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Metal-free [3 + 2 + 1]/[2 + 2 + 1] Biscyclization: Stereospecific Construction With Concomitant Functionalization Of Indolizin-5(1H)-one.

Tuanjie Li, Zhong-Qiu Liu, Hongmei Yin, C. Yao, B. Jiang, Xiang-Shan Wang, Shu-Jiang Tu, Xiu-ling Li, Guigen Li
Published 2013 · Chemistry, Medicine

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A metal-free [3 + 2 + 1]/[2 + 2 + 1] biscyclization strategy has been developed for the stereospecific construction with concomitant derivation of biologically significant indolizin-5(1H)-ones from simple and commercial starting materials. The transformations are notable because they can yield five new σ bonds and six stereocenters including a quaternary carbon center in a single operation.
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