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Nickel-catalyzed Highly Regioselective Multicomponent Coupling Of Ynamides, Aldehydes, And Silane: A New Access To Functionalized Enamides.

Nozomi Saito, T. Katayama, Yoshihiro Sato
Published 2008 · Chemistry, Medicine

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A new method for preparation of functionalized enamides by a nickel-catalyzed multicomponent coupling of ynamides, aldehydes, and silane has been developed. The coupling reaction proceeded in the presence of a nickel-IMes catalyst to give the corresponding gamma-silyloxyenamide derivative, which has an allylic alcohol moiety in the molecule, in a highly stereoselective manner.



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