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Catechol Chemistry Inspired Approach To Construct Self-cross-linked Polymer Nanolayers As Versatile Biointerfaces.
Xinyue Liu, J. Deng, Lang Ma, Chong Cheng, Chuanxiong Nie, Chao He, Changsheng Zhao
Published 2014 · Chemistry, Medicine
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In this study, we proposed a catechol chemistry inspired approach to construct surface self-cross-linked polymer nanolayers for the design of versatile biointerfaces. Several representative biofunctional polymers, P(SS-co-AA), P(SBMA-co-AA), P(EGMA-co-AA), P(VP-co-AA), and P(MTAC-co-AA), were first synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization, and then the catecholic molecules (dopamine, DA) were conjugated to the acrylic acid (AA) units by the facile carbodiimide chemistry. Then, the catechol (Cat) group conjugated biofunctional polymers, named PSS-Cat, PSBMA-Cat, PEGMA-Cat, PVP-Cat, and PMTAC-Cat, were applied for the construction of self-cross-linked nanolayers on polymeric substrates via the pH induced catechol cross-linking and immobilization. The XPS spectra, surface morphology, and wettability gave robust evidence that the catechol conjugated polymers were successfully coated, and the coated substrates possessed increased surface roughness and hydrophilicity. Furthermore, the systematic in vitro investigation of protein adsorption, platelet adhesion, activated partial thromboplastin time (APTT), thrombin time (TT), cell viability, and antibacterial ability confirmed that the coated nanolayers conferred the substrates with versatile biological performances. The PSS-Cat coated substrate had low blood component activation and excellent anticoagulant activity; while the PEGMA-Cat and PSBMA-Cat showed ideal resistance to protein fouling and inhibition of platelet activation. The PSS-Cat and PVP-Cat coated substrates exhibited promoted endothelial cell proliferation and viability. The PMTAC-Cat coated substrate showed an outstanding activity on bacterial inhibition. In conclusion, the catechol chemistry inspired approach allows the self-cross-linked nanolayers to be easily immobilized on polymeric substrates with the stable conformation and multiple biofunctionalities. It is expected that this low-cost and facile bioinspired coating system will present great potential in creating novel and versatile biointerfaces.
This paper references
Engineering the regenerative microenvironment with biomaterials.
J. J. Rice (2013)
Anti-adhesive coating and clearance of device associated uropathogenic Escherichia coli cystitis.
Andrea Pechey (2009)
Multifunctional silk-heparin biomaterials for vascular tissue engineering applications.
F. P. Seib (2014)
One-step modification of superhydrophobic surfaces by a mussel-inspired polymer coating.
S. M. Kang (2010)
Dopamine-Mediated Continuous Assembly of Biodegradable Capsules
Christopher J. Ochs (2011)
Regime to a Coarse-Grained Regime on Osteoblast Functions Using a Novel Metal DeformationAnnealing Sequence
F. Ran (2013)
The Contribution of DOPA to Substrate-Peptide Adhesion and Internal Cohesion of Mussel-Inspired Synthetic Peptide Films.
T. Anderson (2010)
Functionalized Biomedical Membranes
R. Mammadov (2011)
Infection resistance of degradable versus non-degradable biomaterials: an assessment of the potential mechanisms.
S. Daghighi (2013)
General and biomimetic approach to biopolymer-functionalized graphene oxide nanosheet through adhesive dopamine.
Chong Cheng (2012)
Single-molecule mechanics of mussel adhesion
H. Lee (2006)
A Functional DNase I Coating to Prevent Adhesion of Bacteria and the Formation of Biofilm
J. J. T. M. Swartjes (2013)
Adsorption and Cell Adhesion Using Well-Defined Mixed Self-Assembled Monolayers
G. Li (2007)
One-step dip coating of zwitterionic sulfobetaine polymers on hydrophobic and hydrophilic surfaces.
Harihara S. Sundaram (2014)
Evaluation of blood compatibility of plasma deposited heparin-like films and SF6 plasma treated surfaces
Ivanira Antunes Perrenoud (2010)
Modification of polyethersulfone membranes – A review of methods
Changsheng Zhao (2013)
A universal approach to crosslinked hierarchical polymer multilayers as stable and highly effective antifouling coatings.
Q. Wei (2014)
Cationic antiseptics: diversity of action under a common epithet
P. Gilbert (2005)
Heparin mimetic peptide nanofibers promote angiogenesis.
R. Mammadov (2011)
Ultra low fouling zwitterionic polymers with a biomimetic adhesive group.
Guozhu Li (2008)
Polydopamine and its derivative materials: synthesis and promising applications in energy, environmental, and biomedical fields.
Yanlan Liu (2014)
Mussel-Inspired Surface Chemistry for Multifunctional Coatings
H. Lee (2007)
Controlled release of paclitaxel from heparinized metal stent fabricated by layer-by-layer assembly of polylysine and hyaluronic acid-g-poly(lactic-co-glycolic acid) micelles encapsulating paclitaxel.
T. Kim (2009)
Osteoblast functions on functionalized PMMA-based polymers exhibiting Staphylococcus aureus adhesion inhibition.
F. Anagnostou (2006)
Ultra-low fouling and functionalizable zwitterionic coatings grafted onto SiO2 via a biomimetic adhesive group for sensing and detection in complex media.
Norman D. Brault (2010)
Immobilization of amphiphilic polycations by catechol functionality for antimicrobial coatings.
H. Han (2011)
Single molecule evidence for the adaptive binding of DOPA to different wet surfaces.
Yiran Li (2014)
Effect of wettability and surface functional groups on protein adsorption and cell adhesion using well-defined mixed self-assembled monolayers.
Yusuke Arima (2007)
Progress in heparin and heparin-like/mimicking polymer-functionalized biomedical membranes.
Chong Cheng (2014)
Mussel-inspired self-coating at macro-interface with improved biocompatibility and bioactivity via dopamine grafted heparin-like polymers and heparin.
Lang Ma (2014)
Biopolymer functionalized reduced graphene oxide with enhanced biocompatibility via mussel inspired coatings/anchors.
Chong Cheng (2013)
Biomaterial-associated thrombosis: roles of coagulation factors, complement, platelets and leukocytes.
M. Gorbet (2004)
Progressive Macromolecular Self‐Assembly: From Biomimetic Chemistry to Bio‐Inspired Materials
Y. Zhao (2013)
Surface Complexation at the TiO(2) (anatase)/Aqueous Solution Interface: Chemisorption of Catechol.
Surface characteristics of a self-polymerized dopamine coating deposited on hydrophobic polymer films.
Jinhong Jiang (2011)
Bioinspired catecholic chemistry for surface modification.
Q. Ye (2011)
Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering
M. Lutolf (2005)
A Survey of Structure−Property Relationships of Surfaces that Resist the Adsorption of Protein
E. Ostuni (2001)
Current progress in Reactive Oxygen Species (ROS)-Responsive materials for biomedical applications.
S. Lee (2013)
Heparin-like macromolecules for the modification of anticoagulant biomaterials.
F. Ran (2012)
Multivalent anchoring and cross-linking of mussel-inspired antifouling surface coatings.
Q. Wei (2014)
Catechol-Modified Polyions in Layer-by-Layer Assembly to Enhance Stability and Sustain Release of Biomolecules: A Bioinspired Approach
Y. Min (2011)
Poly(DL-lactic acid) film surface modification with heparin for improving hemocompatibility of blood-contacting bioresorbable devices.
T. Sharkawi (2011)
Microbial adhesion to poly(ethylene oxide) brushes: influence of polymer chain length and temperature.
A. Roosjen (2004)
Inhibition of bacterial adhesion and biofilm formation on zwitterionic surfaces.
G. Cheng (2007)
Protein interactions with polymer coatings and biomaterials.
Q. Wei (2014)
Enhancement of blood compatibility of poly(urethane) substrates by mussel-inspired adhesive heparin coating.
Inseong You (2011)
Understanding the impact of grain structure in austenitic stainless steel from a nanograined regime to a coarse-grained regime on osteoblast functions using a novel metal deformation-annealing sequence.
R. Misra (2013)
Towards antibiofouling ultrafiltration membranes by blending silver containing surface modifying macromolecules.
Yekyung Kim (2012)
Mussel-inspired chemistry for robust and surface-modifiable multilayer films.
J. Wu (2011)
Catechol-grafted poly(ethylene glycol) for PEGylation on versatile substrates.
H. Lee (2010)
Heparin conjugated polylactide as a blood compatible material.
K. S. Jee (2004)
Polydopamine--a nature-inspired polymer coating for biomedical science.
Martin E. Lynge (2011)
Self-assembled 3D biocompatible and bioactive layer at the macro-interface via graphene-based supermolecules
Hongju Zhou (2014)
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Positively-charged polyethersulfone nanofibrous membranes for bacteria and anionic dyes removal.
Chunyan Lv (2019)
Synthesis and stability against oxidation of random brush copolymers carrying PEO side chains and catechol moieties
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Surface-initiated PET-ATRP and mussel-inspired chemistry for surface engineering of MWCNTs and application in self-healing nanocomposite hydrogels.
X. Jiang (2020)
Construction of microgels embedded robust ultrafiltration membranes for highly effective bioadhesion resistance.
Yi Xia (2016)
Silicone rubber with mussel-inspired adhesive coatings for enhancing antifouling property and blood compatibility
Y. Cho (2017)
Ceramic membranes with mussel-inspired and nanostructured coatings for water-in-oil emulsions separation
Nengwen Gao (2019)
Bio-inspired multifunctional catecholic assembly for photo-programmable biointerface.
C. Huang (2015)
Hemocompatible magnetic particles with broad-spectrum bacteria capture capability for blood purification.
Zhenqiang Shi (2020)
Advanced Surfaces by Anchoring Thin Hydrogel Layers of Functional Polymers
Farzad Seidi (2020)
Antifouling Coatings of Catecholamine Copolymers on Stainless Steel
L. Xu (2015)
pH-Dependent Ordered Fibrinogen Adsorption on Polyethylene Single Crystals.
Christian Helbing (2016)
Effect of plant-based catecholic molecules on the prevention and eradication of Escherichia coli biofilms: a structure activity relationship study
J. Baptista (2019)
One-pot cross-linked copolymerization for the construction of robust antifouling and antibacterial composite membranes.
Chong Cheng (2015)
Tea Stains-Inspired Antifouling Coatings Based on Tannic Acid-Functionalized Agarose
L. Xu (2017)
Recent developments in polydopamine: an emerging soft matter for surface modification and biomedical applications.
Meiying Liu (2016)
bFGF and Poly-RGD Cooperatively Establish Biointerface for Stem Cell Adhesion, Proliferation, and Differentiation
N. Jiang (2018)
Characterization and antifouling properties of polyethylene glycol doped PAN–CAP blend membrane
Mrinmoy Mondal (2015)
Towards development of a versatile and efficient strategy for fabrication of GO based polymer nanocomposites
Q. Wan (2015)
Surface-Initiated ARGET ATRP of Poly(Glycidyl Methacrylate) from Carbon Nanotubes via Bioinspired Catechol Chemistry for Efficient Adsorption of Uranium Ions
Y. Song (2016)
Antibacterial hydrogel coating: Strategies in surface chemistry.
Changwen Zhao (2020)
LCST-type thermoresponsive behaviour of interpolymer complexes of well-defined poly(poly(ethylene glycol) methacrylate)s and poly(acrylic acid) synthesized by ATRP
Ákos Szabó (2017)
Versatile and Rapid Postfunctionalization from Cyclodextrin Modified Host Polymeric Membrane Substrate.
J. Deng (2015)
Controlled Architecture of Dual-Functional Block Copolymer Brushes on Thin-Film Composite Membranes for Integrated "Defending" and "Attacking" Strategies against Biofouling.
Gang Ye (2015)
Dynamic Covalent Bond‐Assisted Anchor of PEG Brushes on Cationic Surfaces with Antibacterial and Antithrombotic Dual Capabilities
J. Deng (2016)
Antifouling Coatings via Tethering of Hyperbranched Polyglycerols on Biomimetic Anchors
Dicky Pranantyo (2016)
Engineering of hemocompatible and antifouling polyethersulfone membranes by blending with heparin-mimicking microgels.
H. Ji (2017)
Highly Stable, Protein-Resistant Surfaces via the Layer-by-Layer Assembly of Poly(sulfobetaine methacrylate) and Tannic Acid.
Peng-fei Ren (2015)
Anionic Polymerization of Vinylcatechol Derivatives: Reversal of the Monomer Gradient Directed by the Position of the Catechol Moiety in the Copolymerization with Styrene
Daniel Leibig (2016)
Capitalizing on Protecting Groups to Influence Vinyl Catechol Monomer Reactivity and Monomer Gradient in Carbanionic Copolymerization
Daniel Leibig (2017)
Enhanced Cell Adhesion on a Nano-Embossed, Sticky Surface Prepared by the Printing of a DOPA-Bolaamphiphile Assembly Ink
Chaemyeong Lee (2017)
Self‐Healable Materials for Underwater Applications
T. Huynh (2019)
Synthesis of catechol and zwitterion-bifunctionalized poly(ethylene glycol) for the construction of antifouling surfaces
L. Xu (2016)See more