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Asymmetric Total Synthesis Of Clavolonine.

K. Nakahara, Kie Hirano, Ryota Maehata, Yasuyuki Kita, H. Fujioka
Published 2011 · Chemistry, Medicine

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The asymmetric total synthesis of clavolonine (1) has been achieved based on chiral auxiliary multiple-use methodology. Our synthetic route features stereoselective transformations on the cyclohexane ring utilizing the steric environment of the chiral auxiliary and an intramolecular Mannich reaction to construct the fused ring system.
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