← Back to Search
In Vivo Tumor Targeting And Image-guided Drug Delivery With Antibody-conjugated, Radiolabeled Mesoporous Silica Nanoparticles.
F. Chen, Hao Hong, Yin Zhang, H. Valdovinos, Sixiang Shi, G. Kwon, C. Theuer, T. Barnhart, W. Cai
Published 2013 · Materials Science, Medicine
Save to my Library
Download PDFAnalyze on Scholarcy
Since the first use of biocompatible mesoporous silica (mSiO2) nanoparticles as drug delivery vehicles, in vivo tumor targeted imaging and enhanced anticancer drug delivery has remained a major challenge. In this work, we describe the development of functionalized mSiO2 nanoparticles for actively targeted positron emission tomography (PET) imaging and drug delivery in 4T1 murine breast tumor-bearing mice. Our structural design involves the synthesis, surface functionalization with thiol groups, PEGylation, TRC105 antibody (specific for CD105/endoglin) conjugation, and (64)Cu-labeling of uniform 80 nm sized mSiO2 nanoparticles. Systematic in vivo tumor targeting studies clearly demonstrated that (64)Cu-NOTA-mSiO2-PEG-TRC105 could accumulate prominently at the 4T1 tumor site via both the enhanced permeability and retention effect and TRC105-mediated binding to tumor vasculature CD105. As a proof-of-concept, we also demonstrated successful enhanced tumor targeted delivery of doxorubicin (DOX) in 4T1 tumor-bearing mice after intravenous injection of DOX-loaded NOTA-mSiO2-PEG-TRC105, which holds great potential for future image-guided drug delivery and targeted cancer therapy.
This paper references
Surface charge-mediated rapid hepatobiliary excretion of mesoporous silica nanoparticles.
Jeffrey S. Souris (2010)
Monodisperse magnetic nanoparticles for theranostic applications.
Don N. Ho (2011)
Multifunctional unimolecular micelles for cancer-targeted drug delivery and positron emission tomography imaging.
Yuling Xiao (2012)
Use of size and a copolymer design feature to improve the biodistribution and the enhanced permeability and retention effect of doxorubicin-loaded mesoporous silica nanoparticles in a murine xenograft tumor model.
Huan Meng (2011)
A uniform sub-50 nm-sized magnetic/upconversion fluorescent bimodal imaging agent capable of generating singlet oxygen by using a 980 nm laser.
Feng Chen (2012)
PET radiopharmaceuticals for probing enzymes in the brain.
J. Holland (2013)
Positive and negative lattice shielding effects co-existing in Gd (III) ion doped bifunctional upconversion nanoprobes
F. Chen (2011)
In vivo study of biodistribution and urinary excretion of surface-modified silica nanoparticles.
X. He (2008)
Molecular imaging and therapy of cancer with radiolabeled nanoparticles.
Hao Hong (2009)
Targeting gold nanoshells on silica nanorattles: a drug cocktail to fight breast tumors via a single irradiation with near-infrared laser light.
H. Liu (2012)
HaloTag as a reporter gene: positron emission tomography imaging with (64)Cu-labeled second generation HaloTag ligands.
Hao Hong (2013)
Synthesis of biomolecule-modified mesoporous silica nanoparticles for targeted hydrophobic drug delivery to cancer cells.
D. Ferris (2011)
Nuclear-targeted drug delivery of TAT peptide-conjugated monodisperse mesoporous silica nanoparticles.
Limin Pan (2012)
In vivo targeting and positron emission tomography imaging of tumor vasculature with (66)Ga-labeled nano-graphene.
Hao Hong (2012)
An efficient cell-targeting and intracellular controlled-release drug delivery system based on MSN-PEM-aptamer conjugates
C. Zhu (2009)
X. Chen (2011)
In vivo biodistribution of nanoparticles.
Joao Paulo Mattos Almeida (2011)
Endoglin (CD105): A Marker of Tumor Vasculature and Potential Target for Therapy
N. Dallas (2008)
Angiogenesis in cancer, vascular, rheumatoid and other disease
J. Folkman (1995)
Monoclonal antibody-functionalized mesoporous silica nanoparticles (MSN) for selective targeting breast cancer cells
Chih-Pin Tsai (2009)
In vivo biodistribution and clearance studies using multimodal organically modified silica nanoparticles.
R. Kumar (2010)
Molecular imaging probe development: a chemistry perspective.
Donald D. Nolting (2012)
Positron Emission Tomography and Near-Infrared Fluorescence Imaging of Vascular Endothelial Growth Factor with Dual-Labeled Bevacizumab.
Yin Zhang (2012)
Uniform mesoporous dye-doped silica nanoparticles decorated with multiple magnetite nanocrystals for simultaneous enhanced magnetic resonance imaging, fluorescence imaging, and drug delivery.
J. Lee (2010)
Endoglin-targeted cancer therapy.
B. Seon (2011)
In vivo targeting and imaging of tumor vasculature with radiolabeled, antibody-conjugated nanographene.
Hao Hong (2012)
Biocompatibility, biodistribution, and drug-delivery efficiency of mesoporous silica nanoparticles for cancer therapy in animals.
J. Lu (2010)
Nanoparticle therapeutics: an emerging treatment modality for cancer
M. Davis (2008)
Mesoporous silica nanoparticle nanocarriers: biofunctionality and biocompatibility.
Derrick Tarn (2013)
Gold nanocages: from synthesis to theranostic applications.
Y. Xia (2011)
Functionalized mesoporous silica materials for controlled drug delivery.
P. Yang (2012)
Positron emission tomography imaging of CD105 expression during tumor angiogenesis
Hao Hong (2011)
Nano-Graphene in Biomedicine: Theranostic Applications
K. Yang (2013)
Targeting cancer vasculature via endoglin/CD105: a novel antibody-based diagnostic and therapeutic strategy in solid tumours.
E. Fonsatti (2010)
Tumor vasculature targeting and imaging in living mice with reduced graphene oxide.
Sixiang Shi (2013)
Multifunctional mesoporous silica nanocomposite nanoparticles for theranostic applications.
J. Lee (2011)
Angiogenesis: Tumorigenesis and the angiogenic switch
G. Bergers (2003)
Positron emission tomography imaging of CD105 expression with 89Zr-Df-TRC105
Hao Hong (2011)
A Phase I First-in-Human Study of TRC105 (Anti-Endoglin Antibody) in Patients with Advanced Cancer
L. Rosen (2012)
The absorption, distribution, excretion and toxicity of mesoporous silica nanoparticles in mice following different exposure routes.
Changhui Fu (2013)
In vivo tumor suppression efficacy of mesoporous silica nanoparticles-based drug-delivery system: enhanced efficacy by folate modification.
J. Lu (2012)
Theranostic nanomedicine with functional nanoarchitecture.
D. Pan (2013)
Nano-Carbons as Theranostics
Zhuang Liu (2012)
Multimodality Imaging of Breast Cancer Experimental Lung Metastasis with Bioluminescence and a Monoclonal Antibody DualLabeled with 89
H. Hong (2012)
Targeting of porous hybrid silica nanoparticles to cancer cells.
J. Rosenholm (2009)
Preparation of pH-Responsive Mesoporous Silica Nanoparticles and Their Application in Controlled Drug Delivery
L. Yuan (2011)
Nano-graphene in biomedicine: theranostic applications.
K. Yang (2013)
Multifunctional uniform nanoparticles composed of a magnetite nanocrystal core and a mesoporous silica shell for magnetic resonance and fluorescence imaging and for drug delivery.
J. Kim (2008)
Influence of geometry, porosity, and surface characteristics of silica nanoparticles on acute toxicity: their vasculature effect and tolerance threshold.
T. Yu (2012)
Odyssey of a cancer nanoparticle: from injection site to site of action.
Joseph W. Nichols (2012)
Multimodality imaging of breast cancer experimental lung metastasis with bioluminescence and a monoclonal antibody dual-labeled with 89Zr and IRDye 800CW.
Hao Hong (2012)
This paper is referenced by
Biodegradable Hollow Mesoporous Organosilica Nanotheranostics for Mild Hyperthermia-Induced Bubble-Enhanced Oxygen-Sensitized Radiotherapy.
N. Lu (2018)
Development and characterization of targeted MART-1-nanoparticles for melanoma treatment and β-lapachone-loaded liposomal in hydrogel for wound healing
Sarah Brandão Palácio (2017)
Understanding the Connection between Nanoparticle Uptake and Cancer Treatment Efficacy using Mathematical Modeling
T. Brocato (2018)
Mechanically Tunable Hollow Silica Ultrathin Nanoshells for Ultrasound Contrast Agents.
Alex Liberman (2015)
Theranostic nanomedicine for cancer detection and treatment 5
Zhiping Fan ()
Selective Photokilling of Human Pancreatic Cancer Cells Using Cetuximab-Targeted Mesoporous Silica Nanoparticles for Delivery of Zinc Phthalocyanine
Özge Er (2018)
Smart Mesoporous Silica Nanoparticles for Protein Delivery
Hai-jun Liu (2019)
FeSe2-Decorated Bi2Se3 Nanosheets Fabricated via Cation Exchange for Chelator-Free 64Cu-labeling and Multimodal Image-Guided Photothermal-Radiation Therapy.
Liang Cheng (2016)
Nanoparticles for Diagnostics and Imaging
M. Larguinho (2015)
Tumor Theranostics of Transition Metal Ions Loaded Polyaminopyrrole Nanoparticles
Shu-yao Li (2018)
Light‐Activatable Assembled Nanoparticles to Improve Tumor Penetration and Eradicate Metastasis in Triple Negative Breast Cancer
Jianfeng Ji (2018)
In Vivo Tumor Vasculature Targeting of CuS@MSN Based Theranostic Nanomedicine
F. Chen (2015)
Recent advances in photodynamic therapy for cancer and infectious diseases.
Xutong Shi (2019)
A champagne inspired dual chain-responsive thrombolytic drug release platform based on black phosphorus nanosheets for accelerated thrombolysis
X. Ding (2019)
A targeted approach to cancer imaging and therapy.
Chun Xing Li (2014)
Targeting strategies for improving the efficacy of nanomedicine in oncology
Gonzalo Villaverde (2019)
Two-dimensional magnetic WS2@Fe3O4 nanocomposite with mesoporous silica coating for drug delivery and imaging-guided therapy of cancer.
Guangbao Yang (2015)
Thiol-ene click hydrogels for therapeutic delivery.
Prathamesh M Kharkar (2016)
Quantification of endocytosis using a folate functionalized silica hollow nanoshell platform
S. Sandoval (2015)
Advances in Peptide Functionalization on Mesoporous Silica Nanoparticles for Controlled Drug Release.
Jing-jing Hu (2016)
Multifunctional Mesoporous/Hollow Silica for Cancer Nanotheranostics
H. Liu (2016)
A 89Zr-labeled lipoplex nanosystem for image-guided gene delivery: design, evaluation of stability and in vivo behavior
I. Hajdú (2018)
Field Guide to Challenges and Opportunities in Antibody-Drug Conjugates for Chemists.
Mallory R Gordon (2015)
Current Approaches for Improving Intratumoral Accumulation and Distribution of Nanomedicines
M. Durymanov (2015)
Hybrid Particles: Conjugation of Biomolecules to Nanomaterials
N. Knežević (2017)
Doxorubicin-loaded NaYF4:Yb/Tm-TiO2 inorganic photosensitizers for NIR-triggered photodynamic therapy and enhanced chemotherapy in drug-resistant breast cancers.
Leyong Zeng (2015)
Image-guided nanomedicine for cancer
J. Choi (2016)
Hierarchical bioresponsive nanocarriers for codelivery of curcumin and doxorubicin.
Jian-tao Lin (2019)
Biocomposites from Nanoparticles
C. Aimé (2017)
Serum Protein Adsorption Enhances Active Leukemia Stem Cell Targeting of Mesoporous Silica Nanoparticles.
Michaela Beck (2017)
Nanoparticle Functionalization and Its Potentials for Molecular Imaging
R. Thiruppathi (2017)
Antibody-drug conjugates for cancer therapy: The technological and regulatory challenges of developing drug-biologic hybrids.
G. S. Hamilton (2015)See more