprazole on gastric emptying in patients with duodenal ulcer disease.
M. Horowitz (1984)
10.1540/JSMR.29.131
[Effects of various histamine H2-receptor antagonists on gastrointestinal motility and gastric emptying].
Y. Ohira (1993)
10.1016/0005-2760(88)90029-X
Concerted action of human carboxyl ester lipase and pancreatic lipase during lipid digestion in vitro: importance of the physicochemical state of the substrate.
M. Lindström (1988)
10.1038/clpt.1990.43
Influence of single and multiple doses of oral ranitidine on the gastric transit of an indigestible capsule in humans
P. Mojaverian (1990)
10.5555/URI:PII:0016508585906389
Omeprazole inhibits oxidative drug metabolism. Studies with diazepam and phenytoin in vivo and 7-ethoxycoumarin in vitro.
R. Gugler (1985)
10.1172/JCI105267
The composition and structure of lymph chylomicrons in dog, rat, and man.
D. B. Zilversmit (1965)
10.1016/0378-5173(86)90049-9
An experimental system designed to study the in situ intestinal lymphatic transport of lipophilic drugs in anesthetized rats
W. Charman (1986)
10.1016/0378-5173(89)90234-2
Gastrointestinal transit of non-disintegrating tablets in fed subjects
R. Khosla (1989)
10.1172/JCI111769
Identification, isolation, and partial characterization of a fatty acid binding protein from rat jejunal microvillous membranes.
W. Stremmel (1985)
10.1016/0378-5173(94)90459-6
The effect of simple micellar systems on the solubility and intestinal absorption of clofazimine (B663) in the anaesthetised rat
J. R. O'Reilly (1994)
10.1021/JS950221G
Lymphatic transport of halofantrine in the triple-cannulated anesthetized rat model: effect of lipid vehicle dispersion.
C. J. Porter (1996)
10.1001/ARCHINTE.1972.03650040040005
Micelle formation by bile salts. Physical-chemical and thermodynamic considerations.
M. Carey (1972)
10.1139/Y89-031
Intestinal aspects of lipid absorption: in review.
A. Thomson (1989)
10.1002/j.1552-4604.1993.tb04673.x
Effect of Food and a Monoglyceride Emulsion Formulation on Danazol Bioavailability
W. Charman (1993)
10.1016/0016-5085(86)90873-5
Intraluminal pH in the stomach, duodenum, and proximal jejunum in normal subjects and patients with exocrine pancreatic insufficiency.
L. Ovesen (1986)
Pharmacologic evaluation of orally administered antibiotics in infants and children: effect of feeding on bioavailability.
G. Mccracken (1978)
10.1016/0006-2952(86)90763-X
Effect of five structurally diverse H2-receptor antagonists on drug metabolism.
M. Pasanen (1986)
10.1016/S0002-9343(70)80127-9
The characteristics of mixed micellar solutions with particular reference to bile.
M. Carey (1970)
10.1016/0378-5173(82)90175-2
Study of the influence of sodium taurocholate (STC) and sodium glycocholate (SGC) on the mass transfer of certain drugs. Diethylstilbestrol
A. Mattha (1982)
10.1111/j.1365-2362.1983.tb00128.x
Duodenal bulb pH in normal subjects
S. Hannibal (1983)
10.1021/BI00460A011
Physical-chemical behavior of dietary and biliary lipids during intestinal digestion and absorption. 1. Phase behavior and aggregation states of model lipid systems patterned after aqueous duodenal contents of healthy adult human beings.
J. Staggers (1990)
10.1002/JPS.2600620618
Mechanisms of dissolution of human cholesterol gallstones.
W. Higuchi (1973)
10.1093/BJA/73.4.475
Effects of oral ranitidine, famotidine and omeprazole on gastric volume and pH at induction and recovery from general anaesthesia.
K. Boulay (1994)
10.1128/AAC.36.4.796
Pharmacokinetics of cefpodoxime proxetil and interactions with an antacid and an H2 receptor antagonist.
N. Saathoff (1992)
10.1111/j.2042-7158.1986.tb04501.x
The effect of pH and concentration on α‐methyldopa absorption in man
A. E. Merfeld (1986)
10.1016/0378-5173(86)90108-0
Gastric acidity dependent bioavailability of cinnarizine from two commercial capsules in healthy volunteers
Hiroyasu Ogata (1986)
10.1111/j.1365-2036.1988.tb00674.x
The effects of roxatidine acetate (HOE‐760) on 24‐hour intragastric acidity in healthy volunteers: comparison with ranitidine and placebo
H. Merki (1988)
10.1016/0031-6989(85)90124-9
The effects of H2 receptor antagonists on hepatic microsomal drug metabolism and fine morphology of rat liver.
P. Mosca (1985)
10.1136/gut.22.1.49
Comparison of the effects of ranitidine, cimetidine and placebo on the 24 hour intragastric acidity and nocturnal acid secretion in patients with duodenal ulcer.
R. Walt (1981)
10.2165/00003088-197803050-00001
Influence of Food on the Bioavailability of Drugs
A. Melander (1978)
10.1136/gut.10.7.569
Duodenal pH values in normal controls and in patients with duodenal ulcer.
S. Rune (1969)
10.1113/jphysiol.1968.sp008411
A relation between the chain length of fatty acids and the slowing of gastric emptying
J. N. Hunt (1968)
10.1159/000136627
The lymphocytic absorption of p,p'-DDT and some structurally-related compounds in the rat.
S. Sieber (1976)
10.1016/0016-5085(81)90498-4
Duodenogastric reflux in humans: Its relationship to fasting antroduodenal motility and gastric, pancreatic, and biliary secretion
F. Keane (1981)
10.5555/URI:PII:0016508578908661
Lipase, colipase, amphipathic dietary proteins, and bile acids: new interactions at an old interface.
A. Hofmann (1978)
10.1248/CPB.28.323
Interaction of drugs with bile components. II. Effect of bile on the absorption of indomethacin and phenylbutazine in rats.
S. Miyazaki (1980)
Influence of food on the bioavailability of penicillamine.
A. Schuna (1983)
10.3109/00365527109181126
Intraluminal pH of duodenum and jejunum in fasting subjects with normal and abnormal gastric or pancreatic function.
A. Benn (1971)
10.1016/0378-5173(94)90142-2
The effect of mixed micellar systems, bile salt/fatty acids, on the solubility and intestinal absorption of clofazimine (B663) in the anaesthetised rat
J. R. O'Reilly (1994)
Drug Absorption Enhancement
S Muranishi
10.1038/clpt.1980.151
Effect of cimetidine and antacids on gastrointestinal absorption of tetracycline
M. Garty (1980)
10.1248/CPB.37.439
Enhancement of oral bioavailability of d-alpha-tocopherol acetate by lecithin-dispersed aqueous preparation containing medium-chain triglycerides in rats.
T. Kimura (1989)
10.1007/978-1-349-14416-7
Physicochemical Principles of Pharmacy
A. Florence (1988)
10.3109/00498258409151414
The role of the lymphatic transport in the enteral absorption of naftifine by the rat.
R. Grimus (1984)
10.1016/S0016-5107(86)71871-3
The Exocrine Pancreas—Biology, Pathology, and Diseases, Vay Liang W. Go, Jerry D. Gardner, Frank P. Brooks (Eds.), et al.. Raven Press, New York (1986), 872, $135.00
P. Cotton (1986)
10.1136/gut.25.4.386
Duodenal pH in health and duodenal ulcer disease: effect of a meal, Coca-Cola, smoking, and cimetidine.
R. McCloy (1984)
10.1016/0378-5173(80)90003-4
Mechanism for the inducement of the intestinal absorption of poorly absorbed drugs by mixed micelles II. Effect of the incorporation of various lipids on the permeability of liposomal membranes
Muranushi Noriyuki (1980)
10.1016/0378-5173(91)90364-T
Compared effects of synthetic and natural bile acid surfactants on xenobiotic absorption I. Studies with polysorbate and taurocholate in rat colon
M. Bermejo (1991)
10.1007/978-1-4899-1863-5
Models for Assessing Drug Absorption and Metabolism
R. Borchardt (1996)
10.1111/J.1365-2125.1984.TB05031.X
Comparative effects of famotidine and cimetidine on antipyrine kinetics in healthy volunteers.
C. Staiger (1984)
10.1146/ANNUREV.PH.45.030183.003205
Intestinal synthesis, secretion, and transport of lipoproteins.
C. Bisgaier (1983)
10.1038/clpt.1992.138
Effect of gastric acidity on enoxacin absorption
M. Lebsack (1992)
10.1016/0378-5173(86)90027-X
Estimating the maximal potential for intestinal lymphatic transport of lipophilic drug molecules
W. Charman (1986)
10.1016/0016-5085(80)90777-5
Importance of phospholipids, pancreatic phospholipase A2, and fatty acid for the digestion of dietary fat: in vitro experiments with the porcine enzymes.
B. Borgström (1980)
10.1136/gut.7.6.700
Radiotelemetering studies of jejunal pH before and after vagotomy and gastro-enterostomy.
W. Watson (1966)
10.1038/2101331a0
Rate of Dissolution of Griseofulvin and Hexoestrol in Bile Salt Solutions
THEODORE R. Bates (1966)
10.1038/JID.1961.154
Human pharmacology of griseofulvin: the effect of fat intake on gastrointestinal absorption.
R. G. Crounse (1961)
10.1172/JCI104909
THE INTRALUMINAL PHASE OF FAT DIGESTION IN MAN: THE LIPID CONTENT OF THE MICELLAR AND OIL PHASES OF INTESTINAL CONTENT OBTAINED DURING FAT DIGESTION AND ABSORPTION.
A. Hofmann (1964)
10.1016/0163-7258(81)90017-6
Drug interactions occurring during absorption from the gastrointestinal tract.
J. Griffin (1981)
10.1111/J.1365-2125.1992.TB04139.X
A comparison of gastric emptying rate after cimetidine and ranitidine measured by applied potential tomography.
M. Mushambi (1992)
10.1038/clpt.1982.36
Effects of cimetidine and ranitidine on hepatic drug metabolism
K. Breen (1982)
10.1136/bmj.281.6243.775
Cimetidine and ranitidine: comparison of effects on hepatic drug metabolism.
D. Henry (1980)
10.1159/000200691
Effect of omeprazole on nocturnal intragastric pH in cirrhotics with inadequate antisecretory response to ranitidine.
S. Walker (1991)
10.1016/0378-5173(86)90050-5
Effects of lipid class and lipid vehicle volume on the intestinal lymphatic transport of DDT
W. Charman (1986)
10.1111/j.1749-6632.1966.tb43008.x
EFFECT OF NEOMYCIN AND KANAMYCIN UPON INTESTINAL ABSORPTION *
W. Faloon (1966)
10.7326/0003-4819-114-9-755
Increased gastric pH and the bioavailability of fluconazole and ketoconazole.
R. Blum (1991)
10.2165/00003088-198409050-00002
Interactions Affecting Drug Absorption
Peter G. Welling (1984)
10.1016/S0016-5085(76)80200-4
Effects of antacids on gastric emptying.
A. Hurwitz (1976)
10.1111/J.1365-2125.1994.TB04232.X
Examination of some factors responsible for a food-induced increase in absorption of atovaquone.
P. Rolan (1994)
10.1016/0378-5173(94)90453-7
Compared effects of synthetic and natural bile acid surfactants on xenobiotic absorption. III: studies with mixed micelles
M. J. Segura-Bono (1994)
10.1002/JPS.2600620633
Soft gelatin capsules. I. Factors affecting capsule shell dissolution rate.
F. Hom (1973)
10.7326/0003-4819-97-4-638_2
Physiology of the digestive tract.
John E. Thomas (1956)
10.1016/0378-5173(92)90042-Z
Evaluation of pH-independent sustained-release granules of dipyridamole by using gastric-acidity-controlled rabbits and human subjects
N. Kohri (1992)
10.1016/0002-9343(86)90593-0
Pharmacodynamics of famotidine in humans.
A N Chremos (1986)
10.1126/science.178.4061.633
Cholesterol Dissolution Rate in Micellar Bile Acid Solutions: Retarding Effect of Added Lecithin
W. Higuchi (1972)
10.1016/0022-5193(80)90115-0
A convective mass transfer model for determining intestinal wall permeabilities: laminar flow in a circular tube.
R. Elliott (1980)
10.1016/0169-409X(95)00105-G
Lipophilic prodrugs designed for intestinal lymphatic transport
W. Charman (1996)
10.1016/S0009-9236(96)80007-5
The effect of water‐soluble vitamin E on cyclosporine pharmacokinetics in healthy volunteers
T. Chang (1996)
10.1172/JCI111850
Pancreatic enzyme response to a liquid meal and to hormonal stimulation. Correlation with plasma secretin and cholecystokinin levels.
C. Beglinger (1985)
10.1016/S0016-5085(76)80010-8
Measurement of gastric functions during digestion of ordinary solid meals in man.
J. Malagelada (1976)
10.1111/j.2042-7158.1992.tb05464.x
Effect of Oily Vehicles on Absorption of Mepitiostane by the Lymphatic System in Rats
T. Ichihashi (1992)
10.1016/S0140-6736(74)92174-6
SPLEEN IN HODGKINS-DISEASE
Halie (1974)
10.1016/0378-5173(81)90070-3
Micellar interaction of indomethacin and bile salts
Miyazaki Shozo (1981)
10.1038/clpt.1985.101
Effect of sucralfate and an aluminum hydroxide gel on gastric emptying of solids and liquids
A. Marano (1985)
10.1093/AJHP/40.8.1334
Effect of pH on disintegration and dissolution of ketoconazole tablets.
J. Carlson (1983)
10.7326/0003-4819-109-6-502
Gastric secretory failure in patients with the acquired immunodeficiency syndrome (AIDS).
G. Lake-Bakaar (1988)
10.1111/1523-1747.EP12261476
Etretinate: effect of milk intake on absorption.
J. DiGiovanna (1984)
10.1113/EXPPHYSIOL.1987.SP003059
Partitioning of polar fatty acids into lymph and portal vein after intestinal absorption in the rat.
G. McDonald (1987)
10.1016/0378-5173(89)90082-3
Gastric emptying and small and large bowel transit of non-disintegrating tablets in fasted subjects
R. Khosla (1989)
10.1016/0163-7258(89)90019-3
Effects of food on drug absorption.
Peter G. Welling (1989)
10.1128/AAC.35.9.1765
Effects of ranitidine and sucralfate on ketoconazole bioavailability.
S. Piscitelli (1991)
A study of achlorhydria among southwestern American Indians.
Sievers Ml (1966)
10.1016/c2009-1-64521-4
Physiology of the Gastrointestinal Tract
L. Johnson (1994)
10.3109/00365527909181934
The secretory component of the interdigestive migrating motor complex in man.
G. Vantrappen (1979)
10.3109/00365528809090150
Effect of a single dose of antacid on gastric and duodenal bulb pH in duodenal ulcer patients.
F. Bendsten (1988)
10.1016/0378-5173(87)90009-3
Absorption-partition relationships for true homologous series of xenobiotics as a possible approach to study mechanisms of surfactants in absorption. II. Aromatic amines in rat small intestine
J. Plá-Delfina (1987)
10.1021/BI00460A012
Physical-chemical behavior of dietary and biliary lipids during intestinal digestion and absorption. 2. Phase analysis and aggregation states of luminal lipids during duodenal fat digestion in healthy adult human beings.
O. Hernell (1990)
10.1159/000197476
Pure cholecystokinin: pancreatic protein and bicarbonate response.
H. Debas (1973)
The gastric secretion of drugs: a pH partition hypothesis.
P. A. Shore (1957)
10.1038/clpt.1986.198
Food effects on propranolol systemic and oral clearance: Support for a blood flow hypothesis
L. Olanoff (1986)
10.1111/J.1365-2125.1989.TB03507.X
Pharmacokinetics of halofantrine in man: effects of food and dose size.
K. Milton (1989)
10.1002/JPS.2600730922
Physicochemical model for dose-dependent drug absorption.
J. Dressman (1984)
10.7326/0003-4819-115-7-540
Influence of gastric acidity on the bioavailability of digoxin.
A. Cohen (1991)
10.1016/S0016-5085(19)33408-0
Unstirred water layers and absorption across the intestinal mucosa.
J. Dietschy (1971)
10.1016/0378-5173(85)90156-5
BIavailability of metronidazole from sugar-coated tablets in humans. I. Effect of gastric acidity and correlation with in vitro dissolution rate
Hiroyasu Ogata (1985)
In Handbood of Physiology, Section 6 Alimentary Canal; Code
J N Hunt (1972)
10.1159/000409057
Influence of food and different nutrients on drug bioavailability.
A. Melander (1984)
10.1016/S0140-6736(83)91057-7
24 HOUR INTRAGASTRIC ACIDITY AND SINGLE NIGHT-TIME DOSE OF THREE H2-BLOCKERS
H. Dammann (1983)
10.1002/JPS.2600720333
Estimation of the extent of drug-excipient interactions involving croscarmellose sodium.
R. Hollenbeck (1983)
10.1136/gut.16.12.961
Post-prandial changes in PH and electrolyte concentration, in the upper jejunum after truncal vagotomy and drainage in man.
J. Temple (1975)
10.1111/j.2042-7158.1984.tb04919.x
The effect of different oils on the absorption of probucol in the rat
K. Palin (1984)
10.1002/BDD.2510040203
Intestinal lymphatic absorption of cyclosporin A following oral administration in an olive oil solution in rats.
C. Ueda (1983)
10.1002/JPS.2600770506
Fluorescence study of the membrane-perturbing action of sodium caprylate as related to promotion of drug absorption.
H. Kajii (1988)
10.1002/JPS.2600750313
Comparison of gastrointestinal pH in dogs and humans: implications on the use of the beagle dog as a model for oral absorption in humans.
C. Y. Lui (1986)
10.1111/j.1365-2036.1991.tb00009.x
Short report: a double‐blind placebo‐controlled trial of omeprazole on characteristics of gastric emptying in healthy subjects
L. Rasmussen (1991)
10.1002/j.1552-4604.1985.tb02881.x
Effect of Meals on the Kinetics of Etretinate
W. Colburn (1985)
10.1248/CPB.27.2468
Interaction of drugs with bile components. I. Effects of bile salts on the dissolution behavior of indomethacin and phenylbutazone.
S. Miyazaki (1979)
10.1136/gut.25.5.500
Effect of intrajejunal acidity on aqueous phase bile acid and lipid concentrations in pancreatic steatorrhoea due to cystic fibrosis.
P. L. Zentler-Munro (1984)
10.1016/s0021-9258(18)44850-8
The portal transport of absorbed fatty acids.
J. Kiyasu (1952)



This paper is referenced by
10.1023/B:PHAM.0000016283.87709.a9
Drug Solubilization Behavior During in Vitro Digestion of Suspension Formulations of Poorly Water-Soluble Drugs in Triglyceride Lipids
A. Kaukonen (2004)
Pharmacokinetics of celecoxib after oral administration in dogs and humans: effect of food and site of absorption.
S. Paulson (2001)
10.2745/DDS.25.384
A novel oral dosage form that reduces food-drug interactions responsible for low drug absorption in the fed state: utilization of enteric coating agents that start to dissolve at higher pH
Fumié K Tanno (2010)
An Emerging Technique For Poorly Soluble Drugs: Self Emulsifying Drug Delivery System
Neelam Patel (2011)
Mechanisms and Permanence of Sequestered Pb and As in Soils: Impact on Human Bioavailability
N. Basta (2016)
10.1159/000449508
Oral Contraceptives after Bariatric Surgery
J. Schlatter (2017)
10.1080/03639045.2020.1742142
Development, characterization, comparative pharmacokinetic and pharmacodynamic studies of iloperidone solid SMEDDS and liquisolid compact
Dinesh Suram (2020)
10.22038/JFH.2015.6142
Is it safe for Multiple Sclerosis patients to fast
S. R. Jahromi (2015)
10.1016/J.SCITOTENV.2018.12.459
Ingestion bioaccessibility of indoor dust-bound PAHs: Inclusion of a sorption sink to simulate passive transfer across the small intestine.
P. Gao (2019)
10.1021/acscentsci.6b00297
Assessing Physicochemical Properties of Drug Molecules via Microsolvation Measurements with Differential Mobility Spectrometry
Chang Liu (2017)
10.1002/jps.23034
A formulation strategy for gamma secretase inhibitor ELND006, a BCS class II compound: development of a nanosuspension formulation with improved oral bioavailability and reduced food effects in dogs.
K. Quinn (2012)
10.1211/jpp.62.02.0004
Enhanced oral bioavailability of etodolac by self‐emulsifying systems: in‐vitro and in‐vivo evaluation
N. Barakat (2010)
10.1080/17474124.2018.1399794
The biological challenges and pharmacological opportunities of orally administered nanomedicine delivery
D. Moss (2018)
10.1080/21691401.2017.1299160
Development of olmesartan medoxomil lipid-based nanoparticles and nanosuspension: preparation, characterization and comparative pharmacokinetic evaluation
A. B (2018)
10.1016/j.ijpharm.2008.06.021
Development of SMEDDS using natural lipophile: application to beta-Artemether delivery.
S. D. Mandawgade (2008)
10.1111/j.1745-7254.2008.00825.x
Redispersible, dry emulsion of lovastatin protects against intestinal metabolism and improves bioavailability
Zhen Ge (2008)
10.1124/jpet.109.154542
Lymphatic Transport of Methylnortestosterone Undecanoate (MU) and the Bioavailability of Methylnortestosterone Are Highly Sensitive to the Mass of Coadministered Lipid after Oral Administration of MU
K. White (2009)
Chemicals in toys. A general methodology for assessment of chemical safety of toys with a focus on elements
van Engelen Jgm (2009)
10.3109/9781420073188-7
Biopharmaceutical Support in Candidate Drug Selection
A. Ungell (2016)
10.1208/s12249-019-1337-8
Potential of Lipid Nanoparticles (SLNs and NLCs) in Enhancing Oral Bioavailability of Drugs with Poor Intestinal Permeability
S. Talegaonkar (2019)
10.1016/S0939-6411(99)00080-6
Interaction of Bay t 3839 coprecipitates with insoluble excipients.
A. Ohm (2000)
10.2133/DMPK.20.244
The novel formulation design of self-emulsifying drug delivery systems (SEDDS) type O/W microemulsion I: enhancing effects on oral bioavailability of poorly water soluble compounds in rats and beagle dogs.
H. Araya (2005)
10.3109/9781420020298-6
Approaches for Improving Bioavailability of Poorly Soluble Drugs
N. Shah (2008)
The Influence of Guar Gum on Lipid Emulsion Digestion and Beta-Carotene Bioaccessibility
Jamal Amyoony (2013)
10.17925/ENR.2007.00.02.21
The Significance of Optimized Formulation for Dipyridamole in Stroke Risk Reduction
H. Derendorf (2007)
10.21767/2349-7238.100047
Complex Behavior of Bile Salts (SC and SDC) at Various Temperatures under the Influence of Tricyclic Antidepressant Drug (Imipramine) in Aqueous Solution
S. Sar (2016)
10.1016/J.ADDR.2007.10.014
Enhancing intestinal drug solubilisation using lipid-based delivery systems.
C. H. Porter (2008)
10.1002/JPS.20886
Evaluation of drug precipitation of solubility-enhancing liquid formulations using milligram quantities of a new molecular entity (NME).
Wei-guo Dai (2007)
A REVIEW ON SELF MICRO EMULSIFYING DRUG DELIVERY SYSTEM: AN APPROACH TO E NHANCE THE ORAL BIOAVAILABILITY OF POORLY WATER SOLUBLE DRUGS
S. Prachi (2012)
Mobilization of hydrophobic contaminants from soil in a model digestive system
J. Minhas (2004)
10.1021/acs.analchem.7b01903
Optical pH Sensor Covering the Range from pH 0-14 Compatible with Mobile-Device Readout and Based on a Set of Rationally Designed Indicator Dyes.
Raúl Gotor (2017)
10.3168/jds.2015-9620
Effect of biotin and pantothenic acid on performance and concentrations of avidin-binding substances in blood and milk of lactating dairy cows.
G. Ferreira (2015)
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