Online citations, reference lists, and bibliographies.
← Back to Search

Lysis Of Human Red Blood Cells. 4. Comparison Of In Vitro And In Vivo Hemolysis Data.

J. Krzyzaniak, F. A. Alvarez Núñez, D. Raymond, S. Yalkowsky
Published 1997 · Chemistry, Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
The dynamic in vitro method developed by the authors and other available in vitro methods were used to determine the degree of hemolysis induced by several cosolvent vehicles that have previously been evaluated in vivo. The in vitro data generated for each of these vehicles was compared with the in vivo hemolysis data to assess the ability of the method to estimate in vivo hemolysis. The results show that the in vitro data generated by the dynamic method are in agreement with the in vivo data for each vehicle. Therefore, the potential for formulations to induce intravascular hemolysis after injection can be determined by this dynamic in vitro method. With this information, hemolytically safe formulations can more easily be prepared.
This paper references



This paper is referenced by
10.1002/jps.23453
Polar solvents decrease the viscosity of high concentration IgG1 solutions through hydrophobic solvation and interaction: formulation and biocompatibility considerations.
Tim J. Kamerzell (2013)
10.1191/1078155205jp142oa
Compatibility and stability of the novel anti-cancer agent C1311 in infusion devices and its in vitro biocompatibility
M. W. J. den Brok (2005)
10.3109/10717544.2013.869275
Optimization of PEGylated nanoemulsions for improved pharmacokinetics of BCS class II compounds
Harikrishna Devalapally (2015)
10.1136/fn.83.2.F130
Effects of various arterial infusion solutions on red blood cells in the newborn
J. K. Jackson (2000)
10.1016/S0378-5173(99)00389-0
In vitro biocompatibility studies with the experimental anticancer agent BIBX1382BS.
B. Nuijen (2000)
10.1097/01.CAD.0000172833.70444.BA
Compatibility and stability of Imexon in infusion devices and its in vitro biocompatibility
M. W. J. den Brok (2005)
10.1016/j.ijpharm.2016.09.036
Comparison in toxicity and solubilizing capacity of hydroxypropyl-β-cyclodextrin with different degree of substitution.
Pengyu Li (2016)
10.4103/0975-7406.124309
Buparvaquone loaded solid lipid nanoparticles for targeted delivery in theleriosis
M. Soni (2014)
10.1021/acs.langmuir.7b00742
Elegant pH-Responsive Nanovehicle for Drug Delivery Based on Triazine Dendrimer Modified Magnetic Nanoparticles.
Amir Landarani-Isfahani (2017)
10.1016/j.ijpharm.2019.118561
Investigation of ultrafine gold nanoparticles (AuNPs) based nanoformulation as single conjugates target delivery for improved methotrexate chemotherapy in breast cancer.
Farhat Naz (2019)
10.1021/JS980051I
Formulation-related problems associated with intravenous drug delivery.
S. Yalkowsky (1998)
10.1046/J.1365-2257.2003.00495.X
Feasibility of a new in vitro approach to evaluate cellular damage following co-infusion of red blood cell concentrates and intravenous drug solutions.
A. G. van den Bos (2003)
10.1097/00001813-200210000-00003
Stability and compatibility of the investigational polymer-conjugated platinum anticancer agent AP 5280 in infusion systems and its hemolytic potential
M. Bouma (2002)
10.1016/j.ejps.2017.10.005
Development and evaluation of camptothecin loaded polymer stabilized nanoemulsion: Targeting potential in 4T1‐breast tumour xenograft model
Abimanyu Sugumaran (2018)
FORMULATION DEVELOPMENT OF ANTICANCER DRUG—FB642
T. Sanghvi (2004)
10.1016/j.jconrel.2011.12.010
Hemocompatibility of liposomes loaded with lipophilic prodrugs of methotrexate and melphalan in the lipid bilayer.
N. R. Kuznetsova (2012)
10.1016/S0887-2333(00)00063-1
Effect of O(2)/O(3) atmosphere on the rate of osmotic hemolysis of bovine erythrocytes in the presence of some antioxidants.
W. Bialas (2001)
10.1021/acs.biomac.5b00244
Folic Acid and Trastuzumab Functionalized Redox Responsive Polymersomes for Intracellular Doxorubicin Delivery in Breast Cancer.
S. V. Lale (2015)
10.1007/978-1-4614-1144-4_1
Route-Specific Challenges in the Delivery of Poorly Water-Soluble Drugs
S. Bosselmann (2012)
10.1016/j.jpba.2016.03.024
Norelgestromin/ethinyl estradiol intravenous infusion formulation optimization, stability and compatibility testing: A case study to overcome polysorbate 80 interference in chromatographic analysis.
I. Abdallah (2016)
10.1021/acsami.5b01731
ROP and ATRP Fabricated Dual Targeted Redox Sensitive Polymersomes Based on pPEGMA-PCL-ss-PCL-pPEGMA Triblock Copolymers for Breast Cancer Therapeutics.
Arun Kumar (2015)
10.1039/C7TB00848A
Dually crosslinked injectable hydrogels of poly(ethylene glycol) and poly[(2-dimethylamino)ethyl methacrylate]-b-poly(N-isopropyl acrylamide) as a wound healing promoter.
Arvind K Singh Chandel (2017)
10.1542/PEDS.114.2.377
Can an alternative umbilical arterial catheter solution and flush regimen decrease iatrogenic hemolysis while enhancing nutrition? A double-blind, randomized, clinical trial comparing an isotonic amino acid with a hypotonic salt infusion.
J. K. Jackson (2004)
10.1039/C5TB01251A
Degradable/cytocompatible and pH responsive amphiphilic conetwork gels based on agarose-graft copolymers and polycaprolactone.
A. Bera (2015)
10.1002/ddr.21007
Cytotoxicity of a Novel Oil/Water Microemulsion System Loaded with Mitomycin‐C in In Vitro Lung Cancer Models
Mustafa Kotmakchiev (2012)
10.1016/j.ijpharm.2018.06.046
Evaluation of novel formulations of d‐&bgr;‐hydroxybutyrate and melatonin in a rat model of hemorrhagic shock
Andrea Wolf (2018)
Liposomale Formulierungen von Hypericin zur Anwendung in der photodynamischen Therapie
Nikola Plenagl (2019)
10.1201/B14378-22
Formulation and Administration Techniques to Minimize Injection Pain and Tissue Damage Associated with Parenteral Products
L. Gatlin (1999)
10.1039/C5PY00898K
Synthesis and biological evaluation of dual functionalized glutathione sensitive poly(ester-urethane) multiblock polymeric nanoparticles for cancer targeted drug delivery
Arun N Kumar (2015)
10.1089/cbr.2012.1428
Determination of in vivo behavior of mitomycin C-loaded o/w soybean oil microemulsion and mitomycin C solution via gamma camera imaging.
Mustafa Kotmakci (2013)
10.1021/mp5003762
Moxifloxacin-loaded nanoemulsions having tocopheryl succinate as the integral component improves pharmacokinetics and enhances survival in E. coli-induced complicated intra-abdominal infection.
P. Shukla (2014)
10.1191/1078155204jp118oa
Stability and compatibility of the investigational antimetastatic ruthenium complex NAMI-A in infusion systems and its hemolytic potential
M. Bouma (2004)
See more
Semantic Scholar Logo Some data provided by SemanticScholar