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Palladium-catalyzed Z-selective Oxidative Amination Of Ortho-substituted Primary Anilines With Olefins Under An Open Air Atmosphere.

Yohei Mizuta, K. Yasuda, Y. Obora
Published 2013 · Chemistry, Medicine

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The Pd-catalyzed oxidative amination of olefins with primary anilines has been achieved using molecular dioxygen as the sole oxidant. The use of ortho-substituted primary anilines such as ortho-toluidine was the key to the successful development of this reaction, providing the corresponding N-alkenyl substituted anilines in high yields with unusually high levels of Z-selectivity.
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