Online citations, reference lists, and bibliographies.
← Back to Search

Formation And Properties Of Chitosan-cellulose Nanocrystal Polyelectrolyte-macroion Complexes For Drug Delivery Applications.

Hezhong Wang, M. Roman
Published 2011 · Medicine, Chemistry

Cite This
Download PDF
Analyze on Scholarcy
Share
This study examines a novel polyelectrolyte-macroion complex (PMC) between chitosan, a cationic polysaccharide, and cellulose nanocrystals (CNCs), anionic, cylindrical nanoparticles, for potential applications in drug delivery. CNCs were prepared by H(2)SO(4) hydrolysis of wood pulp. The formation of PMCs was monitored by turbidimetric titration. In titrations of a chitosan solution with a CNC suspension, the turbidity reached a plateau, but it had a maximum and then decreased when the direction of titration was reversed. PMC particles were characterized by Fourier transform infrared spectroscopy, scanning electron microscopy, dynamic light scattering, and laser Doppler electrophoresis. The particles were composed primarily of CNCs and ranged in size from a few hundred nanometers to several micrometers, depending on the cellulose/chitosan ratio. Particles formed at amino/sulfate group molar ratios >1 were nearly spherical in shape and positively charged, whereas particles formed at ratios <1 had well-defined nonspherical shapes and were negatively charged.
This paper references
10.1021/BM049786+
Versatile and efficient formation of colloids of biopolymer-based polyelectrolyte complexes.
C. Schatz (2004)
10.1002/jbm.a.32466
Development of new chitosan/carrageenan nanoparticles for drug delivery applications.
A. Grenha (2010)
10.1016/S0144-8617(96)00035-5
Chitosan-chondroitin sulfate and chitosan-hyaluronate polyelectrolyte complexes. Physico-chemical aspects
A. Denuzière (1996)
10.1021/BM049312A
Preparation of nanoparticles composed of chitosan/poly-gamma-glutamic acid and evaluation of their permeability through Caco-2 cells.
Y. Lin (2005)
10.1016/J.CARRES.2005.08.007
Crystalline structure analysis of cellulose treated with sodium hydroxide and carbon dioxide by means of X-ray diffraction and FTIR spectroscopy.
S. Y. Oh (2005)
10.1016/J.MOLSTRUC.2005.05.015
Spectroscopic manifestation of stretching vibrations of glycosidic linkage in polysaccharides
N. A. Nikonenko (2005)
10.1016/J.JCONREL.2006.04.017
Polyionic hydrocolloids for the intestinal delivery of protein drugs: alginate and chitosan--a review.
M. George (2006)
10.1615/CRITREVTHERDRUGCARRIERSYST.V22.I5.10
Polymeric nanoparticles for oral delivery of drugs and vaccines: a critical evaluation of in vivo studies.
S. Galindo-Rodriguez (2005)
10.1211/jpp.58.8.0002
Advances and potential applications of chitosan derivatives as mucoadhesive biomaterials in modern drug delivery
S. Chopra (2006)
10.1016/S0927-7757(98)00404-X
Flow properties of microcrystalline cellulose suspension prepared by acid treatment of native cellulose
J. Araki (1998)
10.1002/1521-3900(200103)168:1<1::AID-MASY1>3.0.CO;2-W
Overview on structural characterization of chitosan molecules in relation with their behavior in solution.
J. Brugnerotto (2001)
10.1023/A:1012160102740
Chitosans as Absorption Enhancers for Poorly Absorbable Drugs 2: Mechanism of Absorption Enhancement
N. G. Schipper (2004)
10.1016/S0168-3659(99)00285-0
Preparation and evaluation of the in vitro drug release properties and mucoadhesion of novel microspheres of hyaluronic acid and chitosan.
S. T. Lim (2000)
10.1002/APP.1993.070501121
Preparation of a polyelectrolyte complex gel from chitosan and κ‐carrageenan and its pH‐sensitive swelling
T. Sakiyama (1993)
10.1016/S0141-8130(02)00039-9
An optimised method to determine the degree of acetylation of chitin and chitosan by FTIR spectroscopy.
M. L. Duarte (2002)
10.1271/BBB.59.717
pH-Sensitive Swelling of a Polyelectrolyte Complex Gel Prepared from Xanthan and Chitosan
C. Chu (1995)
10.1615/CRITREVTHERDRUGCARRIERSYST.V25.I2.10
Cracking the junction: update on the progress of gastrointestinal absorption enhancement in the delivery of poorly absorbed drugs.
S. Maher (2008)
10.1002/1097-0282(2000)57:4<257::AID-BIP7>3.0.CO;2-3
Investigation of stretching vibrations of glycosidic linkages in disaccharides and polysaccharides with use of IR spectra deconvolution.
N. A. Nikonenko (2000)
10.1081/DDC-120018382
Adsorption of an Amine Drug onto Microcrystalline Cellulose and Silicified Microcrystalline Cellulose Samples
D. Fraser Steele (2003)
10.1016/0378-5173(93)90241-7
Effect of interpolymer complex formation of chitosan with pectin or acacia on the release behaviour of chlorpromazine HCl
M. Meshali (1993)
10.1016/S0939-6411(03)00161-9
Structure and interactions in covalently and ionically crosslinked chitosan hydrogels for biomedical applications.
J. Berger (2004)
10.1021/BM049300P
Effect of reaction conditions on the properties and behavior of wood cellulose nanocrystal suspensions.
Stephanie Beck-Candanedo (2005)
10.1016/S0141-8130(05)80008-X
Helicoidal self-ordering of cellulose microfibrils in aqueous suspension.
J. F. Revol (1992)
10.1016/0032-3861(96)82908-9
A Fourier transform infra-red spectroscopic analysis of the character of hydrogen bonds in amorphous cellulose
Tetsuo Kondo (1996)
10.1016/S0022-2860(99)00389-0
The hydrogen bond network in I β cellulose as observed by infrared spectrometry
Y. Maréchal (2000)
10.1016/J.COCIS.2006.08.002
The many facets of polyelectrolytes and oppositely charged macroions complex formation
Serge Ulrich (2006)
10.1016/J.IJPHARM.2003.12.026
Chitosan microspheres as a potential carrier for drugs.
V. Sinha (2004)
10.1134/S1061933X08050165
Chitosan-cellulose sulfate acetate complexation in acetic acid solutions
T. N. Shybaila (2008)
10.1016/S0169-409X(01)00180-6
Chitosan and its derivatives as intestinal absorption enhancers.
M. Thanou (2001)
10.1016/0141-8130(93)90027-J
Characterization of chitosan. Influence of ionic strength and degree of acetylation on chain expansion.
M. Rinaudo (1993)
10.1177/088391159400900205
Polyionic Hydrogels Obtained by Complexation between Xanthan and Chitosan: Their Properties as Supports for Enzyme Immobilization
S. Dumitriu (1994)
10.1016/S0731-7085(03)00155-9
A validated 1H NMR method for the determination of the degree of deacetylation of chitosan.
M. Lavertu (2003)
10.1021/BM0200130
Polyelectrolyte complexes and layer-by-layer capsules from chitosan/chitosan sulfate.
G. Berth (2002)
10.1002/MARC.1988.030091004
Study of the interpolyelectrolyte reaction between chitosan and carboxymethyl cellulose
W. Argüelles-Monal (1988)
10.1016/J.JCONREL.2004.08.010
Recent advances on chitosan-based micro- and nanoparticles in drug delivery.
S. Agnihotri (2004)
10.1002/POL.1960.1204314107
Infrared spectra of crystalline polysaccharides. III. Mercerized cellulose
R. Marchessault (1960)
10.3891/ACTA.CHEM.SCAND.03-0649
Aqueous Colloidal Solutions of Cellulose Micelles.
B. Rånby (1949)
10.1002/(SICI)1097-4628(19990912)73:11<2227::AID-APP20>3.0.CO;2-4
Polyelectrolyte complex gel with high pH‐sensitivity prepared from dextran sulfate and chitosan
T. Sakiyama (1999)
10.1023/A:1009225815913
Two‐dimensional step‐scan FTIR: a tool to unravel the OH‐valency‐range of the spectrum of Cellulose I
B. Hinterstoisser (1999)
10.1016/0095-8522(61)90033-2
Some hydrodynamic properties of neutral suspensions of cellulose crystallites as related to size and shape
R. Marchessault (1961)
10.1002/APP.1976.070200924
Polyelectrolyte complexes of heparin with chitosan
Yasuo Kikuchi (1976)
10.1080/02678299408036525
Chiral nematic suspensions of cellulose crystallites; phase separation and magnetic field orientation
J.-F. Revol (1994)
10.1016/S0144-8617(99)00142-3
Structural diversity of chitosan and its complexes
K. Okuyama (2000)



This paper is referenced by
10.1002/9783527803835.CH1
Application of Nanocellulose for Controlled Drug Delivery
L. Pachuau (2017)
10.1007/978-3-030-21614-6_2
Chitosan and chitosan based nanocomposites for applications as a drug delivery carrier: A review
E. A. K. Nivethaa (2020)
10.1016/j.carbpol.2014.10.072
The reuse of wastepaper for the extraction of cellulose nanocrystals.
W. H. Danial (2015)
10.1134/S1560090413070063
Modification of cellulose as a promising direction in the design of new materials
N. I. Tkacheva (2013)
10.1016/j.biopha.2018.07.136
A review of natural polysaccharides for drug delivery applications: Special focus on cellulose, starch and glycogen.
V. Gopinath (2018)
10.1039/c2nr30260h
Preparation, properties and applications of polysaccharide nanocrystals in advanced functional nanomaterials: a review.
N. Lin (2012)
10.3390/ijms14011629
Biopolymer-Based Nanoparticles for Drug/Gene Delivery and Tissue Engineering
Sachiko Nitta (2013)
10.1016/J.FOODHYD.2018.03.047
Pickering high internal phase emulsions stabilized by protein-covered cellulose nanocrystals
F. Liu (2018)
Cellulose nanocrystals : surface modification and advanced materials
Ning Lin (2014)
10.1155/2015/687490
Use of cellulose and oxidized cellulose nanocrystals from olive stones in chitosan bionanocomposites
R. Abou-Zeid (2015)
10.1016/J.APSUSC.2016.01.133
The modified nanocrystalline cellulose for hydrophobic drug delivery
Weixia Qing (2016)
10.1088/1757-899x/547/1/012046
Preparation of Nanocellulose-Alginate Nanocomposites for Chlorhexidine Digluconate Drug Carrier
Angela Evelyna (2019)
10.1080/09205063.2015.1077919
Cell outer membrane mimetic chitosan nanoparticles: preparation, characterization and cytotoxicity
Jing Zhao (2015)
10.1016/j.carbpol.2016.04.073
Polyelectrolyte complex nanoparticles from cationised gelatin and sodium alginate for curcumin delivery.
P. Sarika (2016)
10.3390/polym11010166
Mechanical and Water-Resistant Properties of Eco-Friendly Chitosan Membrane Reinforced with Cellulose Nanocrystals
Hai-Quan Mao (2019)
10.2174/187221012798109255
Review of cellulose nanocrystals patents: preparation, composites and general applications.
N. Duran (2012)
10.1021/la302483e
Electrophoresis and dielectric dispersion of spherical polyelectrolyte brushes.
S. Ahualli (2012)
10.1016/j.pmatsci.2020.100668
Cellulose nanocrystal based multifunctional nanohybrids
E. Lizundia (2020)
10.1002/CPLU.201300434
Self-Assembly of Nanocellulose and Indomethacin into Hierarchically Ordered Structures with High Encapsulation Efficiency for Sustained Release Applications
Jiali Gao (2014)
10.1002/jbm.a.36922
Composite nanocellulose-based hydrogels with spatially oriented degradation and retarded release of macromolecules.
C. A. Maestri (2020)
10.30919/ES.1803302
Applications of Cellulose Nanocrystals: A Review
Shaoqu Xie (2018)
eview review on chitosan-cellulose blends and nanocellulose reinforced hitosan biocomposites : Properties and their applications bdul
P. KhalilH. (2016)
10.5307/JBE.2018.43.1.059
Cellulose-based Nanocrystals: Sources and Applications via Agricultural Byproducts
Yuri Seo (2018)
10.1007/s11051-013-1636-z
Reinforced plastics and aerogels by nanocrystalline cellulose
Alfred C. W. Leung (2013)
10.1016/j.reactfunctpolym.2020.104613
On the taught new tricks of enzymes immobilization: An all-inclusive overview
R. A. Wahab (2020)
10.1007/s13233-014-2134-6
Synthesis of thermo-sensitive polyelectrolyte complex nanoparticles from CS-g-PNIPAM and SA-g-PNIPAM for controlled drug release
Minyi Qi (2014)
10.1002/cmdc.201200052
Docetaxel Nanotechnology in Anticancer Therapy
Pengxiang Zhao (2012)
10.1007/s10570-013-9954-y
Surface modification of cellulose nanocrystal with chitosan oligosaccharide for drug delivery applications
Seyedeh Parinaz Akhlaghi (2013)
10.1016/j.clay.2019.105277
Cellulose nanocrystal/clay based macroion nanogel as support for stable platinum catalyst for electrochemical oxidation of methanol in alkaline medium
Surendra Singh Gaur (2019)
10.1016/J.FOODHYD.2018.02.003
Improved eco-friendly barrier materials based on crystalline nanocellulose/chitosan/carboxymethyl cellulose polyelectrolyte complexes
K. Chi (2018)
10.1021/bm2009685
Effects of pH and salt concentration on the formation and properties of chitosan-cellulose nanocrystal polyelectrolyte-macroion complexes.
Hezhong Wang (2011)
10.1080/07388551.2016.1189871
Recent developments in the production and applications of bacterial cellulose fibers and nanocrystals
Isabela Reiniati (2017)
See more
Semantic Scholar Logo Some data provided by SemanticScholar