← Back to Search
Noninvasive Visualization Of In Vivo Drug Delivery Of Poly(L-glutamic Acid) Using Contrast-enhanced MRI.
Furong Ye, Tianyi Ke, Eun-Kee Jeong, X. Wang, Y. Sun, Melody Johnson, Zheng-Rong Lu
Published 2006 · Chemistry, Medicine
Download PDFAnalyze on Scholarcy
Biomedical imaging is valuable for noninvasive investigation of in vivo drug delivery with polymer conjugates. It can provide real-time information on pharmacokinetics, biodistribution, and drug delivery efficiency of the conjugates. Noninvasive visualization of in vivo drug delivery of polymer conjugates with contrast-enhanced magnetic resonance imaging (MRI) was studied with paramagnetically labeled poly(L-glutamic acid) in an animal tumor model. Poly(L-glutamic acid) is a biocompatible and biodegradable drug carrier for diagnostics and therapeutics. Poly(L-glutamic acid)-1,6-hexanediamine--(Gd-DO3A) conjugates with molecular weights of 87, 50, and 28 kDa and narrow molecular weight distributions were prepared and studied in mice bearing MDA-MB-231 human breast cancer xenografts. Contrast-enhanced MRI resulted in real-time and three-dimensional visualization of blood circulation, pharmacokinetics, biodistribution, and tumor accumulation of the conjugates, and the size effect on these pharmaceutics properties. The conjugate of 28 kDa rapidly cleared from the circulation and had a relatively lower tumor accumulation. The conjugates with higher molecular weights exhibited a more prolonged blood circulation and higher tumor accumulation. The difference between the conjugates of 87 and 50 kDa was not significant. Contrast-enhanced MRI is effective for noninvasive real-time visualization of in vivo drug delivery of paramagnetically labeled polymer conjugates.
This paper references
Contrast‐enhanced MRI with new biodegradable macromolecular Gd(III) complexes in tumor‐bearing mice
Yuda Zong (2005)
Experimental Pulse NMR: A Nuts and Bolts Approach
E. Fukushima (1993)
Chronic exposure to HPMA copolymer-bound adriamycin does not induce multidrug resistance in a human ovarian carcinoma cell line.
T. Minko (1999)
HPMA copolymer-anticancer drug conjugates: design, activity, and mechanism of action.
J. Kopeček (2000)
PEG-doxorubicin conjugates: influence of polymer structure on drug release, in vitro cytotoxicity, biodistribution, and antitumor activity.
F. Veronese (2005)
Synthetic macromolecular drug carriers: biodistribution of poly[(N-2-hydroxypropyl)methacrylamide] copolymers and their accumulation in solid rat tumors.
M. Kissel (2001)
Polymer therapeutics: concepts and applications.
R. Haag (2006)
Conjugates of anticancer agents and polymers: advantages of macromolecular therapeutics in vivo.
H. Maeda (1992)
A novel surgical glue composed of gelatin and N-hydroxysuccinimide activated poly(L-glutamic acid): Part 1. Synthesis of activated poly(L-glutamic acid) and its gelation with gelatin.
H. Iwata (1998)
Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment.
S. Hobbs (1998)
Intramolecular sensitisation of lanthanide(III) luminescence by acetophenone-containing ligands: the critical effect of para-substituents and solvent
A. Beeby (2002)
Influence of molecular weight on passive tumour accumulation of a soluble macromolecular drug carrier.
L. Seymour (1995)
Pharmacokinetics of adriamycin (NSC-123127) in patients with sarcomas.
R. Benjamin (1974)
The Demonstration of Human Tumors on Nude Mice Using Gadolinium‐Labelled Monoclonal Antibodies for Magnetic Resonance Imaging
S. Göhr-Rosenthal (1993)
Pharmaceutical applications of magnetic resonance imaging (MRI).
J. C. Richardson (2005)
Molecular imaging in living subjects: seeing fundamental biological processes in a new light.
T. Massoud (2003)
Effect of physicochemical modification on the biodistribution and tumor accumulation of HPMA copolymers.
T. Lammers (2005)
Synthesis and in Vivo Antitumor Activity of Poly(l-glutamic acid) Conjugates of 20(S)-Camptothecin
R. Bhatt (2003)
Evolution from empirical dynamic contrast-enhanced magnetic resonance imaging to pharmacokinetic MRI.
J. Taylor (2000)
Imaging techniques for assessing drug delivery in man.
Anticancer agents coupled to N-(2-hydroxypropyl)methacrylamide copolymers. I. Evaluation of daunomycin and puromycin conjugates in vitro.
R. Duncan (1987)
Polymeric radiotracers in nuclear imaging.
Xiaoxia Wen (2004)
Superior therapeutic profile of poly-L-glutamic acid-paclitaxel copolymer compared with taxol in xenogeneic compartmental models of human ovarian carcinoma.
E. Auzenne (2002)
Transport Phenomena in Tumors
R. Jain (1994)
Monitoring pharmacokinetics of anticancer drugs: non-invasive investigation using magnetic resonance spectroscopy.
J. Griffiths (2000)
Structure-activity relationships of novel vasopressin antagonists containing C-terminal diaminoalkanes and (aminoalkyl)guanidines.
J. Callahan (1989)
Phase II study of CT-2103 in patients with recurrent epithelial ovarian, fallopian tube, or primary peritoneal carcinoma.
P. Sabbatini (2004)
High Molecular Weight Poly-α,L-glutamic Acid: Preparation and Optical Rotation Changes1
M. Idelson (1958)
Poly(l-glutamic acid) Gd(III)-DOTA conjugate with a degradable spacer for magnetic resonance imaging.
Zheng-Rong Lu (2003)
Pharmacokinetic determinants of the activity and toxicity of antitumour agents.
Newell Dr (1989)
This paper is referenced by
Macromolecular MRI contrast agents: Structures, properties and applications
Jianbin Tang (2013)
Multifunctional Synthetic Poly(l-Glutamic Acid)–Based Cancer Therapeutic and Imaging Agents
M. Melancon (2011)
An effective targeted nanoglobular manganese(II) chelate conjugate for magnetic resonance molecular imaging of tumor extracellular matrix.
M. Tan (2010)
MRI in ocular drug delivery
S. Kevin Li (2008)
Synthesis and Characterization of Ligands and their Gadolinium(III) Complexes
J. Kotek (2013)
A novel anti-VEGF targeting and MRI-visible smart drug delivery system for specific diagnosis and therapy of liver cancer.
Hailong Huang (2013)
Noninvasive Visualization of Pharmacokinetics, Biodistribution and Tumor Targeting of Poly[N-(2-hydroxypropyl)methacrylamide] in Mice Using Contrast Enhanced MRI
Y. Wang (2007)
Polypeptide-Based Conjugates as Therapeutics: Opportunities and Challenges.
Oleksandr Zagorodko (2017)
Fabrication of Polymer-Gadolinium (III) Complex Nanomicelle from Poly(ethylene glycol)-Polysuccinimide Conjugate and Diethylenetriaminetetraacetic Acid-Gadolinium as Magnetic Resonance Imaging Contrast Agents
W. Zhang (2011)
Polymeric multifunctional nanomaterials for theranostics.
Haisheng Peng (2015)
Macromolecular Imaging Agents Containing Lanthanides: Can Conceptual Promise Lead to Clinical Potential?
Joshua M. Bryson (2012)
Synthesis of poly-L-glutamic acid grafted silica nanoparticles and their assembly into macroporous structures.
Mrityunjoy Kar (2011)
Contrast-Enhanced MRI-Guided Photodynamic Cancer Therapy with a Pegylated Bifunctional Polymer Conjugate
Anagha Vaidya (2008)
A novel aptamer functionalized CuInS2 quantum dots probe for daunorubicin sensing and near infrared imaging of prostate cancer cells.
Zihan Lin (2014)
Magnetic resonance imaging (MRI) contrast agents for tumor diagnosis.
Weiren Cheng (2013)
Stability evaluation of Gd chelates for macromolecular MRI contrast agents
M. Yokoyama (2019)
CuInS(2) quantum dots/poly((L)-glutamic acid)-drug conjugates for drug delivery and cell imaging.
X. Gao (2014)
Effects of PEGylation on the physicochemical properties and in vivo distribution of organic nanotubes
Wuxiao Ding (2014)
Polymer platforms for drug delivery and biomedical imaging.
Zheng-Rong Lu (2007)
Synthesis of degradable functional poly(ethylene glycol) analogs as versatile drug delivery carriers.
N. Wang (2007)
Cancer Therapy: Intratumoral Drug Delivery
B. Weinberg (2015)
Polyion complex micelle MRI contrast agents from poly(ethylene glycol)-b-poly(l-lysine) block copolymers having Gd-DOTA; preparations and their control of T(1)-relaxivities and blood circulation characteristics.
K. Shiraishi (2010)
Utilising polymers to understand diseases: advanced molecular imaging agents
A. Fuchs (2015)
One-step synthesis of iron oxide polypyrrole nanoparticles encapsulating ketoprofen as model of hydrophobic drug.
Mohamed F Attia (2016)
Inorganic Nanomaterials as Revolutionary Devices in Drug Delivery Systems
Kuen-Song Lin (2012)
Modular Biomimetic Drug Delivery Systems
S. Dumitriu (2013)
Intratumoral Chemotherapy for Liver Cancer Using Biodegradable Polymer Implants
B. Weinberg (2007)
Nanotechnology Applications in Cardiology: Proof of Principle
Ashim Malhotra (2015)
Folate-targeted gadolinium-lipid-based nanoparticles as a bimodal contrast agent for tumor fluorescent and magnetic resonance imaging.
Taro Nakamura (2014)
Trinuclear Gd(III) Metal Complex with Amide Core Display Remarkable Enhancement in Relaxivity
T. Pushparaj (2017)
Lipid- and Polymer-Based Nanostructures for Cancer Theranostics
Brian T. Luk (2012)
Current Advances in Polymer-Based Nanotheranostics for Cancer Treatment and Diagnosis
Brian T. Luk (2014)See more