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Asymmetric Alkyl-alkyl Cross-couplings Of Unactivated Secondary Alkyl Electrophiles: Stereoconvergent Suzuki Reactions Of Racemic Acylated Halohydrins.

Nathan A. Owston, G. Fu
Published 2010 · Medicine, Chemistry

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A method for asymmetric alkyl-alkyl Suzuki reactions of unactivated secondary alkyl electrophiles, specifically, cross-couplings of racemic acylated halohydrins with alkylborane reagents, has been developed. A range of protected bromohydrins, as well as a protected chlorohydrin and a homologated bromohydrin, are coupled in good ee by a catalyst derived from commercially available components.
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