Online citations, reference lists, and bibliographies.
← Back to Search

Ultrasmall Reduced Graphene Oxide With High Near-infrared Absorbance For Photothermal Therapy.

J. Robinson, Scott M. Tabakman, Yongye Liang, H. Wang, H. S. Casalongue, D. Vinh, H. Dai
Published 2011 · Chemistry, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
We developed nanosized, reduced graphene oxide (nano-rGO) sheets with high near-infrared (NIR) light absorbance and biocompatibility for potential photothermal therapy. The single-layered nano-rGO sheets were ∼20 nm in average lateral dimension, functionalized noncovalently by amphiphilic PEGylated polymer chains to render stability in biological solutions and exhibited 6-fold higher NIR absorption than nonreduced, covalently PEGylated nano-GO. Attaching a targeting peptide bearing the Arg-Gly-Asp (RGD) motif to nano-rGO afforded selective cellular uptake in U87MG cancer cells and highly effective photoablation of cells in vitro. In the absence of any NIR irradiation, nano-rGO exhibited little toxicity in vitro at concentrations well above the doses needed for photothermal heating. This work established nano-rGO as a novel photothermal agent due to its small size, high photothermal efficiency, and low cost as compared to other NIR photothermal agents including gold nanomaterials and carbon nanotubes.
This paper references
10.1007/S12274-009-9009-8
Carbon nanotubes in biology and medicine: In vitro and in vivo detection, imaging and drug delivery
Zhuang Liu (2009)
10.1117/1.3078803
Cancer photothermal therapy in the near-infrared region by using single-walled carbon nanotubes.
Feifan Zhou (2009)
10.1021/JP806751K
High-Efficiency Loading and Controlled Release of Doxorubicin Hydrochloride on Graphene Oxide
X. Yang (2008)
10.1016/S0032-3861(02)00245-8
Molar mass determination of poly(octadecene-alt-maleic anhydride) copolymers by size exclusion chromatography and dilute solution viscometry
M. Davies (2002)
10.1111/j.1751-1097.2008.00507.x
Gold Nanorods as Contrast Agents for Biological Imaging: Optical Properties, Surface Conjugation and Photothermal Effects †
Ling Tong (2009)
10.1073/PNAS.0502680102
Carbon nanotubes as multifunctional biological transporters and near-infrared agents for selective cancer cell destruction.
N. W. Kam (2005)
10.1016/j.toxlet.2010.11.016
In vitro toxicity evaluation of graphene oxide on A549 cells.
Yanli Chang (2011)
10.1073/pnas.2232479100
Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance
L. R. Hirsch (2003)
10.1158/0008-5472.CAN-08-4242
Computationally guided photothermal tumor therapy using long-circulating gold nanorod antennas.
G. von Maltzahn (2009)
10.1021/nl803647n
Tailoring the structure of nanopyramids for optimal heat generation.
Warefta Hasan (2009)
10.1021/ja803688x
PEGylated nanographene oxide for delivery of water-insoluble cancer drugs.
Zhuang Liu (2008)
10.1038/nnano.2007.451
Processable aqueous dispersions of graphene nanosheets.
Dan Li (2008)
10.1021/nn900215k
Multifunctional nanoparticles for combined doxorubicin and photothermal treatments.
Huiyul Park (2009)
10.1038/nnano.2009.294
A route to brightly fluorescent carbon nanotubes for near-infrared imaging in mice.
Kevin Welsher (2009)
10.1016/J.CPLETT.2009.10.066
UV-reduction of graphene oxide and its application as an interfacial layer to reduce the back-transport reactions in dye-sensitized solar cells
S. Kim (2009)
10.1038/nprot.2009.146
Preparation of carbon nanotube bioconjugates for biomedical applications
Zhuang Liu (2009)
10.1007/s12274-010-0045-1
High performance in vivo near-IR (>1 μm) imaging and photothermal cancer therapy with carbon nanotubes
J. Robinson (2010)
10.1021/nn900368b
Increased Heating Efficiency and Selective Thermal Ablation of Malignant Tissue with DNA-Encased Multiwalled Carbon Nanotubes
Supratim Ghosh (2009)
10.1021/ja105296a
Mn3O4-graphene hybrid as a high-capacity anode material for lithium ion batteries.
H. Wang (2010)
10.1038/nbt872
The 'right' size in nanobiotechnology
G. Whitesides (2003)
10.1021/ja102267j
Ni(OH)2 nanoplates grown on graphene as advanced electrochemical pseudocapacitor materials.
H. Wang (2010)
10.1021/ja809086q
PEG branched polymer for functionalization of nanomaterials with ultralong blood circulation.
G. Prencipe (2009)
10.1002/smll.200901934
Graphene oxide, highly reduced graphene oxide, and graphene: versatile building blocks for carbon-based materials.
Owen C. Compton (2010)
10.1016/S1369-7021(10)70031-6
Seeing graphene-based sheets
J. Kim (2010)
10.1038/nmat2858
Unusual infrared-absorption mechanism in thermally reduced graphene oxide.
M. Acik (2010)
10.1007/S12274-008-8021-8
Nano-graphene oxide for cellular imaging and drug delivery
X. Sun (2008)
10.1002/anie.201004497
Amphiphilic graphene composites.
Xiaoying Qi (2010)
10.1016/j.canlet.2008.04.026
Gold nanorod assisted near-infrared plasmonic photothermal therapy (PPTT) of squamous cell carcinoma in mice.
E. Dickerson (2008)
10.1007/S12274-009-9031-X
Chemical self-assembly of graphene sheets
Hailiang Wang (2009)
10.1021/nl100996u
Graphene in mice: ultrahigh in vivo tumor uptake and efficient photothermal therapy.
K. Yang (2010)
10.1021/nl8013007
Reduced graphene oxide molecular sensors.
J. Robinson (2008)
10.1201/9781420011838
An Introduction to Biomedical Optics
R. Splinter (2006)
10.1021/ja904251p
Solvothermal reduction of chemically exfoliated graphene sheets.
H. Wang (2009)
10.1007/S12274-010-0033-5
TiO2 nanocrystals grown on graphene as advanced photocatalytic hybrid materials
Yongye Liang (2010)



This paper is referenced by
10.7150/thno.40068
Graphene and other 2D materials: a multidisciplinary analysis to uncover the hidden potential as cancer theranostics
L. Fusco (2020)
10.1021/nn506516p
Amplified photoacoustic performance and enhanced photothermal stability of reduced graphene oxide coated gold nanorods for sensitive photoacoustic imaging.
Hyungwon Moon (2015)
10.1039/c2cs15260f
The unique role of nanoparticles in nanomedicine: imaging, drug delivery and therapy.
T. Doane (2012)
10.1002/smll.201203106
Graphene nanomesh promises extremely efficient in vivo photothermal therapy.
O. Akhavan (2013)
10.1002/adhm.201300550
Graphene-based patterning and differentiation of C2C12 myoblasts.
P. Bajaj (2014)
10.1016/J.CPLETT.2016.02.056
Enhanced photothermal effect of surface oxidized silicon nanocrystals anchored to reduced graphene oxide nanosheets
Parichehr Afshani (2016)
10.1002/adma.201205292
In vivo bio-safety evaluations and diagnostic/therapeutic applications of chemically designed mesoporous silica nanoparticles.
Y. Chen (2013)
10.1002/JRS.4142
pH‐dependent surface‐enhanced Raman scattering of aromatic molecules on graphene oxide
Z. Liu (2013)
10.1021/nl401088b
Light-controlled graphene-elastin composite hydrogel actuators.
Eddie Wang (2013)
10.1021/am406031n
Golden single-walled carbon nanotubes prepared using double layer polysaccharides bridge for photothermal therapy.
L. Meng (2014)
10.1016/J.JIEC.2019.07.031
Enhancing therapeutic efficacy of photothermal therapy using poloxamer-reduced graphene oxide and mesenchymal stem cells
J. H. Park (2019)
10.1021/jacs.7b07818
A Two-Dimensional Biodegradable Niobium Carbide (MXene) for Photothermal Tumor Eradication in NIR-I and NIR-II Biowindows.
H. Lin (2017)
10.1016/j.msec.2017.05.131
Construction of ICG encapsulated W18O49@MSN as a fluorescence carrier for real-time tracked photothermal therapy.
Huiquan Wang (2017)
10.1088/2053-1591/1/4/045007
Facile fabrication of graphene oxide loaded with silver nanoparticles as antifungal materials
J. Cui (2014)
10.1038/srep31427
Mitochondria-Mediated Protein Regulation Mechanism of Polymorphs-Dependent Inhibition of Nanoselenium on Cancer Cells
Ge Wang (2016)
10.1039/c5nr06501a
Rational assembly of a biointerfaced core@shell nanocomplex towards selective and highly efficient synergistic photothermal/photodynamic therapy.
Chenchen Qin (2015)
10.1002/adma.201502777
A Graphene-Based Bimorph Structure for Design of High Performance Photoactuators.
Ying Hu (2015)
10.1002/anie.201506154
Ultrasmall Black Phosphorus Quantum Dots: Synthesis and Use as Photothermal Agents.
Zhengbo Sun (2015)
10.1021/acs.chemrev.5b00396
Copper-Mediated Living Radical Polymerization (Atom Transfer Radical Polymerization and Copper(0) Mediated Polymerization): From Fundamentals to Bioapplications.
C. Boyer (2016)
10.1021/am505084s
In vitro hemocompatibility and toxic mechanism of graphene oxide on human peripheral blood T lymphocytes and serum albumin.
Zhijia Ding (2014)
10.1021/bc500332c
Surface Engineering of Graphene-Based Nanomaterials for Biomedical Applications
Sixiang Shi (2014)
10.1016/B978-0-323-47906-6.00003-5
Application of Carbon-Based Nanomaterials as Biosensor
S. C. Ray (2017)
10.1021/am500254e
Strong and Selective Adsorption of Lysozyme on Graphene Oxide
Shanghao Li (2014)
10.1007/978-3-030-62761-4_7
Two-Dimensional Transition Metal Carbides and Nitrides (MXenes): Synthesis to Applications
Muhammad Zahir Iqbal (2021)
10.1039/d0nr03771k
A thieno-isoindigo derivative-based conjugated polymer nanoparticle for photothermal therapy in the NIR-II bio-window.
Zuwu Wei (2020)
10.1021/am508476d
Silicon phthalocyanine covalently functionalized N-doped ultrasmall reduced graphene oxide decorated with Pt nanoparticles for hydrogen evolution from water.
J. Huang (2015)
10.1002/ADFM.201900318
Recent Advances on Black Phosphorus for Biomedicine and Biosensing
Xiaoxiao Ge (2019)
10.1002/adma.201502422
Two-Dimensional Nanomaterials for Biomedical Applications: Emerging Trends and Future Prospects.
David Chimene (2015)
10.1039/C7TB02853A
Design and fabrication of nanofibrillated cellulose-containing bilayer hydrogel actuators with temperature and near infrared laser responses.
Qian Zhao (2018)
10.1016/j.mtadv.2019.100049
Nanoparticle-based photodynamic therapy: new trends in wound healing applications
G. Cheng (2020)
10.1002/SOLR.201600032
Highly Efficient Solar-Driven Photothermal Performance in Au-Carbon Core-Shell Nanospheres
Z. Gan (2017)
10.1002/chem.201701916
A Target-Directed Chemo-Photothermal System Based on Transferrin and Copolymer-Modified MoS2 Nanoplates with pH-Activated Drug Release.
Aitang Zhang (2017)
See more
Semantic Scholar Logo Some data provided by SemanticScholar