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Ruthenium Hydride Catalyzed Silylvinylation Of Internal Alkynes Using Ethylene As An Additive.

Robert J Wilson, Lauren Kaminsky, Ijaz Ahmed, Daniel A. Clark
Published 2015 · Chemistry, Medicine

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An efficient synthetic strategy for the regiospecific silylvinylation of internal alkynes is described. This transformation is catalyzed by RuHCl(CO)(SIMes)PPh3 and provides a net 5-exo-dig trans-silylvinylation of internal alkynes. Ethylene was used to decrease reaction times and displayed altered selectivity at increased pressure. Furthermore, alkyl-substituted alkynes were acceptable substrates at 80 psi of ethylene.
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