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Regioselective Iridium-Catalyzed Asymmetric Monohydrogenation Of 1,4-Dienes.

J. Liu, Suppachai Krajangsri, T. Singh, Giulia De Seriis, N. Chumnanvej, H. Wu, P. Andersson
Published 2017 · Chemistry, Medicine

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A highly efficient regio- and enantioselective monohydrogenation of 1,4-dienes has been realized using an iridium catalyst with a chiral N,P-ligand under mild conditions. The substrate scope was studied and included both unfunctionalized as well as functionalized substituents on the meta- or para-position. Substrates having substituents with functionalities such as silyl protected alcohols or ketals were monohydrogenated in high regioselectivity and high enantiomeric excess (up to 98% ee).
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