← Back to Search
An Efficient Route To Acyclic C-nucleosides And Fused-ring Analogues Of Uridine From Exo-glycals.
Published 2009 · Chemistry, Medicine
Beta-amino esters prepared from activated exo-glycals are transformed into acyclic C-nucleoside with a C-4-substituted uracil derivative that can be cyclized under Mitsunobu conditions to provide a new family of fused-ring analogues of uridine nucleoside in which the N-1 nitrogen atom is embedded in an imino sugar ring. An analogue of uridine of D-ribo configuration is prepared.