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An Efficient Route To Acyclic C-nucleosides And Fused-ring Analogues Of Uridine From Exo-glycals.

Gérald Enderlin, C. Taillefumier, C. Didierjean, Y. Chapleur
Published 2009 · Chemistry, Medicine

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Beta-amino esters prepared from activated exo-glycals are transformed into acyclic C-nucleoside with a C-4-substituted uracil derivative that can be cyclized under Mitsunobu conditions to provide a new family of fused-ring analogues of uridine nucleoside in which the N-1 nitrogen atom is embedded in an imino sugar ring. An analogue of uridine of D-ribo configuration is prepared.

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