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Acetylcholinesterase Inhibition By Territrem B Derivatives.
Published 1995 · Biology, Medicine
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Five derivatives of territrem B , a potent acetylcholinesterase inhibitor isolated from a rice culture of Aspergillus terreus, were prepared from 2 as well as from its major metabolite, 4 beta-hydroxymethyl-4 beta-demethylterritrem B . The inhibitory activities of these derivatives against electric eel acetylcholinesterase (E.C. 188.8.131.52) were tested and it was concluded that the enone and the pyrone groups present in 2 may play an important biological role.
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