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Microwave-assisted Synthesis Of 2'-O-aryluridine Derivatives.
Yusuke Oeda, Yoshihiro Iijima, H. Taguchi, A. Ohkubo, K. Seio, M. Sekine
Published 2009 · Chemistry, Medicine
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A new method for the synthesis of 2'-O-aryluridines was developed via the microwave-mediated reaction of 2,2'-anhydrouridine with aromatic alcohols. Aminophenol and aminonaphthol derivatives underwent selective 2'-O-arylation with 2,2'-anhydrouridine to produce 2'-O-(aminoaryl)uridine derivatives. These reactions proved to proceed without the need for any bases or solvents, but better results were obtained by use of N,N-dimethylacetamide (DMA) as the solvent in some cases.
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