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Palladacycle-catalyzed Asymmetric Intermolecular Construction Of Chiral Tertiary P-heterocycles By Stepwise Addition Of H–P–H Bonds To Bis(enones)

Yinhua Huang, S. Pullarkat, S. Teong, R. J. Chew, Y. Li, P. Leung
Published 2012 · Chemistry

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A palladacycle-catalyzed diastereo- and enantioselective stepwise double hydrophosphination of bis(enones) with PhPH2 has been developed, allowing intermolecular construction of chiral tertiary bulky P-heterocycles in one pot in high yields. A catalytic cycle for the reaction is proposed as well.
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