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Peptide-labeled Near-infrared Quantum Dots For Imaging Tumor Vasculature In Living Subjects.

W. Cai, Dong-woon Shin, K. Chen, O. Gheysens, Qizhen Cao, S. Wang, S. Gambhir, X. Chen
Published 2006 · Materials Science, Medicine

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We report the in vivo targeting and imaging of tumor vasculature using arginine-glycine-aspartic acid (RGD) peptide-labeled quantum dots (QDs). Athymic nude mice bearing subcutaneous U87MG human glioblastoma tumors were administered QD705-RGD intravenously. The tumor fluorescence intensity reached maximum at 6 h postinjection with good contrast. The results reported here open up new perspectives for integrin-targeted near-infrared optical imaging and may aid in cancer detection and management including imaging-guided surgery.
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