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Addition Of Chitosan To Silicate Cross-linked PEO For Tuning Osteoblast Cell Adhesion And Mineralization.

A. Gaharwar, Patrick J. Schexnailder, Q. Jin, C. Wu, G. Schmidt
Published 2010 · Materials Science, Medicine

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The addition of chitosan to silicate (Laponite) cross-linked poly(ethylene oxide) (PEO) is used for tuning nanocomposite material properties and tailoring cellular adhesion and bioactivity. By combining the characteristics of chitosan (which promotes cell adhesion and growth, antimicrobial) with properties of PEO (prevents protein and cell adhesion) and those of Laponite (bioactive), the resulting material properties can be used to tune cellular adhesion and control biomineralization. Here, we present the hydration, dissolution, degradation, and mechanical properties of multiphase bio-nanocomposites and relate these to the cell growth of MC3T3-E1 mouse preosteoblast cells. We find that the structural integrity of these bio-nanocomposites is improved by the addition of chitosan, but the release of entrapped proteins is suppressed. Overall, this study shows how chitosan can be used to tune properties in Laponite cross-linked PEO for creating bioactive scaffolds to be considered for bone repair.
This paper references
Am100609t Article Www
Macromol. Biosci
P J Schexnailder (2010)
10.1126/science.225.4658.197
Materials
L. Napolitano (1984)
Bone Miner. Res
G Rawadi (2003)
Chem. Mater
M Darder (2003)
Biomed. Mater. Res., Part A
J J Blaker (2003)
Adv. Funct. Mater
A K Gaharwar (2010)
Rheology: Principles, Measurements, and Applications
C. Macosko (1994)
React. Funct. Polym
J P Zheng (2007)
J. Mater. Sci.: Mater. Med
H Zhuang (2007)
10.1179/174328408x369933
Biomaterials
R. Misra (2008)
Biomacromolecules
R.-N Chen (2006)
Biomed. Mater. Res., Part A
M D Weir (2010)
Clin. Biochem
B Porstmann (1989)
Eur. Polym. J
M R Guilherme (2010)
Biomacromolecules
X Yang (2009)
Annu. Rev. Biomed. Eng
B D Ratner (2004)
AND NOTES Biotechnol. Adv. Biomaterials
D L Nettles (2002)
Acta Biomater
D S Couto (2009)
J. Cell Biol
H Sudo (1983)
Macromol. Biosci
Q Jin (2009)
Acta Biomater
D Depan (2009)
J. Cell. Biochem
L Malaval (1999)
N. J. Biomed. Mater. Res., Part A
F Tadanao (2005)
Biomacromolecules
Y.-C Kuo (2008)
Zheng, Q. J. Controlled Release
X Niu (2009)
Appl. Clay Sci
M Darder (2005)
Acta Biomater
P B Malafaya (2009)
J. Appl. Polym. Sci
K Kabiri (2010)
37) Kim, B.; Peppas
P L Ritger (1987)
J. Am. Ceram. Soc
L H Larry (1991)
Macromol. Rapid Commun
A Dundigalla (2005)
Curr. Opin. Cell Biol
A Mammoto (2009)
Soil Sci
C E Clapp (1972)
Biomed. Mater. Res., Part A
Y.-C Kuo (2008)
Biomacromolecules
D F Coutinho (2008)
Biomed. Mater. Res., Part A
K Cai (2002)
J. Mater. Chem. Biomaterials Biomaterials Biomaterials Biomaterials
A M Martins (1997)
Jayakumar, R. Chem. Eng. J
M Peter (2010)
Biomacromolecules
Y Zhou (2007)
Biomacromolecules
S Zivanovic (2007)
J. Eur. Ceram. Soc
L L Hench (2009)
Bone Miner. Res
D Wang (1999)



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10.1557/JMR.2018.260
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Tugba Cebe (2020)
10.1002/adma.201900332
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A. Gaharwar (2019)
10.1002/jbm.b.34487
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V. A. M. Gonzaga (2019)
10.2174/1381612825666190402165845
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S. Das (2019)
10.1016/J.COLSURFA.2019.04.059
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H. M. A. El-Lateef (2019)
10.18502/RMM.V6I4.4799
Injectable Hydrogels: A Review of Injectability Mechanisms and Biomedical Applications
A. Mellati (2019)
10.1016/j.biomaterials.2017.12.024
Clay nanoparticles for regenerative medicine and biomaterial design: A review of clay bioactivity.
M. Mousa (2018)
10.1016/j.carbpol.2018.01.056
Enhancement of bio-stability and mechanical properties of hyaluronic acid hydrogels by tannic acid treatment.
H. Lee (2018)
10.1039/C8NJ01316K
A phosphorylated chitosan armed hydroxyapatite nanocomposite for advancing activity on osteoblast and osteosarcoma cells
M. Sumathra (2018)
10.1177/0885328218809239
The controlled naringin release from TiO2 nanotubes to regulate osteoblast differentiation
Min Lai (2018)
10.1039/C7RA13452E
LAPONITE® nanorods regulating degradability, acidic-alkaline microenvironment, apatite mineralization and MC3T3-E1 cells responses to poly(butylene succinate) based bio-nanocomposite scaffolds
Liangchen Tang (2018)
10.1002/adhm.201701213
Advances in Carbon Nanotubes-Hydrogel Hybrids in Nanomedicine for Therapeutics.
A. Vashist (2018)
10.1002/MAME.201800213
Strategy for Preparing Mechanically Strong Hyaluronic Acid–Silica Nanohybrid Hydrogels via In Situ Sol–Gel Process
H. Lee (2018)
10.1002/9783527807130.CH1
Clay–Organic Interfaces for Design of Functional Hybrid Materials
P. Aranda (2017)
10.1002/9783527689934.CH2
Biomaterials in Tissue Engineering
S. Ahadian (2017)
10.1002/9781119441632.CH158
Biocomposites from Renewable Resources: Preparation and Applications of Chitosan–Clay Nanocomposites
A. B. Reddy (2017)
10.1002/adhm.201600938
Nanocomposite Hydrogels and Their Applications in Tissue Engineering
A. Motealleh (2017)
10.24377/LJMU.T.00007684
The development and evaluation of antibacterial polymer-phyllosilicate composite systems for the treatment of infected wounds
A. R. Hamilton (2017)
10.1021/acsami.6b00291
Engineered Nanomaterials for Infection Control and Healing Acute and Chronic Wounds.
M. Parani (2016)
10.1021/acs.biomac.5b01557
Strong and Biostable Hyaluronic Acid-Calcium Phosphate Nanocomposite Hydrogel via in Situ Precipitation Process.
Seol-Ha Jeong (2016)
10.1007/978-81-322-2511-9_6
Chitin and Chitosan Nanocomposites for Tissue Engineering
A. Mahanta (2016)
10.1002/mabi.201400363
Self-assembled monolayers and nanocomposite hydrogels of functional nanomaterials for tissue engineering applications.
N. S. Kehr (2015)
Programmable Dna Delivery To Cells Using Bioreducible Layer-By-Layer (lbl) Polyelectrolyte Thin Films
María Muñiz (2015)
10.1007/s10856-015-5606-0
Antibiotic-loaded chitosan–Laponite films for local drug delivery by titanium implants: cell proliferation and drug release studies
F. Ordikhani (2015)
10.1039/C4RA16945J
Biomedical applications of cationic clay minerals
M. Ghadiri (2015)
10.1002/9781119044901.CH2
Surface Modification of Chitosan and its Implications in Tissue Engineering and Drug Delivery
D. Depan (2015)
10.1021/IE501891T
Tailoring of Clay/Poly(ethylene oxide) Hydrogel Properties by Chitosan Incorporation
S. Morariu (2014)
10.1021/am501428e
Silver nanoparticles and growth factors incorporated hydroxyapatite coatings on metallic implant surfaces for enhancement of osteoinductivity and antibacterial properties.
C. Xie (2014)
10.1016/j.biomaterials.2014.07.052
The osteogenic differentiation of SSEA-4 sub-population of human adipose derived stem cells using silicate nanoplatelets.
S. Mihaila (2014)
10.1021/am502948g
Sol-gel assisted fabrication of collagen hydrolysate composite scaffold: a novel therapeutic alternative to the traditional collagen scaffold.
Satiesh kumar Ramadass (2014)
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