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Trigger Chemistries For Better Industrial Formulations.

Hsuan-Chin Wang, Y. Zhang, Catherine M. Possanza, S. Zimmerman, J. Cheng, J. Moore, K. Harris, Joshua S Katz
Published 2015 · Materials Science, Medicine

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In recent years, innovations and consumer demands have led to increasingly complex liquid formulations. These growing complexities have provided industrial players and their customers access to new markets through product differentiation, improved performance, and compatibility/stability with other products. One strategy for enabling more complex formulations is the use of active encapsulation. When encapsulation is employed, strategies are required to effect the release of the active at the desired location and time of action. One particular route that has received significant academic research effort is the employment of triggers to induce active release upon a specific stimulus, though little has translated for industrial use to date. To address emerging industrial formulation needs, in this review, we discuss areas of trigger release chemistries and their applications specifically as relevant to industrial use. We focus the discussion on the use of heat, light, shear, and pH triggers as applied in several model polymeric systems for inducing active release. The goal is that through this review trends will emerge for how technologies can be better developed to maximize their value through industrial adaptation.
This paper references
10.1021/nn100968e
Multiresponse Strategies To Modulate Burst Degradation and Release from Nanoparticles
Jagadis Sankaranarayanan (2010)
56) Takacs, L. The Historical Development of Mechanochemistry
(2013)
10.1021/LA0523098
Composition-tunable properties of amphiphilic comb copolymers containing protected methacrylic acid groups for multicomponent protein patterning.
Joshua S Katz (2006)
10.1021/JA00003A054
Formation of reversed vesicles
H. Kunieda (1991)
10.1021/ja3101837
Photoresponsive capture and release of lectins in multilamellar complexes.
Avik Samanta (2012)
10.1002/chem.200800917
Self-immolative comb-polymers: multiple-release of side-reporters by a single stimulus event.
Roy Weinstain (2008)
Invests in Education
M S Reisch (2011)
10.1021/CR030037C
Coumarins in polymers: from light harvesting to photo-cross-linkable tissue scaffolds.
S. R. Trenor (2004)
10.1016/J.COLSURFA.2013.08.026
Controlled-release of ibuprofen on multilayer mesoporous vesicle
Z. Bian (2013)
10.1021/MA802434G
Synthesis of Photocleavable Poly(styrene-block-ethylene oxide) and Its Self-Assembly into Nanoporous Thin Films
Minhyuck Kang (2009)
10.1039/C1JM13288A
Photoactivated nanomaterials for biomedical release applications
S. Sortino (2012)
10.1039/C3TB20922A
Visible-light degradable polymer coated hollow mesoporous silica nanoparticles for controlled drug release and cell imaging.
Shun Yang (2013)
10.1021/MA9023679
Photodegradable Hydrogels to Generate Positive and Negative Features over Multiple Length Scales
Darice Y. Wong (2010)
10.1002/ADFM.201101303
Harnessing Interfacial Phenomena to Program the Release Properties of Hollow Microcapsules
Myung Han Lee (2012)
10.1021/MP050103U
Shrinkage of a rapidly growing tumor by drug-loaded polymersomes: pH-triggered release through copolymer degradation.
Fariyal Ahmed (2006)
10.1021/ja104812p
Programmable microcapsules from self-immolative polymers.
A. Esser-Kahn (2010)
10.1021/JA039071Z
Photochemical reaction mechanisms of 2-nitrobenzyl compounds: methyl ethers and caged ATP.
Y. V. Il'ichev (2004)
10.1016/j.ijpharm.2010.08.029
Novel pH-sensitive polyacetal-based block copolymers for controlled drug delivery.
Jin-Ki Kim (2010)
10.1039/c1cs15179g
Photoisomerization in different classes of azobenzene.
H. Bandara (2012)
10.1021/bm2018382
Controlled release of ionic drugs from complex micelles with charged channels.
X. Liu (2012)
10.1021/ja801895n
A facile route for creating "reverse" vesicles: insights into "reverse" self-assembly in organic liquids.
S. Tung (2008)
10.1002/mabi.200900232
Fabrication of complex micelles with tunable shell for application in controlled drug release.
C. Wu (2009)
10.1016/J.POLYMER.2009.04.032
Thermosensitive hydrogels synthesized by fast Diels–Alder reaction in water
Hong-liang Wei (2009)
10.1002/ADFM.201000659
A Generalized System for Photo-Responsive Membrane Rupture in Polymersomes.
Neha P. Kamat (2010)
10.1038/nnano.2012.84
Shear-stress sensitive lenticular vesicles for targeted drug delivery.
M. N. Holme (2012)
10.1021/ja1027502
Voltage-responsive vesicles based on orthogonal assembly of two homopolymers.
Qiang Yan (2010)
Modulated Approach to Control and Sustain the Release of Dexamethasone and Induce Osteogenic Differentiation of Human Mesenchymal Stem Cells
− Diels (2013)
Silica Nanoparticles for Controlled Drug Release and Cell Imaging
S. Sortino (2011)
10.1021/JA038142R
Preparation and pH triggered inversion of vesicles from poly(acrylic acid)-block-polystyrene-block-poly(4-vinyl pyridine).
F. Liu (2003)
10.1021/MA1016264
Novel Photolabile Diblock Copolymers Bearing Truxillic Acid Derivative Junctions
Hong Yang (2011)
10.1039/C0SM00094A
Tuning responsiveness and structural integrity of a pH responsive hydrogel using a poly(ethylene glycol) cross-linker
J. H. Jeong (2010)
ACS Applied Materials & Interfaces Review DOI: 10.1021/acsami.5b00485 ACS Appl. Mater. Interfaces 2015
10.1007/s10856-012-4555-0
PEG-based bioresponsive hydrogels with redox-mediated formation and degradation
F. Yang (2012)
10.1016/J.JCONREL.2007.03.023
Triggered destabilisation of polymeric micelles and vesicles by changing polymers polarity: an attractive tool for drug delivery.
C. Rijcken (2007)
10.1016/j.addr.2012.09.024
Environment-sensitive hydrogels for drug delivery.
Y. Qiu (2001)
10.1021/MA4009725
Light Responsive Vesicles Based on Linear-Dendritic Block Copolymers Using Azobenzene-Aliphatic Codendrons
E. Blasco (2013)
10.1016/j.addr.2012.02.006
Photochemical mechanisms of light-triggered release from nanocarriers.
N. Fomina (2012)
10.1021/JA0521019
A new design for light-breakable polymer micelles.
Jinqiang Jiang (2005)
10.1002/anie.201300497
Chain-shattering polymeric therapeutics with on-demand drug-release capability.
Y. Zhang (2013)
10.1002/anie.201108814
Synthetic bio-nanoreactor: mechanical and chemical control of polymersome membrane permeability.
J. Gaitzsch (2012)
10.1021/MA4009753
Kinetics of Self-Immolative Degradation in a Linear Polymeric System: Demonstrating the Effect of Chain Length
Ryan A. McBride (2013)
10.1021/LA010663+
Effect of Sodium Dodecyl Sulfate on the Morphology of Polystyrene-b-Poly(acrylic acid) Aggregates in Dioxane−Water Mixtures
Susan E. Burke and (2001)
Experiment, Theory and Application
K. M. Khritov (2002)
10.1002/anie.200805572
Near-IR remote release from assemblies of liposomes and nanoparticles.
D. Volodkin (2009)
10.1021/ja808586q
Photoinitiated destruction of composite porphyrin-protein polymersomes.
Gregory P. Robbins (2009)
10.1016/j.biomaterials.2011.03.060
Redox-responsive nanocapsules for intracellular protein delivery.
Muxun Zhao (2011)
10.1039/c3cs60181a
Spiropyran-based dynamic materials.
R. Klajn (2014)
10.1039/c0cc04096g
Clickable polyglycerol hyperbranched polymers and their application to gold nanoparticles and acid-labile nanocarriers.
Andrew T. Zill (2011)
10.1039/c1pp05231d
Using photolabile protecting groups for the controlled release of bioactive volatiles.
Andreas Herrmann (2012)
10.1039/c2cs35103j
Enzyme-responsive polymeric assemblies, nanoparticles and hydrogels.
J. Hu (2012)
10.1021/ja910606y
Modular synthesis of biodegradable diblock copolymers for designing functional polymersomes.
Joshua S Katz (2010)
10.1021/MA201014N
Triggered Release from Polymer Capsules
A. Esser-Kahn (2011)
10.1021/ja110468v
A biocompatible oxidation-triggered carrier polymer with potential in therapeutics.
Kyle E. Broaders (2011)
10.1016/j.jconrel.2008.05.006
Reverse polymeric micelles for pharmaceutical applications.
M. Jones (2008)
10.1016/j.biomaterials.2010.07.005
Core-crosslinked polymeric micelles with controlled release of covalently entrapped doxorubicin.
M. Talelli (2010)
J. S. Triggered Release from Polymer Capsules. Macromolecules
A P Esser-Kahn (2011)
10.1021/BC050176W
Polyketal nanoparticles: a new pH-sensitive biodegradable drug delivery vehicle.
Michael J. Heffernan (2005)
10.1021/JA0349960
Dendrimer disassembly by benzyl ether depolymerization.
S. Li (2003)
10.1021/cr300177k
Photoremovable Protecting Groups in Chemistry and Biology: Reaction Mechanisms and Efficacy
P. Klán (2013)
Chem.Eur. J
(1222)
10.1021/ja9036548
gem-Dichlorocyclopropanes as abundant and efficient mechanophores in polybutadiene copolymers under mechanical stress.
Jeremy M. Lenhardt (2009)
10.1016/j.actbio.2009.07.005
A novel thermosensitive polymer with pH-dependent degradation for drug delivery.
V. K. Garripelli (2010)
10.1021/acsami.5b00484
New frontiers for encapsulation in the chemical industry.
B. Andrade (2015)
10.1039/B714741D
pH-Responsive polymers: synthesis, properties and applications.
S. Dai (2008)
10.1002/smll.201001348
Encapsulation and release of molecular cargos via temperature-induced vesicle-to-micelle transitions.
Q. Chen (2010)
10.1039/c0cc01288b
Thermo- and light responsive micellation of azobenzene containing block copolymers.
F. Jochum (2010)
10.1021/MA062862B
Synthesis of Photocleavable Linear Macromonomers by ATRP and Star Macromonomers by a Tandem ATRP-Click Reaction: Precursors to Photodegradable Model Networks
J. A. Johnson (2007)
10.1016/S0168-3659(99)00242-4
Inner core segment design for drug delivery control of thermo-responsive polymeric micelles.
J. E. Chung (2000)
10.1021/ja905343x
A cascade biodegradable polymer based on alternating cyclization and elimination reactions.
Matthew A Dewit (2009)
10.1016/j.jconrel.2009.10.002
Targeted temperature sensitive magnetic liposomes for thermo-chemotherapy.
P. Pradhan (2010)
10.1016/S1359-0294(96)80128-2
Self-assembly of block copolymers
M. Matsen (1996)
10.1021/MA062493J
Polymer Micelles Stabilization on Demand through Reversible Photo-Cross-Linking
Jinqiang Jiang (2007)
10.1039/b818183g
Degradable dendrimers divergently synthesized via click chemistry.
Richie E. Kohman (2009)
10.1016/j.addr.2012.01.020
Stimuli-responsive polymeric nanocarriers for the controlled transport of active compounds: concepts and applications.
E. Fleige (2012)
10.1039/c3cc44799e
Application of new photolabile protecting groups as photocleavable joints of block copolymers.
Wen-ya Lu (2013)
10.1002/anie.200802474
Self-immolative polymers.
W. Wang (2008)
10.1021/MA0519009
Bioresorbable Vesicles Formed through Spontaneous Self-Assembly of Amphiphilic Poly(ethylene oxide)-block-polycaprolactone.
P. Ghoroghchian (2006)
10.1021/ja809475a
Multi-stimuli sensitive amphiphilic block copolymer assemblies.
Akamol Klaikherd (2009)
10.1021/LA062770F
Thermoresponsive transport through ordered mesoporous silica/PNIPAAm copolymer membranes and microspheres.
Qiang Fu (2007)
10.1039/c2cc17397b
Synthesis and self-assembly of dynamic covalent block copolymers: towards a general route to pore-functionalized membranes.
Jingyi Rao (2012)
10.1021/CR030697H
Mechanochemistry: the mechanical activation of covalent bonds.
M. Beyer (2005)
10.1038/NMAT1081
Oxidation-responsive polymeric vesicles
A. Napoli (2004)
Microencapsulation: Processes and Applications; Vandegaer
(1974)
Photocontrolled Release Using Light-Dissociable Block Copolymer Micelles
Y. V. Il’ichev (2006)
10.1002/mabi.200900297
Light-responsive biomaterials: development and applications.
Joshua S Katz (2010)
10.1021/MP050047X
Dendrimer disassembly as a new paradigm for the application of dendritic structures.
D. Mcgrath (2005)
10.1039/C3PY00685A
pH and redox responsive hydrogels and nanogels made from poly(2-ethyl-2-oxazoline)
C. Legros (2013)
10.1021/ja5030832
Self-immolative polymersomes for high-efficiency triggered release and programmed enzymatic reactions.
Guhuan Liu (2014)
10.1039/C001548B
Tuning hydrogel properties and function using substituent effects.
Richie E. Kohman (2010)
10.1021/ja403757p
"Flex-activated" mechanophores: using polymer mechanochemistry to direct bond bending activation.
Michael B Larsen (2013)
10.1021/CEN-V089N041.P009
DOW INVESTS IN EDUCATION
M. Reisch (2011)
10.1002/CHIN.201321242
Acid‐Degradable Polymers for Drug Delivery: A Decade of Innovation
S. Binauld (2013)
10.1038/nchem.1938
Mechanically triggered heterolytic unzipping of a low-ceiling-temperature polymer
C. Diesendruck (2014)
Trigger-responsive chain-shattering polymers
程建军 (2013)
10.1002/anie.200900255
A new two-photon-sensitive block copolymer nanocarrier.
J. Babin (2009)
10.1016/0168-3659(89)90048-5
Solute and penetrant diffusion in swellable polymers. IX: The mechanisms of drug release from pH-sensitive swelling-controlled systems
L. Brannon-Peppas (1989)
J. Am. Chem. Soc
Photoresponsive Polymersomes as Smart
E Cabane (2011)
Microencapsulation: Processes and Applications
Wirz, J. Photoremovable Protecting Groups in Chemistry and Biology: Reaction Mechanisms and Efficacy. Chem. Rev
P Kláklán (2013)
10.1021/am404696u
New strategy for controlled release of drugs. Potential pinpoint targeting with multiresponsive tetraaniline diblock polymer vesicles: site-directed burst release with voltage.
Yupeng Wu (2014)
10.1021/MA900665V
Photoresponsive Nanogels Based on Photocontrollable Cross-Links
J. He (2009)
10.4324/9781315834689-25
To J.S.
C. Ricks (2014)
10.1021/ja211888a
Photoswitchable Nanoparticles for Triggered Tissue Penetration and Drug Delivery
R. Tong (2012)
10.1002/MACP.201000151
Synthesis of Photocleavable Amphiphilic Block Copolymers: Toward the Design of Photosensitive Nanocarriers
E. Cabane (2010)
10.1039/C3TB21103G
Injectable and redox-responsive hydrogel with adaptive degradation rate for bone regeneration.
Fan Yang (2014)
10.1002/adma.200904386
Probe-based 3-D nanolithography using self-amplified depolymerization polymers.
A. Knoll (2010)
10.1021/MA060142Z
Toward Photocontrolled Release Using Light-Dissociable Block Copolymer Micelles
Jinqiang Jiang (2006)
10.1021/JA026925R
A novel strategy for encapsulation and release of proteins: hydrogels and microgels with acid-labile acetal cross-linkers.
N. Murthy (2002)
10.1021/bm301789d
Diels-Alder mediated controlled release from a poly(ethylene glycol) based hydrogel.
K. C. Koehler (2013)
10.3390/ma7020805
Fabrications and Applications of Stimulus-Responsive Polymer Films and Patterns on Surfaces: A Review
Jem-Kun Chen (2014)
10.1021/la2036746
Controlled-release system mediated by a retro Diels-Alder reaction induced by the photothermal effect of gold nanorods.
S. Yamashita (2011)
10.1021/ja411891x
Successive mechanochemical activation and small molecule release in an elastomeric material.
Michael B Larsen (2014)
10.1039/B922341J
Self-immolative dendrimers: A distinctive approach to molecular amplification
Michal Avital-Shmilovici (2010)
10.1002/anie.200802222
Substituted 1,3,5-triazaadamantanes: biocompatible and degradable building blocks.
Amy M. Balija (2008)
Co2 -Stimuli Responsive Polymers
A. C. Feng (2003)
10.1021/JA043920G
Reversible inside-out micellization of pH-responsive and water-soluble vesicles based on polypeptide diblock copolymers.
J. Rodríguez-Hernández (2005)
10.1039/C1SM05880K
Photoresponsive polymersomes as smart, triggerable nanocarriers
E. Cabane (2011)
10.1021/la204930n
Block copolymer micelles with a dual-stimuli-responsive core for fast or slow degradation.
D. Han (2012)
10.1126/science.1169494
Photodegradable Hydrogels for Dynamic Tuning of Physical and Chemical Properties
April M Kloxin (2009)
10.1021/la4047897
Encapsulation of amylase in colloidosomes.
Polly H R Keen (2014)
10.1039/C3PY00804E
Main-chain photoresponsive polymers with controlled location of light-cleavable units: from synthetic strategies to structural engineering
Qiang Yan (2013)
10.1021/MA402402P
Construction of Multifunctionalizable, Core-Cross-Linked Polymeric Nanoparticles via Dynamic Covalent Bond
Xiao-bei Wang (2014)
N-Isopropylacrylamide): Experiment, Theory and Application
H G Schild (1992)
Trigger - Responsive Poly ( Beta - Amino Ester ) Hydrogels
Y. Zhang (2014)
10.1021/ja104420k
Patterned plastics that change physical structure in response to applied chemical signals.
Wanji Seo (2010)
10.1146/ANNUREV.MS.17.080187.001315
Polymer Materials for Microlithography
E. Reichmanis (1987)
10.1016/J.EURPOLYMJ.2009.03.005
Protein encapsulation and release from degradable sugar based hydrogels
Karen Heyden (2009)
10.1016/0079-6700(92)90023-R
Poly(N-isopropylacrylamide): experiment, theory and application
H. G. Schild (1992)
10.1021/BM070085X
PEG-SS-PPS: reduction-sensitive disulfide block copolymer vesicles for intracellular drug delivery.
S. Cerritelli (2007)
10.1021/ja201135y
Mechanically facilitated retro [4+2] cycloadditions.
Kelly M. Wiggins (2011)
10.1021/MA800648E
Photo-Cross-Linking and Cleavage Induced Reversible Size Change of Bio-Based Nanoparticles
Dongjian Shi (2008)
10.1021/nl101157z
Targeted cytosolic delivery of cell-impermeable compounds by nanoparticle-mediated, light-triggered endosome disruption.
S. Febvay (2010)
10.1016/S0168-3659(03)00239-6
Polymeric micelle for tumor pH and folate-mediated targeting.
E. Lee (2003)
10.1073/pnas.0813157106
Bursting of sensitive polymersomes induced by curling
E. Mabrouk (2009)
10.1039/B9PY00218A
A versatile strategy for the synthesis of block copolymers bearing a photocleavable junction
Jean-Marc Schumers (2010)
10.1039/b803043j
Copper-free click chemistry for the in situ crosslinking of photodegradable star polymers.
J. A. Johnson (2008)
10.1002/anie.201206531
Photo- and thermoresponsive polymersomes for triggered release.
E. Amstad (2012)
24) Klajn, R. Spiropyran-Based Dynamic Materials
(2014)
10.1002/CHIN.201343273
The Historical Development of Mechanochemistry
László Takács (2013)
10.1016/j.jconrel.2009.09.023
pH-Sensitive degradable polymersomes for triggered release of anticancer drugs: a comparative study with micelles.
W. Chen (2010)
10.1007/s13233-012-0059-5
pH-sensitive polymers for drug delivery
K. Huh (2012)
10.1021/ja305280w
Photodegradable macromers and hydrogels for live cell encapsulation and release.
D. Griffin (2012)
10.1021/MA3015728
pH-Sensitive Block Copolymer Vesicles with Variable Trigger Points for Drug Delivery
J. Du (2012)
10.1016/J.MEMSCI.2006.07.028
The effect of ethanol on the permeability of block copolymer vesicle membranes
A. Bauer (2006)
10.1038/nmat2859
Orally delivered thioketal nanoparticles loaded with TNF-α-siRNA target inflammation and inhibit gene expression in the intestines.
D. S. Wilson (2010)
10.1021/MA051394N
Ultrasound-Induced Site-Specific Cleavage of Azo-Functionalized Poly(ethylene glycol)
Kimberly L. Berkowski (2005)
10.1021/ja407514z
Enzyme sensitive synthetic polymer micelles based on the azobenzene motif.
Jingyi Rao (2013)
10.1021/MZ500277J
Trigger-Responsive Poly(β-amino ester) Hydrogels
Y. Zhang (2014)
J. S. Proton- Coupled
N Sottos
10.1039/B406727D
Stimuli responsive polymers for biomedical applications.
Carolina de las Heras Alarcón (2005)
10.1002/marc.201300863
Polymer nanoparticles based on pyrene-functionalized poly(acrylic acid) for controlled release under photo and pH stimulation.
N. Feng (2014)
Controlled Release of Bioactive Volatiles
H.M.D. Bandara (2012)
10.1002/anie.201310589
Concurrent block copolymer polymersome stabilization and bilayer permeabilization by stimuli-regulated "traceless" crosslinking.
X. Wang (2014)
10.1002/ADMA.200601019
Temperature‐Controlled Assembly and Release from Polymer Vesicles of Poly(ethylene oxide)‐block‐ poly(N‐isopropylacrylamide)
Shuhui Qin (2006)
10.1002/chem.201201312
pH-dependent release of doxorubicin from fast photo-cross-linkable polymersomes based on benzophenone units.
M. Yassin (2012)
Trigger-Responsive Poly(Beta-Amino Ester) Hydrogels. ACS Macro Lett
Y Zhang (2014)
ACS Applied Materials & Interfaces Review DOI ACS Appl. Mater. Interfaces
(2015)
10.1038/NMAT1934
Self-healing materials with microvascular networks.
K. S. Toohey (2007)
10.1002/smll.200900395
Light-induced temperature transitions in biodegradable polymer and nanorod composites.
K. Hribar (2009)
10.1021/JA054755N
pH-responsive vesicles based on a hydrolytically self-cross-linkable copolymer.
J. Du (2005)
10.1016/j.biomaterials.2013.02.020
A Diels-Alder modulated approach to control and sustain the release of dexamethasone and induce osteogenic differentiation of human mesenchymal stem cells.
K. C. Koehler (2013)
10.1007/s11095-010-0233-4
Polymeric Micelles in Anticancer Therapy: Targeting, Imaging and Triggered Release
C. Oerlemans (2010)
10.1021/la105045m
Block copolymer vesicle permeability measured by osmotic swelling and shrinking.
Autumn Carlsen (2011)
10.1016/j.addr.2011.09.012
Amplified release through the stimulus triggered degradation of self-immolative oligomers, dendrimers, and linear polymers.
Andrew D. Wong (2012)
10.1016/J.JCONREL.2003.12.021
Self-porating polymersomes of PEG-PLA and PEG-PCL: hydrolysis-triggered controlled release vesicles.
Fariyal Ahmed (2004)
10.1016/J.PROGPOLYMSCI.2009.10.002
Recent advances and challenges in designing stimuli-responsive polymers
F. Liu (2010)
10.1002/POLA.1994.080321312
Thermoreversible reaction of diels—alder polymer composed of difurufuryladipate with bismaleimidodiphenylmethane
N. Kuramoto (1994)
10.1021/ja305645x
Proton-coupled mechanochemical transduction: a mechanogenerated acid.
C. Diesendruck (2012)
10.1021/NL0619305
Toward intelligent nanosize bioreactors: a pH-switchable, channel-equipped, functional polymer nanocontainer.
P. Brož (2006)
10.1021/MA102778D
Fast Photodegradable Block Copolymer Micelles for Burst Release
D. Han (2011)



This paper is referenced by
10.1021/ACSMACROLETT.6B00124
pH-Induced Softening of Polyelectrolyte Microcapsules without Apparent Swelling
Miju Kim (2016)
10.1016/J.EURPOLYMJ.2016.02.022
Responsive nanogels for application as smart carriers in endocytic pH-triggered drug delivery systems
J. C. Cuggino (2016)
10.1021/acsami.6b08935
Synthesis of Photo- and pH Dual-Sensitive Amphiphilic Copolymer PEG43-b-P(AA76-co-NBA35-co-tBA9) and Its Micellization as Leakage-Free Drug Delivery System for UV-Triggered Intracellular Delivery of Doxorubicin.
Xubo Zhao (2016)
10.1021/ACSMACROLETT.6B00968
pH-Triggered Release from Polyamide Microcapsules Prepared by Interfacial Polymerization of a Simple Diester Monomer
H. Wang (2017)
10.1021/acsami.7b00498
Membrane-Anchoring, Comb-Like Pseudopeptides for Efficient, pH-Mediated Membrane Destabilization and Intracellular Delivery.
Siyuan Chen (2017)
10.1021/acs.chemrev.5b00589
Targeted Drug Delivery with Polymers and Magnetic Nanoparticles: Covalent and Noncovalent Approaches, Release Control, and Clinical Studies.
K. Ulbrich (2016)
10.1021/ACSMACROLETT.6B00698
Base-Triggered Degradation of Poly(vinyl ester sulfone)s with Tunable Sensitivity
C. Casey (2016)
10.1016/J.COELEC.2017.04.002
Electrochemically controlled hydrogen bonding for supramolecular assembly: Challenges and opportunities
D. Smith (2017)
10.1021/acsami.7b02281
Polyphosphoester-Camptothecin Prodrug with Reduction-Response Prepared via Michael Addition Polymerization and Click Reaction.
Xueqiong Du (2017)
10.1016/j.actbio.2018.09.005
Electroneutral polymersomes for combined cancer chemotherapy.
Noorjahan Aibani (2018)
10.1021/jacs.5b02799
Surface-accessible detection units in self-immolative polymers enable translation of selective molecular detection events into amplified responses in macroscopic, solid-state plastics.
K. Yeung (2015)
10.1002/anie.202010099
Shear stress-responsive polymersome nanoreactors inspired by the marine bioluminescence of dinoflagellates.
Omar Rifaie-Graham (2020)
10.1007/978-3-662-59596-1
Nanotechnology Characterization Tools for Tissue Engineering and Medical Therapy
Challa S. S. R. Kumar (2019)
10.1021/ACSAMI.6B10097
"Killer" Microcapsules That Can Selectively Destroy Target Microparticles in Their Vicinity.
C. Arya (2016)
10.1039/C8MH00117K
Cross-linked networks that selectively and controllably disassemble on-demand via cascading bond cleavage
G. C. Daniels (2018)
10.1021/jacs.0c02774
Poly(carboxypyrrole)s that Depolymerize from Head to Tail in the Solid State in Response to Specific Applied Signals.
Hyungwoo Kim (2020)
10.1039/C7PY01844D
Designing a main-chain visible-light-labile picolinium-caged polymer and its biological applications
Tongtong Zhou (2018)
10.2217/nnm-2017-0320
Magnetic iron oxide nanoparticles as drug carriers: preparation, conjugation and delivery.
Kheireddine El-Boubbou (2018)
10.1021/acsnano.5b02702
One-Step Generation of Multifunctional Polyelectrolyte Microcapsules via Nanoscale Interfacial Complexation in Emulsion (NICE).
Miju Kim (2015)
10.1016/j.polymer.2020.122639
The “labile” chemical bond: A perspective on mechanochemistry in polymers
W. Binder (2020)
10.1021/acsami.7b05266
Low-Ceiling-Temperature Polymer Microcapsules with Hydrophobic Payloads via Rapid Emulsion-Solvent Evaporation.
Shijia Tang (2017)
10.1002/anie.201607693
A Dynamic and Responsive Host in Action: Light‐Controlled Molecular Encapsulation
S. T. Ryan (2016)
10.1021/acsami.6b05041
A Virus-Mimicking, Endosomolytic Liposomal System for Efficient, pH-Triggered Intracellular Drug Delivery.
Siyuan Chen (2016)
10.1002/marc.201500389
A Light-Controlled Release System Based on Molecular Recognition of Cyclodextrins.
Isaac Eng Ting Lee (2015)
10.1016/J.COMPSCITECH.2016.07.022
Pickering emulsion-based fabrication of epoxy and amine microcapsules for dual core self-healing coating
Huan Yi (2016)
10.1039/c6pp00206d
Photolabile acetals as profragrances: the effect of structural modifications on the light-induced release of volatile aldehydes on cotton.
Alain Trachsel (2016)
10.1039/c9sc06582b
Base-triggered self-amplifying degradable polyurethanes with the ability to translate local stimulation to continuous long-range degradation
Yanhua Xu (2020)
10.1021/jacs.8b07705
Acid-Triggered, Acid-Generating, and Self-Amplifying Degradable Polymers.
Kali A Miller (2019)
10.1002/MAME.201800599
Developing Multi Stimuli‐Responsive Core/Shell Microcapsules to Control the Release of Volatile Compounds
Nicolas Paret (2019)
10.1021/acsami.5b00484
New frontiers for encapsulation in the chemical industry.
B. Andrade (2015)
10.1021/acsami.6b16501
Stimuli-Responsive Self-Immolative Polymer Nanofiber Membranes Formed by Coaxial Electrospinning.
D. Han (2017)
10.1002/chem.201902418
An Electron-Rich Helical Host for Exclusive Removal of a Planar Electron Deficient Organic Guest.
A. Srivastava (2019)
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