Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

Photochemoprevention Of Skin Cancer By Botanical Agents

S. F'guyer, F. Afaq, H. Mukhtar
Published 2003 · Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
Photochemoprevention has become an important armamentarium in the fight against ultraviolet radiation (UVR)‐induced damage to the skin. Among many UVR‐induced damages, skin cancer is of the greatest concern as its rates have been steadily increasing in recent years and the same trend is expected to continue in the future. Ultraviolet radiation increases oxidative stress in skin cells by causing excessive generation of reactive oxygen species (ROS), leading to cancer initiation and promotion. Antioxidants have the capability to quench these ROS and much recent work shows that some of these can inhibit many UVR‐induced signal transduction pathways. Thus, identifying nontoxic strong antioxidants – capable of preventing UVR‐induced skin cancer – has become an important area of research. The use of botanical antioxidants in skin care products is growing in popularity. A wide range of such agents has been shown to prevent skin cancer in animal model systems. New agents are constantly being investigated; however, only a few have been tested for their efficacy in humans. Animal model and cell culture studies have clarified that antioxidants act by several mechanisms at various stages of skin carcinogenesis. This review focuses on skin cancer photochemopreventive effects of selected botanical antioxidants.
This paper references
10.2340/0001555576264268
Effectiveness of antioxidants (vitamin C and E) with and without sunscreens as topical photoprotectants.
D. Darr (1996)
10.1038/JID.1995.14
Involvement of cytokines, DNA damage, and reactive oxygen intermediates in ultraviolet radiation-induced modulation of intercellular adhesion molecule-1 expression.
J. Krutmann (1995)
10.1562/0031-8655(2002)0750503DOLOLC2.0.CO2
Divergent Optimum Levels of Lycopene, β‐Carotene and Lutein Protecting Against UVB Irradiation in Human Fibroblasts ¶
O. Eichler (2002)
10.1111/j.1751-1097.1997.tb03213.x
UVB‐induced Cyclobutane Pyrimidine Dimer Frequency Correlates with Skin Cancer Mutational Hotspots in p53
R. Drouin (1997)
10.1111/J.1440-0960.1998.TB01251.X
Sunscreens and vitamin E provide some protection to the skin immune system from solar‐simulated UV radiation
G. Halliday (1998)
10.1080/10715760290006501
Scavenging of Benzylperoxyl Radicals by Carotenoids
A. Mortensen (2002)
10.1016/S0041-008X(02)00014-5
Prevention of short-term ultraviolet B radiation-mediated damages by resveratrol in SKH-1 hairless mice.
F. Afaq (2003)
10.1080/01635589209514174
Chemopreventive effect of turmeric against stomach and skin tumors induced by chemical carcinogens in Swiss mice.
M. Azuine (1992)
10.1074/JBC.M107897200
Inhibitory Mechanisms of Tea Polyphenols on the Ultraviolet B-activated Phosphatidylinositol 3-Kinase-dependent Pathway*
M. Nomura (2001)
10.1093/JNCI/69.1.279
Photosensitization by porphyrins and prevention of photosensitization by carotenoids.
M. M. Mathews-Roth (1982)
10.1046/J.0022-202X.2002.01674.X
Oxidative stress-independent depletion of epidermal vitamin A by UVA.
O. Sorg (2002)
10.1093/JNCI/89.8.556
Protective effects of silymarin against photocarcinogenesis in a mouse skin model.
S. Katiyar (1997)
10.1016/s0959-8049(99)00283-x
Skin cancer and solar UV radiation.
F. D. de Gruijl (1999)
10.1007/s11745-998-0216-8
Stoichiometric and kinetic studies on Ginkgo biloba extract and related antioxidants
H. Shi (1998)
10.1159/000064534
Photoprotection of UV-Irradiated Human Skin: An Antioxidative Combination of Vitamins E and C, Carotenoids, Selenium and Proanthocyanidins
Anne-Katrin Greul (2002)
10.1016/S0891-5849(00)00264-1
Biphasic effect of UVA radiation on STAT1 activity and tyrosine phosphorylation in cultured human keratinocytes.
C. Maziére (2000)
10.1007/BF01989795
Dietary carotenoids block photocarcinogenic enhancement by benzo (a)pyrene and inhibit its carcinogenesis in the dark
L. Santamaría (2005)
10.1006/EXCR.2001.5381
Curcumin induces apoptosis in human melanoma cells through a Fas receptor/caspase-8 pathway independent of p53.
J. Bush (2001)
10.1007/BF01689091
Evaluation of mutagenic activity of turmeric extract containing curcumin, before and after activation with mammalian cecal microbial extract of liver microsomal fraction, in the amesSalmonella test
R. Shah (1988)
10.1111/j.1751-1097.1993.tb04954.x
PROTECTION AGAINST ULTRAVIOLET B RADIATION‐INDUCED EFFECTS IN THE SKIN OF SKH‐1 HAIRLESS MICE BY A POLYPHENOLIC FRACTION ISOLATED FROM GREEN TEA
R. Agarwal (1993)
10.1093/CARCIN/20.11.2117
Prevention of UVB-induced immunosuppression in mice by the green tea polyphenol (-)-epigallocatechin-3-gallate may be associated with alterations in IL-10 and IL-12 production.
S. Katiyar (1999)
10.1038/sj.onc.1206206
Inhibition of ultraviolet B-mediated activation of nuclear factor κB in normal human epidermal keratinocytes by green tea Constituent (-)-epigallocatechin-3-gallate
F. Afaq (2003)
Protective effect of alpha-tocopherol in carrier liposomes on ultraviolet-mediated human epidermal cell damage in vitro.
K. Werninghaus (1991)
10.1562/0031-8655(2001)074<0465:ICFRCT>2.0.CO;2
Isoflavonoid Compounds from Red Clover (Trifolium pratense) Protect from Inflammation and Immune Suppression Induced by UV Radiation¶
S. Widyarini (2001)
Induction of superoxide dismutase and catalase activity in different rat tissues and protection from UVB irradiation after topical application of Ginkgo biloba extracts.
S. Lin (1997)
10.1207/S15327914NC330205
Effects of oral administration of tea, decaffeinated tea, and caffeine on the formation and growth of tumors in high-risk SKH-1 mice previously treated with ultraviolet B light.
Y. Lou (1999)
10.1006/TAAP.2001.9261
Novel effects of minocycline on Ca(2+)-dependent Cl(-) secretion in human airway epithelial Calu-3 cells.
Y. Ito (2001)
10.1093/CARCIN/17.11.2367
The chemopreventive flavonoid apigenin induces G2/M arrest in keratinocytes.
D. Lepley (1996)
10.3109/10715769009109673
Studies on the antioxidant and free radical scavenging properties of IdB 1016 a new flavanolignan complex.
A. Comoglio (1990)
10.1111/j.1468-3083.1999.tb00860.x
Plasma antioxidant defense in actinic keratosis and basal cell carcinoma
P. Vural (1999)
10.1093/CARCIN/19.8.1509
Isoflavone genistein inhibits the initiation and promotion of two-stage skin carcinogenesis in mice.
H. Wei (1998)
10.1021/BI9708646
Determination of singlet oxygen-specific versus radical-mediated lipid peroxidation in photosensitized oxidation of lipid bilayers: effect of beta-carotene and alpha-tocopherol.
S. Stratton (1997)
10.1006/TAAP.1999.8721
Cancer chemoprevention: future holds in multiple agents.
H. Mukhtar (1999)
10.1002/(SICI)1098-2744(199902)24:2<79::AID-MC1>3.0.CO;2-E
Inhibition of ultraviolet B–induced c‐fos gene expression and p38 mitogen‐activated protein kinase activation by (‐)‐epigallocatechin gallate in a human keratinocyte cell line
W. Chen (1999)
10.1093/CARCIN/18.8.1617
Inhibition of UVB induced DNA photodamage in mouse epidermis by topically applied alpha-tocopherol.
M. Mcvean (1997)
Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or premalignant lesions
A L Cheng (2001)
10.1111/j.1751-1097.1988.tb01664.x
PHOTOSENSITIZED INACTIVATION OF DNA BY MONOCHROMATIC 334‐nm RADIATION IN THE PRESENCE OF 2‐THIOURACIL: GENETIC ACTIVITY AND BACKBONE BREAKS
M. J. Peak (1988)
10.1016/S0891-5849(98)00132-4
Modulation of UV-light-induced skin inflammation by D-alpha-tocopherol and L-ascorbic acid: a clinical study using solar simulated radiation.
J. Fuchs (1998)
10.1111/j.1751-1097.1977.tb06901.x
EFFECTS OF β‐CAROTENE ON ULTRAVIOLET INDUCED CANCER FORMATION IN THE HAIRLESS MOUSE SKIN
J. H. Epstein (1977)
10.1034/j.1600-0781.2002.00727.x
The effects of EGb 761 on lipid peroxide levels and superoxide dismutase activity in sunburn
M. Ozkur (2002)
10.1016/S1476-5586(03)80019-2
Suppression of ultraviolet B exposure-mediated activation of NF-kappaB in normal human keratinocytes by resveratrol.
V. Adhami (2003)
10.1159/000246276
Enhancing effect of ultraviolet A on ornithine decarboxylase induction and dermatitis evoked by 12-o-tetradecanoylphorbol-13-acetate and its inhibition by curcumin in mouse skin.
C. Ishizaki (1996)
10.1111/1523-1747.EP12339344
Antioxidant nutrients protect against UVB-induced oxidative damage to DNA of mouse keratinocytes in culture.
M. S. Stewart (1996)
10.1002/(SICI)1098-2744(199707)19:2<74::AID-MC2>3.0.CO;2-L
Induction of p21/WAF1 and G1 cell‐cycle arrest by the chemopreventive agent apigenin
D. Lepley (1997)
10.1207/S15327914nc392_20
Differential Responses of Skin Cancer-Chemopreventive Agents Silibinin, Quercetin, and Epigallocatechin 3-Gallate on Mitogenic Signaling and Cell Cycle Regulators in Human Epidermoid Carcinoma A431 Cells
N. Bhatia (2001)
10.1186/1471-2326-2-3
Aged garlic extract therapy for sickle cell anemia patients
J. Takasu (2002)
10.1111/1523-1747.EP12276349
Vitamin C abrogates the deleterious effects of UVB radiation on cutaneous immunity by a mechanism that does not depend on TNF-alpha.
T. Nakamura (1997)
10.1111/j.1751-1097.1992.tb09598.x
EFFECT OF VITAMIN E ON CYTOTOXICITY, DNA SINGLE STRAND BREAKS, CHROMOSOMAL ABERRATIONS, AND MUTATION IN CHINESE HAMSTER V‐79 CELLS EXPOSED TO ULTRAVIOLET‐B LIGHT
M. Sugiyama (1992)
10.1007/S003940070010
Bioavailability and potency of natural-source and all-racemicα-tocopherol in the human: a dispute
P. P. Hoppe (2000)
10.1177/030089168707300105
Turmeric and Curcumin as Topical Agents in Cancer Therapy
R. Kuttan (1987)
10.3892/IJO.21.6.1213
Treatment of silymarin, a plant flavonoid, prevents ultraviolet light-induced immune suppression and oxidative stress in mouse skin.
S. Katiyar (2002)
10.1159/000047945
Neuropsychological Sequelae of Patients Treated with Microsurgical Clipping or Endovascular Embolization for Anterior Communicating Artery Aneurysm
A. Chan (2002)
10.1034/j.1600-0625.2001.010003204.x
UV‐A‐induced AP‐1 activation requires the Raf/ERK pathway in human NCTC 2544 keratinocytes
M. Djavaheri-Mergny (2001)
10.1562/0031-8655(2002)075<0503:DOLOLC>2.0.CO;2
Divergent Optimum Levels of Lycopene, β-Carotene and Lutein Protecting Against UVB Irradiation in Human Fibroblasts¶
O. Eichler (2002)
10.1080/10408399709527797
The chemistry of tea flavonoids.
D. A. Balentine (1997)
10.1002/(SICI)1097-4644(1997)27+<26::AID-JCB7>3.0.CO;2-3
Inhibitory effects of curcumin on tumorigenesis in mice
M. Huang (1997)
10.1126/SCIENCE.6710156
beta-Carotene: an unusual type of lipid antioxidant.
G. W. Burton (1984)
10.1016/S0027-5107(98)00192-4
Protection by black tea and green tea against UVB and UVA + B induced skin cancer in hairless mice.
I. Record (1998)
10.1067/MJD.2001.112919
Cutaneous photoprotection from ultraviolet injury by green tea polyphenols.
C. Elmets (2001)
10.1093/AJCN/71.3.795
Carotenoids and carotenoids plus vitamin E protect against ultraviolet light-induced erythema in humans.
W. Stahl (2000)
10.1159/000060651
The antioxidant network of the stratum corneum.
J. Thiele (2001)
10.1007/S00216-002-1436-2
Analysis of flavonoids in Ginkgo biloba L. and its phytopharmaceuticals by capillary electrophoresis with electrochemical detection
Y. Cao (2002)
10.1159/000060656
UV-induced oxidative stress and photoaging.
J. Wenk (2001)
Inhibitory effect of curcumin, chlorogenic acid, caffeic acid, and ferulic acid on tumor promotion in mouse skin by 12-O-tetradecanoylphorbol-13-acetate.
M. Huang (1988)
10.1046/j.1365-2133.1999.02897.x
Ultraviolet irradiation induces cyclooxygenase‐2 expression in keratinocytes
Isoherranen (1999)
10.1073/pnas.182429899
Topical applications of caffeine or (−)-epigallocatechin gallate (EGCG) inhibit carcinogenesis and selectively increase apoptosis in UVB-induced skin tumors in mice
Yao-Ping Lu (2002)
10.1034/j.1600-0781.2001.017002071.x
Effect of ultraviolet A on ornithine decarboxylase and metallothionein gene expression in mouse skin
T. Oguro (2001)
10.1002/1098-2744(200007)28:3<148::AID-MC3>3.0.CO;2-Q
Inhibition of Ultraviolet B–Induced AP‐1 Activation by Theaflavins From Black Tea
M. Nomura (2000)
10.1562/0031-8655(2002)076<0073:CEIMAH>2.0.CO;2
Cyclooxygenase-2 Expression in Murine and Human Nonmelanoma Skin Cancers: Implications for Therapeutic Approaches¶
K. An (2002)
10.1159/000064533
Photochemoprevention by Botanical Antioxidants
F. Afaq (2002)
10.1016/S0014-5793(97)00748-5
Active oxygen species mediate the solar ultraviolet radiation‐dependent increase in the tumour suppressor protein p53 in human skin fibroblasts
G. Vile (1997)
10.1021/JF020408A
Antioxidant activities and phenolic composition of extracts from Greek oregano, Greek sage, and summer savory.
V. Exarchou (2002)
10.1038/361153A0
Disease resistance results from foreign phytoalexin expression in a novel plant
R. Hain (1993)
10.2741/a811
Botanical antioxidants for chemoprevention of photocarcinogenesis.
F. Afaq (2002)
10.1016/S0009-2797(96)03739-8
Inhibition of glutathione S-transferase activity in human melanoma cells by alpha,beta-unsaturated carbonyl derivatives. Effects of acrolein, cinnamaldehyde, citral, crotonaldehyde, curcumin, ethacrynic acid, and trans-2-hexenal.
M. Iersel (1996)
Inhibitory effects of curcumin on in vitro lipoxygenase and cyclooxygenase activities in mouse epidermis.
M. Huang (1991)
10.1189/jlb.69.5.719
Green tea polyphenol (−)‐epigallocatechin‐3‐gallate treatment to mouse skin prevents UVB‐induced infiltration of leukocytes, depletion of antigen‐presenting cells, and oxidative stress
S. Katiyar (2001)
10.2741/A830
Pro-oxidant and anti-oxidant mechanism(s) of BHT and beta-carotene in photocarcinogenesis.
H. Black (2002)
10.1111/j.2042-7158.1997.tb06134.x
Garlic Compounds Protect Vascular Endothelial Cells from Oxidized Low Density Lipoprotein‐induced Injury
N. Ide (1997)
10.1016/S0378-8741(01)00379-8
Antioxidant and photoprotective activity of a crude extract of Culcitium reflexum H.B.K. leaves and their major flavonoids.
R. Aquino (2002)
[The chemistry and analysis of silymarin from Silybum marianum Gaertn].
H. Wagner (1974)
Inhibitory effects of orally administered green tea, black tea, and caffeine on skin carcinogenesis in mice previously treated with ultraviolet B light (high-risk mice): relationship to decreased tissue fat.
Y. Lu (2001)
10.1126/SCIENCE.275.5297.218
Cancer Chemopreventive Activity of Resveratrol, a Natural Product Derived from Grapes
M. Jang (1997)
10.1016/S0304-3835(97)00187-0
Inhibitory effect of dietary curcumin on skin carcinogenesis in mice.
P. Limtrakul (1997)
10.1074/JBC.272.15.9962
Inhibition of Activator Protein 1 Activity and Neoplastic Transformation by Aspirin*
Z. Dong (1997)
10.1111/j.1751-1097.1985.tb03544.x
CAROTENOID DOSE LEVEL and PROTECTION AGAINST UV‐B INDUCED SKIN TUMORS
M. Mathews-Roth (1985)
10.1016/S0014-5793(01)03169-6
The effect of β‐carotene on the expression of interleukin‐6 and heme oxygenase‐1 in UV‐irradiated human skin fibroblasts in vitro
U. Obermueller-Jevic (2001)
Protective effect of dl-alpha-tocopherol on the cytotoxicity of ultraviolet B against human skin fibroblasts in vitro.
S. Kondo (1990)
10.1016/s0021-9673(02)00172-3
Chemical analysis of Ginkgo biloba leaves and extracts.
T. V. van Beek (2002)
Wavelength dependence of skin cancer induction by ultraviolet irradiation of albino hairless mice.
F. D. de Gruijl (1993)
Green tea polyphenol treatment to human skin prevents formation of ultraviolet light B-induced pyrimidine dimers in DNA.
S. Katiyar (2000)
10.1016/S0891-5849(98)00212-3
Antioxidants modulate acute solar ultraviolet radiation-induced NF-kappa-B activation in a human keratinocyte cell line.
C. Saliou (1999)
10.1074/jbc.273.34.21875
Resveratrol Inhibits Cyclooxygenase-2 Transcription and Activity in Phorbol Ester-treated Human Mammary Epithelial Cells*
K. Subbaramaiah (1998)
Prevention of skin neoplasia by resveratrol: involvement of nuclear transcription factor NF-kB
V M Adhami (2003)
10.1016/s0021-9258(17)41895-3
Ultraviolet B injury increases prostaglandin synthesis through a tyrosine kinase-dependent pathway. Evidence for UVB-induced epidermal growth factor receptor activation.
C. C. Miller (1994)
10.1093/CARCIN/19.4.663
Potentiating effect of dietary vitamin A on photocarcinogenesis in hairless mice.
S. Mikkelsen (1998)
In vitro antioxidant and in vivo photoprotective effects of a lyophilized extract of Capparis spinosa L buds.
F. Bonina (2002)
10.1093/CARCIN/19.12.2201
(-)-Epigallocatechin-3-gallate inhibition of ultraviolet B-induced AP-1 activity.
M. Barthelman (1998)
10.1179/135100000101535555
Protective effect of isoflavone derivative against photocarcinogenesis in a mouse model
S. Widyarini (2000)
10.1042/0264-6021:3560077
Induction of gene expression via activator protein-1 in the ascorbate protection against UV-induced damage.
M. Catani (2001)
10.1093/CARCIN/14.2.293
Inhibitory effect of curcumin on 12-O-tetradecanoylphorbol-13-acetate-induced increase in ornithine decarboxylase mRNA in mouse epidermis.
Y. Lu (1993)
10.2188/JEA.9.6SUP_7
Sun exposure, skin cancers and related skin conditions.
A. Green (1999)
10.1046/J.1523-1747.2002.00077.X
Parameters related to oxygen free radicals in human skin: a study comparing healthy epidermis and skin cancer tissue.
M. R. Nogués (2002)
10.1093/AJCN/67.2.255
Effects of the flavonoids quercetin and apigenin on hemostasis in healthy volunteers: results from an in vitro and a dietary supplement study.
K. Janssen (1998)
10.1002/mc.10016
A p21waf1‐independent pathway for inhibitory phosphorylation of cyclin‐dependent kinase p34cdc2 and concomitant G2/M arrest by the chemopreventive flavonoid apigenin
M. Mcvean (2002)
10.1093/jn/131.3.955S
Intake of garlic and its bioactive components.
H. Amagase (2001)
Chemical exposures, medical history, and risk of squamous and basal cell carcinoma of the skin.
R. Gallagher (1996)
10.1111/j.1346-8138.2000.tb02259.x
Novel Approaches to Chemoprevention of Skin Cancer
D. Bickers (2000)
10.1046/j.1365-2133.1996.d01-732.x
UVA‐induced immune suppression in human skin: protective effect of vitamin E in human epidermal cells in vitro
P. Clément-Lacroix (1996)
10.1016/0091-7435(92)90042-G
Tea components: antimutagenic and anticarcinogenic effects.
H. Mukhtar (1992)
10.1055/S-2006-959522
Antioxidant and radical scavenging effects of aged garlic extract and its constituents.
J. Imai (1994)
10.1016/S0891-5849(98)00311-6
Ascorbic acid maintenance in HaCaT cells prevents radical formation and apoptosis by UV-B.
I. Savini (1999)
10.1089/15230860260220166
Flavonoid antioxidant silymarin and skin cancer.
R. Singh (2002)
10.1159/000056329
Protective Effects of (–)-Epigallocatechin-3-Gallate on UVA- and UVB-Induced Skin Damage
J. Kim (2001)
Induction of superoxide dismutase and catalase activity in different rat tissues and protection from UVB irradiation after topical application of Ginkgo biloba extracts.
Lin Sy (1997)
10.1111/j.1751-1097.1993.tb04975.x
A GARLIC EXTRACT PROTECTS FROM ULTRAVIOLET B (280–320 nm) RADIATION‐INDUCED SUPPRESSION OF CONTACT HYPERSENSITIVITY
V. Reeve (1993)
10.1111/j.1751-1097.1999.tb03267.x
Polyphenolic Antioxidant (‐)‐Epigallocatechin‐3‐Gallate from Green Tea Reduces UVB‐lnduced Inflammatory Responses and Infiltration of Leukocytes in Human Skin
S. Katiyar (1999)
10.1080/000155502753600830
UVB photoprotection with antioxidants: effects of oral therapy with d-alpha-tocopherol and ascorbic acid on the minimal erythema dose.
Homero Mireles-Rocha (2002)
10.1093/CARCIN/23.3.499
Silymarin inhibits growth and causes regression of established skin tumors in SENCAR mice via modulation of mitogen-activated protein kinases and induction of apoptosis.
R. Singh (2002)
10.1046/J.1523-1747.1999.00467.X
UVA-induced immune suppression through an oxidative pathway.
I. Iwai (1999)
10.1111/j.1349-7006.1998.tb00572.x
Inhibitory Effects of Curcumin and Tetrahydrocurcuminoids on the Tumor Promoter‐induced Reactive Oxygen Species Generation in Leukocytes in vitro and in vivo
Y. Nakamura (1998)
10.1111/j.1440-1681.1997.tb01813.x
ANTI‐AGEING EFFECT OF AGED GARLIC EXTRACT IN THE INBRED BRAIN ATROPHY MOUSE MODEL
T. Moriguchi (1997)
10.1111/j.1751-1097.1965.tb07923.x
THE RELATIONSHIP BETWEEN CAROTENOID PIGMENTS AND RESISTANCE TO RADIATION IN NON‐PHOTOSYNTHETIC BACTERIA
M. Mathews (1965)
Antioxidant properties of fractions and polyphenol constituents from green, oolong and black teas.
B. Xie (1993)
Effects of beta-carotene on ultraviolet induced cancer formation in the hairless mouse skin.
J. Epstein (1977)
Inhibitory effect of green tea on the growth of established skin papillomas in mice.
Z. Wang (1992)
10.3322/CANJCLIN.47.1.5
Cancer statistics, 1997
S. Parker (1997)
10.1016/S0378-5173(00)00358-6
In vitro and in vivo evaluation of caffeic and ferulic acids as topical photoprotective agents.
A. Saija (2000)
10.1159/000064532
Carotenoids and Protection against Solar UV Radiation
W. Stahl (2002)
Green tea constituent (±)± epigallocatechin-3-gallate inhibits ultraviolet B-mediated activation of nuclear factor kappa B signaling pathway in normal human epidermal keratinocytes
F Afaq (2003)
10.1038/SCIENTIFICAMERICAN0385-114
The chemistry of garlic and onions.
E. Block (1985)
10.1016/0065-2571(91)90025-H
Inhibitory effect of curcumin and some related dietary compounds on tumor promotion and arachidonic acid metabolism in mouse skin.
A. Conney (1991)
10.1016/1011-1344(92)85019-Q
Beta-carotene does not act as an optical filter in skin.
R. Sayre (1992)
10.1093/CARCIN/19.4.649
Inhibition of ultraviolet B (UVB)-induced c-fos and c-jun expression in vivo by a tyrosine kinase inhibitor genistein.
Y. Wang (1998)
Inhibition of ultraviolet light induced skin carcinogenesis in SKH-1 mice by apigenin, a plant flavonoid.
D. Birt (1997)
10.1080/01635589709514625
Inhibition of cyclobutane pyrimidine dimer formation in epidermal p53 gene of UV-irradiated mice by alpha-tocopherol.
W. Chen (1997)
10.1021/JF011097R
Phenolic compounds and antioxidant capacity of Georgia-grown blueberries and blackberries.
S. Sellappan (2002)
10.1002/mc.10055
Protective effect of vitamin E on ultraviolet B light–induced damage in keratinocytes
Samar Maalouf (2002)
10.3727/096504002108747944
Inhibition of mouse skin tumor promotion by anti-inflammatory diarylheptanoids derived from Alpinia oxyphylla Miquel (Zingiberaceae).
Kyung-soo Chun (2002)
Ultraviolet A radiation-induced expression of human genes: molecular and photobiological mechanisms.
S. Grether-Beck (1997)
10.1093/JN/126.4.817
Dietary components modify the ability of garlic to suppress 7,12-dimethylbenz(a)anthracene-induced mammary DNA adducts.
H. Amagase (1996)
10.1111/1523-1747.EP12335984
Epidermal proliferation but not quantity of DNA photodamage is correlated with UV-induced mouse skin carcinogenesis.
T. Berton (1997)
10.1001/ARCHDERM.1994.01690100041005
Evaluation of the photoprotective effect of oral vitamin E supplementation.
K. Werninghaus (1994)
10.1056/NEJM199009203231204
A clinical trial of beta carotene to prevent basal-cell and squamous-cell cancers of the skin. The Skin Cancer Prevention Study Group.
E. R. Greenberg (1990)
10.1111/j.1751-1097.1997.tb08610.x
α‐Tocopherol, an Inhibitor of Epidermal Lipid Peroxidation, Prevents Ultraviolet Radiation from Suppressing the Skin Immune System
K. S. Yuen (1997)
10.1093/CARCIN/21.4.633
Increase in wild-type p53 stability and transactivational activity by the chemopreventive agent apigenin in keratinocytes.
M. Mcvean (2000)
10.1016/J.JAAD.2004.12.044
Green tea and the skin.
S. Hsu (2005)
Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions.
A. Cheng (2001)
Stimulatory effect of oral administration of green tea or caffeine on ultraviolet light-induced increases in epidermal wild-type p53, p21(WAF1/CIP1), and apoptotic sunburn cells in SKH-1 mice.
Y. Lu (2000)
10.1046/J.1523-1747.1998.00352.X
Curcumin induces a p53-dependent apoptosis in human basal cell carcinoma cells.
S. H. Jee (1998)
10.1093/CARCIN/18.1.89
Biological activities of natural and synthetic carotenoids: induction of gap junctional communication and singlet oxygen quenching.
W. Stahl (1997)
10.1080/01635589309514265
Inhibition of tumor promoter-induced hydrogen peroxide formation in vitro and in vivo by genistein.
H. Wei (1993)



This paper is referenced by
10.4062/biomolther.2014.006
The Polyphenol Chlorogenic Acid Attenuates UVB-mediated Oxidative Stress in Human HaCaT Keratinocytes
J. Cha (2014)
10.1016/j.fct.2016.07.034
UVB exposure enhanced benzanthrone-induced inflammatory responses in SKH-1 mouse skin by activating the expression of COX-2 and iNOS through MAP kinases/NF-κB/AP-1 signalling pathways.
S. Abbas (2016)
10.1111/jcmm.12968
Thymus vulgaris alleviates UVB irradiation induced skin damage via inhibition of MAPK/AP‐1 and activation of Nrf2‐ARE antioxidant system
Zhengwang Sun (2017)
PLANEJAMENTO, SÍNTESE E AVALIAÇÃO FOTOPROTETORA DE NOVOS COMPOSTOS HÍBRIDOS DERIVADOS DO RESVERATROL, CINAMATOS E AVOBENZONA PLANEJADOS COMO FILTROS SOLARES
Mesquita Filho (2014)
10.4236/JCDSA.2014.43027
Antioxidant Activity of Cosmetic Formulations Based on Novel Extracts from Seeds of Brazilian Araucaria angustifolia (Bertoll) Kuntze
Gabriela Sprada Tavares da Mota (2014)
10.1016/j.carbpol.2015.08.038
Pinhão starch and coat extract as new natural cosmetic ingredients: Topical formulation stability and sensory analysis.
Renata Moschini Daudt (2015)
10.1371/journal.pone.0103248
Biotransformed Soybean Extract (BSE) Inhibits Melanoma Cell Growth and Viability In Vitro: Involvement of Nuclear Factor-Kappa B Signaling
F. Vilela (2014)
10.1039/c9fo00706g
Anthocyanins from black peanut skin protect against UV-B induced keratinocyte cell and skin oxidative damage through activating Nrf 2 signaling.
Kaikai Li (2019)
10.1111/j.1473-2165.2008.00369.x
Novel approaches in herbal cosmetics
Deep Chanchal (2008)
10.3109/09553002.2010.501842
Solar radiation induced skin damage: Review of protective and preventive options
A. Svobodová (2010)
10.5657/KFAS.2017.0714
Protective Effects of Ecklonia cava Film on UV-B-induced Photodamages
H. G. Lee (2017)
10.1111/php.12543
Novel In Vitro Antioxidant and Photoprotection Capacity of Plants from High Altitude Ecosystems of Colombia
Juan C Mejía-Giraldo (2016)
10.1016/J.MRGENTOX.2005.04.003
Protective effect of apigenin on radiation-induced chromosomal damage in human lymphocytes.
K. Rithidech (2005)
10.1046/j.1439-0353.2004.04052.x
Alpha‐Glucosylrutin: ein hochwirksames Flavonoid zum Schutz vor oxidativem Streß
R. Wolber (2004)
10.4103/0973-7847.65319
Phytoconstituents as photoprotective novel cosmetic formulations
S. Saraf (2010)
10.1038/SJ.JID.5700340
Oxidative stress in the pathogenesis of skin disease.
D. Bickers (2006)
10.1007/s12291-012-0278-8
Oxidative Stress and Skin Cancer: An Overview
R. T. Narendhirakannan (2012)
10.1111/j.1600-0625.2006.00466.x
Botanical antioxidants in the prevention of photocarcinogenesis and photoaging
F. Afaq (2006)
AVALIAÇÃO DO EFEITO FOTOPROTETOR DE TRÊS EXTRATOS DE PLANTAS DA ANTÁRTICA POR DIFERENTES MODELOS BIOLÓGICOS
B. K. Pereira (2007)
10.1007/S00394-006-0627-6
Consumption of flavanol-rich cocoa acutely increases microcirculation in human skin
Karin Neukam (2007)
10.3923/rjmp.2015.435.441
Screening of UVA/UVB Absorption and in vitro Antioxidant Capacity of Bejaria aestuans, Cavendishia pubescens and Cavendishia bracteata Leaf Extracts
Miguel Angel Puertas-Me (2015)
10.1016/J.MRFMMM.2004.07.019
Photochemoprevention of ultraviolet B signaling and photocarcinogenesis.
F. Afaq (2005)
10.1562/2005-10-14-RA-715
In Vitro Antioxidant and In Vivo Photoprotective Effects of an Association of Bioflavonoids with Liposoluble Vitamins
P. M. Maia Campos (2006)
Evaluación antioxidante y antienzimática in vitro y antiinflamatoria in vivo del extracto hidroalcohólico de la Caesalpinia spinosa “tara”
Wilder Javier Nuñez Enero (2015)
10.1080/15569520902784014
Photoprotective effect of Pothomorphe umbellata on UVB radiation-induced biomarkers involved in carcinogenesis of hairless mouse epidermis
V. V. da Silva (2009)
10.1002/ptr.6100
Paeonol extracted from Paeonia suffruticosa Andr. ameliorated UVB‐induced skin photoaging via DLD/Nrf2/ARE and MAPK/AP‐1 pathway
Zhengwang Sun (2018)
10.3389/fphar.2018.00392
Natural Antioxidants: Multiple Mechanisms to Protect Skin From Solar Radiation
Spencer Dunaway (2018)
10.1007/s13596-012-0069-z
Formulation, characterization and in vitro evaluation of herbal sunscreen lotion
Arun Rasheed (2012)
10.1093/CARCIN/BGM070
Involvement of ERKs, RSK2 and PKR in UVA-induced signal transduction toward phosphorylation of eIF2alpha (Ser(51)).
T. Zykova (2007)
10.1016/J.MEHY.2005.12.025
An adjunctive preventive treatment for cancer: ultraviolet light and ginkgo biloba, together with other antioxidants, are a safe and powerful, but largely ignored, treatment option for the prevention of cancer.
R. Eli (2006)
The dermatoxicological profile of Labisia pumila extract for cosmetic application
Nurain Ali (2014)
10.4314/AJB.V4I2.15066
Antioxidant potential of African medicinal plants
S. E. Atawodi (2005)
See more
Semantic Scholar Logo Some data provided by SemanticScholar