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Lysis Of Human Red Blood Cells. 4. Comparison Of In Vitro And In Vivo Hemolysis Data.
J. Krzyzaniak, F. A. Alvarez Núñez, D. Raymond, S. Yalkowsky
Published 1997 · Chemistry, Medicine
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The dynamic in vitro method developed by the authors and other available in vitro methods were used to determine the degree of hemolysis induced by several cosolvent vehicles that have previously been evaluated in vivo. The in vitro data generated for each of these vehicles was compared with the in vivo hemolysis data to assess the ability of the method to estimate in vivo hemolysis. The results show that the in vitro data generated by the dynamic method are in agreement with the in vivo data for each vehicle. Therefore, the potential for formulations to induce intravascular hemolysis after injection can be determined by this dynamic in vitro method. With this information, hemolytically safe formulations can more easily be prepared.
This paper references
Lysis of human red blood cells 2: effect of contact time on cosolvent induced hemolysis
J. Krzyzaniak (1997)
Hemolytic activity of polyoxyethylene cholesteryl ethers
Koichiro Miyajima (1987)
Physico-chemical properties and local toxic effects of injectables.
S. Oshida (1979)
Superoxide dismutase with prolonged in vivo half-life inhibits intravascular hemolysis and renal injury in burned rats.
D. Saitoh (1993)
The effect of nonionic surfactant structure on hemolysis
M. Ohnishi (1993)
Isotonic solutions. III. Amino acids and sugars.
T. S. Grosicki (1954)
Isotonic solutions. II. The permeability of red corpuscles to various substances
W. J. Husa (1944)
The Merck Manual of Diagnosis and Therapy
M. Beers (1982)
Nursing pharmacology and therapeutics
M. Gerald (1981)
Influence of pentobarbital sodium anesthesia on hematologic values in the dog.
Gentry Pa (1976)
Lysis of human red blood cells 1: Effect of contact time on water induced hemolysis.
J. Krzyzaniak (1996)
The renal lesion associated with hemoglobinemia. I. Its production and functional evolution in the rat.
J. Jaenike (1966)
Haemolytic properties of pluronic surfactants and effects of purification.
K. C. Lowe (1995)
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